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P30998

- PLAK_XENLA

UniProt

P30998 - PLAK_XENLA

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Protein
Junction plakoglobin
Gene
jup
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Junction plakoglobin
Alternative name(s):
Desmoplakin III
Desmoplakin-3
Gene namesi
Name:jup
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254182. jup.

Subcellular locationi

Cell junctionadherens junction. Cell junctiondesmosome. Cytoplasmcytoskeleton. Membrane; Peripheral membrane protein
Note: Cytoplasmic in a soluble and membrane-associated form.

GO - Cellular componenti

  1. adherens junction Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-SubCell
  4. desmosome Source: UniProtKB-SubCell
  5. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Junction plakoglobin
PRO_0000064282Add
BLAST

Proteomic databases

PRIDEiP30998.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP30998.
SMRiP30998. Positions 114-668.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati128 – 16740ARM 1
Add
BLAST
Repeati168 – 21144ARM 2
Add
BLAST
Repeati212 – 25140ARM 3
Add
BLAST
Repeati254 – 29340ARM 4
Add
BLAST
Repeati294 – 33744ARM 5
Add
BLAST
Repeati338 – 37740ARM 6
Add
BLAST
Repeati379 – 41638ARM 7
Add
BLAST
Repeati419 – 46042ARM 8
Add
BLAST
Repeati466 – 50641ARM 9
Add
BLAST
Repeati508 – 54740ARM 10
Add
BLAST
Repeati570 – 60940ARM 11
Add
BLAST
Repeati611 – 65747ARM 12
Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 12 ARM repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG000919.
KOiK10056.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 5 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30998-1 [UniParc]FASTAAdd to Basket

« Hide

MDLGDVVEMP MKVTEWQKTY TYDSGINSGI NTSVPSLNGK MVIEDDSLAY    50
PNSYTTVKTT TYTQQQNPDM ESHLNMTRAQ RVRAAMYPET VEDHSYLFST 100
QIEGQQTNVQ KLAEPSQMLK SAIMHLINYQ DDAELATRAI PELTKLLNDE 150
DPMVVNKASM IVNQLSKKEA SRKALMQSPQ IVAAIVRTMQ HTSDMDTARC 200
TTSILHNLSH HREGLLSIFK SGGIPALVRM LSSPVESVLF YAITTLHNLL 250
LYQEGAKMAV RLADGLQKMV PLLNKNNPKF LAITTDCLQL LAYGNQESKL 300
IILGNGGPQG LVQIMRNYNY EKLLWTTSRV LKVLSVCPSN KPAIVEAGGM 350
QALGKHLTSN SPRLVQNCLW TLRNLSDVAT KQEGLDNVLK ILVNQLSSDD 400
VNVLTCATGT LSNLTCNNGR NKTLVTQSNG VESLIHTILR ASDKDDIAEP 450
AVCAMRHLTS RHQDAEVAQN SVRLHYGIPA IVKLLNPPYQ WPLVKATIGL 500
IRNLALCPAN HAPLYDAGVI PRLVQLLVKS HQDAQRHAAS GTQQPYTDGV 550
KMEEIVEGCT GALHILARDP VNRMDIYKLN TIPLFVQLLY SPVENIQRVS 600
SGVLCELAQD KEAADTIDAE GASAPLMELL HSRNEGIATY AAAVLFRISE 650
DKNADYRKRV SVELTNAIFR QDPAAWEAAQ SMIPLNDPYS DEMENYRAMY 700
PEDIPLEPMG GDMDVEYAMD GYSDHPGRGH YADNHMMA 738
Length:738
Mass (Da):81,711
Last modified:July 1, 1993 - v1
Checksum:i569DBE69D08BBC58
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851I → V in CAA47463. 1 Publication
Sequence conflicti226 – 2261A → T in CAA47463. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95593 mRNA. Translation: AAA49931.1.
BC094116 mRNA. Translation: AAH94116.1.
X67078 mRNA. Translation: CAA47463.1.
PIRiS35093.
RefSeqiNP_001084051.1. NM_001090582.1.
UniGeneiXl.2844.

Genome annotation databases

GeneIDi399278.
KEGGixla:399278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95593 mRNA. Translation: AAA49931.1 .
BC094116 mRNA. Translation: AAH94116.1 .
X67078 mRNA. Translation: CAA47463.1 .
PIRi S35093.
RefSeqi NP_001084051.1. NM_001090582.1.
UniGenei Xl.2844.

3D structure databases

ProteinModelPortali P30998.
SMRi P30998. Positions 114-668.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P30998.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399278.
KEGGi xla:399278.

Organism-specific databases

CTDi 399278.
Xenbasei XB-GENE-6254182. jup.

Phylogenomic databases

HOVERGENi HBG000919.
KOi K10056.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view ]
Pfami PF00514. Arm. 5 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 12 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of plakoglobin in oocytes and early embryos of Xenopus laevis: maternal expression of a gene encoding a junctional plaque protein."
    Fouquet B., Zimbelmann R., Franke W.W.
    Differentiation 51:187-194(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis."
    de Marais A.A., Moon R.T.
    Dev. Biol. 153:337-346(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-292.

Entry informationi

Entry nameiPLAK_XENLA
AccessioniPrimary (citable) accession number: P30998
Secondary accession number(s): Q52L07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 16, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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