P31001 (DESM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Desmin

Gene names

Name:

Des

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
Subunit structure	Homopolymer. Interacts with MTM1 By similarity. Interacts with DST. Ref.4
Subcellular location	Cytoplasm.
Post-translational modification	ADP-ribosylation prevents ability to form intermediate filaments By similarity.
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Cytoplasm Intermediate filament
Domain	Coiled coil
Molecular function	Muscle protein
PTM	ADP-ribosylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	muscle organ development Traceable author statement PubMed 7720554. Source: MGI
Cellular_component	Z disc Inferred from direct assay PubMed 10532952PubMed 11694502PubMed 14627610PubMed 15138196. Source: MGI cytoskeleton Inferred from direct assay PubMed 11694502. Source: MGI fascia adherens Inferred from direct assay PubMed 11732910. Source: MGI intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW neuromuscular junction Inferred from direct assay PubMed 11694502. Source: MGI sarcolemma Inferred from direct assay PubMed 11694502. Source: MGI
Molecular_function	structural constituent of cytoskeleton Traceable author statement PubMed 2370005. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Desmin		PRO_0000063773
Regions
	Region	1 – 108	108	Head
	Region	109 – 411	303	Rod
	Region	109 – 140	32	Coil 1A
	Region	141 – 150	10	Linker 1
	Region	151 – 251	101	Coil 1B
	Region	252 – 267	16	Linker 12
	Region	268 – 286	19	Coil 2A
	Region	287 – 294	8	Linker 2
	Region	295 – 411	117	Coil 2B
	Region	412 – 469	58	Tail
	Compositional bias	45 – 48	4	Poly-Ser
Sites
	Site	353	1	Stutter
Amino acid modifications
	Modified residue	12	1	Phosphoserine; by AURKB By similarity
	Modified residue	17	1	Phosphothreonine; by AURKB By similarity
	Modified residue	58	1	ADP-ribosylarginine By similarity
	Modified residue	60	1	Phosphoserine; by AURKB By similarity

Sequences

	Sequence		Length	Mass (Da)
	P31001 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 58A8A13C7CC11EEF	FASTA	469	53,498
	10 20 30 40 50 60 MSQAYSSSQR VSSYRRTFGG APGFSLGSPL SSPVFPRAGF GTKGSSSSMT SRVYQVSRTS 70 80 90 100 110 120 GGAGGLGSLR SSRLGTTRAP SYGAGELLDF SLADAVNQEF LATRTNEKVE LQELNDRFAN 130 140 150 160 170 180 YIEKVRFLEQ QNAALAAEVN RLKGREPTRV AELYEEEMRE LRRQVEVLTN QRARVDVERD 190 200 210 220 230 240 NLIDDLQRLK AKLQEEIQLR EEAENNLAAF RADVDAATLA RIDLERRIES LNEEIAFLKK 250 260 270 280 290 300 VHEEEIRELQ AQLQEQQVQV EMDMSKPDLT AALRDIRAQY ETIAAKNISE AEEWYKSKVS 310 320 330 340 350 360 DLTQAANKNN DALRQAKQEM MEYRHQIQSY TCEIDALKGT NDSLMRQMRE LEDRFASEAN 370 380 390 400 410 420 GYQDNIARLE EEIRHLKDEM ARHLREYQDL LNVKMALDVE IATYRKLLEG EESRINLPIQ 430 440 450 460 TFSALNFRET SPEQRGSEVH TKKTVMIKTI ETRDGEVVSE ATQQQHEVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin." Li H., Choudhary S.K., Milner D.J., Munir M.I., Kuisk I.R., Capetanaki Y. J. Cell Biol. 124:827-841(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
[3]	"Regulation of the mouse desmin gene: transactivated by MyoD, myogenin, MRF4 and Myf5." Li H., Capetanaki Y. Nucleic Acids Res. 21:335-343(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40. Strain: BALB/c. Tissue: Spleen.
[4]	"Dystonin-deficient mice exhibit an intrinsic muscle weakness and an instability of skeletal muscle cytoarchitecture." Dalpe G., Mathieu M., Comtois A., Zhu E., Wasiak S., De Repentigny Y., Leclerc N., Kothary R. Dev. Biol. 210:367-380(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DST.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22550 mRNA. No translation available. BC031760 mRNA. Translation: AAH31760.1. Z18892 Genomic DNA. Translation: CAA79330.1.
IPI	IPI00130102.
PIR	A54104.
RefSeq	NP_034173.1. NM_010043.1.
UniGene	Mm.6712.
3D structure databases
ProteinModelPortal	P31001.
SMR	P31001. Positions 103-252, 267-410.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-256N.
IntAct	P31001. 1 interaction.
MINT	MINT-220806.
PTM databases
PhosphoSite	P31001.
2D gel databases
SWISS-2DPAGE	P31001.
Proteomic databases
PaxDb	P31001.
PRIDE	P31001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027409; ENSMUSP00000027409; ENSMUSG00000026208.
GeneID	13346.
KEGG	mmu:13346.
Organism-specific databases
CTD	1674.
MGI	MGI:94885. Des.
Phylogenomic databases
eggNOG	NOG147125.
HOGENOM	HOG000230977.
HOVERGEN	HBG013015.
InParanoid	P31001.
KO	K07610.
OMA	SSEMHSK.
OrthoDB	EOG4H9XKM.
Gene expression databases
ArrayExpress	P31001.
Bgee	P31001.
CleanEx	MM_DES.
Genevestigator	P31001.
GermOnline	ENSMUSG00000026208. Mus musculus.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR006821. Intermed_filament_DNA-bd. IPR018039. Intermediate_filament_CS. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit.
Pfam	PF00038. Filament. 1 hit. PF04732. Filament_head. 1 hit. [Graphical view]
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283662.
PMAP-CutDB	P31001.
SOURCE	Search...

Entry information

Entry name

DESM_MOUSE

Accession

Primary (citable) accession number: P31001

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program