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Protein

Catenin alpha-2

Gene

CTNNA2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system.1 Publication

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: UniProtKB
  • brain morphogenesis Source: UniProtKB
  • dendrite morphogenesis Source: UniProtKB
  • epithelial cell differentiation Source: UniProtKB
  • neural crest cell migration Source: AgBase
  • protein localization Source: AgBase
  • regulation of synapse structural plasticity Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
  • trigeminal ganglion formation Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin alpha-2
Alternative name(s):
Alpha N-catenin
Neural alpha-catenin
Gene namesi
Name:CTNNA2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton By similarity
  • Cell junctionadherens junction 1 Publication
  • Cell projectionaxon 1 Publication
  • Nucleus By similarity

GO - Cellular componenti

  • actin cytoskeleton Source: InterPro
  • adherens junction Source: UniProtKB
  • axon Source: UniProtKB
  • cell-cell adherens junction Source: InterPro
  • cytoplasm Source: UniProtKB
  • cytosol Source: AgBase
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642651 – 906Catenin alpha-2Add BLAST906

Proteomic databases

PaxDbiP30997.
PRIDEiP30997.

Expressioni

Tissue specificityi

Mainly in the nervous system (at protein level).1 Publication

Developmental stagei

Expressed in the neural tube, dorsal root glanglia, spinal nerves and myotome at E4. Expressed in neuronal and glial cell populations as detected at E10 (at protein level).1 Publication

Gene expression databases

BgeeiENSGALG00000027853.

Interactioni

Subunit structurei

Interacts with CDH1 and CDH2.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025681.

Structurei

3D structure databases

ProteinModelPortaliP30997.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
HOGENOMiHOG000280724.
HOVERGENiHBG000069.
InParanoidiP30997.
KOiK05691.
OrthoDBiEOG091G01KR.
PhylomeDBiP30997.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR030046. CTNNA2.
IPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 1 hit.
PTHR18914:SF23. PTHR18914:SF23. 1 hit.
PfamiPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 4 hits.
PROSITEiPS00663. VINCULIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK
60 70 80 90 100
KGRSKKAHVL AASVEQATQN FLEKGDQIAK ESQDLKEELV AAVEDVRKQG
110 120 130 140 150
ETMRIASSEF ADDPCSSVKR GTMVRAARAL LSAVTRLLIL ADMADVMRLL
160 170 180 190 200
SHLKIVEEAL EAVKNATNEQ DLANRFKEFG KEMVKLNYVA ARRQQELKDP
210 220 230 240 250
HCRDEMAAAR GALKKNATML YTASQAFLRH PDVAATRANR DYVFKQVQEA
260 270 280 290 300
IAGISNAAQA TSPTDENKGH TGIGELAAAL NEFDNKIILD PMTFSEARFR
310 320 330 340 350
PSLEERLESI ISGAALMADS SCTRDDRRKR IVAECKRAVR QALQDLLSEY
360 370 380 390 400
MNNTGRKEKG DPLNIAIDKM TKKTRDLRRQ LRKAVMDHIS DSFLETNVPL
410 420 430 440 450
LVLIEAAKSG NEKEVKEYAQ VFREHANKLV EVANLACSIS NNEEGVKLVR
460 470 480 490 500
MAATQIDSLC PQVINAALTL AARPQSKVAQ DNMDVFKDQW EKQVRVLTEA
510 520 530 540 550
VDDITSVDDF LSVSENHILE DVNKCVIALQ EGDVDTLDRT AGAIRGRAAR
560 570 580 590 600
VIHIINAEME NYETGVYTEK VLEATKLLSE TVMPRFAEQV EVAIEALSAN
610 620 630 640 650
VPQPFEENEF IDASRLVYDG VRDIRKAVLM IRTPEELEDD SDFEQEDYDV
660 670 680 690 700
RSRTSVQTED DQLIAGQSAR AIMAQLPQEE KAKIAEQVEI FHQEKSKLDA
710 720 730 740 750
EVAKWDDSGN DIIVLAKQMC MIMMEMTDFT RGKGPLKNTS DVINAAKKIA
760 770 780 790 800
EAGSRMDKLA RAVADQCPDS ACKQDLLAYL QRIALYCHQL NICSKVKAEV
810 820 830 840 850
QNLGGELIVS GLDSATSLIQ AAKNLMNAVV LTVKASYVAS TKYQKVYGTA
860 870 880 890 900
AVNSPVVSWK MKAPEKKPLV KREKPEEYQT RVRRGSQKKH ISPVQALSEF

KAMDSF
Length:906
Mass (Da):100,691
Last modified:July 1, 1993 - v1
Checksum:i7714D04918572DB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11090 mRNA. Translation: BAA01863.1.
PIRiA43000.
RefSeqiNP_990467.1. NM_205136.1.
UniGeneiGga.2375.

Genome annotation databases

GeneIDi396035.
KEGGigga:396035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11090 mRNA. Translation: BAA01863.1.
PIRiA43000.
RefSeqiNP_990467.1. NM_205136.1.
UniGeneiGga.2375.

3D structure databases

ProteinModelPortaliP30997.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025681.

Proteomic databases

PaxDbiP30997.
PRIDEiP30997.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396035.
KEGGigga:396035.

Organism-specific databases

CTDi1496.

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
HOGENOMiHOG000280724.
HOVERGENiHBG000069.
InParanoidiP30997.
KOiK05691.
OrthoDBiEOG091G01KR.
PhylomeDBiP30997.

Miscellaneous databases

PROiP30997.

Gene expression databases

BgeeiENSGALG00000027853.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR030046. CTNNA2.
IPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 1 hit.
PTHR18914:SF23. PTHR18914:SF23. 1 hit.
PfamiPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 4 hits.
PROSITEiPS00663. VINCULIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTNA2_CHICK
AccessioniPrimary (citable) accession number: P30997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.