Calcitonin receptor precursor - Homo sapiens (Human)

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Names and origin

Protein names

Recommended name:
Calcitonin receptor
Short name=CT-R

Gene names

Name:

CALCR

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
Subunit structure	Interacts with GPRASP2. Ref.12
Subcellular location	Cell membrane; Multi-pass membrane protein.
Polymorphism	Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	activation of adenylate cyclase activity by G-protein signaling pathway Ref.1 Inferred from direct assay. Source: UniProtKB elevation of cytosolic calcium ion concentration Inferred from direct assay. Source: UniProtKB positive regulation of adenylate cyclase activity Inferred from direct assay. Source: UniProtKB response to glucocorticoid stimulus Inferred from direct assay. Source: UniProtKB
Cellular component	integral to plasma membrane Ref.3 Non-traceable author statement. Source: UniProtKB
Molecular function	calcitonin binding Ref.2 Inferred from direct assay. Source: UniProtKB calcitonin receptor activity Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P30988-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P30988-2) The sequence of this isoform differs from the canonical sequence as follows: 175-190: Missing.

Isoform 3 (identifier: P30988-3) The sequence of this isoform differs from the canonical sequence as follows: 1-47: Missing. 175-190: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Ref.9

Chain

25 – 490

466

Calcitonin receptor

PRO_0000012806

Regions

Topological domain

25 – 153

129

Extracellular Potential

Transmembrane

154 – 173

20

1 Potential

Topological domain

174 – 196

23

Cytoplasmic Potential

Transmembrane

197 – 216

20

2 Potential

Topological domain

217 – 236

20

Extracellular Potential

Transmembrane

237 – 259

23

3 Potential

Topological domain

260 – 276

17

Cytoplasmic Potential

Transmembrane

277 – 296

20

4 Potential

Topological domain

297 – 312

16

Extracellular Potential

Transmembrane

313 – 336

24

5 Potential

Topological domain

337 – 359

23

Cytoplasmic Potential

Transmembrane

360 – 377

18

6 Potential

Topological domain

378 – 389

12

Extracellular Potential

Transmembrane

390 – 411

22

7 Potential

Topological domain

412 – 490

79

Cytoplasmic Potential

Compositional bias

444 – 449

6

Poly-Ala

Amino acid modifications

Glycosylation

28

1

N-linked (GlcNAc...) Potential

Glycosylation

73

1

N-linked (GlcNAc...) Potential

Glycosylation

125

1

N-linked (GlcNAc...) Potential

Glycosylation

130

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

1 – 47

47

Missing in isoform 3.

VSP_001991

Alternative sequence

175 – 190

16

Missing in isoform 2 and isoform 3.

VSP_001992

Natural variant

463

1

P → L: dbSNP rs1801197. Ref.4 Ref.6 Ref.8 Ref.14 Ref.15

VAR_003580

Experimental info

Sequence conflict

363

1

I → T in AAC50301. Ref.3

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 38EC7A4A9F07FF5D Show »	FASTA	490	57,303
10 20 30 40 50 60 MRFTFTSRCL ALFLLLNHPT PILPAFSNQT YPTIEPKPFL YVVGRKKMMD AQYKCYDRMQ 70 80 90 100 110 120 QLPAYQGEGP YCNRTWDGWL CWDDTPAGVL SYQFCPDYFP DFDPSEKVTK YCDEKGVWFK 130 140 150 160 170 180 HPENNRTWSN YTMCNAFTPE KLKNAYVLYY LAIVGHSLSI FTLVISLGIF VFFRKLTTIF 190 200 210 220 230 240 PLNWKYRKAL SLGCQRVTLH KNMFLTYILN SMIIIIHLVE VVPNGELVRR DPVSCKILHF 250 260 270 280 290 300 FHQYMMACNY FWMLCEGIYL HTLIVVAVFT EKQRLRWYYL LGWGFPLVPT TIHAITRAVY 310 320 330 340 350 360 FNDNCWLSVE THLLYIIHGP VMAALVVNFF FLLNIVRVLV TKMRETHEAE SHMYLKAVKA 370 380 390 400 410 420 TMILVPLLGI QFVVFPWRPS NKMLGKIYDY VMHSLIHFQG FFVATIYCFC NNEVQTTVKR 430 440 450 460 470 480 QWAQFKIQWN QRWGRRPSNR SARAAAAAAE AGDIPIYICH QEPRNEPANN QGEESAEIIP 490 LNIIEQESSA « Hide
Isoform 2. Checksum: 0D9FA80FF16E82D9 Show »	FASTA	474	55,329
10 20 30 40 50 60 MRFTFTSRCL ALFLLLNHPT PILPAFSNQT YPTIEPKPFL YVVGRKKMMD AQYKCYDRMQ 70 80 90 100 110 120 QLPAYQGEGP YCNRTWDGWL CWDDTPAGVL SYQFCPDYFP DFDPSEKVTK YCDEKGVWFK 130 140 150 160 170 180 HPENNRTWSN YTMCNAFTPE KLKNAYVLYY LAIVGHSLSI FTLVISLGIF VFFRSLGCQR 190 200 210 220 230 240 VTLHKNMFLT YILNSMIIII HLVEVVPNGE LVRRDPVSCK ILHFFHQYMM ACNYFWMLCE 250 260 270 280 290 300 GIYLHTLIVV AVFTEKQRLR WYYLLGWGFP LVPTTIHAIT RAVYFNDNCW LSVETHLLYI 310 320 330 340 350 360 IHGPVMAALV VNFFFLLNIV RVLVTKMRET HEAESHMYLK AVKATMILVP LLGIQFVVFP 370 380 390 400 410 420 WRPSNKMLGK IYDYVMHSLI HFQGFFVATI YCFCNNEVQT TVKRQWAQFK IQWNQRWGRR 430 440 450 460 470 PSNRSARAAA AAAEAGDIPI YICHQEPRNE PANNQGEESA EIIPLNIIEQ ESSA « Hide
Isoform 3. Checksum: 733431C1963B7A83 Show »	FASTA	427	49,878
10 20 30 40 50 60 MMDAQYKCYD RMQQLPAYQG EGPYCNRTWD GWLCWDDTPA GVLSYQFCPD YFPDFDPSEK 70 80 90 100 110 120 VTKYCDEKGV WFKHPENNRT WSNYTMCNAF TPEKLKNAYV LYYLAIVGHS LSIFTLVISL 130 140 150 160 170 180 GIFVFFRSLG CQRVTLHKNM FLTYILNSMI IIIHLVEVVP NGELVRRDPV SCKILHFFHQ 190 200 210 220 230 240 YMMACNYFWM LCEGIYLHTL IVVAVFTEKQ RLRWYYLLGW GFPLVPTTIH AITRAVYFND 250 260 270 280 290 300 NCWLSVETHL LYIIHGPVMA ALVVNFFFLL NIVRVLVTKM RETHEAESHM YLKAVKATMI 310 320 330 340 350 360 LVPLLGIQFV VFPWRPSNKM LGKIYDYVMH SLIHFQGFFV ATIYCFCNNE VQTTVKRQWA 370 380 390 400 410 420 QFKIQWNQRW GRRPSNRSAR AAAAAAEAGD IPIYICHQEP RNEPANNQGE ESAEIIPLNI IEQESSA « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line." Gorn A.H., Lin H.Y., Yamin M., Auron P.E., Flannery M.R., Tapp D.R., Manning C.A., Lodish H.F., Krane S.M., Goldring S.R. J. Clin. Invest. 90:1726-1735(1992) [PubMed: 1331173] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovarian carcinoma.
[2]	"Cloning and characterization of an abundant subtype of the human calcitonin receptor." Kuestner R.E., Elrod R.D., Grant F.J., Hagen F.S., Kuijper J.L., Mathewes S.L., O'Hara P.J., Sheppard P.O., Stroop S.D., Thompson D.L., Whitmore T.E., Findlays D.M., Houssamis S., Sexton P.M., Moore E.E. Mol. Pharmacol. 46:246-255(1994) [PubMed: 8078488] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene." Albrandt K., Brady E.M.G., Moore C.X., Mull E., Sierzega M.E., Beaumont K. Endocrinology 136:5377-5384(1995) [PubMed: 7588285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING. Tissue: Mammary carcinoma.
[4]	"An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid." Frendo J.L., Pichaud F., Delage-Mourroux R., Bouizar Z., Segond N., Moukhtar M.S., Jullienne A. FEBS Lett. 342:214-216(1994) [PubMed: 8143880] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LEU-463.
[5]	"A novel calcitonin receptor gene in human osteoclasts from normal bone marrow." Nishikawa T., Ishikawa H., Yamamoto S., Koshihara Y. FEBS Lett. 458:409-414(1999) [PubMed: 10570950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Mammary carcinoma.
[6]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." King M.M., Aronstam R.S., Sharma S.V. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-463. Tissue: Kidney.
[7]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-463.
[9]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-39.
[10]	"Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor." Nussenzveig D.R., Mathew S., Gershengorn M.C. Endocrinology 136:2047-2051(1995) [PubMed: 7720653] [Abstract] Cited for: ALTERNATIVE SPLICING. Tissue: Placenta.
[11]	"A new type of human calcitonin receptor isoform generated by alternative splicing." Nakamura M., Hashimoto T., Nakajima T., Ichii S., Furuyama J., Ishihara Y., Kakudo K. Biochem. Biophys. Res. Commun. 209:744-751(1995) [PubMed: 7733946] [Abstract] Cited for: ALTERNATIVE SPLICING.
[12]	"Identification of a novel family of G protein-coupled receptor associated sorting proteins." Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L. J. Neurochem. 89:766-775(2004) [PubMed: 15086532] [Abstract] Cited for: INTERACTION WITH GPRASP2.
[13]	"Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women." Masi L., Becherini L., Colli E., Gennari L., Mansani R., Falchetti A., Becorpi A.M., Cepollaro C., Gonnelli S., Tanini A., Brandi M.L. Biochem. Biophys. Res. Commun. 248:190-195(1998) [PubMed: 9675109] [Abstract] Cited for: INVOLVEMENT IN LUMBAR BMD.
[14]	"Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women." Masi L., Becherini L., Gennari L., Colli E., Mansani R., Falchetti A., Cepollaro C., Gonnelli S., Tanini A., Brandi M.L. Biochem. Biophys. Res. Commun. 245:622-626(1998) [PubMed: 9571205] [Abstract] Cited for: ASSOCIATION OF VARIANT LEU-463 WITH LOWER LUMBAR BMD.
[15]	"Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women." Taboulet J., Frenkian M., Frendo J.L., Feingold N., Jullienne A., de Vernejoul M.-C. Hum. Mol. Genet. 7:2129-2133(1998) [PubMed: 9817931] [Abstract] Cited for: VARIANT LEU-463.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	L00587 mRNA. Translation: AAA35640.1. X69920 mRNA. Translation: CAA49541.1. U26553 mRNA. Translation: AAC50300.1. U26554 mRNA. Translation: AAC50301.1. X82466 mRNA. Translation: CAA57849.1. S77876, S77875 Genomic DNA. Translation: AAD14268.1. AB022177 mRNA. Translation: BAA86929.1. AB022178 mRNA. Translation: BAA86928.1. AY430048 mRNA. Translation: AAR06949.1. AC003078 Genomic DNA. Translation: AAB83945.1. BC069611 mRNA. Translation: AAH69611.1. BC075028 mRNA. Translation: AAH75028.2.
IPI	IPI00187004. IPI00220012. IPI00419304.
PIR	I37217. S34486.
RefSeq	NP_001158209.1. NP_001158210.1. NP_001733.1.
UniGene	Hs.489127
3D structure databases
SMR	P30988. Positions 45-136.
ModBase	Search...
Protein-protein interaction databases
STRING	P30988.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P30988.
Genome annotation databases
Ensembl	ENST00000360249; ENSP00000353385; ENSG00000004948; Homo sapiens. [Genome view] ENST00000421592; ENSP00000399552; ENSG00000004948; Homo sapiens. [Genome view]
GeneID	799.
KEGG	hsa:799.
UCSC	uc003umv.1. human.
Organism-specific databases
CTD	799.
GeneCards	GC07M092891.
H-InvDB	HIX0033513.
HGNC	HGNC:1440. CALCR.
MIM	114131. gene.
PharmGKB	PA26032.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG446561.
HOVERGEN	P30988.
InParanoid	P30988.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P30988.
Bgee	P30988.
CleanEx	HS_CALCR.
Genevestigator	P30988.
GermOnline	ENSG00000004948. Homo sapiens.
Family and domain databases
InterPro	IPR003287. GCPR_2_calcitonin_rcpt-like. IPR017981. GPCR_2-like. IPR001688. GPCR_2_calcitonin_rcpt. IPR001879. GPCR_2_extracellular_dom. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. [Graphical view]
PANTHER	PTHR12011:SF67. Calctnin_rcpt. 1 hit.
Pfam	PF00002. 7tm_2. 1 hit. PF02793. HRM. 1 hit. [Graphical view]
PRINTS	PR00361. CALCITONINR. PR01350. CTRFAMILY. PR00249. GPCRSECRETIN.
SMART	SM00008. HormR. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. 1 hit. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00017. Salmon Calcitonin.
NextBio	3248.
SOURCE	Search...

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Entry information

Entry name

CALCR_HUMAN

Accession

Primary (citable) accession number: P30988
Secondary accession number(s): O14585

Q6T712

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	January 19, 2010
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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List of human entries with polymorphisms or disease mutations

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Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents