Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P30990

- NEUT_HUMAN

UniProt

P30990 - NEUT_HUMAN

Protein

Neurotensin/neuromedin N

Gene

NTS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of blood vessel size Source: UniProtKB-KW
    2. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Vasoactive

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotensin/neuromedin N
    Cleaved into the following 4 chains:
    Alternative name(s):
    NmN-125
    Neuromedin N
    Short name:
    NN
    Short name:
    NmN
    Neurotensin
    Short name:
    NT
    Gene namesi
    Name:NTS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:8038. NTS.

    Subcellular locationi

    Secreted. Cytoplasmic vesiclesecretory vesicle
    Note: Packaged within secretory vesicles.

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. transport vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31820.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 148125Large neuromedin NPRO_0000019522Add
    BLAST
    Peptidei144 – 1485Neuromedin NPRO_0000019523
    Peptidei151 – 16313NeurotensinPRO_0000019524Add
    BLAST
    Peptidei166 – 1705Tail peptideSequence AnalysisPRO_0000019525

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Pyrrolidone carboxylic acid1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiP30990.
    PaxDbiP30990.
    PRIDEiP30990.

    PTM databases

    PhosphoSiteiP30990.

    Miscellaneous databases

    PMAP-CutDBP30990.

    Expressioni

    Gene expression databases

    ArrayExpressiP30990.
    BgeeiP30990.
    CleanExiHS_NTS.
    GenevestigatoriP30990.

    Organism-specific databases

    HPAiHPA026664.

    Interactioni

    Subunit structurei

    Interacts with NTSR1. Interacts with SORT1.2 Publications

    Protein-protein interaction databases

    BioGridi110976. 2 interactions.
    DIPiDIP-60978N.
    IntActiP30990. 1 interaction.
    STRINGi9606.ENSP00000256010.

    Structurei

    Secondary structure

    1
    170
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi156 – 1594

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LNENMR-A152-163[»]
    2LNFNMR-A152-163[»]
    2LNGNMR-A152-163[»]
    2LYWNMR-B152-163[»]
    2OYVNMR-A152-163[»]
    2OYWNMR-A152-163[»]
    3F6KX-ray2.00N151-163[»]
    ProteinModelPortaliP30990.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP30990.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the neurotensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46419.
    HOGENOMiHOG000113770.
    HOVERGENiHBG003785.
    InParanoidiP30990.
    KOiK05235.
    OMAiTNMYTSK.
    PhylomeDBiP30990.
    TreeFamiTF330765.

    Family and domain databases

    InterProiIPR008055. NeurotensiN.
    [Graphical view]
    PANTHERiPTHR15356. PTHR15356. 1 hit.
    PfamiPF07421. Pro-NT_NN. 1 hit.
    [Graphical view]
    PRINTSiPR01668. NEUROTENSIN.
    ProDomiPD016590. NeurotensiN. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30990-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMAGMKIQLV CMLLLAFSSW SLCSDSEEEM KALEADFLTN MHTSKISKAH    50
    VPSWKMTLLN VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA 100
    MLTIYQLHKI CHSRAFQHWE LIQEDILDTG NDKNGKEEVI KRKIPYILKR 150
    QLYENKPRRP YILKRDSYYY 170
    Length:170
    Mass (Da):19,795
    Last modified:November 1, 1997 - v2
    Checksum:i66E2E146DA08E3C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91618 mRNA. Translation: AAB50564.1.
    BC010918 mRNA. Translation: AAH10918.1.
    S47339 Genomic DNA. Translation: AAB23934.1.
    CCDSiCCDS9029.1.
    PIRiI58190.
    RefSeqiNP_006174.1. NM_006183.4.
    UniGeneiHs.80962.

    Genome annotation databases

    EnsembliENST00000256010; ENSP00000256010; ENSG00000133636.
    GeneIDi4922.
    KEGGihsa:4922.
    UCSCiuc001tag.3. human.

    Polymorphism databases

    DMDMi2828196.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Neurotensin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91618 mRNA. Translation: AAB50564.1 .
    BC010918 mRNA. Translation: AAH10918.1 .
    S47339 Genomic DNA. Translation: AAB23934.1 .
    CCDSi CCDS9029.1.
    PIRi I58190.
    RefSeqi NP_006174.1. NM_006183.4.
    UniGenei Hs.80962.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LNE NMR - A 152-163 [» ]
    2LNF NMR - A 152-163 [» ]
    2LNG NMR - A 152-163 [» ]
    2LYW NMR - B 152-163 [» ]
    2OYV NMR - A 152-163 [» ]
    2OYW NMR - A 152-163 [» ]
    3F6K X-ray 2.00 N 151-163 [» ]
    ProteinModelPortali P30990.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110976. 2 interactions.
    DIPi DIP-60978N.
    IntActi P30990. 1 interaction.
    STRINGi 9606.ENSP00000256010.

    Chemistry

    BindingDBi P30990.

    PTM databases

    PhosphoSitei P30990.

    Polymorphism databases

    DMDMi 2828196.

    Proteomic databases

    MaxQBi P30990.
    PaxDbi P30990.
    PRIDEi P30990.

    Protocols and materials databases

    DNASUi 4922.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256010 ; ENSP00000256010 ; ENSG00000133636 .
    GeneIDi 4922.
    KEGGi hsa:4922.
    UCSCi uc001tag.3. human.

    Organism-specific databases

    CTDi 4922.
    GeneCardsi GC12P086201.
    HGNCi HGNC:8038. NTS.
    HPAi HPA026664.
    MIMi 162650. gene.
    neXtProti NX_P30990.
    PharmGKBi PA31820.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46419.
    HOGENOMi HOG000113770.
    HOVERGENi HBG003785.
    InParanoidi P30990.
    KOi K05235.
    OMAi TNMYTSK.
    PhylomeDBi P30990.
    TreeFami TF330765.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P30990.
    GeneWikii Neurotensin.
    GenomeRNAii 4922.
    NextBioi 18955.
    PMAP-CutDB P30990.
    PROi P30990.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30990.
    Bgeei P30990.
    CleanExi HS_NTS.
    Genevestigatori P30990.

    Family and domain databases

    InterProi IPR008055. NeurotensiN.
    [Graphical view ]
    PANTHERi PTHR15356. PTHR15356. 1 hit.
    Pfami PF07421. Pro-NT_NN. 1 hit.
    [Graphical view ]
    PRINTSi PR01668. NEUROTENSIN.
    ProDomi PD016590. NeurotensiN. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA methylation contributes to expression of the human neurotensin/neuromedin N gene."
      Dong Z., Wang X., Zhao Q., Townsend C.M. Jr., Evers B.M.
      Am. J. Physiol. 274:G535-G543(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls."
      Bean A.J., Dagerlind A., Hoekfelt T., Dobner P.R.
      Neuroscience 50:259-268(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-120.
    4. "Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain."
      Quistgaard E.M., Madsen P., Groftehauge M.K., Nissen P., Petersen C.M., Thirup S.S.
      Nat. Struct. Mol. Biol. 16:96-98(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 151-163 IN COMPLEX WITH SORT1, INTERACTION WITH SORT1, PYROGLUTAMATE FORMATION AT GLN-151.
    5. "Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor."
      Da Costa G., Bondon A., Coutant J., Curmi P., Monti J.P.
      J. Biomol. Struct. Dyn. 31:1381-1392(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 152-163 IN COMPLEX WITH NTSR1, SUBUNIT.

    Entry informationi

    Entry nameiNEUT_HUMAN
    AccessioniPrimary (citable) accession number: P30990
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3