Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcitonin receptor

Gene

CALCR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

GO - Molecular functioni

  • calcitonin binding Source: UniProtKB
  • calcitonin receptor activity Source: UniProtKB
  • protein transporter activity Source: UniProtKB
  • signaling receptor activity Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • amylin receptor signaling pathway Source: ARUK-UCL
  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: Reactome
  • positive regulation of adenylate cyclase activity Source: UniProtKB
  • positive regulation of calcium ion import across plasma membrane Source: ARUK-UCL
  • positive regulation of cAMP metabolic process Source: ARUK-UCL
  • positive regulation of cell death Source: ARUK-UCL
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
  • positive regulation of gene expression Source: ARUK-UCL
  • positive regulation of peptidyl-serine phosphorylation Source: ARUK-UCL
  • positive regulation of protein kinase A signaling Source: ARUK-UCL
  • positive regulation of protein kinase B signaling Source: ARUK-UCL
  • protein localization to plasma membrane Source: UniProtKB
  • protein transport Source: UniProtKB
  • response to glucocorticoid Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Protein family/group databases

TCDBi9.A.14.4.1 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor
Short name:
CT-R
Gene namesi
Name:CALCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000004948.13
HGNCiHGNC:1440 CALCR
MIMi114131 gene
neXtProtiNX_P30988

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini43 – 171ExtracellularSequence analysisAdd BLAST129
Transmembranei172 – 191Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini192 – 214CytoplasmicSequence analysisAdd BLAST23
Transmembranei215 – 234Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini235 – 254ExtracellularSequence analysisAdd BLAST20
Transmembranei255 – 277Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini278 – 294CytoplasmicSequence analysisAdd BLAST17
Transmembranei295 – 314Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini315 – 330ExtracellularSequence analysisAdd BLAST16
Transmembranei331 – 354Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini355 – 377CytoplasmicSequence analysisAdd BLAST23
Transmembranei378 – 395Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini396 – 407ExtracellularSequence analysisAdd BLAST12
Transmembranei408 – 429Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini430 – 508CytoplasmicSequence analysisAdd BLAST79

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi799
MalaCardsiCALCR
OpenTargetsiENSG00000004948
PharmGKBiPA26032

Chemistry databases

ChEMBLiCHEMBL1832
DrugBankiDB01278 Pramlintide
DB00017 Salmon Calcitonin
GuidetoPHARMACOLOGYi43

Polymorphism and mutation databases

BioMutaiCALCR
DMDMi550544247

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 421 PublicationAdd BLAST42
ChainiPRO_000001280643 – 508Calcitonin receptorAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi73 ↔ 99By similarity
Disulfide bondi90 ↔ 130By similarity
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 152By similarity
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30988
PeptideAtlasiP30988
PRIDEiP30988

PTM databases

iPTMnetiP30988
PhosphoSitePlusiP30988

Expressioni

Gene expression databases

BgeeiENSG00000004948
CleanExiHS_CALCR
ExpressionAtlasiP30988 baseline and differential
GenevisibleiP30988 HS

Organism-specific databases

HPAiHPA028962

Interactioni

Subunit structurei

Interacts with GPRASP2.1 Publication

Protein-protein interaction databases

BioGridi107250, 5 interactors
IntActiP30988, 8 interactors
MINTiP30988
STRINGi9606.ENSP00000352561

Chemistry databases

BindingDBiP30988

Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi59 – 79Combined sources21
Beta strandi85 – 87Combined sources3
Beta strandi108 – 112Combined sources5
Beta strandi115 – 117Combined sources3
Beta strandi124 – 130Combined sources7
Turni140 – 143Combined sources4
Helixi150 – 152Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5II0X-ray2.10A/B/C43-162[»]
5UZ7electron microscopy4.10R43-508[»]
ProteinModelPortaliP30988
SMRiP30988
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi462 – 467Poly-Ala6

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00900000140884
HOGENOMiHOG000230695
HOVERGENiHBG102129
InParanoidiP30988
KOiK04576
TreeFamiTF315710

Family and domain databases

CDDicd15274 7tmB1_calcitonin_R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR003287 GCPR_2_calcitonin_rcpt_fam
IPR017981 GPCR_2-like
IPR001688 GPCR_2_calcitonin_rcpt
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF84 PTHR12011:SF84, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00361 CALCITONINR
PR01350 CTRFAMILY
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30988-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQFSGEKISG QRDLQKSKMR FTFTSRCLAL FLLLNHPTPI LPAFSNQTYP
60 70 80 90 100
TIEPKPFLYV VGRKKMMDAQ YKCYDRMQQL PAYQGEGPYC NRTWDGWLCW
110 120 130 140 150
DDTPAGVLSY QFCPDYFPDF DPSEKVTKYC DEKGVWFKHP ENNRTWSNYT
160 170 180 190 200
MCNAFTPEKL KNAYVLYYLA IVGHSLSIFT LVISLGIFVF FRKLTTIFPL
210 220 230 240 250
NWKYRKALSL GCQRVTLHKN MFLTYILNSM IIIIHLVEVV PNGELVRRDP
260 270 280 290 300
VSCKILHFFH QYMMACNYFW MLCEGIYLHT LIVVAVFTEK QRLRWYYLLG
310 320 330 340 350
WGFPLVPTTI HAITRAVYFN DNCWLSVETH LLYIIHGPVM AALVVNFFFL
360 370 380 390 400
LNIVRVLVTK MRETHEAESH MYLKAVKATM ILVPLLGIQF VVFPWRPSNK
410 420 430 440 450
MLGKIYDYVM HSLIHFQGFF VATIYCFCNN EVQTTVKRQW AQFKIQWNQR
460 470 480 490 500
WGRRPSNRSA RAAAAAAEAG DIPIYICHQE PRNEPANNQG EESAEIIPLN

IIEQESSA
Length:508
Mass (Da):59,352
Last modified:October 16, 2013 - v2
Checksum:iF76D13FD91BF61BA
GO
Isoform 2 (identifier: P30988-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     193-208: Missing.

Show »
Length:474
Mass (Da):55,329
Checksum:i0D9FA80FF16E82D9
GO
Isoform 3 (identifier: P30988-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     193-208: Missing.

Show »
Length:427
Mass (Da):49,878
Checksum:i733431C1963B7A83
GO
Isoform 4 (identifier: P30988-4) [UniParc]FASTAAdd to basket
Also known as: Delta(1-47)hCT((a))

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:443
Mass (Da):51,852
Checksum:iAE090009967D7B08
GO
Isoform 5 (identifier: P30988-5) [UniParc]FASTAAdd to basket
Also known as: HCTR-5

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     302-308: GFPLVPT → APAFHRD
     309-508: Missing.

Show »
Length:290
Mass (Da):34,397
Checksum:iB69ECF2AE4FAD38A
GO
Isoform 6 (identifier: P30988-6) [UniParc]FASTAAdd to basket
Also known as: HCTR-6

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     193-208: Missing.
     302-308: GFPLVPT → APAFHRD
     309-508: Missing.

Show »
Length:274
Mass (Da):32,423
Checksum:i83843885095D43EA
GO

Sequence cautioni

The sequence AAA35640 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti381I → T in AAC50301 (PubMed:7588285).Curated1

Polymorphismi

Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003580481P → L May be correlated with low bone mineral density (BMD). 6 PublicationsCorresponds to variant dbSNP:rs1801197Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0532891 – 65Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST65
Alternative sequenceiVSP_0532901 – 18Missing in isoform 2, isoform 5 and isoform 6. 8 PublicationsAdd BLAST18
Alternative sequenceiVSP_053291193 – 208Missing in isoform 2, isoform 3 and isoform 6. 9 PublicationsAdd BLAST16
Alternative sequenceiVSP_053292302 – 308GFPLVPT → APAFHRD in isoform 5 and isoform 6. 1 Publication7
Alternative sequenceiVSP_053293309 – 508Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00587 mRNA Translation: AAA35640.1 Different initiation.
X69920 mRNA Translation: CAA49541.1
U26553 mRNA Translation: AAC50300.1
U26554 mRNA Translation: AAC50301.1
X82466 mRNA Translation: CAA57849.1
S77876, S77875 Genomic DNA Translation: AAD14268.1
AB022177 mRNA Translation: BAA86929.1
AB022178 mRNA Translation: BAA86928.1
AJ831406 mRNA Translation: CAH40796.1
AJ831407 mRNA Translation: CAH40797.1
FN994995 mRNA Translation: CBN80567.1
FN994996 mRNA Translation: CBN80568.1
AY430048 mRNA Translation: AAR06949.1
AK313996 mRNA Translation: BAG36708.1
AC003078 Genomic DNA Translation: AAB83945.1
AC005024 Genomic DNA No translation available.
CH236949 Genomic DNA Translation: EAL24142.1
CH471091 Genomic DNA Translation: EAW76814.1
BC069611 mRNA Translation: AAH69611.1
BC075028 mRNA Translation: AAH75028.2
CCDSiCCDS55125.1 [P30988-1]
CCDS5631.1 [P30988-2]
PIRiI37217
S34486
RefSeqiNP_001158209.1, NM_001164737.1
NP_001158210.1, NM_001164738.1
NP_001733.1, NM_001742.3
UniGeneiHs.489127

Genome annotation databases

EnsembliENST00000415529; ENSP00000413179; ENSG00000004948 [P30988-6]
ENST00000423724; ENSP00000391369; ENSG00000004948 [P30988-5]
GeneIDi799
KEGGihsa:799
UCSCiuc003umw.3 human [P30988-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCALCR_HUMAN
AccessioniPrimary (citable) accession number: P30988
Secondary accession number(s): A4D1G6
, F5H605, O14585, Q13941, Q5ZGL8, Q659U6, Q6DJU8, Q6T712
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 16, 2013
Last modified: May 23, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health