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Protein

C5a anaphylatoxin chemotactic receptor 1

Gene

C5ar1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.By similarity

GO - Molecular functioni

GO - Biological processi

  • defense response to Gram-positive bacterium Source: MGI
  • inflammatory response Source: GO_Central
  • mRNA transcription by RNA polymerase II Source: UniProtKB
  • neutrophil chemotaxis Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: GO_Central
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of macrophage chemotaxis Source: BHF-UCL
  • positive regulation of neutrophil chemotaxis Source: BHF-UCL
  • positive regulation of vascular endothelial growth factor production Source: BHF-UCL
  • response to peptidoglycan Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events
R-MMU-6798695 Neutrophil degranulation
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 1
Alternative name(s):
C5a anaphylatoxin chemotactic receptor
Short name:
C5a-R
Short name:
C5aR
CD_antigen: CD88
Gene namesi
Name:C5ar1
Synonyms:C5ar, C5r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88232 C5ar1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularCuratedAdd BLAST37
Transmembranei38 – 64Helical; Name=1By similarityAdd BLAST27
Topological domaini65 – 69CytoplasmicCurated5
Transmembranei70 – 93Helical; Name=2By similarityAdd BLAST24
Topological domaini94 – 110ExtracellularCuratedAdd BLAST17
Transmembranei111 – 132Helical; Name=3By similarityAdd BLAST22
Topological domaini133 – 153CytoplasmicCuratedAdd BLAST21
Transmembranei154 – 174Helical; Name=4By similarityAdd BLAST21
Topological domaini175 – 201ExtracellularCuratedAdd BLAST27
Transmembranei202 – 227Helical; Name=5By similarityAdd BLAST26
Topological domaini228 – 243CytoplasmicCuratedAdd BLAST16
Transmembranei244 – 266Helical; Name=6By similarityAdd BLAST23
Topological domaini267 – 283ExtracellularCuratedAdd BLAST17
Transmembranei284 – 304Helical; Name=7By similarityAdd BLAST21
Topological domaini305 – 351CytoplasmicCuratedAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5746
GuidetoPHARMACOLOGYi32

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692111 – 351C5a anaphylatoxin chemotactic receptor 1CuratedAdd BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei13SulfotyrosineBy similarity1
Modified residuei16SulfotyrosineBy similarity1
Disulfide bondi109 ↔ 188PROSITE-ProRule annotation
Modified residuei315PhosphoserineBy similarity1
Modified residuei318PhosphoserineBy similarity1
Modified residuei325PhosphoserineCombined sources1
Modified residuei328PhosphoserineBy similarity1
Modified residuei333PhosphoserineCombined sources1
Modified residuei339PhosphoserineBy similarity1

Post-translational modificationi

Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.By similarity
Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to C5a.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP30993
PeptideAtlasiP30993
PRIDEiP30993

PTM databases

iPTMnetiP30993
PhosphoSitePlusiP30993

Expressioni

Gene expression databases

BgeeiENSMUSG00000049130
CleanExiMM_C5AR1
ExpressionAtlasiP30993 baseline and differential
GenevisibleiP30993 MM

Interactioni

Subunit structurei

Homodimer. May also form higher-order oligomers. Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR.By similarity

Protein-protein interaction databases

IntActiP30993, 1 interactor
STRINGi10090.ENSMUSP00000060003

Structurei

3D structure databases

ProteinModelPortaliP30993
SMRiP30993
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF0K Eukaryota
ENOG410Y9HH LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG107547
InParanoidiP30993
KOiK04010
OMAiYINCCIN
OrthoDBiEOG091G0DT8

Family and domain databases

InterProiView protein in InterPro
IPR001274 Anaphtx_C5AR1/C5AR2
IPR002234 Anphylx_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01104 ANPHYLATOXNR
PR00426 C5ANPHYLTXNR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPIDNSSFE INYDHYGTMD PNIPADGIHL PKRQPGDVAA LIIYSVVFLV
60 70 80 90 100
GVPGNALVVW VTAFEARRAV NAIWFLNLAV ADLLSCLALP VLFTTVLNHN
110 120 130 140 150
YWYFDATACI VLPSLILLNM YASILLLATI SADRFLLVFK PIWCQKVRGT
160 170 180 190 200
GLAWMACGVA WVLALLLTIP SFVYREAYKD FYSEHTVCGI NYGGGSFPKE
210 220 230 240 250
KAVAILRLMV GFVLPLLTLN ICYTFLLLRT WSRKATRSTK TLKVVMAVVI
260 270 280 290 300
CFFIFWLPYQ VTGVMIAWLP PSSPTLKRVE KLNSLCVSLA YINCCVNPII
310 320 330 340 350
YVMAGQGFHG RLLRSLPSII RNALSEDSVG RDSKTFTPST TDTSTRKSQA

V
Length:351
Mass (Da):39,023
Last modified:January 7, 2015 - v2
Checksum:i1186314DBAECC8F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66 – 70ARRAV → PDGPS in AAB97774 (PubMed:1401897).Curated5
Sequence conflicti89L → M in AAB97774 (PubMed:1401897).Curated1
Sequence conflicti341T → D in AAB97774 (PubMed:1401897).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S46665, S50577 Genomic DNA Translation: AAB97774.1
AY220494 mRNA Translation: AAP50849.1
AK158027 mRNA Translation: BAE34324.1
AC156630 Genomic DNA No translation available.
BC125641 mRNA Translation: AAI25642.1
BC125643 mRNA Translation: AAI25644.1
CCDSiCCDS20846.1
PIRiA46525
RefSeqiNP_001167021.1, NM_001173550.1
NP_031603.2, NM_007577.4
UniGeneiMm.247623

Genome annotation databases

EnsembliENSMUST00000050770; ENSMUSP00000060003; ENSMUSG00000049130
ENSMUST00000168818; ENSMUSP00000129972; ENSMUSG00000049130
GeneIDi12273
KEGGimmu:12273
UCSCiuc009fhl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiC5AR1_MOUSE
AccessioniPrimary (citable) accession number: P30993
Secondary accession number(s): Q3TZ86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 7, 2015
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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