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P30990 (NEUT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotensin/neuromedin N

Cleaved into the following 4 chains:

  1. Large neuromedin N
    Alternative name(s):
    NmN-125
  2. Neuromedin N
    Short name=NN
    Short name=NmN
  3. Neurotensin
    Short name=NT
  4. Tail peptide
Gene names
Name:NTS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

Subunit structure

Interacts with NTSR1. Interacts with SORT1. Ref.4 Ref.5

Subcellular location

Secreted. Cytoplasmic vesiclesecretory vesicle. Note: Packaged within secretory vesicles.

Sequence similarities

Belongs to the neurotensin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 148125Large neuromedin N
PRO_0000019522
Peptide144 – 1485Neuromedin N
PRO_0000019523
Peptide151 – 16313Neurotensin
PRO_0000019524
Peptide166 – 1705Tail peptide Potential
PRO_0000019525

Amino acid modifications

Modified residue1511Pyrrolidone carboxylic acid

Secondary structure

... 170
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P30990 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 66E2E146DA08E3C7

FASTA17019,795
        10         20         30         40         50         60 
MMAGMKIQLV CMLLLAFSSW SLCSDSEEEM KALEADFLTN MHTSKISKAH VPSWKMTLLN 

        70         80         90        100        110        120 
VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA MLTIYQLHKI CHSRAFQHWE 

       130        140        150        160        170 
LIQEDILDTG NDKNGKEEVI KRKIPYILKR QLYENKPRRP YILKRDSYYY 

« Hide

References

« Hide 'large scale' references
[1]"DNA methylation contributes to expression of the human neurotensin/neuromedin N gene."
Dong Z., Wang X., Zhao Q., Townsend C.M. Jr., Evers B.M.
Am. J. Physiol. 274:G535-G543(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls."
Bean A.J., Dagerlind A., Hoekfelt T., Dobner P.R.
Neuroscience 50:259-268(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-120.
[4]"Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain."
Quistgaard E.M., Madsen P., Groftehauge M.K., Nissen P., Petersen C.M., Thirup S.S.
Nat. Struct. Mol. Biol. 16:96-98(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 151-163 IN COMPLEX WITH SORT1, INTERACTION WITH SORT1, PYROGLUTAMATE FORMATION AT GLN-151.
[5]"Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor."
Da Costa G., Bondon A., Coutant J., Curmi P., Monti J.P.
J. Biomol. Struct. Dyn. 31:1381-1392(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 152-163 IN COMPLEX WITH NTSR1, SUBUNIT.
+Additional computationally mapped references.

Web resources

Wikipedia

Neurotensin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U91618 mRNA. Translation: AAB50564.1.
BC010918 mRNA. Translation: AAH10918.1.
S47339 Genomic DNA. Translation: AAB23934.1.
CCDSCCDS9029.1.
PIRI58190.
RefSeqNP_006174.1. NM_006183.4.
UniGeneHs.80962.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2LNENMR-A152-163[»]
2LNFNMR-A152-163[»]
2LNGNMR-A152-163[»]
2LYWNMR-B152-163[»]
2OYVNMR-A152-163[»]
2OYWNMR-A152-163[»]
3F6KX-ray2.00N151-163[»]
ProteinModelPortalP30990.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110976. 2 interactions.
IntActP30990. 1 interaction.
STRING9606.ENSP00000256010.

Chemistry

BindingDBP30990.

PTM databases

PhosphoSiteP30990.

Polymorphism databases

DMDM2828196.

Proteomic databases

MaxQBP30990.
PaxDbP30990.
PRIDEP30990.

Protocols and materials databases

DNASU4922.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256010; ENSP00000256010; ENSG00000133636.
GeneID4922.
KEGGhsa:4922.
UCSCuc001tag.3. human.

Organism-specific databases

CTD4922.
GeneCardsGC12P086201.
HGNCHGNC:8038. NTS.
HPAHPA026664.
MIM162650. gene.
neXtProtNX_P30990.
PharmGKBPA31820.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46419.
HOGENOMHOG000113770.
HOVERGENHBG003785.
InParanoidP30990.
KOK05235.
OMATNMYTSK.
PhylomeDBP30990.
TreeFamTF330765.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP30990.
BgeeP30990.
CleanExHS_NTS.
GenevestigatorP30990.

Family and domain databases

InterProIPR008055. NeurotensiN.
[Graphical view]
PANTHERPTHR15356. PTHR15356. 1 hit.
PfamPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSPR01668. NEUROTENSIN.
ProDomPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

EvolutionaryTraceP30990.
GeneWikiNeurotensin.
GenomeRNAi4922.
NextBio18955.
PMAP-CutDBP30990.
PROP30990.
SOURCESearch...

Entry information

Entry nameNEUT_HUMAN
AccessionPrimary (citable) accession number: P30990
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM