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P30990

- NEUT_HUMAN

UniProt

P30990 - NEUT_HUMAN

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Protein

Neurotensin/neuromedin N

Gene

NTS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

GO - Biological processi

  1. regulation of blood vessel size Source: UniProtKB-KW
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin/neuromedin N
Cleaved into the following 4 chains:
Alternative name(s):
NmN-125
Neuromedin N
Short name:
NN
Short name:
NmN
Neurotensin
Short name:
NT
Gene namesi
Name:NTS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:8038. NTS.

Subcellular locationi

Secreted. Cytoplasmic vesiclesecretory vesicle
Note: Packaged within secretory vesicles.

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 148125Large neuromedin NPRO_0000019522Add
BLAST
Peptidei144 – 1485Neuromedin NPRO_0000019523
Peptidei151 – 16313NeurotensinPRO_0000019524Add
BLAST
Peptidei166 – 1705Tail peptideSequence AnalysisPRO_0000019525

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Pyrrolidone carboxylic acid1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP30990.
PaxDbiP30990.
PRIDEiP30990.

PTM databases

PhosphoSiteiP30990.

Miscellaneous databases

PMAP-CutDBP30990.

Expressioni

Gene expression databases

BgeeiP30990.
CleanExiHS_NTS.
ExpressionAtlasiP30990. baseline and differential.
GenevestigatoriP30990.

Organism-specific databases

HPAiHPA026664.

Interactioni

Subunit structurei

Interacts with NTSR1. Interacts with SORT1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NTSR1P309892EBI-6655817,EBI-6655774

Protein-protein interaction databases

BioGridi110976. 2 interactions.
DIPiDIP-60978N.
IntActiP30990. 2 interactions.
STRINGi9606.ENSP00000256010.

Structurei

Secondary structure

1
170
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi156 – 1594

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LNENMR-A152-163[»]
2LNFNMR-A152-163[»]
2LNGNMR-A152-163[»]
2LYWNMR-B152-163[»]
2OYVNMR-A152-163[»]
2OYWNMR-A152-163[»]
3F6KX-ray2.00N151-163[»]
4PO7X-ray2.66N/P151-163[»]
ProteinModelPortaliP30990.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30990.

Family & Domainsi

Sequence similaritiesi

Belongs to the neurotensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46419.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiP30990.
KOiK05235.
OMAiTNMYTSK.
PhylomeDBiP30990.
TreeFamiTF330765.

Family and domain databases

InterProiIPR008055. NeurotensiN.
[Graphical view]
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSiPR01668. NEUROTENSIN.
ProDomiPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30990-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMAGMKIQLV CMLLLAFSSW SLCSDSEEEM KALEADFLTN MHTSKISKAH
60 70 80 90 100
VPSWKMTLLN VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA
110 120 130 140 150
MLTIYQLHKI CHSRAFQHWE LIQEDILDTG NDKNGKEEVI KRKIPYILKR
160 170
QLYENKPRRP YILKRDSYYY
Length:170
Mass (Da):19,795
Last modified:November 1, 1997 - v2
Checksum:i66E2E146DA08E3C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U91618 mRNA. Translation: AAB50564.1.
BC010918 mRNA. Translation: AAH10918.1.
S47339 Genomic DNA. Translation: AAB23934.1.
CCDSiCCDS9029.1.
PIRiI58190.
RefSeqiNP_006174.1. NM_006183.4.
UniGeneiHs.80962.

Genome annotation databases

EnsembliENST00000256010; ENSP00000256010; ENSG00000133636.
GeneIDi4922.
KEGGihsa:4922.
UCSCiuc001tag.3. human.

Polymorphism databases

DMDMi2828196.

Cross-referencesi

Web resourcesi

Wikipedia

Neurotensin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U91618 mRNA. Translation: AAB50564.1 .
BC010918 mRNA. Translation: AAH10918.1 .
S47339 Genomic DNA. Translation: AAB23934.1 .
CCDSi CCDS9029.1.
PIRi I58190.
RefSeqi NP_006174.1. NM_006183.4.
UniGenei Hs.80962.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LNE NMR - A 152-163 [» ]
2LNF NMR - A 152-163 [» ]
2LNG NMR - A 152-163 [» ]
2LYW NMR - B 152-163 [» ]
2OYV NMR - A 152-163 [» ]
2OYW NMR - A 152-163 [» ]
3F6K X-ray 2.00 N 151-163 [» ]
4PO7 X-ray 2.66 N/P 151-163 [» ]
ProteinModelPortali P30990.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110976. 2 interactions.
DIPi DIP-60978N.
IntActi P30990. 2 interactions.
STRINGi 9606.ENSP00000256010.

Chemistry

BindingDBi P30990.

PTM databases

PhosphoSitei P30990.

Polymorphism databases

DMDMi 2828196.

Proteomic databases

MaxQBi P30990.
PaxDbi P30990.
PRIDEi P30990.

Protocols and materials databases

DNASUi 4922.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256010 ; ENSP00000256010 ; ENSG00000133636 .
GeneIDi 4922.
KEGGi hsa:4922.
UCSCi uc001tag.3. human.

Organism-specific databases

CTDi 4922.
GeneCardsi GC12P086201.
HGNCi HGNC:8038. NTS.
HPAi HPA026664.
MIMi 162650. gene.
neXtProti NX_P30990.
PharmGKBi PA31820.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46419.
HOGENOMi HOG000113770.
HOVERGENi HBG003785.
InParanoidi P30990.
KOi K05235.
OMAi TNMYTSK.
PhylomeDBi P30990.
TreeFami TF330765.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTracei P30990.
GeneWikii Neurotensin.
GenomeRNAii 4922.
NextBioi 18955.
PMAP-CutDB P30990.
PROi P30990.
SOURCEi Search...

Gene expression databases

Bgeei P30990.
CleanExi HS_NTS.
ExpressionAtlasi P30990. baseline and differential.
Genevestigatori P30990.

Family and domain databases

InterProi IPR008055. NeurotensiN.
[Graphical view ]
PANTHERi PTHR15356. PTHR15356. 1 hit.
Pfami PF07421. Pro-NT_NN. 1 hit.
[Graphical view ]
PRINTSi PR01668. NEUROTENSIN.
ProDomi PD016590. NeurotensiN. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA methylation contributes to expression of the human neurotensin/neuromedin N gene."
    Dong Z., Wang X., Zhao Q., Townsend C.M. Jr., Evers B.M.
    Am. J. Physiol. 274:G535-G543(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls."
    Bean A.J., Dagerlind A., Hoekfelt T., Dobner P.R.
    Neuroscience 50:259-268(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-120.
  4. "Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain."
    Quistgaard E.M., Madsen P., Groftehauge M.K., Nissen P., Petersen C.M., Thirup S.S.
    Nat. Struct. Mol. Biol. 16:96-98(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 151-163 IN COMPLEX WITH SORT1, INTERACTION WITH SORT1, PYROGLUTAMATE FORMATION AT GLN-151.
  5. "Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor."
    Da Costa G., Bondon A., Coutant J., Curmi P., Monti J.P.
    J. Biomol. Struct. Dyn. 31:1381-1392(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 152-163 IN COMPLEX WITH NTSR1, SUBUNIT.

Entry informationi

Entry nameiNEUT_HUMAN
AccessioniPrimary (citable) accession number: P30990
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3