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Protein

Catenin delta-1

Gene

Ctnnd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei401Essential for interaction with cadherinsBy similarity1
Sitei478Essential for interaction with cadherinsBy similarity1

GO - Molecular functioni

  • cadherin binding Source: MGI
  • cadherin binding involved in cell-cell adhesion Source: MGI
  • protein domain specific binding Source: MGI
  • protein phosphatase binding Source: UniProtKB
  • receptor binding Source: MGI

GO - Biological processi

  • cell adhesion Source: MGI
  • epithelial cell differentiation involved in salivary gland development Source: MGI
  • glomerulus morphogenesis Source: MGI
  • keratinocyte differentiation Source: MGI
  • kidney development Source: MGI
  • morphogenesis of a polarized epithelium Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of peptidyl-tyrosine autophosphorylation Source: MGI
  • positive regulation of protein processing Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • salivary gland morphogenesis Source: MGI
  • single organismal cell-cell adhesion Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.
R-MMU-5218920. VEGFR2 mediated vascular permeability.

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin delta-1
Alternative name(s):
Cadherin-associated Src substrate
Short name:
CAS
p120 catenin
Short name:
p120(ctn)
p120(cas)
Gene namesi
Name:Ctnnd1
Synonyms:Catns, Kiaa0384
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:105100. Ctnnd1.

Subcellular locationi

  • Cytoplasm
  • Nucleus
  • Cell membrane

  • Note: Interaction with GLIS2 promotes nuclear translocation. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (By similarity).By similarity

GO - Cellular componenti

  • bicellular tight junction Source: MGI
  • cell-cell adherens junction Source: MGI
  • cell-cell junction Source: MGI
  • cytoplasm Source: UniProtKB
  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • flotillin complex Source: UniProtKB
  • lamellipodium Source: MGI
  • membrane Source: MGI
  • midbody Source: UniProtKB
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi622 – 623KK → AA: Abolishes nuclear localization. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642971 – 938Catenin delta-1Add BLAST938

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei4PhosphoserineBy similarity1
Modified residuei47PhosphoserineCombined sources1
Modified residuei59PhosphothreonineCombined sources1
Modified residuei112Phosphotyrosine; by FYNBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei217PhosphotyrosineCombined sources1
Modified residuei221PhosphotyrosineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei228PhosphotyrosineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei257PhosphotyrosineCombined sources1
Modified residuei268PhosphoserineBy similarity1
Modified residuei269PhosphoserineCombined sources1
Modified residuei280PhosphotyrosineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei291PhosphotyrosineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei304PhosphothreonineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei346PhosphoserineBy similarity1
Modified residuei349PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei617PhosphoserineBy similarity1
Modified residuei713PhosphoserineCombined sources1
Modified residuei811PhosphoserineBy similarity1
Modified residuei847PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei859PhosphoserineBy similarity1
Modified residuei861PhosphoserineBy similarity1
Modified residuei864PhosphoserineCombined sources1
Modified residuei865PhosphotyrosineCombined sources1
Modified residuei868PhosphoserineCombined sources1
Modified residuei869PhosphothreonineCombined sources1
Modified residuei879PhosphoserineBy similarity1
Modified residuei899PhosphoserineCombined sources1
Modified residuei904PhosphotyrosineCombined sources1
Modified residuei906PhosphothreonineBy similarity1
Modified residuei916PhosphothreonineBy similarity1
Modified residuei920PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP30999.
PaxDbiP30999.
PeptideAtlasiP30999.
PRIDEiP30999.

PTM databases

iPTMnetiP30999.
PhosphoSitePlusiP30999.
SwissPalmiP30999.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034101.
CleanExiMM_CTNND1.
ExpressionAtlasiP30999. baseline and differential.
GenevisibleiP30999. MM.

Interactioni

Subunit structurei

Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin (By similarity). Interacts with ZBTB33. Interacts with GLIS2 and FER. Interacts with NANOS1 (via N-terminal region) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ptpn11P352353EBI-529924,EBI-397236
Zbtb33Q8BN783EBI-529924,EBI-1216314

GO - Molecular functioni

  • cadherin binding Source: MGI
  • cadherin binding involved in cell-cell adhesion Source: MGI
  • protein domain specific binding Source: MGI
  • protein phosphatase binding Source: UniProtKB
  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi198513. 19 interactors.
DIPiDIP-31972N.
IntActiP30999. 17 interactors.
MINTiMINT-89877.
STRINGi10090.ENSMUSP00000064518.

Structurei

3D structure databases

ProteinModelPortaliP30999.
SMRiP30999.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati358 – 395ARM 1Add BLAST38
Repeati398 – 437ARM 2Add BLAST40
Repeati441 – 475ARM 3Add BLAST35
Repeati476 – 516ARM 4Add BLAST41
Repeati534 – 573ARM 5Add BLAST40
Repeati583 – 624ARM 6Add BLAST42
Repeati653 – 693ARM 7Add BLAST41
Repeati700 – 739ARM 8Add BLAST40
Repeati740 – 780ARM 9Add BLAST41
Repeati781 – 826ARM 10Add BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 46Sequence analysisAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi622 – 635Nuclear localization signal1 PublicationAdd BLAST14

Domaini

ARM repeats 1 to 5 mediate interaction with cadherins.By similarity

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 10 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000231862.
HOVERGENiHBG004284.
InParanoidiP30999.
KOiK05690.
PhylomeDBiP30999.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028439. Catenin_d1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF6. PTHR10372:SF6. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30999-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD
60 70 80 90 100
ANSLMANGTL TRRHQNGRFV GDADLERQKF SDLKLNGPQD HNHLLYSTIP
110 120 130 140 150
RMQEPGQIVE TYTEEDPEGA MSVVSVETTD DGTTRRTETT VKKVVKTMTT
160 170 180 190 200
RTVQPVPMGP DGLPVDASAV SNNYIQTLGR DFRKNGNGGP GPYVGQAGTA
210 220 230 240 250
TLPRNFHYPP DGYGRHYEDG YPGGSDNYGS LSRVTRIEER YRPSMEGYRA
260 270 280 290 300
PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS
310 320 330 340 350
DYGTARRTGT PSDPRRRLRS YEDMIGEEVP PDQYYWAPLA QHERGSLASL
360 370 380 390 400
DSLRKGMPPP SNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV
410 420 430 440 450
KTDVRKLKGI PILVGLLDHP KKEVHLGACG ALKNISFGRD QDNKIAIKNC
460 470 480 490 500
DGVPALVRLL RKARDMDLTE VITGTLWNLS SHDSIKMEIV DHALHALTDE
510 520 530 540 550
VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE RSEARRKLRE
560 570 580 590 600
CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY
610 620 630 640 650
QEALPTVANS TGPHAASCFG AKKGKDEWFS RGKKPTEDPA NDTVDFPKRT
660 670 680 690 700
SPARGYELLF QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR
710 720 730 740 750
YIRSALRQEK ALSAIAELLT SEHERVVKAA SGALRNLAVD ARNKELIGKH
760 770 780 790 800
AIPNLVKNLP GGQQNSSWNF SEDTVVSILN TINEVIAENL EAAKKLRETQ
810 820 830 840 850
GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE KEGWKKSDFQ
860 870 880 890 900
VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD KKPDREEIPM SNMGSNTKSL
910 920 930
DNNYSTLNER GDHNRTLDRS GDLGDMEPLK GAPLMQKI
Length:938
Mass (Da):104,925
Last modified:January 15, 2008 - v2
Checksum:i2F13DB7350355832
GO
Isoform 2 (identifier: P30999-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-631: Missing.
     880-900: Missing.

Show »
Length:911
Mass (Da):101,744
Checksum:i8EBEA0D3FA88C843
GO
Isoform 3 (identifier: P30999-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     880-900: Missing.

Show »
Length:917
Mass (Da):102,565
Checksum:i8FA40C72176733E8
GO

Sequence cautioni

The sequence BAC41421 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti405R → A in CAA79078 (PubMed:1334250).Curated1
Sequence conflicti676K → N in CAA79078 (PubMed:1334250).Curated1
Sequence conflicti715I → R in CAA79078 (PubMed:1334250).Curated1
Sequence conflicti752I → R in CAA79078 (PubMed:1334250).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030567626 – 631Missing in isoform 2. 1 Publication6
Alternative sequenceiVSP_030568880 – 900Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17804 mRNA. Translation: CAA79078.1.
AB093237 mRNA. Translation: BAC41421.1. Different initiation.
AK133193 mRNA. Translation: BAE21551.1.
AK161790 mRNA. Translation: BAE36576.1.
BC043108 mRNA. Translation: AAH43108.1.
BC054544 mRNA. Translation: AAH54544.1.
CCDSiCCDS16186.1. [P30999-1]
CCDS50622.1. [P30999-2]
CCDS50623.1. [P30999-3]
PIRiI48701. S28498.
RefSeqiNP_001078917.1. NM_001085448.1. [P30999-3]
NP_001078918.1. NM_001085449.1.
NP_001078919.1. NM_001085450.1. [P30999-1]
NP_001078922.1. NM_001085453.1. [P30999-2]
NP_031641.2. NM_007615.4. [P30999-1]
XP_006498698.1. XM_006498635.1. [P30999-1]
XP_017170690.1. XM_017315201.1. [P30999-1]
XP_017170697.1. XM_017315208.1. [P30999-3]
UniGeneiMm.35738.

Genome annotation databases

EnsembliENSMUST00000036811; ENSMUSP00000042543; ENSMUSG00000034101. [P30999-3]
ENSMUST00000066177; ENSMUSP00000065252; ENSMUSG00000034101. [P30999-2]
ENSMUST00000067232; ENSMUSP00000064518; ENSMUSG00000034101. [P30999-1]
ENSMUST00000111691; ENSMUSP00000107320; ENSMUSG00000034101. [P30999-1]
ENSMUST00000111697; ENSMUSP00000107326; ENSMUSG00000034101. [P30999-3]
ENSMUST00000189772; ENSMUSP00000141166; ENSMUSG00000101645. [P30999-1]
GeneIDi12388.
KEGGimmu:12388.
UCSCiuc008kio.1. mouse. [P30999-3]
uc008kip.1. mouse. [P30999-1]
uc008kit.1. mouse. [P30999-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17804 mRNA. Translation: CAA79078.1.
AB093237 mRNA. Translation: BAC41421.1. Different initiation.
AK133193 mRNA. Translation: BAE21551.1.
AK161790 mRNA. Translation: BAE36576.1.
BC043108 mRNA. Translation: AAH43108.1.
BC054544 mRNA. Translation: AAH54544.1.
CCDSiCCDS16186.1. [P30999-1]
CCDS50622.1. [P30999-2]
CCDS50623.1. [P30999-3]
PIRiI48701. S28498.
RefSeqiNP_001078917.1. NM_001085448.1. [P30999-3]
NP_001078918.1. NM_001085449.1.
NP_001078919.1. NM_001085450.1. [P30999-1]
NP_001078922.1. NM_001085453.1. [P30999-2]
NP_031641.2. NM_007615.4. [P30999-1]
XP_006498698.1. XM_006498635.1. [P30999-1]
XP_017170690.1. XM_017315201.1. [P30999-1]
XP_017170697.1. XM_017315208.1. [P30999-3]
UniGeneiMm.35738.

3D structure databases

ProteinModelPortaliP30999.
SMRiP30999.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198513. 19 interactors.
DIPiDIP-31972N.
IntActiP30999. 17 interactors.
MINTiMINT-89877.
STRINGi10090.ENSMUSP00000064518.

PTM databases

iPTMnetiP30999.
PhosphoSitePlusiP30999.
SwissPalmiP30999.

Proteomic databases

MaxQBiP30999.
PaxDbiP30999.
PeptideAtlasiP30999.
PRIDEiP30999.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036811; ENSMUSP00000042543; ENSMUSG00000034101. [P30999-3]
ENSMUST00000066177; ENSMUSP00000065252; ENSMUSG00000034101. [P30999-2]
ENSMUST00000067232; ENSMUSP00000064518; ENSMUSG00000034101. [P30999-1]
ENSMUST00000111691; ENSMUSP00000107320; ENSMUSG00000034101. [P30999-1]
ENSMUST00000111697; ENSMUSP00000107326; ENSMUSG00000034101. [P30999-3]
ENSMUST00000189772; ENSMUSP00000141166; ENSMUSG00000101645. [P30999-1]
GeneIDi12388.
KEGGimmu:12388.
UCSCiuc008kio.1. mouse. [P30999-3]
uc008kip.1. mouse. [P30999-1]
uc008kit.1. mouse. [P30999-2]

Organism-specific databases

CTDi1500.
MGIiMGI:105100. Ctnnd1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000231862.
HOVERGENiHBG004284.
InParanoidiP30999.
KOiK05690.
PhylomeDBiP30999.
TreeFamiTF321877.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.
R-MMU-5218920. VEGFR2 mediated vascular permeability.

Miscellaneous databases

ChiTaRSiCtnnd1. mouse.
PROiP30999.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034101.
CleanExiMM_CTNND1.
ExpressionAtlasiP30999. baseline and differential.
GenevisibleiP30999. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028439. Catenin_d1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF6. PTHR10372:SF6. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTND1_MOUSE
AccessioniPrimary (citable) accession number: P30999
Secondary accession number(s): Q3TSU9, Q80XQ4, Q8CHF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.