Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P31001

- DESM_MOUSE

UniProt

P31001 - DESM_MOUSE

Protein

Desmin

Gene

Des

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei353 – 3531Stutter

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. structural constituent of cytoskeleton Source: MGI

    GO - Biological processi

    1. muscle organ development Source: MGI

    Keywords - Molecular functioni

    Muscle protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Desmin
    Gene namesi
    Name:Des
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:94885. Des.

    Subcellular locationi

    GO - Cellular componenti

    1. contractile fiber Source: MGI
    2. cytoplasm Source: MGI
    3. cytoskeleton Source: MGI
    4. fascia adherens Source: MGI
    5. intermediate filament Source: UniProtKB-KW
    6. intracellular Source: MGI
    7. neuromuscular junction Source: MGI
    8. sarcolemma Source: MGI
    9. Z disc Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Intermediate filament

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469DesminPRO_0000063773Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121Phosphoserine; by AURKBBy similarity
    Modified residuei17 – 171Phosphothreonine; by AURKBBy similarity
    Modified residuei58 – 581ADP-ribosylarginineBy similarity
    Modified residuei60 – 601Phosphoserine; by AURKBBy similarity
    Modified residuei68 – 681Phosphoserine1 Publication

    Post-translational modificationi

    ADP-ribosylation prevents ability to form intermediate filaments.By similarity

    Keywords - PTMi

    ADP-ribosylation, Phosphoprotein

    Proteomic databases

    MaxQBiP31001.
    PaxDbiP31001.
    PRIDEiP31001.

    2D gel databases

    SWISS-2DPAGEP31001.

    PTM databases

    PhosphoSiteiP31001.

    Miscellaneous databases

    PMAP-CutDBP31001.

    Expressioni

    Gene expression databases

    ArrayExpressiP31001.
    BgeeiP31001.
    CleanExiMM_DES.
    GenevestigatoriP31001.

    Interactioni

    Subunit structurei

    Homopolymer. Interacts with MTM1 By similarity. Interacts with DST.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MTM1Q134964EBI-298565,EBI-2864109From a different organism.
    Mtm1Q9Z2C54EBI-298565,EBI-6861578

    Protein-protein interaction databases

    BioGridi199210. 3 interactions.
    DIPiDIP-256N.
    IntActiP31001. 6 interactions.
    MINTiMINT-220806.

    Structurei

    3D structure databases

    ProteinModelPortaliP31001.
    SMRiP31001. Positions 103-252, 267-410.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 108108HeadAdd
    BLAST
    Regioni109 – 411303RodAdd
    BLAST
    Regioni109 – 14032Coil 1AAdd
    BLAST
    Regioni141 – 15010Linker 1
    Regioni151 – 251101Coil 1BAdd
    BLAST
    Regioni252 – 26716Linker 12Add
    BLAST
    Regioni268 – 28619Coil 2AAdd
    BLAST
    Regioni287 – 2948Linker 2
    Regioni295 – 411117Coil 2BAdd
    BLAST
    Regioni412 – 46958TailAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi45 – 484Poly-Ser

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG147125.
    HOGENOMiHOG000230977.
    HOVERGENiHBG013015.
    InParanoidiP31001.
    KOiK07610.
    OMAiSSEMHSK.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiP31001.
    TreeFamiTF330122.

    Family and domain databases

    InterProiIPR027698. DES.
    IPR001664. IF.
    IPR006821. Intermed_filament_DNA-bd.
    IPR018039. Intermediate_filament_CS.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PTHR23239:SF28. PTHR23239:SF28. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    PF04732. Filament_head. 1 hit.
    [Graphical view]
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31001-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQAYSSSQR VSSYRRTFGG APGFSLGSPL SSPVFPRAGF GTKGSSSSMT    50
    SRVYQVSRTS GGAGGLGSLR SSRLGTTRAP SYGAGELLDF SLADAVNQEF 100
    LATRTNEKVE LQELNDRFAN YIEKVRFLEQ QNAALAAEVN RLKGREPTRV 150
    AELYEEEMRE LRRQVEVLTN QRARVDVERD NLIDDLQRLK AKLQEEIQLR 200
    EEAENNLAAF RADVDAATLA RIDLERRIES LNEEIAFLKK VHEEEIRELQ 250
    AQLQEQQVQV EMDMSKPDLT AALRDIRAQY ETIAAKNISE AEEWYKSKVS 300
    DLTQAANKNN DALRQAKQEM MEYRHQIQSY TCEIDALKGT NDSLMRQMRE 350
    LEDRFASEAN GYQDNIARLE EEIRHLKDEM ARHLREYQDL LNVKMALDVE 400
    IATYRKLLEG EESRINLPIQ TFSALNFRET SPEQRGSEVH TKKTVMIKTI 450
    ETRDGEVVSE ATQQQHEVL 469
    Length:469
    Mass (Da):53,498
    Last modified:January 23, 2007 - v3
    Checksum:i58A8A13C7CC11EEF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22550 mRNA. No translation available.
    BC031760 mRNA. Translation: AAH31760.1.
    Z18892 Genomic DNA. Translation: CAA79330.1.
    CCDSiCCDS15071.1.
    PIRiA54104.
    RefSeqiNP_034173.1. NM_010043.2.
    UniGeneiMm.6712.

    Genome annotation databases

    EnsembliENSMUST00000027409; ENSMUSP00000027409; ENSMUSG00000026208.
    GeneIDi13346.
    KEGGimmu:13346.
    UCSCiuc007box.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22550 mRNA. No translation available.
    BC031760 mRNA. Translation: AAH31760.1 .
    Z18892 Genomic DNA. Translation: CAA79330.1 .
    CCDSi CCDS15071.1.
    PIRi A54104.
    RefSeqi NP_034173.1. NM_010043.2.
    UniGenei Mm.6712.

    3D structure databases

    ProteinModelPortali P31001.
    SMRi P31001. Positions 103-252, 267-410.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199210. 3 interactions.
    DIPi DIP-256N.
    IntActi P31001. 6 interactions.
    MINTi MINT-220806.

    PTM databases

    PhosphoSitei P31001.

    2D gel databases

    SWISS-2DPAGE P31001.

    Proteomic databases

    MaxQBi P31001.
    PaxDbi P31001.
    PRIDEi P31001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027409 ; ENSMUSP00000027409 ; ENSMUSG00000026208 .
    GeneIDi 13346.
    KEGGi mmu:13346.
    UCSCi uc007box.1. mouse.

    Organism-specific databases

    CTDi 1674.
    MGIi MGI:94885. Des.

    Phylogenomic databases

    eggNOGi NOG147125.
    HOGENOMi HOG000230977.
    HOVERGENi HBG013015.
    InParanoidi P31001.
    KOi K07610.
    OMAi SSEMHSK.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi P31001.
    TreeFami TF330122.

    Miscellaneous databases

    NextBioi 283662.
    PMAP-CutDB P31001.
    PROi P31001.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P31001.
    Bgeei P31001.
    CleanExi MM_DES.
    Genevestigatori P31001.

    Family and domain databases

    InterProi IPR027698. DES.
    IPR001664. IF.
    IPR006821. Intermed_filament_DNA-bd.
    IPR018039. Intermediate_filament_CS.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    PTHR23239:SF28. PTHR23239:SF28. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    PF04732. Filament_head. 1 hit.
    [Graphical view ]
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin."
      Li H., Choudhary S.K., Milner D.J., Munir M.I., Kuisk I.R., Capetanaki Y.
      J. Cell Biol. 124:827-841(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    3. "Regulation of the mouse desmin gene: transactivated by MyoD, myogenin, MRF4 and Myf5."
      Li H., Capetanaki Y.
      Nucleic Acids Res. 21:335-343(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.
      Strain: BALB/c.
      Tissue: Spleen.
    4. "Dystonin-deficient mice exhibit an intrinsic muscle weakness and an instability of skeletal muscle cytoarchitecture."
      Dalpe G., Mathieu M., Comtois A., Zhu E., Wasiak S., De Repentigny Y., Leclerc N., Kothary R.
      Dev. Biol. 210:367-380(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DST.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiDESM_MOUSE
    AccessioniPrimary (citable) accession number: P31001
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3