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P30988

- CALCR_HUMAN

UniProt

P30988 - CALCR_HUMAN

Protein

Calcitonin receptor

Gene

CALCR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 2 (16 Oct 2013)
      Previous versions | rss
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    Functioni

    This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

    GO - Molecular functioni

    1. calcitonin binding Source: UniProtKB
    2. calcitonin receptor activity Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein transporter activity Source: UniProtKB
    5. receptor activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    2. G-protein coupled receptor signaling pathway Source: GOC
    3. positive regulation of adenylate cyclase activity Source: UniProtKB
    4. positive regulation of cAMP biosynthetic process Source: UniProtKB
    5. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    6. protein localization to plasma membrane Source: UniProtKB
    7. protein transport Source: UniProtKB
    8. receptor internalization Source: UniProtKB
    9. response to glucocorticoid Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18290. Calcitonin-like ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Protein family/group databases

    TCDBi9.A.14.4.1. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcitonin receptor
    Short name:
    CT-R
    Gene namesi
    Name:CALCR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:1440. CALCR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26032.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 42421 PublicationAdd
    BLAST
    Chaini43 – 508466Calcitonin receptorPRO_0000012806Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi73 ↔ 99By similarity
    Disulfide bondi90 ↔ 130By similarity
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi113 ↔ 152By similarity
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP30988.
    PRIDEiP30988.

    PTM databases

    PhosphoSiteiP30988.

    Expressioni

    Gene expression databases

    ArrayExpressiP30988.
    BgeeiP30988.
    CleanExiHS_CALCR.
    GenevestigatoriP30988.

    Organism-specific databases

    HPAiHPA028962.

    Interactioni

    Subunit structurei

    Interacts with GPRASP2.1 Publication

    Protein-protein interaction databases

    BioGridi107250. 7 interactions.
    IntActiP30988. 8 interactions.
    MINTiMINT-1217503.
    STRINGi9606.ENSP00000352561.

    Structurei

    3D structure databases

    ProteinModelPortaliP30988.
    SMRiP30988. Positions 61-153, 163-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini43 – 171129ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 21423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini235 – 25420ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini278 – 29417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini315 – 33016ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini355 – 37723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini396 – 40712ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini430 – 50879CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei172 – 19120Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei215 – 23420Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27723Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31420Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei331 – 35424Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei378 – 39518Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei408 – 42922Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi462 – 4676Poly-Ala

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG255868.
    HOGENOMiHOG000230695.
    HOVERGENiHBG102129.
    InParanoidiP30988.
    KOiK04576.
    OrthoDBiEOG712TW2.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR017981. GPCR_2-like.
    IPR001688. GPCR_2_calcitonin_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00361. CALCITONINR.
    PR01350. CTRFAMILY.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: P30988-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQFSGEKISG QRDLQKSKMR FTFTSRCLAL FLLLNHPTPI LPAFSNQTYP    50
    TIEPKPFLYV VGRKKMMDAQ YKCYDRMQQL PAYQGEGPYC NRTWDGWLCW 100
    DDTPAGVLSY QFCPDYFPDF DPSEKVTKYC DEKGVWFKHP ENNRTWSNYT 150
    MCNAFTPEKL KNAYVLYYLA IVGHSLSIFT LVISLGIFVF FRKLTTIFPL 200
    NWKYRKALSL GCQRVTLHKN MFLTYILNSM IIIIHLVEVV PNGELVRRDP 250
    VSCKILHFFH QYMMACNYFW MLCEGIYLHT LIVVAVFTEK QRLRWYYLLG 300
    WGFPLVPTTI HAITRAVYFN DNCWLSVETH LLYIIHGPVM AALVVNFFFL 350
    LNIVRVLVTK MRETHEAESH MYLKAVKATM ILVPLLGIQF VVFPWRPSNK 400
    MLGKIYDYVM HSLIHFQGFF VATIYCFCNN EVQTTVKRQW AQFKIQWNQR 450
    WGRRPSNRSA RAAAAAAEAG DIPIYICHQE PRNEPANNQG EESAEIIPLN 500
    IIEQESSA 508
    Length:508
    Mass (Da):59,352
    Last modified:October 16, 2013 - v2
    Checksum:iF76D13FD91BF61BA
    GO
    Isoform 2 (identifier: P30988-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: Missing.
         193-208: Missing.

    Show »
    Length:474
    Mass (Da):55,329
    Checksum:i0D9FA80FF16E82D9
    GO
    Isoform 3 (identifier: P30988-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.
         193-208: Missing.

    Show »
    Length:427
    Mass (Da):49,878
    Checksum:i733431C1963B7A83
    GO
    Isoform 4 (identifier: P30988-4) [UniParc]FASTAAdd to Basket

    Also known as: Delta(1-47)hCT((a))

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.

    Show »
    Length:443
    Mass (Da):51,852
    Checksum:iAE090009967D7B08
    GO
    Isoform 5 (identifier: P30988-5) [UniParc]FASTAAdd to Basket

    Also known as: HCTR-5

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: Missing.
         302-308: GFPLVPT → APAFHRD
         309-508: Missing.

    Show »
    Length:290
    Mass (Da):34,397
    Checksum:iB69ECF2AE4FAD38A
    GO
    Isoform 6 (identifier: P30988-6) [UniParc]FASTAAdd to Basket

    Also known as: HCTR-6

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: Missing.
         193-208: Missing.
         302-308: GFPLVPT → APAFHRD
         309-508: Missing.

    Show »
    Length:274
    Mass (Da):32,423
    Checksum:i83843885095D43EA
    GO

    Sequence cautioni

    The sequence AAA35640.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti381 – 3811I → T in AAC50301. (PubMed:7588285)Curated

    Polymorphismi

    Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti481 – 4811P → L May be correlated with low bone mineral density (BMD). 4 Publications
    Corresponds to variant rs1801197 [ dbSNP | Ensembl ].
    VAR_003580

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6565Missing in isoform 3 and isoform 4. 2 PublicationsVSP_053289Add
    BLAST
    Alternative sequencei1 – 1818Missing in isoform 2, isoform 5 and isoform 6. 6 PublicationsVSP_053290Add
    BLAST
    Alternative sequencei193 – 20816Missing in isoform 2, isoform 3 and isoform 6. 7 PublicationsVSP_053291Add
    BLAST
    Alternative sequencei302 – 3087GFPLVPT → APAFHRD in isoform 5 and isoform 6. 1 PublicationVSP_053292
    Alternative sequencei309 – 508200Missing in isoform 5 and isoform 6. 1 PublicationVSP_053293Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00587 mRNA. Translation: AAA35640.1. Different initiation.
    X69920 mRNA. Translation: CAA49541.1.
    U26553 mRNA. Translation: AAC50300.1.
    U26554 mRNA. Translation: AAC50301.1.
    X82466 mRNA. Translation: CAA57849.1.
    S77876, S77875 Genomic DNA. Translation: AAD14268.1.
    AB022177 mRNA. Translation: BAA86929.1.
    AB022178 mRNA. Translation: BAA86928.1.
    AJ831406 mRNA. Translation: CAH40796.1.
    AJ831407 mRNA. Translation: CAH40797.1.
    AY430048 mRNA. Translation: AAR06949.1.
    AC003078 Genomic DNA. Translation: AAB83945.1.
    AC005024 Genomic DNA. No translation available.
    BC069611 mRNA. Translation: AAH69611.1.
    BC075028 mRNA. Translation: AAH75028.2.
    CCDSiCCDS55125.1. [P30988-1]
    CCDS5631.1. [P30988-2]
    PIRiI37217.
    S34486.
    RefSeqiNP_001158209.1. NM_001164737.1.
    NP_001158210.1. NM_001164738.1.
    NP_001733.1. NM_001742.3.
    UniGeneiHs.489127.

    Genome annotation databases

    EnsembliENST00000415529; ENSP00000413179; ENSG00000004948. [P30988-6]
    ENST00000423724; ENSP00000391369; ENSG00000004948. [P30988-5]
    GeneIDi799.
    KEGGihsa:799.

    Polymorphism databases

    DMDMi550544247.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00587 mRNA. Translation: AAA35640.1 . Different initiation.
    X69920 mRNA. Translation: CAA49541.1 .
    U26553 mRNA. Translation: AAC50300.1 .
    U26554 mRNA. Translation: AAC50301.1 .
    X82466 mRNA. Translation: CAA57849.1 .
    S77876 , S77875 Genomic DNA. Translation: AAD14268.1 .
    AB022177 mRNA. Translation: BAA86929.1 .
    AB022178 mRNA. Translation: BAA86928.1 .
    AJ831406 mRNA. Translation: CAH40796.1 .
    AJ831407 mRNA. Translation: CAH40797.1 .
    AY430048 mRNA. Translation: AAR06949.1 .
    AC003078 Genomic DNA. Translation: AAB83945.1 .
    AC005024 Genomic DNA. No translation available.
    BC069611 mRNA. Translation: AAH69611.1 .
    BC075028 mRNA. Translation: AAH75028.2 .
    CCDSi CCDS55125.1. [P30988-1 ]
    CCDS5631.1. [P30988-2 ]
    PIRi I37217.
    S34486.
    RefSeqi NP_001158209.1. NM_001164737.1.
    NP_001158210.1. NM_001164738.1.
    NP_001733.1. NM_001742.3.
    UniGenei Hs.489127.

    3D structure databases

    ProteinModelPortali P30988.
    SMRi P30988. Positions 61-153, 163-430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107250. 7 interactions.
    IntActi P30988. 8 interactions.
    MINTi MINT-1217503.
    STRINGi 9606.ENSP00000352561.

    Chemistry

    BindingDBi P30988.
    ChEMBLi CHEMBL1832.
    DrugBanki DB00017. Salmon Calcitonin.
    GuidetoPHARMACOLOGYi 43.

    Protein family/group databases

    TCDBi 9.A.14.4.1. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30988.

    Polymorphism databases

    DMDMi 550544247.

    Proteomic databases

    PaxDbi P30988.
    PRIDEi P30988.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000415529 ; ENSP00000413179 ; ENSG00000004948 . [P30988-6 ]
    ENST00000423724 ; ENSP00000391369 ; ENSG00000004948 . [P30988-5 ]
    GeneIDi 799.
    KEGGi hsa:799.

    Organism-specific databases

    CTDi 799.
    GeneCardsi GC07M093053.
    H-InvDB HIX0033513.
    HGNCi HGNC:1440. CALCR.
    HPAi HPA028962.
    MIMi 114131. gene.
    neXtProti NX_P30988.
    PharmGKBi PA26032.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255868.
    HOGENOMi HOG000230695.
    HOVERGENi HBG102129.
    InParanoidi P30988.
    KOi K04576.
    OrthoDBi EOG712TW2.
    TreeFami TF315710.

    Enzyme and pathway databases

    Reactomei REACT_18290. Calcitonin-like ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Calcitonin_receptor.
    GenomeRNAii 799.
    NextBioi 3248.
    PROi P30988.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30988.
    Bgeei P30988.
    CleanExi HS_CALCR.
    Genevestigatori P30988.

    Family and domain databases

    InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR017981. GPCR_2-like.
    IPR001688. GPCR_2_calcitonin_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00361. CALCITONINR.
    PR01350. CTRFAMILY.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line."
      Gorn A.H., Lin H.Y., Yamin M., Auron P.E., Flannery M.R., Tapp D.R., Manning C.A., Lodish H.F., Krane S.M., Goldring S.R.
      J. Clin. Invest. 90:1726-1735(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Ovarian carcinoma.
    2. "Cloning and characterization of an abundant subtype of the human calcitonin receptor."
      Kuestner R.E., Elrod R.D., Grant F.J., Hagen F.S., Kuijper J.L., Mathewes S.L., O'Hara P.J., Sheppard P.O., Stroop S.D., Thompson D.L., Whitmore T.E., Findlays D.M., Houssamis S., Sexton P.M., Moore E.E.
      Mol. Pharmacol. 46:246-255(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene."
      Albrandt K., Brady E.M.G., Moore C.X., Mull E., Sierzega M.E., Beaumont K.
      Endocrinology 136:5377-5384(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), ALTERNATIVE SPLICING.
      Tissue: Mammary carcinoma.
    4. "An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid."
      Frendo J.L., Pichaud F., Delage-Mourroux R., Bouizar Z., Segond N., Moukhtar M.S., Jullienne A.
      FEBS Lett. 342:214-216(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LEU-481.
    5. "A novel calcitonin receptor gene in human osteoclasts from normal bone marrow."
      Nishikawa T., Ishikawa H., Yamamoto S., Koshihara Y.
      FEBS Lett. 458:409-414(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Mammary carcinoma.
    6. "Molecular characterization of two novel isoforms of the human calcitonin receptor."
      Beaudreuil J., Balasubramanian S., Chenais J., Taboulet J., Frenkian M., Orcel P., Jullienne A., Horne W., de Vernejoul M.C., Cressent M.
      Gene 343:143-151(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6).
    7. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-481.
      Tissue: Kidney.
    8. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-481.
    10. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 43-57.
    11. "Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor."
      Nussenzveig D.R., Mathew S., Gershengorn M.C.
      Endocrinology 136:2047-2051(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
      Tissue: Placenta.
    12. "A new type of human calcitonin receptor isoform generated by alternative splicing."
      Nakamura M., Hashimoto T., Nakajima T., Ichii S., Furuyama J., Ishihara Y., Kakudo K.
      Biochem. Biophys. Res. Commun. 209:744-751(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    13. "Multiple promoters regulate human calcitonin receptor gene expression."
      Hebden C., Smalt R., Chambers T., Pondel M.D.
      Biochem. Biophys. Res. Commun. 272:738-743(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE PROMOTER USAGE.
    14. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
      Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L.
      J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GPRASP2.
    15. "Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women."
      Masi L., Becherini L., Colli E., Gennari L., Mansani R., Falchetti A., Becorpi A.M., Cepollaro C., Gonnelli S., Tanini A., Brandi M.L.
      Biochem. Biophys. Res. Commun. 248:190-195(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN LUMBAR BMD.
    16. "Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function."
      Qi T., Dong M., Watkins H.A., Wootten D., Miller L.J., Hay D.L.
      Br. J. Pharmacol. 168:644-657(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM 4).
    17. "Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women."
      Masi L., Becherini L., Gennari L., Colli E., Mansani R., Falchetti A., Cepollaro C., Gonnelli S., Tanini A., Brandi M.L.
      Biochem. Biophys. Res. Commun. 245:622-626(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION OF VARIANT LEU-481 WITH LOWER LUMBAR BMD.
    18. "Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women."
      Taboulet J., Frenkian M., Frendo J.L., Feingold N., Jullienne A., de Vernejoul M.-C.
      Hum. Mol. Genet. 7:2129-2133(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-481.

    Entry informationi

    Entry nameiCALCR_HUMAN
    AccessioniPrimary (citable) accession number: P30988
    Secondary accession number(s): F5H605
    , O14585, Q13941, Q5ZGL8, Q659U6, Q6DJU8, Q6T712
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: October 16, 2013
    Last modified: October 1, 2014
    This is version 151 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3