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Protein

Neurotensin/neuromedin N

Gene

NTS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

GO - Molecular functioni

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • killing of cells of other organism Source: UniProtKB
  • regulation of blood vessel size Source: UniProtKB-KW
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionVasoactive

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP30990.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin/neuromedin N
Cleaved into the following 4 chains:
Alternative name(s):
NmN-125
Neuromedin N
Short name:
NN
Short name:
NmN
Neurotensin
Short name:
NT
Gene namesi
Name:NTS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000133636.10.
HGNCiHGNC:8038. NTS.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4922.
OpenTargetsiENSG00000133636.
PharmGKBiPA31820.

Polymorphism and mutation databases

BioMutaiNTS.
DMDMi2828196.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001952224 – 148Large neuromedin NAdd BLAST125
PeptideiPRO_0000019523144 – 148Neuromedin N5
PeptideiPRO_0000019524151 – 163NeurotensinAdd BLAST13
PeptideiPRO_0000019525166 – 170Tail peptideSequence analysis5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151Pyrrolidone carboxylic acid1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP30990.
PaxDbiP30990.
PeptideAtlasiP30990.
PRIDEiP30990.

PTM databases

iPTMnetiP30990.
PhosphoSitePlusiP30990.

Miscellaneous databases

PMAP-CutDBiP30990.

Expressioni

Gene expression databases

BgeeiENSG00000133636.
CleanExiHS_NTS.
ExpressionAtlasiP30990. baseline and differential.
GenevisibleiP30990. HS.

Organism-specific databases

HPAiHPA026664.

Interactioni

Subunit structurei

Interacts with NTSR1. Interacts with SORT1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NTSR1P309892EBI-6655817,EBI-6655774

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110976. 2 interactors.
DIPiDIP-60978N.
IntActiP30990. 3 interactors.
STRINGi9606.ENSP00000256010.

Chemistry databases

BindingDBiP30990.

Structurei

Secondary structure

1170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi152 – 154Combined sources3
Beta strandi156 – 159Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LNENMR-A152-163[»]
2LNFNMR-A152-163[»]
2LNGNMR-A152-163[»]
2LYWNMR-B152-163[»]
2OYVNMR-A152-163[»]
2OYWNMR-A152-163[»]
3F6KX-ray2.00N151-163[»]
4PO7X-ray2.66N/P151-163[»]
ProteinModelPortaliP30990.
SMRiP30990.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30990.

Family & Domainsi

Sequence similaritiesi

Belongs to the neurotensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDE. Eukaryota.
ENOG410YV74. LUCA.
GeneTreeiENSGT00640000091574.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiP30990.
KOiK05235.
OMAiLTNMYTS.
OrthoDBiEOG091G0PRU.
PhylomeDBiP30990.
TreeFamiTF330765.

Family and domain databases

InterProiView protein in InterPro
IPR008055. NeurotensiN.
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiView protein in Pfam
PF07421. Pro-NT_NN. 1 hit.
PRINTSiPR01668. NEUROTENSIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016590. NeurotensiN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAGMKIQLV CMLLLAFSSW SLCSDSEEEM KALEADFLTN MHTSKISKAH
60 70 80 90 100
VPSWKMTLLN VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA
110 120 130 140 150
MLTIYQLHKI CHSRAFQHWE LIQEDILDTG NDKNGKEEVI KRKIPYILKR
160 170
QLYENKPRRP YILKRDSYYY
Length:170
Mass (Da):19,795
Last modified:November 1, 1997 - v2
Checksum:i66E2E146DA08E3C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91618 mRNA. Translation: AAB50564.1.
BC010918 mRNA. Translation: AAH10918.1.
S47339 Genomic DNA. Translation: AAB23934.1.
CCDSiCCDS9029.1.
PIRiI58190.
RefSeqiNP_006174.1. NM_006183.4.
UniGeneiHs.80962.

Genome annotation databases

EnsembliENST00000256010; ENSP00000256010; ENSG00000133636.
GeneIDi4922.
KEGGihsa:4922.

Similar proteinsi

Entry informationi

Entry nameiNEUT_HUMAN
AccessioniPrimary (citable) accession number: P30990
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: September 27, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families