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P31001 (DESM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Desmin
Gene names
Name:Des
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.

Subunit structure

Homopolymer. Interacts with MTM1 By similarity. Interacts with DST. Ref.4

Subcellular location

Cytoplasm.

Post-translational modification

ADP-ribosylation prevents ability to form intermediate filaments By similarity.

Sequence similarities

Belongs to the intermediate filament family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MTM1Q134964EBI-298565,EBI-2864109From a different organism.
Mtm1Q9Z2C54EBI-298565,EBI-6861578

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469Desmin
PRO_0000063773

Regions

Region1 – 108108Head
Region109 – 411303Rod
Region109 – 14032Coil 1A
Region141 – 15010Linker 1
Region151 – 251101Coil 1B
Region252 – 26716Linker 12
Region268 – 28619Coil 2A
Region287 – 2948Linker 2
Region295 – 411117Coil 2B
Region412 – 46958Tail
Compositional bias45 – 484Poly-Ser

Sites

Site3531Stutter

Amino acid modifications

Modified residue121Phosphoserine; by AURKB By similarity
Modified residue171Phosphothreonine; by AURKB By similarity
Modified residue581ADP-ribosylarginine By similarity
Modified residue601Phosphoserine; by AURKB By similarity
Modified residue681Phosphoserine Ref.5

Sequences

Sequence LengthMass (Da)Tools
P31001 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 58A8A13C7CC11EEF

FASTA46953,498
        10         20         30         40         50         60 
MSQAYSSSQR VSSYRRTFGG APGFSLGSPL SSPVFPRAGF GTKGSSSSMT SRVYQVSRTS 

        70         80         90        100        110        120 
GGAGGLGSLR SSRLGTTRAP SYGAGELLDF SLADAVNQEF LATRTNEKVE LQELNDRFAN 

       130        140        150        160        170        180 
YIEKVRFLEQ QNAALAAEVN RLKGREPTRV AELYEEEMRE LRRQVEVLTN QRARVDVERD 

       190        200        210        220        230        240 
NLIDDLQRLK AKLQEEIQLR EEAENNLAAF RADVDAATLA RIDLERRIES LNEEIAFLKK 

       250        260        270        280        290        300 
VHEEEIRELQ AQLQEQQVQV EMDMSKPDLT AALRDIRAQY ETIAAKNISE AEEWYKSKVS 

       310        320        330        340        350        360 
DLTQAANKNN DALRQAKQEM MEYRHQIQSY TCEIDALKGT NDSLMRQMRE LEDRFASEAN 

       370        380        390        400        410        420 
GYQDNIARLE EEIRHLKDEM ARHLREYQDL LNVKMALDVE IATYRKLLEG EESRINLPIQ 

       430        440        450        460 
TFSALNFRET SPEQRGSEVH TKKTVMIKTI ETRDGEVVSE ATQQQHEVL 

« Hide

References

« Hide 'large scale' references
[1]"Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin."
Li H., Choudhary S.K., Milner D.J., Munir M.I., Kuisk I.R., Capetanaki Y.
J. Cell Biol. 124:827-841(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[3]"Regulation of the mouse desmin gene: transactivated by MyoD, myogenin, MRF4 and Myf5."
Li H., Capetanaki Y.
Nucleic Acids Res. 21:335-343(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.
Strain: BALB/c.
Tissue: Spleen.
[4]"Dystonin-deficient mice exhibit an intrinsic muscle weakness and an instability of skeletal muscle cytoarchitecture."
Dalpe G., Mathieu M., Comtois A., Zhu E., Wasiak S., De Repentigny Y., Leclerc N., Kothary R.
Dev. Biol. 210:367-380(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DST.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22550 mRNA. No translation available.
BC031760 mRNA. Translation: AAH31760.1.
Z18892 Genomic DNA. Translation: CAA79330.1.
CCDSCCDS15071.1.
PIRA54104.
RefSeqNP_034173.1. NM_010043.2.
UniGeneMm.6712.

3D structure databases

ProteinModelPortalP31001.
SMRP31001. Positions 103-252, 267-410.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199210. 3 interactions.
DIPDIP-256N.
IntActP31001. 6 interactions.
MINTMINT-220806.

PTM databases

PhosphoSiteP31001.

2D gel databases

SWISS-2DPAGEP31001.

Proteomic databases

MaxQBP31001.
PaxDbP31001.
PRIDEP31001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027409; ENSMUSP00000027409; ENSMUSG00000026208.
GeneID13346.
KEGGmmu:13346.
UCSCuc007box.1. mouse.

Organism-specific databases

CTD1674.
MGIMGI:94885. Des.

Phylogenomic databases

eggNOGNOG147125.
HOGENOMHOG000230977.
HOVERGENHBG013015.
InParanoidP31001.
KOK07610.
OMASSEMHSK.
OrthoDBEOG7FV3Q8.
PhylomeDBP31001.
TreeFamTF330122.

Gene expression databases

ArrayExpressP31001.
BgeeP31001.
CleanExMM_DES.
GenevestigatorP31001.

Family and domain databases

InterProIPR027698. DES.
IPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF28. PTHR23239:SF28. 1 hit.
PfamPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283662.
PMAP-CutDBP31001.
PROP31001.
SOURCESearch...

Entry information

Entry nameDESM_MOUSE
AccessionPrimary (citable) accession number: P31001
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot