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P30998 (PLAK_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Junction plakoglobin
Alternative name(s):
Desmoplakin III
Desmoplakin-3
Gene names
Name:jup
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length738 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.

Subunit structure

Homodimer.

Subcellular location

Cell junctionadherens junction. Cell junctiondesmosome. Cytoplasmcytoskeleton. Membrane; Peripheral membrane protein. Note: Cytoplasmic in a soluble and membrane-associated form.

Sequence similarities

Belongs to the beta-catenin family.

Contains 12 ARM repeats.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell junction
Cytoplasm
Cytoskeleton
Membrane
   DomainRepeat
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentadherens junction

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

desmosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 738738Junction plakoglobin
PRO_0000064282

Regions

Repeat128 – 16740ARM 1
Repeat168 – 21144ARM 2
Repeat212 – 25140ARM 3
Repeat254 – 29340ARM 4
Repeat294 – 33744ARM 5
Repeat338 – 37740ARM 6
Repeat379 – 41638ARM 7
Repeat419 – 46042ARM 8
Repeat466 – 50641ARM 9
Repeat508 – 54740ARM 10
Repeat570 – 60940ARM 11
Repeat611 – 65747ARM 12

Experimental info

Sequence conflict1851I → V in CAA47463. Ref.3
Sequence conflict2261A → T in CAA47463. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P30998 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 569DBE69D08BBC58

FASTA73881,711
        10         20         30         40         50         60 
MDLGDVVEMP MKVTEWQKTY TYDSGINSGI NTSVPSLNGK MVIEDDSLAY PNSYTTVKTT 

        70         80         90        100        110        120 
TYTQQQNPDM ESHLNMTRAQ RVRAAMYPET VEDHSYLFST QIEGQQTNVQ KLAEPSQMLK 

       130        140        150        160        170        180 
SAIMHLINYQ DDAELATRAI PELTKLLNDE DPMVVNKASM IVNQLSKKEA SRKALMQSPQ 

       190        200        210        220        230        240 
IVAAIVRTMQ HTSDMDTARC TTSILHNLSH HREGLLSIFK SGGIPALVRM LSSPVESVLF 

       250        260        270        280        290        300 
YAITTLHNLL LYQEGAKMAV RLADGLQKMV PLLNKNNPKF LAITTDCLQL LAYGNQESKL 

       310        320        330        340        350        360 
IILGNGGPQG LVQIMRNYNY EKLLWTTSRV LKVLSVCPSN KPAIVEAGGM QALGKHLTSN 

       370        380        390        400        410        420 
SPRLVQNCLW TLRNLSDVAT KQEGLDNVLK ILVNQLSSDD VNVLTCATGT LSNLTCNNGR 

       430        440        450        460        470        480 
NKTLVTQSNG VESLIHTILR ASDKDDIAEP AVCAMRHLTS RHQDAEVAQN SVRLHYGIPA 

       490        500        510        520        530        540 
IVKLLNPPYQ WPLVKATIGL IRNLALCPAN HAPLYDAGVI PRLVQLLVKS HQDAQRHAAS 

       550        560        570        580        590        600 
GTQQPYTDGV KMEEIVEGCT GALHILARDP VNRMDIYKLN TIPLFVQLLY SPVENIQRVS 

       610        620        630        640        650        660 
SGVLCELAQD KEAADTIDAE GASAPLMELL HSRNEGIATY AAAVLFRISE DKNADYRKRV 

       670        680        690        700        710        720 
SVELTNAIFR QDPAAWEAAQ SMIPLNDPYS DEMENYRAMY PEDIPLEPMG GDMDVEYAMD 

       730 
GYSDHPGRGH YADNHMMA 

« Hide

References

« Hide 'large scale' references
[1]"Identification of plakoglobin in oocytes and early embryos of Xenopus laevis: maternal expression of a gene encoding a junctional plaque protein."
Fouquet B., Zimbelmann R., Franke W.W.
Differentiation 51:187-194(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[3]"The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis."
de Marais A.A., Moon R.T.
Dev. Biol. 153:337-346(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-292.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95593 mRNA. Translation: AAA49931.1.
BC094116 mRNA. Translation: AAH94116.1.
X67078 mRNA. Translation: CAA47463.1.
PIRS35093.
RefSeqNP_001084051.1. NM_001090582.1.
UniGeneXl.2844.

3D structure databases

ProteinModelPortalP30998.
SMRP30998. Positions 114-668.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP30998.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID399278.
KEGGxla:399278.

Organism-specific databases

CTD399278.
XenbaseXB-GENE-6254182. jup.

Phylogenomic databases

HOVERGENHBG000919.
KOK10056.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamPF00514. Arm. 5 hits.
[Graphical view]
PRINTSPR01869. BCATNINFAMLY.
SMARTSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLAK_XENLA
AccessionPrimary (citable) accession number: P30998
Secondary accession number(s): Q52L07
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 16, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families