P30989 (NTR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurotensin receptor type 1
Short name=NT-R-1
Short name=NTR1

Alternative name(s):
High-affinity levocabastine-insensitive neurotensin receptor
NTRH

Gene names

Name:	NTSR1
Synonyms:	NTRR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult locomotory behavior Inferred from electronic annotation. Source: Compara synaptic transmission Traceable author statement PubMed 9763490. Source: ProtInc
Cellular_component	Golgi apparatus Traceable author statement PubMed 9763490. Source: ProtInc endoplasmic reticulum Traceable author statement PubMed 9763490. Source: ProtInc integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled neurotensin receptor activity Inferred from electronic annotation. Source: InterPro G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 418

418

Neurotensin receptor type 1

PRO_0000069946

Regions

Topological domain

1 – 63

63

Extracellular Potential

Transmembrane

64 – 86

23

Helical; Name=1; Potential

Topological domain

87 – 95

9

Cytoplasmic Potential

Transmembrane

96 – 120

25

Helical; Name=2; Potential

Topological domain

121 – 142

22

Extracellular Potential

Transmembrane

143 – 164

22

Helical; Name=3; Potential

Topological domain

165 – 187

23

Cytoplasmic Potential

Transmembrane

188 – 209

22

Helical; Name=4; Potential

Topological domain

210 – 234

25

Extracellular Potential

Transmembrane

235 – 259

25

Helical; Name=5; Potential

Topological domain

260 – 303

44

Cytoplasmic Potential

Transmembrane

304 – 325

22

Helical; Name=6; Potential

Topological domain

326 – 343

18

Extracellular Potential

Transmembrane

344 – 367

24

Helical; Name=7; Potential

Topological domain

368 – 418

51

Cytoplasmic Potential

Amino acid modifications

Lipidation

383

1

S-palmitoyl cysteine Potential

Glycosylation

4

1

N-linked (GlcNAc...) Potential

Glycosylation

37

1

N-linked (GlcNAc...) Potential

Glycosylation

41

1

N-linked (GlcNAc...) Potential

Disulfide bond

141 ↔ 224

By similarity

Natural variations

Natural variant

72

1

A → V.
Corresponds to variant rs11698783 [ dbSNP | Ensembl ].

VAR_059328

Natural variant

275

1

Q → H.
Corresponds to variant rs35373650 [ dbSNP | Ensembl ].

VAR_049424

Natural variant

304

1

V → I.
Corresponds to variant rs2273075 [ dbSNP | Ensembl ].

VAR_020071

Experimental info

Sequence conflict

200

1

A → T in CAA49675. Ref.1

Secondary structure

1

.

.

.

.

.

418

Helix Strand Turn

Details...

Beta strand

326 – 328

3

Beta strand

338 – 341

4

Sequences

	Sequence		Length	Mass (Da)
	P30989 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: 471AD1C49D29C2C8	FASTA	418	46,259
	10 20 30 40 50 60 MRLNSSAPGT PGTPAADPFQ RAQAGLEEAL LAPGFGNASG NASERVLAAP SSELDVNTDI 70 80 90 100 110 120 YSKVLVTAVY LALFVVGTVG NTVTAFTLAR KKSLQSLQST VHYHLGSLAL SDLLTLLLAM 130 140 150 160 170 180 PVELYNFIWV HHPWAFGDAG CRGYYFLRDA CTYATALNVA SLSVERYLAI CHPFKAKTLM 190 200 210 220 230 240 SRSRTKKFIS AIWLASALLA VPMLFTMGEQ NRSADGQHAG GLVCTPTIHT ATVKVVIQVN 250 260 270 280 290 300 TFMSFIFPMV VISVLNTIIA NKLTVMVRQA AEQGQVCTVG GEHSTFSMAI EPGRVQALRH 310 320 330 340 350 360 GVRVLRAVVI AFVVCWLPYH VRRLMFCYIS DEQWTPFLYD FYHYFYMVTN ALFYVSSTIN 370 380 390 400 410 PILYNLVSAN FRHIFLATLA CLCPVWRRRR KRPAFSRKAD SVSSNHTLSS NATRETLY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor." Vita N., Laurent P., Lefort S., Chalon P., Dumont X., Kaghad M., Gully D., le Fur G., Ferrara P., Caput D. FEBS Lett. 317:139-142(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

Neurotensin receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X70070 mRNA. Translation: CAA49675.1.
AY429106 mRNA. Translation: AAR07901.1.
AL035669, AL357033 Genomic DNA. Translation: CAC12747.2.
AL357033 Genomic DNA. Translation: CAC14923.2.

IPI

IPI00028150.

PIR

S29506.

RefSeq

NP_002522.2. NM_002531.2.

UniGene

Hs.590869.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LYW	NMR	-	A	321-344	[»]

ProteinModelPortal

P30989.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000359532.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

P30989.

Polymorphism databases

DMDM

62297312.

Proteomic databases

PaxDb

P30989.

PeptideAtlas

P30989.

PRIDE

P30989.

Protocols and materials databases

DNASU

4923.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000370501; ENSP00000359532; ENSG00000101188.

GeneID

4923.

KEGG

hsa:4923.

UCSC

uc002ydf.3. human.

Organism-specific databases

CTD

4923.

GeneCards

GC20P061340.

HGNC

HGNC:8039. NTSR1.

MIM

162651. gene.

neXtProt

NX_P30989.

PharmGKB

PA31821.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG303702.

HOGENOM

HOG000231271.

HOVERGEN

HBG098285.

InParanoid

P30989.

KO

K04211.

OMA

TVMVRQA.

OrthoDB

EOG4V438D.

PhylomeDB

P30989.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

Bgee

P30989.

CleanEx

HS_NTSR1.

Genevestigator

P30989.

GermOnline

ENSG00000101188. Homo sapiens.

Family and domain databases

InterPro

IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003985. NT1_rcpt.
IPR003984. NT_rcpt.
[Graphical view]

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01480. NEUROTENSN1R.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P30989.

ChEMBL

CHEMBL4123.

GenomeRNAi

4923.

NextBio

18959.

SOURCE

Search...

Entry information

Entry name

NTR1_HUMAN

Accession

Primary (citable) accession number: P30989
Secondary accession number(s): Q9H4H1, Q9H4T5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	March 29, 2005
Last modified:	May 1, 2013
This is version 127 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.