ID   PLAK_XENLA              Reviewed;         738 AA.
AC   P30998; Q52L07;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   RecName: Full=Junction plakoglobin;
DE   AltName: Full=Desmoplakin III;
DE   AltName: Full=Desmoplakin-3;
GN   Name=jup;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1459359; DOI=10.1111/j.1432-0436.1992.tb00695.x;
RA   Fouquet B., Zimbelmann R., Franke W.W.;
RT   "Identification of plakoglobin in oocytes and early embryos of Xenopus
RT   laevis: maternal expression of a gene encoding a junctional plaque
RT   protein.";
RL   Differentiation 51:187-194(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 133-292.
RX   PubMed=1397690; DOI=10.1016/0012-1606(92)90118-z;
RA   de Marais A.A., Moon R.T.;
RT   "The armadillo homologs beta-catenin and plakoglobin are differentially
RT   expressed during early development of Xenopus laevis.";
RL   Dev. Biol. 153:337-346(1992).
CC   -!- FUNCTION: Common junctional plaque protein. The membrane-associated
CC       plaques are architectural elements in an important strategic position
CC       to influence the arrangement and function of both the cytoskeleton and
CC       the cells within the tissue. The presence of plakoglobin in both the
CC       desmosomes and in the intermediate junctions suggests that it plays a
CC       central role in the structure and function of submembranous plaques.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell junction,
CC       desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane
CC       protein. Note=Cytoplasmic in a soluble and membrane-associated form.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; M95593; AAA49931.1; -; mRNA.
DR   EMBL; BC094116; AAH94116.1; -; mRNA.
DR   EMBL; X67078; CAA47463.1; -; mRNA.
DR   PIR; S35093; S35093.
DR   RefSeq; NP_001084051.1; NM_001090582.1.
DR   AlphaFoldDB; P30998; -.
DR   SMR; P30998; -.
DR   BioGRID; 100603; 1.
DR   DNASU; 399278; -.
DR   GeneID; 399278; -.
DR   KEGG; xla:399278; -.
DR   AGR; Xenbase:XB-GENE-6254182; -.
DR   CTD; 399278; -.
DR   Xenbase; XB-GENE-6254182; jup.S.
DR   OrthoDB; 50711at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 399278; Expressed in zone of skin and 19 other cell types or tissues.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd21725; CTNNAbd_CTNNG; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR013284; Beta-catenin.
DR   PANTHER; PTHR45976; ARMADILLO SEGMENT POLARITY PROTEIN; 1.
DR   PANTHER; PTHR45976:SF3; JUNCTION PLAKOGLOBIN; 1.
DR   Pfam; PF00514; Arm; 3.
DR   PRINTS; PR01869; BCATNINFAMLY.
DR   SMART; SM00185; ARM; 12.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 9.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell junction; Cytoplasm; Cytoskeleton; Membrane;
KW   Reference proteome; Repeat.
FT   CHAIN           1..738
FT                   /note="Junction plakoglobin"
FT                   /id="PRO_0000064282"
FT   REPEAT          128..167
FT                   /note="ARM 1"
FT   REPEAT          168..211
FT                   /note="ARM 2"
FT   REPEAT          212..251
FT                   /note="ARM 3"
FT   REPEAT          254..293
FT                   /note="ARM 4"
FT   REPEAT          294..337
FT                   /note="ARM 5"
FT   REPEAT          338..377
FT                   /note="ARM 6"
FT   REPEAT          379..416
FT                   /note="ARM 7"
FT   REPEAT          419..460
FT                   /note="ARM 8"
FT   REPEAT          466..506
FT                   /note="ARM 9"
FT   REPEAT          508..547
FT                   /note="ARM 10"
FT   REPEAT          570..609
FT                   /note="ARM 11"
FT   REPEAT          611..657
FT                   /note="ARM 12"
FT   CONFLICT        185
FT                   /note="I -> V (in Ref. 3; CAA47463)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        226
FT                   /note="A -> T (in Ref. 3; CAA47463)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   738 AA;  81711 MW;  569DBE69D08BBC58 CRC64;
     MDLGDVVEMP MKVTEWQKTY TYDSGINSGI NTSVPSLNGK MVIEDDSLAY PNSYTTVKTT
     TYTQQQNPDM ESHLNMTRAQ RVRAAMYPET VEDHSYLFST QIEGQQTNVQ KLAEPSQMLK
     SAIMHLINYQ DDAELATRAI PELTKLLNDE DPMVVNKASM IVNQLSKKEA SRKALMQSPQ
     IVAAIVRTMQ HTSDMDTARC TTSILHNLSH HREGLLSIFK SGGIPALVRM LSSPVESVLF
     YAITTLHNLL LYQEGAKMAV RLADGLQKMV PLLNKNNPKF LAITTDCLQL LAYGNQESKL
     IILGNGGPQG LVQIMRNYNY EKLLWTTSRV LKVLSVCPSN KPAIVEAGGM QALGKHLTSN
     SPRLVQNCLW TLRNLSDVAT KQEGLDNVLK ILVNQLSSDD VNVLTCATGT LSNLTCNNGR
     NKTLVTQSNG VESLIHTILR ASDKDDIAEP AVCAMRHLTS RHQDAEVAQN SVRLHYGIPA
     IVKLLNPPYQ WPLVKATIGL IRNLALCPAN HAPLYDAGVI PRLVQLLVKS HQDAQRHAAS
     GTQQPYTDGV KMEEIVEGCT GALHILARDP VNRMDIYKLN TIPLFVQLLY SPVENIQRVS
     SGVLCELAQD KEAADTIDAE GASAPLMELL HSRNEGIATY AAAVLFRISE DKNADYRKRV
     SVELTNAIFR QDPAAWEAAQ SMIPLNDPYS DEMENYRAMY PEDIPLEPMG GDMDVEYAMD
     GYSDHPGRGH YADNHMMA
//