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P30998

- PLAK_XENLA

UniProt

P30998 - PLAK_XENLA

Protein

Junction plakoglobin

Gene

jup

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Junction plakoglobin
    Alternative name(s):
    Desmoplakin III
    Desmoplakin-3
    Gene namesi
    Name:jup
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6254182. jup.

    Subcellular locationi

    Cell junctionadherens junction. Cell junctiondesmosome. Cytoplasmcytoskeleton. Membrane; Peripheral membrane protein
    Note: Cytoplasmic in a soluble and membrane-associated form.

    GO - Cellular componenti

    1. adherens junction Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-KW
    3. cytoskeleton Source: UniProtKB-SubCell
    4. desmosome Source: UniProtKB-SubCell
    5. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 738738Junction plakoglobinPRO_0000064282Add
    BLAST

    Proteomic databases

    PRIDEiP30998.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP30998.
    SMRiP30998. Positions 114-668.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati128 – 16740ARM 1Add
    BLAST
    Repeati168 – 21144ARM 2Add
    BLAST
    Repeati212 – 25140ARM 3Add
    BLAST
    Repeati254 – 29340ARM 4Add
    BLAST
    Repeati294 – 33744ARM 5Add
    BLAST
    Repeati338 – 37740ARM 6Add
    BLAST
    Repeati379 – 41638ARM 7Add
    BLAST
    Repeati419 – 46042ARM 8Add
    BLAST
    Repeati466 – 50641ARM 9Add
    BLAST
    Repeati508 – 54740ARM 10Add
    BLAST
    Repeati570 – 60940ARM 11Add
    BLAST
    Repeati611 – 65747ARM 12Add
    BLAST

    Sequence similaritiesi

    Belongs to the beta-catenin family.Curated
    Contains 12 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG000919.
    KOiK10056.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view]
    PfamiPF00514. Arm. 5 hits.
    [Graphical view]
    PRINTSiPR01869. BCATNINFAMLY.
    SMARTiSM00185. ARM. 12 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30998-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLGDVVEMP MKVTEWQKTY TYDSGINSGI NTSVPSLNGK MVIEDDSLAY    50
    PNSYTTVKTT TYTQQQNPDM ESHLNMTRAQ RVRAAMYPET VEDHSYLFST 100
    QIEGQQTNVQ KLAEPSQMLK SAIMHLINYQ DDAELATRAI PELTKLLNDE 150
    DPMVVNKASM IVNQLSKKEA SRKALMQSPQ IVAAIVRTMQ HTSDMDTARC 200
    TTSILHNLSH HREGLLSIFK SGGIPALVRM LSSPVESVLF YAITTLHNLL 250
    LYQEGAKMAV RLADGLQKMV PLLNKNNPKF LAITTDCLQL LAYGNQESKL 300
    IILGNGGPQG LVQIMRNYNY EKLLWTTSRV LKVLSVCPSN KPAIVEAGGM 350
    QALGKHLTSN SPRLVQNCLW TLRNLSDVAT KQEGLDNVLK ILVNQLSSDD 400
    VNVLTCATGT LSNLTCNNGR NKTLVTQSNG VESLIHTILR ASDKDDIAEP 450
    AVCAMRHLTS RHQDAEVAQN SVRLHYGIPA IVKLLNPPYQ WPLVKATIGL 500
    IRNLALCPAN HAPLYDAGVI PRLVQLLVKS HQDAQRHAAS GTQQPYTDGV 550
    KMEEIVEGCT GALHILARDP VNRMDIYKLN TIPLFVQLLY SPVENIQRVS 600
    SGVLCELAQD KEAADTIDAE GASAPLMELL HSRNEGIATY AAAVLFRISE 650
    DKNADYRKRV SVELTNAIFR QDPAAWEAAQ SMIPLNDPYS DEMENYRAMY 700
    PEDIPLEPMG GDMDVEYAMD GYSDHPGRGH YADNHMMA 738
    Length:738
    Mass (Da):81,711
    Last modified:July 1, 1993 - v1
    Checksum:i569DBE69D08BBC58
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti185 – 1851I → V in CAA47463. (PubMed:1397690)Curated
    Sequence conflicti226 – 2261A → T in CAA47463. (PubMed:1397690)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95593 mRNA. Translation: AAA49931.1.
    BC094116 mRNA. Translation: AAH94116.1.
    X67078 mRNA. Translation: CAA47463.1.
    PIRiS35093.
    RefSeqiNP_001084051.1. NM_001090582.1.
    UniGeneiXl.2844.

    Genome annotation databases

    GeneIDi399278.
    KEGGixla:399278.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95593 mRNA. Translation: AAA49931.1 .
    BC094116 mRNA. Translation: AAH94116.1 .
    X67078 mRNA. Translation: CAA47463.1 .
    PIRi S35093.
    RefSeqi NP_001084051.1. NM_001090582.1.
    UniGenei Xl.2844.

    3D structure databases

    ProteinModelPortali P30998.
    SMRi P30998. Positions 114-668.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P30998.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 399278.
    KEGGi xla:399278.

    Organism-specific databases

    CTDi 399278.
    Xenbasei XB-GENE-6254182. jup.

    Phylogenomic databases

    HOVERGENi HBG000919.
    KOi K10056.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view ]
    Pfami PF00514. Arm. 5 hits.
    [Graphical view ]
    PRINTSi PR01869. BCATNINFAMLY.
    SMARTi SM00185. ARM. 12 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of plakoglobin in oocytes and early embryos of Xenopus laevis: maternal expression of a gene encoding a junctional plaque protein."
      Fouquet B., Zimbelmann R., Franke W.W.
      Differentiation 51:187-194(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    3. "The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis."
      de Marais A.A., Moon R.T.
      Dev. Biol. 153:337-346(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-292.

    Entry informationi

    Entry nameiPLAK_XENLA
    AccessioniPrimary (citable) accession number: P30998
    Secondary accession number(s): Q52L07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3