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P30988

- CALCR_HUMAN

UniProt

P30988 - CALCR_HUMAN

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Protein

Calcitonin receptor

Gene

CALCR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

GO - Molecular functioni

  1. calcitonin binding Source: UniProtKB
  2. calcitonin receptor activity Source: UniProtKB
  3. protein transporter activity Source: UniProtKB
  4. receptor activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  2. G-protein coupled receptor signaling pathway Source: GOC
  3. positive regulation of adenylate cyclase activity Source: UniProtKB
  4. positive regulation of cAMP biosynthetic process Source: UniProtKB
  5. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  6. protein localization to plasma membrane Source: UniProtKB
  7. protein transport Source: UniProtKB
  8. receptor internalization Source: UniProtKB
  9. response to glucocorticoid Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18290. Calcitonin-like ligand receptors.
REACT_19327. G alpha (s) signalling events.

Protein family/group databases

TCDBi9.A.14.4.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor
Short name:
CT-R
Gene namesi
Name:CALCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:1440. CALCR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini43 – 171129ExtracellularSequence AnalysisAdd
BLAST
Transmembranei172 – 19120Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini192 – 21423CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei215 – 23420Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini235 – 25420ExtracellularSequence AnalysisAdd
BLAST
Transmembranei255 – 27723Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini278 – 29417CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei295 – 31420Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini315 – 33016ExtracellularSequence AnalysisAdd
BLAST
Transmembranei331 – 35424Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini355 – 37723CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei378 – 39518Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini396 – 40712ExtracellularSequence AnalysisAdd
BLAST
Transmembranei408 – 42922Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini430 – 50879CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26032.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 42421 PublicationAdd
BLAST
Chaini43 – 508466Calcitonin receptorPRO_0000012806Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi73 ↔ 99By similarity
Disulfide bondi90 ↔ 130By similarity
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi113 ↔ 152By similarity
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30988.
PRIDEiP30988.

PTM databases

PhosphoSiteiP30988.

Expressioni

Gene expression databases

BgeeiP30988.
CleanExiHS_CALCR.
ExpressionAtlasiP30988. baseline and differential.
GenevestigatoriP30988.

Organism-specific databases

HPAiHPA028962.

Interactioni

Subunit structurei

Interacts with GPRASP2.1 Publication

Protein-protein interaction databases

BioGridi107250. 7 interactions.
IntActiP30988. 8 interactions.
MINTiMINT-1217503.
STRINGi9606.ENSP00000352561.

Structurei

3D structure databases

ProteinModelPortaliP30988.
SMRiP30988. Positions 61-153, 163-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi462 – 4676Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiP30988.
KOiK04576.
OrthoDBiEOG712TW2.
TreeFamiTF315710.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: P30988-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQFSGEKISG QRDLQKSKMR FTFTSRCLAL FLLLNHPTPI LPAFSNQTYP
60 70 80 90 100
TIEPKPFLYV VGRKKMMDAQ YKCYDRMQQL PAYQGEGPYC NRTWDGWLCW
110 120 130 140 150
DDTPAGVLSY QFCPDYFPDF DPSEKVTKYC DEKGVWFKHP ENNRTWSNYT
160 170 180 190 200
MCNAFTPEKL KNAYVLYYLA IVGHSLSIFT LVISLGIFVF FRKLTTIFPL
210 220 230 240 250
NWKYRKALSL GCQRVTLHKN MFLTYILNSM IIIIHLVEVV PNGELVRRDP
260 270 280 290 300
VSCKILHFFH QYMMACNYFW MLCEGIYLHT LIVVAVFTEK QRLRWYYLLG
310 320 330 340 350
WGFPLVPTTI HAITRAVYFN DNCWLSVETH LLYIIHGPVM AALVVNFFFL
360 370 380 390 400
LNIVRVLVTK MRETHEAESH MYLKAVKATM ILVPLLGIQF VVFPWRPSNK
410 420 430 440 450
MLGKIYDYVM HSLIHFQGFF VATIYCFCNN EVQTTVKRQW AQFKIQWNQR
460 470 480 490 500
WGRRPSNRSA RAAAAAAEAG DIPIYICHQE PRNEPANNQG EESAEIIPLN

IIEQESSA
Length:508
Mass (Da):59,352
Last modified:October 16, 2013 - v2
Checksum:iF76D13FD91BF61BA
GO
Isoform 2 (identifier: P30988-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     193-208: Missing.

Show »
Length:474
Mass (Da):55,329
Checksum:i0D9FA80FF16E82D9
GO
Isoform 3 (identifier: P30988-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     193-208: Missing.

Show »
Length:427
Mass (Da):49,878
Checksum:i733431C1963B7A83
GO
Isoform 4 (identifier: P30988-4) [UniParc]FASTAAdd to Basket

Also known as: Delta(1-47)hCT((a))

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:443
Mass (Da):51,852
Checksum:iAE090009967D7B08
GO
Isoform 5 (identifier: P30988-5) [UniParc]FASTAAdd to Basket

Also known as: HCTR-5

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     302-308: GFPLVPT → APAFHRD
     309-508: Missing.

Show »
Length:290
Mass (Da):34,397
Checksum:iB69ECF2AE4FAD38A
GO
Isoform 6 (identifier: P30988-6) [UniParc]FASTAAdd to Basket

Also known as: HCTR-6

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     193-208: Missing.
     302-308: GFPLVPT → APAFHRD
     309-508: Missing.

Show »
Length:274
Mass (Da):32,423
Checksum:i83843885095D43EA
GO

Sequence cautioni

The sequence AAA35640.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti381 – 3811I → T in AAC50301. (PubMed:7588285)Curated

Polymorphismi

Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti481 – 4811P → L May be correlated with low bone mineral density (BMD). 6 Publications
Corresponds to variant rs1801197 [ dbSNP | Ensembl ].
VAR_003580

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6565Missing in isoform 3 and isoform 4. 2 PublicationsVSP_053289Add
BLAST
Alternative sequencei1 – 1818Missing in isoform 2, isoform 5 and isoform 6. 8 PublicationsVSP_053290Add
BLAST
Alternative sequencei193 – 20816Missing in isoform 2, isoform 3 and isoform 6. 9 PublicationsVSP_053291Add
BLAST
Alternative sequencei302 – 3087GFPLVPT → APAFHRD in isoform 5 and isoform 6. 1 PublicationVSP_053292
Alternative sequencei309 – 508200Missing in isoform 5 and isoform 6. 1 PublicationVSP_053293Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00587 mRNA. Translation: AAA35640.1. Different initiation.
X69920 mRNA. Translation: CAA49541.1.
U26553 mRNA. Translation: AAC50300.1.
U26554 mRNA. Translation: AAC50301.1.
X82466 mRNA. Translation: CAA57849.1.
S77876, S77875 Genomic DNA. Translation: AAD14268.1.
AB022177 mRNA. Translation: BAA86929.1.
AB022178 mRNA. Translation: BAA86928.1.
AJ831406 mRNA. Translation: CAH40796.1.
AJ831407 mRNA. Translation: CAH40797.1.
FN994995 mRNA. Translation: CBN80567.1.
FN994996 mRNA. Translation: CBN80568.1.
AY430048 mRNA. Translation: AAR06949.1.
AK313996 mRNA. Translation: BAG36708.1.
AC003078 Genomic DNA. Translation: AAB83945.1.
AC005024 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24142.1.
CH471091 Genomic DNA. Translation: EAW76814.1.
BC069611 mRNA. Translation: AAH69611.1.
BC075028 mRNA. Translation: AAH75028.2.
CCDSiCCDS55125.1. [P30988-1]
CCDS5631.1. [P30988-2]
PIRiI37217.
S34486.
RefSeqiNP_001158209.1. NM_001164737.1.
NP_001158210.1. NM_001164738.1.
NP_001733.1. NM_001742.3.
UniGeneiHs.489127.

Genome annotation databases

EnsembliENST00000415529; ENSP00000413179; ENSG00000004948. [P30988-6]
ENST00000423724; ENSP00000391369; ENSG00000004948. [P30988-5]
GeneIDi799.
KEGGihsa:799.

Polymorphism databases

DMDMi550544247.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00587 mRNA. Translation: AAA35640.1 . Different initiation.
X69920 mRNA. Translation: CAA49541.1 .
U26553 mRNA. Translation: AAC50300.1 .
U26554 mRNA. Translation: AAC50301.1 .
X82466 mRNA. Translation: CAA57849.1 .
S77876 , S77875 Genomic DNA. Translation: AAD14268.1 .
AB022177 mRNA. Translation: BAA86929.1 .
AB022178 mRNA. Translation: BAA86928.1 .
AJ831406 mRNA. Translation: CAH40796.1 .
AJ831407 mRNA. Translation: CAH40797.1 .
FN994995 mRNA. Translation: CBN80567.1 .
FN994996 mRNA. Translation: CBN80568.1 .
AY430048 mRNA. Translation: AAR06949.1 .
AK313996 mRNA. Translation: BAG36708.1 .
AC003078 Genomic DNA. Translation: AAB83945.1 .
AC005024 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24142.1 .
CH471091 Genomic DNA. Translation: EAW76814.1 .
BC069611 mRNA. Translation: AAH69611.1 .
BC075028 mRNA. Translation: AAH75028.2 .
CCDSi CCDS55125.1. [P30988-1 ]
CCDS5631.1. [P30988-2 ]
PIRi I37217.
S34486.
RefSeqi NP_001158209.1. NM_001164737.1.
NP_001158210.1. NM_001164738.1.
NP_001733.1. NM_001742.3.
UniGenei Hs.489127.

3D structure databases

ProteinModelPortali P30988.
SMRi P30988. Positions 61-153, 163-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107250. 7 interactions.
IntActi P30988. 8 interactions.
MINTi MINT-1217503.
STRINGi 9606.ENSP00000352561.

Chemistry

BindingDBi P30988.
ChEMBLi CHEMBL2111189.
DrugBanki DB01278. Pramlintide.
DB00017. Salmon Calcitonin.
GuidetoPHARMACOLOGYi 43.

Protein family/group databases

TCDBi 9.A.14.4.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei P30988.

Polymorphism databases

DMDMi 550544247.

Proteomic databases

PaxDbi P30988.
PRIDEi P30988.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000415529 ; ENSP00000413179 ; ENSG00000004948 . [P30988-6 ]
ENST00000423724 ; ENSP00000391369 ; ENSG00000004948 . [P30988-5 ]
GeneIDi 799.
KEGGi hsa:799.

Organism-specific databases

CTDi 799.
GeneCardsi GC07M093053.
H-InvDB HIX0033513.
HGNCi HGNC:1440. CALCR.
HPAi HPA028962.
MIMi 114131. gene.
neXtProti NX_P30988.
PharmGKBi PA26032.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255868.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000230695.
HOVERGENi HBG102129.
InParanoidi P30988.
KOi K04576.
OrthoDBi EOG712TW2.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_18290. Calcitonin-like ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

ChiTaRSi CALCR. human.
GeneWikii Calcitonin_receptor.
GenomeRNAii 799.
NextBioi 3248.
PROi P30988.
SOURCEi Search...

Gene expression databases

Bgeei P30988.
CleanExi HS_CALCR.
ExpressionAtlasi P30988. baseline and differential.
Genevestigatori P30988.

Family and domain databases

InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line."
    Gorn A.H., Lin H.Y., Yamin M., Auron P.E., Flannery M.R., Tapp D.R., Manning C.A., Lodish H.F., Krane S.M., Goldring S.R.
    J. Clin. Invest. 90:1726-1735(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Ovarian carcinoma.
  2. "Cloning and characterization of an abundant subtype of the human calcitonin receptor."
    Kuestner R.E., Elrod R.D., Grant F.J., Hagen F.S., Kuijper J.L., Mathewes S.L., O'Hara P.J., Sheppard P.O., Stroop S.D., Thompson D.L., Whitmore T.E., Findlays D.M., Houssamis S., Sexton P.M., Moore E.E.
    Mol. Pharmacol. 46:246-255(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene."
    Albrandt K., Brady E.M.G., Moore C.X., Mull E., Sierzega M.E., Beaumont K.
    Endocrinology 136:5377-5384(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), ALTERNATIVE SPLICING.
    Tissue: Mammary carcinoma.
  4. "An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid."
    Frendo J.L., Pichaud F., Delage-Mourroux R., Bouizar Z., Segond N., Moukhtar M.S., Jullienne A.
    FEBS Lett. 342:214-216(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LEU-481.
  5. "A novel calcitonin receptor gene in human osteoclasts from normal bone marrow."
    Nishikawa T., Ishikawa H., Yamamoto S., Koshihara Y.
    FEBS Lett. 458:409-414(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Mammary carcinoma.
  6. "Molecular characterization of two novel isoforms of the human calcitonin receptor."
    Beaudreuil J., Balasubramanian S., Chenais J., Taboulet J., Frenkian M., Orcel P., Jullienne A., Horne W., de Vernejoul M.C., Cressent M.
    Gene 343:143-151(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6).
  7. "Identification of the human calcitonin receptor expressed in osteoarthritis chondrocytes."
    Bonnefond C.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Cartilage.
  8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-481.
    Tissue: Kidney.
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  10. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-481.
  14. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 43-57.
  15. "Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor."
    Nussenzveig D.R., Mathew S., Gershengorn M.C.
    Endocrinology 136:2047-2051(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
    Tissue: Placenta.
  16. "A new type of human calcitonin receptor isoform generated by alternative splicing."
    Nakamura M., Hashimoto T., Nakajima T., Ichii S., Furuyama J., Ishihara Y., Kakudo K.
    Biochem. Biophys. Res. Commun. 209:744-751(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  17. "Multiple promoters regulate human calcitonin receptor gene expression."
    Hebden C., Smalt R., Chambers T., Pondel M.D.
    Biochem. Biophys. Res. Commun. 272:738-743(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE PROMOTER USAGE.
  18. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
    Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L.
    J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GPRASP2.
  19. "Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women."
    Masi L., Becherini L., Colli E., Gennari L., Mansani R., Falchetti A., Becorpi A.M., Cepollaro C., Gonnelli S., Tanini A., Brandi M.L.
    Biochem. Biophys. Res. Commun. 248:190-195(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN LUMBAR BMD.
  20. "Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function."
    Qi T., Dong M., Watkins H.A., Wootten D., Miller L.J., Hay D.L.
    Br. J. Pharmacol. 168:644-657(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM 4).
  21. "Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women."
    Masi L., Becherini L., Gennari L., Colli E., Mansani R., Falchetti A., Cepollaro C., Gonnelli S., Tanini A., Brandi M.L.
    Biochem. Biophys. Res. Commun. 245:622-626(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION OF VARIANT LEU-481 WITH LOWER LUMBAR BMD.
  22. "Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women."
    Taboulet J., Frenkian M., Frendo J.L., Feingold N., Jullienne A., de Vernejoul M.-C.
    Hum. Mol. Genet. 7:2129-2133(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-481.

Entry informationi

Entry nameiCALCR_HUMAN
AccessioniPrimary (citable) accession number: P30988
Secondary accession number(s): A4D1G6
, F5H605, O14585, Q13941, Q5ZGL8, Q659U6, Q6DJU8, Q6T712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 16, 2013
Last modified: November 26, 2014
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3