P30990 (NEUT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurotensin/neuromedin N

Cleaved into the following 4 chains:

1. Large neuromedin N
   Alternative name(s):
   NmN-125
2. Neuromedin N
   Short name=NN
   Short name=NmN
3. Neurotensin
   Short name=NT
4. Tail peptide

Gene names

Name:

NTS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
Subcellular location	Secreted. Cytoplasmic vesicle › secretory vesicle. Note: Packaged within secretory vesicles.
Sequence similarities	Belongs to the neurotensin family.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Secreted
Domain	Signal
Molecular function	Vasoactive
PTM	Cleavage on pair of basic residues Pyrrolidone carboxylic acid
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of blood vessel size Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Non-traceable author statement PubMed 8954810. Source: ProtInc
Cellular_component	extracellular region Traceable author statement. Source: Reactome transport vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Potential

Chain

24 – 148

125

Large neuromedin N

PRO_0000019522

Peptide

144 – 148

5

Neuromedin N

PRO_0000019523

Peptide

151 – 163

13

Neurotensin

PRO_0000019524

Peptide

166 – 170

5

Tail peptide Potential

PRO_0000019525

Amino acid modifications

Modified residue

151

1

Pyrrolidone carboxylic acid

Secondary structure

1

.

.

.

170

Helix Strand Turn

Details...

Beta strand

156 – 159

4

Sequences

	Sequence		Length	Mass (Da)
	P30990 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 66E2E146DA08E3C7	FASTA	170	19,795
	10 20 30 40 50 60 MMAGMKIQLV CMLLLAFSSW SLCSDSEEEM KALEADFLTN MHTSKISKAH VPSWKMTLLN 70 80 90 100 110 120 VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA MLTIYQLHKI CHSRAFQHWE 130 140 150 160 170 LIQEDILDTG NDKNGKEEVI KRKIPYILKR QLYENKPRRP YILKRDSYYY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA methylation contributes to expression of the human neurotensin/neuromedin N gene." Dong Z., Wang X., Zhao Q., Townsend C.M. Jr., Evers B.M. Am. J. Physiol. 274:G535-G543(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls." Bean A.J., Dagerlind A., Hoekfelt T., Dobner P.R. Neuroscience 50:259-268(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-120.
[4]	"Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain." Quistgaard E.M., Madsen P., Groftehauge M.K., Nissen P., Petersen C.M., Thirup S.S. Nat. Struct. Mol. Biol. 16:96-98(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 151-163, PYROGLUTAMATE FORMATION AT GLN-151.
+	Additional computationally mapped references.

Web resources

Wikipedia

Neurotensin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U91618 mRNA. Translation: AAB50564.1.
BC010918 mRNA. Translation: AAH10918.1.
S47339 Genomic DNA. Translation: AAB23934.1.

IPI

IPI00028158.

PIR

I58190.

RefSeq

NP_006174.1. NM_006183.4.

UniGene

Hs.80962.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LNE	NMR	-	A	152-163	[»]
2LNF	NMR	-	A	152-163	[»]
2LNG	NMR	-	A	152-163	[»]
2LYW	NMR	-	B	152-163	[»]
3F6K	X-ray	2.00	N	152-163	[»]

ProteinModelPortal

P30990.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000256010.

PTM databases

PhosphoSite

P30990.

Polymorphism databases

DMDM

2828196.

Proteomic databases

PaxDb

P30990.

PRIDE

P30990.

Protocols and materials databases

DNASU

4922.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000256010; ENSP00000256010; ENSG00000133636.

GeneID

4922.

KEGG

hsa:4922.

UCSC

uc001tag.3. human.

Organism-specific databases

CTD

4922.

GeneCards

GC12P086201.

HGNC

HGNC:8038. NTS.

HPA

CAB022386.

MIM

162650. gene.

neXtProt

NX_P30990.

PharmGKB

PA31820.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG46419.

HOGENOM

HOG000113770.

HOVERGEN

HBG003785.

InParanoid

P30990.

KO

K05235.

OMA

NSQAEET.

OrthoDB

EOG4CVG82.

PhylomeDB

P30990.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

P30990.

Bgee

P30990.

CleanEx

HS_NTS.

Genevestigator

P30990.

GermOnline

ENSG00000133636. Homo sapiens.

Family and domain databases

InterPro

IPR008055. NeurotensiN.
[Graphical view]

PANTHER

PTHR15356. PTHR15356. 1 hit.

Pfam

PF07421. Pro-NT_NN. 1 hit.
[Graphical view]

PRINTS

PR01668. NEUROTENSIN.

ProDom

PD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Search...

Other

BindingDB

P30990.

EvolutionaryTrace

P30990.

GenomeRNAi

4922.

NextBio

18955.

PMAP-CutDB

P30990.

SOURCE

Search...

Entry information

Entry name

NEUT_HUMAN

Accession

Primary (citable) accession number: P30990

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.