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P31001

- DESM_MOUSE

UniProt

P31001 - DESM_MOUSE

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Protein

Desmin

Gene

Des

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei353 – 3531Stutter

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: MGI

GO - Biological processi

  1. muscle organ development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Desmin
Gene namesi
Name:Des
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:94885. Des.

Subcellular locationi

GO - Cellular componenti

  1. contractile fiber Source: MGI
  2. cytoplasm Source: MGI
  3. cytoskeleton Source: MGI
  4. fascia adherens Source: MGI
  5. intermediate filament Source: UniProtKB-KW
  6. intracellular Source: MGI
  7. neuromuscular junction Source: MGI
  8. sarcolemma Source: MGI
  9. Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469DesminPRO_0000063773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphoserine; by AURKBBy similarity
Modified residuei17 – 171Phosphothreonine; by AURKBBy similarity
Modified residuei58 – 581ADP-ribosylarginineBy similarity
Modified residuei60 – 601Phosphoserine; by AURKBBy similarity
Modified residuei68 – 681Phosphoserine1 Publication

Post-translational modificationi

ADP-ribosylation prevents ability to form intermediate filaments.By similarity

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Proteomic databases

MaxQBiP31001.
PaxDbiP31001.
PRIDEiP31001.

2D gel databases

SWISS-2DPAGEP31001.

PTM databases

PhosphoSiteiP31001.

Miscellaneous databases

PMAP-CutDBP31001.

Expressioni

Gene expression databases

BgeeiP31001.
CleanExiMM_DES.
ExpressionAtlasiP31001. baseline and differential.
GenevestigatoriP31001.

Interactioni

Subunit structurei

Homopolymer. Interacts with MTM1 (By similarity). Interacts with DST.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MTM1Q134964EBI-298565,EBI-2864109From a different organism.
Mtm1Q9Z2C54EBI-298565,EBI-6861578

Protein-protein interaction databases

BioGridi199210. 3 interactions.
DIPiDIP-256N.
IntActiP31001. 6 interactions.
MINTiMINT-220806.

Structurei

3D structure databases

ProteinModelPortaliP31001.
SMRiP31001. Positions 103-252, 267-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 108108HeadAdd
BLAST
Regioni109 – 411303RodAdd
BLAST
Regioni109 – 14032Coil 1AAdd
BLAST
Regioni141 – 15010Linker 1
Regioni151 – 251101Coil 1BAdd
BLAST
Regioni252 – 26716Linker 12Add
BLAST
Regioni268 – 28619Coil 2AAdd
BLAST
Regioni287 – 2948Linker 2
Regioni295 – 411117Coil 2BAdd
BLAST
Regioni412 – 46958TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 484Poly-Ser

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG147125.
HOGENOMiHOG000230977.
HOVERGENiHBG013015.
InParanoidiP31001.
KOiK07610.
OMAiSSEMHSK.
OrthoDBiEOG7FV3Q8.
PhylomeDBiP31001.
TreeFamiTF330122.

Family and domain databases

InterProiIPR027698. DES.
IPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF28. PTHR23239:SF28. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31001-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQAYSSSQR VSSYRRTFGG APGFSLGSPL SSPVFPRAGF GTKGSSSSMT
60 70 80 90 100
SRVYQVSRTS GGAGGLGSLR SSRLGTTRAP SYGAGELLDF SLADAVNQEF
110 120 130 140 150
LATRTNEKVE LQELNDRFAN YIEKVRFLEQ QNAALAAEVN RLKGREPTRV
160 170 180 190 200
AELYEEEMRE LRRQVEVLTN QRARVDVERD NLIDDLQRLK AKLQEEIQLR
210 220 230 240 250
EEAENNLAAF RADVDAATLA RIDLERRIES LNEEIAFLKK VHEEEIRELQ
260 270 280 290 300
AQLQEQQVQV EMDMSKPDLT AALRDIRAQY ETIAAKNISE AEEWYKSKVS
310 320 330 340 350
DLTQAANKNN DALRQAKQEM MEYRHQIQSY TCEIDALKGT NDSLMRQMRE
360 370 380 390 400
LEDRFASEAN GYQDNIARLE EEIRHLKDEM ARHLREYQDL LNVKMALDVE
410 420 430 440 450
IATYRKLLEG EESRINLPIQ TFSALNFRET SPEQRGSEVH TKKTVMIKTI
460
ETRDGEVVSE ATQQQHEVL
Length:469
Mass (Da):53,498
Last modified:January 23, 2007 - v3
Checksum:i58A8A13C7CC11EEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22550 mRNA. No translation available.
BC031760 mRNA. Translation: AAH31760.1.
Z18892 Genomic DNA. Translation: CAA79330.1.
CCDSiCCDS15071.1.
PIRiA54104.
RefSeqiNP_034173.1. NM_010043.2.
UniGeneiMm.6712.

Genome annotation databases

EnsembliENSMUST00000027409; ENSMUSP00000027409; ENSMUSG00000026208.
GeneIDi13346.
KEGGimmu:13346.
UCSCiuc007box.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22550 mRNA. No translation available.
BC031760 mRNA. Translation: AAH31760.1 .
Z18892 Genomic DNA. Translation: CAA79330.1 .
CCDSi CCDS15071.1.
PIRi A54104.
RefSeqi NP_034173.1. NM_010043.2.
UniGenei Mm.6712.

3D structure databases

ProteinModelPortali P31001.
SMRi P31001. Positions 103-252, 267-410.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199210. 3 interactions.
DIPi DIP-256N.
IntActi P31001. 6 interactions.
MINTi MINT-220806.

PTM databases

PhosphoSitei P31001.

2D gel databases

SWISS-2DPAGE P31001.

Proteomic databases

MaxQBi P31001.
PaxDbi P31001.
PRIDEi P31001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027409 ; ENSMUSP00000027409 ; ENSMUSG00000026208 .
GeneIDi 13346.
KEGGi mmu:13346.
UCSCi uc007box.1. mouse.

Organism-specific databases

CTDi 1674.
MGIi MGI:94885. Des.

Phylogenomic databases

eggNOGi NOG147125.
HOGENOMi HOG000230977.
HOVERGENi HBG013015.
InParanoidi P31001.
KOi K07610.
OMAi SSEMHSK.
OrthoDBi EOG7FV3Q8.
PhylomeDBi P31001.
TreeFami TF330122.

Miscellaneous databases

NextBioi 283662.
PMAP-CutDB P31001.
PROi P31001.
SOURCEi Search...

Gene expression databases

Bgeei P31001.
CleanExi MM_DES.
ExpressionAtlasi P31001. baseline and differential.
Genevestigatori P31001.

Family and domain databases

InterProi IPR027698. DES.
IPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
PTHR23239:SF28. PTHR23239:SF28. 1 hit.
Pfami PF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view ]
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin."
    Li H., Choudhary S.K., Milner D.J., Munir M.I., Kuisk I.R., Capetanaki Y.
    J. Cell Biol. 124:827-841(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Regulation of the mouse desmin gene: transactivated by MyoD, myogenin, MRF4 and Myf5."
    Li H., Capetanaki Y.
    Nucleic Acids Res. 21:335-343(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.
    Strain: BALB/c.
    Tissue: Spleen.
  4. "Dystonin-deficient mice exhibit an intrinsic muscle weakness and an instability of skeletal muscle cytoarchitecture."
    Dalpe G., Mathieu M., Comtois A., Zhu E., Wasiak S., De Repentigny Y., Leclerc N., Kothary R.
    Dev. Biol. 210:367-380(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DST.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDESM_MOUSE
AccessioniPrimary (citable) accession number: P31001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3