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UniProtKB - P30999 (CTND1_MOUSE)

UniProt

P30999 - CTND1_MOUSE

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Protein

Catenin delta-1

Gene

Ctnnd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.By similarity3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei401 – 4011Essential for interaction with cadherinsBy similarity
Sitei478 – 4781Essential for interaction with cadherinsBy similarity

GO - Molecular functioni

  • cadherin binding Source: MGI
  • protein domain specific binding Source: MGI
  • protein phosphatase binding Source: UniProtKB
  • receptor binding Source: MGI

GO - Biological processi

  • cell adhesion Source: MGI
  • epithelial cell differentiation involved in salivary gland development Source: MGI
  • glomerulus morphogenesis Source: MGI
  • keratinocyte differentiation Source: MGI
  • kidney development Source: MGI
  • morphogenesis of a polarized epithelium Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of peptidyl-tyrosine autophosphorylation Source: MGI
  • positive regulation of protein processing Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • salivary gland morphogenesis Source: MGI
  • single organismal cell-cell adhesion Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.
R-MMU-5218920. VEGFR2 mediated vascular permeability.

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin delta-1
Alternative name(s):
Cadherin-associated Src substrate
Short name:
CAS
p120 catenin
Short name:
p120(ctn)
p120(cas)
Gene namesi
Name:Ctnnd1
Synonyms:Catns, Kiaa0384
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:105100. Ctnnd1.

Subcellular locationi

  • Cytoplasm
  • Nucleus
  • Cell membrane

    • Note: Interaction with GLIS2 promotes nuclear translocation. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (By similarity).By similarity

GO - Cellular componenti

  • bicellular tight junction Source: MGI
  • cell-cell adherens junction Source: MGI
  • cell-cell junction Source: MGI
  • cytoplasm Source: UniProtKB
  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • flotillin complex Source: UniProtKB
  • lamellipodium Source: MGI
  • membrane Source: MGI
  • midbody Source: UniProtKB
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi622 – 6232KK → AA: Abolishes nuclear localization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 938938Catenin delta-1PRO_0000064297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei47 – 471PhosphoserineCombined sources
Modified residuei59 – 591PhosphothreonineCombined sources
Modified residuei112 – 1121Phosphotyrosine; by FYNBy similarity
Modified residuei125 – 1251PhosphoserineBy similarity
Modified residuei217 – 2171PhosphotyrosineCombined sources
Modified residuei221 – 2211PhosphotyrosineCombined sources
Modified residuei225 – 2251PhosphoserineCombined sources
Modified residuei228 – 2281PhosphotyrosineCombined sources
Modified residuei230 – 2301PhosphoserineCombined sources
Modified residuei252 – 2521PhosphoserineCombined sources
Modified residuei257 – 2571PhosphotyrosineCombined sources
Modified residuei268 – 2681PhosphoserineBy similarity
Modified residuei269 – 2691PhosphoserineCombined sources
Modified residuei280 – 2801PhosphotyrosineCombined sources
Modified residuei288 – 2881PhosphoserineCombined sources
Modified residuei291 – 2911PhosphotyrosineCombined sources
Modified residuei300 – 3001PhosphoserineCombined sources
Modified residuei304 – 3041PhosphothreonineCombined sources
Modified residuei320 – 3201PhosphoserineCombined sources
Modified residuei346 – 3461PhosphoserineBy similarity
Modified residuei349 – 3491PhosphoserineCombined sources
Modified residuei352 – 3521PhosphoserineCombined sources
Modified residuei617 – 6171PhosphoserineBy similarity
Modified residuei713 – 7131PhosphoserineCombined sources
Modified residuei811 – 8111PhosphoserineBy similarity
Modified residuei847 – 8471PhosphoserineCombined sources
Modified residuei857 – 8571PhosphoserineCombined sources
Modified residuei859 – 8591PhosphoserineBy similarity
Modified residuei861 – 8611PhosphoserineBy similarity
Modified residuei864 – 8641PhosphoserineCombined sources
Modified residuei865 – 8651PhosphotyrosineCombined sources
Modified residuei868 – 8681PhosphoserineCombined sources
Modified residuei869 – 8691PhosphothreonineCombined sources
Modified residuei879 – 8791PhosphoserineBy similarity
Modified residuei899 – 8991PhosphoserineCombined sources
Modified residuei904 – 9041PhosphotyrosineCombined sources
Modified residuei906 – 9061PhosphothreonineBy similarity
Modified residuei916 – 9161PhosphothreonineBy similarity
Modified residuei920 – 9201PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP30999.
PaxDbiP30999.
PeptideAtlasiP30999.
PRIDEiP30999.

PTM databases

iPTMnetiP30999.
PhosphoSiteiP30999.
SwissPalmiP30999.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034101.
CleanExiMM_CTNND1.
ExpressionAtlasiP30999. baseline and differential.
GenevisibleiP30999. MM.

Interactioni

Subunit structurei

Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin (By similarity). Interacts with ZBTB33. Interacts with GLIS2 and FER. Interacts with NANOS1 (via N-terminal region) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ptpn11P352353EBI-529924,EBI-397236
Zbtb33Q8BN783EBI-529924,EBI-1216314

GO - Molecular functioni

  • cadherin binding Source: MGI
  • protein domain specific binding Source: MGI
  • protein phosphatase binding Source: UniProtKB
  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi198513. 19 interactions.
DIPiDIP-31972N.
IntActiP30999. 17 interactions.
MINTiMINT-89877.
STRINGi10090.ENSMUSP00000064518.

Structurei

3D structure databases

ProteinModelPortaliP30999.
SMRiP30999. Positions 358-852.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati358 – 39538ARM 1Add
BLAST
Repeati398 – 43740ARM 2Add
BLAST
Repeati441 – 47535ARM 3Add
BLAST
Repeati476 – 51641ARM 4Add
BLAST
Repeati534 – 57340ARM 5Add
BLAST
Repeati583 – 62442ARM 6Add
BLAST
Repeati653 – 69341ARM 7Add
BLAST
Repeati700 – 73940ARM 8Add
BLAST
Repeati740 – 78041ARM 9Add
BLAST
Repeati781 – 82646ARM 10Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili10 – 4637Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi622 – 63514Nuclear localization signal1 PublicationAdd
BLAST

Domaini

ARM repeats 1 to 5 mediate interaction with cadherins.By similarity

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 10 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000231862.
HOVERGENiHBG004284.
InParanoidiP30999.
KOiK05690.
PhylomeDBiP30999.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028439. Catenin_d1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF6. PTHR10372:SF6. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30999-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD 
        60         70         80         90        100
ANSLMANGTL TRRHQNGRFV GDADLERQKF SDLKLNGPQD HNHLLYSTIP 
       110        120        130        140        150
RMQEPGQIVE TYTEEDPEGA MSVVSVETTD DGTTRRTETT VKKVVKTMTT 
       160        170        180        190        200
RTVQPVPMGP DGLPVDASAV SNNYIQTLGR DFRKNGNGGP GPYVGQAGTA 
       210        220        230        240        250
TLPRNFHYPP DGYGRHYEDG YPGGSDNYGS LSRVTRIEER YRPSMEGYRA 
       260        270        280        290        300
PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 
       310        320        330        340        350
DYGTARRTGT PSDPRRRLRS YEDMIGEEVP PDQYYWAPLA QHERGSLASL 
       360        370        380        390        400
DSLRKGMPPP SNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV 
       410        420        430        440        450
KTDVRKLKGI PILVGLLDHP KKEVHLGACG ALKNISFGRD QDNKIAIKNC 
       460        470        480        490        500
DGVPALVRLL RKARDMDLTE VITGTLWNLS SHDSIKMEIV DHALHALTDE 
       510        520        530        540        550
VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE RSEARRKLRE 
       560        570        580        590        600
CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 
       610        620        630        640        650
QEALPTVANS TGPHAASCFG AKKGKDEWFS RGKKPTEDPA NDTVDFPKRT 
       660        670        680        690        700
SPARGYELLF QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR 
       710        720        730        740        750
YIRSALRQEK ALSAIAELLT SEHERVVKAA SGALRNLAVD ARNKELIGKH 
       760        770        780        790        800
AIPNLVKNLP GGQQNSSWNF SEDTVVSILN TINEVIAENL EAAKKLRETQ 
       810        820        830        840        850
GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE KEGWKKSDFQ 
       860        870        880        890        900
VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD KKPDREEIPM SNMGSNTKSL 
       910        920        930 
DNNYSTLNER GDHNRTLDRS GDLGDMEPLK GAPLMQKI
Length:938
Mass (Da):104,925
Last modified:January 15, 2008 - v2
Checksum:i2F13DB7350355832
GO
Isoform 2 (identifier: P30999-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     880-900: Missing.

Show »
Length:911
Mass (Da):101,744
Checksum:i8EBEA0D3FA88C843
GO
Isoform 3 (identifier: P30999-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     880-900: Missing.

Show »
Length:917
Mass (Da):102,565
Checksum:i8FA40C72176733E8
GO

Sequence cautioni

The sequence BAC41421 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti405 – 4051R → A in CAA79078 (PubMed:1334250).Curated
Sequence conflicti676 – 6761K → N in CAA79078 (PubMed:1334250).Curated
Sequence conflicti715 – 7151I → R in CAA79078 (PubMed:1334250).Curated
Sequence conflicti752 – 7521I → R in CAA79078 (PubMed:1334250).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei626 – 6316Missing in isoform 2. 1 PublicationVSP_030567
Alternative sequencei880 – 90021Missing in isoform 2 and isoform 3. 3 PublicationsVSP_030568Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17804 mRNA. Translation: CAA79078.1.
AB093237 mRNA. Translation: BAC41421.1. Different initiation.
AK133193 mRNA. Translation: BAE21551.1.
AK161790 mRNA. Translation: BAE36576.1.
BC043108 mRNA. Translation: AAH43108.1.
BC054544 mRNA. Translation: AAH54544.1.
CCDSiCCDS16186.1. [P30999-1]
CCDS50622.1. [P30999-2]
CCDS50623.1. [P30999-3]
PIRiI48701. S28498.
RefSeqiNP_001078917.1. NM_001085448.1. [P30999-3]
NP_001078918.1. NM_001085449.1.
NP_001078919.1. NM_001085450.1. [P30999-1]
NP_001078922.1. NM_001085453.1. [P30999-2]
NP_031641.2. NM_007615.4. [P30999-1]
XP_006498698.1. XM_006498635.1. [P30999-1]
XP_011237569.1. XM_011239267.1. [P30999-3]
UniGeneiMm.35738.

Genome annotation databases

EnsembliENSMUST00000036811; ENSMUSP00000042543; ENSMUSG00000034101. [P30999-3]
ENSMUST00000066177; ENSMUSP00000065252; ENSMUSG00000034101. [P30999-2]
ENSMUST00000067232; ENSMUSP00000064518; ENSMUSG00000034101. [P30999-1]
ENSMUST00000111691; ENSMUSP00000107320; ENSMUSG00000034101. [P30999-1]
ENSMUST00000111697; ENSMUSP00000107326; ENSMUSG00000034101. [P30999-3]
ENSMUST00000189772; ENSMUSP00000141166; ENSMUSG00000101645. [P30999-1]
GeneIDi12388.
KEGGimmu:12388.
UCSCiuc008kio.1. mouse. [P30999-3]
uc008kip.1. mouse. [P30999-1]
uc008kit.1. mouse. [P30999-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17804 mRNA. Translation: CAA79078.1.
AB093237 mRNA. Translation: BAC41421.1. Different initiation.
AK133193 mRNA. Translation: BAE21551.1.
AK161790 mRNA. Translation: BAE36576.1.
BC043108 mRNA. Translation: AAH43108.1.
BC054544 mRNA. Translation: AAH54544.1.
CCDSiCCDS16186.1. [P30999-1]
CCDS50622.1. [P30999-2]
CCDS50623.1. [P30999-3]
PIRiI48701. S28498.
RefSeqiNP_001078917.1. NM_001085448.1. [P30999-3]
NP_001078918.1. NM_001085449.1.
NP_001078919.1. NM_001085450.1. [P30999-1]
NP_001078922.1. NM_001085453.1. [P30999-2]
NP_031641.2. NM_007615.4. [P30999-1]
XP_006498698.1. XM_006498635.1. [P30999-1]
XP_011237569.1. XM_011239267.1. [P30999-3]
UniGeneiMm.35738.

3D structure databases

ProteinModelPortaliP30999.
SMRiP30999. Positions 358-852.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198513. 19 interactions.
DIPiDIP-31972N.
IntActiP30999. 17 interactions.
MINTiMINT-89877.
STRINGi10090.ENSMUSP00000064518.

PTM databases

iPTMnetiP30999.
PhosphoSiteiP30999.
SwissPalmiP30999.

Proteomic databases

MaxQBiP30999.
PaxDbiP30999.
PeptideAtlasiP30999.
PRIDEiP30999.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036811; ENSMUSP00000042543; ENSMUSG00000034101. [P30999-3]
ENSMUST00000066177; ENSMUSP00000065252; ENSMUSG00000034101. [P30999-2]
ENSMUST00000067232; ENSMUSP00000064518; ENSMUSG00000034101. [P30999-1]
ENSMUST00000111691; ENSMUSP00000107320; ENSMUSG00000034101. [P30999-1]
ENSMUST00000111697; ENSMUSP00000107326; ENSMUSG00000034101. [P30999-3]
ENSMUST00000189772; ENSMUSP00000141166; ENSMUSG00000101645. [P30999-1]
GeneIDi12388.
KEGGimmu:12388.
UCSCiuc008kio.1. mouse. [P30999-3]
uc008kip.1. mouse. [P30999-1]
uc008kit.1. mouse. [P30999-2]

Organism-specific databases

CTDi1500.
MGIiMGI:105100. Ctnnd1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000231862.
HOVERGENiHBG004284.
InParanoidiP30999.
KOiK05690.
PhylomeDBiP30999.
TreeFamiTF321877.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.
R-MMU-5218920. VEGFR2 mediated vascular permeability.

Miscellaneous databases

ChiTaRSiCtnnd1. mouse.
PROiP30999.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034101.
CleanExiMM_CTNND1.
ExpressionAtlasiP30999. baseline and differential.
GenevisibleiP30999. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028439. Catenin_d1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF6. PTHR10372:SF6. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTND1_MOUSE
AccessioniPrimary (citable) accession number: P30999
Secondary accession number(s): Q3TSU9, Q80XQ4, Q8CHF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.