SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P31002

- IMDH_ACICA

UniProt

P31002 - IMDH_ACICA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Inosine-5'-monophosphate dehydrogenase
Gene
guaB
Organism
Acinetobacter calcoaceticus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei247 – 2471NAD By similarity
Metal bindingi299 – 2991Potassium; via carbonyl oxygen By similarity
Metal bindingi301 – 3011Potassium; via carbonyl oxygen By similarity
Binding sitei302 – 3021IMP By similarity
Active sitei304 – 3041Thioimidate intermediate By similarity
Metal bindingi304 – 3041Potassium; via carbonyl oxygen By similarity
Binding sitei416 – 4161IMP By similarity
Metal bindingi470 – 4701Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi471 – 4711Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi472 – 4721Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi297 – 2993NAD By similarity

GO - Molecular functioni

  1. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  2. adenyl nucleotide binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
OrganismiAcinetobacter calcoaceticus
Taxonomic identifieri471 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Inosine-5'-monophosphate dehydrogenaseUniRule annotation
PRO_0000093688Add
BLAST

Proteomic databases

PRIDEiP31002.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP31002.
SMRiP31002. Positions 4-486.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 14856CBS 1
Add
BLAST
Domaini152 – 21059CBS 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni336 – 3383IMP binding By similarity
Regioni359 – 3602IMP binding By similarity
Regioni383 – 3875IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31002-1 [UniParc]FASTAAdd to Basket

« Hide

MLTIVQEALT FDDVLLLPAY STVLPKDVSL KTRLTRGIYL NIPLVSAAMD    50
TVTESRMAIA MAQNGGIGIL HKNMDIAAQA AEVRRVKKFE AGMVKDPITV 100
SPETTVRELI AITSANNISG VPVVKDSKVV GIVTGRDTRF ETNLEQPVSN 150
IMTGQDRLVT VREGESKENI QALLQKHRIE KVLVVGESNE LKGLITVTDF 200
RKAESYPNSC KDDLGRLRVG AAVGTGADTP SRVEALVEAG VDVIVVDTAH 250
GHSAGVIERV RWVKQNFPQV QVIGGNIATG DAALALLDAG ADAVKVGIGP 300
GSICTTRIVA GIGMPQISAI DSVASALKDQ IPLIADGGIP FSGDMAKAIG 350
AGASTIMVGS LLAGTEEAPG EVEFFQGRYY KAYRGMGSLG AMAGRTGSAD 400
RYFQDSKAGA EKLVPEGIEG RVPYKGPMGN IVHQMMGGLR SSMGYTGSAV 450
IEDLRQNAKF VKITSAGMSE SHVHDVTITK EAPNYRVG 488
Length:488
Mass (Da):51,530
Last modified:July 1, 1993 - v1
Checksum:i3DE0F8F9B5157A03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66859 Genomic DNA. Translation: CAA47328.1.
PIRiS23226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66859 Genomic DNA. Translation: CAA47328.1 .
PIRi S23226.

3D structure databases

ProteinModelPortali P31002.
SMRi P31002. Positions 4-486.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P31002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Anderegg U., Schnuck W.H., Asperger O., Kleber H.-P.
    Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EB 104.

Entry informationi

Entry nameiIMDH_ACICA
AccessioniPrimary (citable) accession number: P31002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi