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Protein

Junction plakoglobin

Gene

jup

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Junction plakoglobin
Alternative name(s):
Desmoplakin III
Desmoplakin-3
Gene namesi
Name:jup
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254182. jup.

Subcellular locationi

Cell junctionadherens junction. Cell junctiondesmosome. Cytoplasmcytoskeleton. Membrane; Peripheral membrane protein
Note: Cytoplasmic in a soluble and membrane-associated form.

GO - Cellular componenti

  1. adherens junction Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-SubCell
  4. desmosome Source: UniProtKB-SubCell
  5. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Junction plakoglobinPRO_0000064282Add
BLAST

Proteomic databases

PRIDEiP30998.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP30998.
SMRiP30998. Positions 114-668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati128 – 16740ARM 1Add
BLAST
Repeati168 – 21144ARM 2Add
BLAST
Repeati212 – 25140ARM 3Add
BLAST
Repeati254 – 29340ARM 4Add
BLAST
Repeati294 – 33744ARM 5Add
BLAST
Repeati338 – 37740ARM 6Add
BLAST
Repeati379 – 41638ARM 7Add
BLAST
Repeati419 – 46042ARM 8Add
BLAST
Repeati466 – 50641ARM 9Add
BLAST
Repeati508 – 54740ARM 10Add
BLAST
Repeati570 – 60940ARM 11Add
BLAST
Repeati611 – 65747ARM 12Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 12 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG000919.
KOiK10056.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 5 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30998-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLGDVVEMP MKVTEWQKTY TYDSGINSGI NTSVPSLNGK MVIEDDSLAY
60 70 80 90 100
PNSYTTVKTT TYTQQQNPDM ESHLNMTRAQ RVRAAMYPET VEDHSYLFST
110 120 130 140 150
QIEGQQTNVQ KLAEPSQMLK SAIMHLINYQ DDAELATRAI PELTKLLNDE
160 170 180 190 200
DPMVVNKASM IVNQLSKKEA SRKALMQSPQ IVAAIVRTMQ HTSDMDTARC
210 220 230 240 250
TTSILHNLSH HREGLLSIFK SGGIPALVRM LSSPVESVLF YAITTLHNLL
260 270 280 290 300
LYQEGAKMAV RLADGLQKMV PLLNKNNPKF LAITTDCLQL LAYGNQESKL
310 320 330 340 350
IILGNGGPQG LVQIMRNYNY EKLLWTTSRV LKVLSVCPSN KPAIVEAGGM
360 370 380 390 400
QALGKHLTSN SPRLVQNCLW TLRNLSDVAT KQEGLDNVLK ILVNQLSSDD
410 420 430 440 450
VNVLTCATGT LSNLTCNNGR NKTLVTQSNG VESLIHTILR ASDKDDIAEP
460 470 480 490 500
AVCAMRHLTS RHQDAEVAQN SVRLHYGIPA IVKLLNPPYQ WPLVKATIGL
510 520 530 540 550
IRNLALCPAN HAPLYDAGVI PRLVQLLVKS HQDAQRHAAS GTQQPYTDGV
560 570 580 590 600
KMEEIVEGCT GALHILARDP VNRMDIYKLN TIPLFVQLLY SPVENIQRVS
610 620 630 640 650
SGVLCELAQD KEAADTIDAE GASAPLMELL HSRNEGIATY AAAVLFRISE
660 670 680 690 700
DKNADYRKRV SVELTNAIFR QDPAAWEAAQ SMIPLNDPYS DEMENYRAMY
710 720 730
PEDIPLEPMG GDMDVEYAMD GYSDHPGRGH YADNHMMA
Length:738
Mass (Da):81,711
Last modified:July 1, 1993 - v1
Checksum:i569DBE69D08BBC58
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851I → V in CAA47463. (PubMed:1397690)Curated
Sequence conflicti226 – 2261A → T in CAA47463. (PubMed:1397690)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95593 mRNA. Translation: AAA49931.1.
BC094116 mRNA. Translation: AAH94116.1.
X67078 mRNA. Translation: CAA47463.1.
PIRiS35093.
RefSeqiNP_001084051.1. NM_001090582.1.
UniGeneiXl.2844.

Genome annotation databases

GeneIDi399278.
KEGGixla:399278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95593 mRNA. Translation: AAA49931.1.
BC094116 mRNA. Translation: AAH94116.1.
X67078 mRNA. Translation: CAA47463.1.
PIRiS35093.
RefSeqiNP_001084051.1. NM_001090582.1.
UniGeneiXl.2844.

3D structure databases

ProteinModelPortaliP30998.
SMRiP30998. Positions 114-668.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP30998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399278.
KEGGixla:399278.

Organism-specific databases

CTDi399278.
XenbaseiXB-GENE-6254182. jup.

Phylogenomic databases

HOVERGENiHBG000919.
KOiK10056.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 5 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of plakoglobin in oocytes and early embryos of Xenopus laevis: maternal expression of a gene encoding a junctional plaque protein."
    Fouquet B., Zimbelmann R., Franke W.W.
    Differentiation 51:187-194(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis."
    de Marais A.A., Moon R.T.
    Dev. Biol. 153:337-346(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-292.

Entry informationi

Entry nameiPLAK_XENLA
AccessioniPrimary (citable) accession number: P30998
Secondary accession number(s): Q52L07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: January 7, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.