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P30987

- TA2R_MOUSE

UniProt

P30987 - TA2R_MOUSE

Protein

Thromboxane A2 receptor

Gene

Tbxa2r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

    GO - Molecular functioni

    1. thromboxane receptor activity Source: MGI

    GO - Biological processi

    1. inflammatory response Source: MGI
    2. positive regulation of angiogenesis Source: Ensembl
    3. positive regulation of blood pressure Source: Ensembl
    4. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    5. positive regulation of smooth muscle contraction Source: MGI
    6. positive regulation of vasoconstriction Source: Ensembl
    7. regulation of vasoconstriction Source: MGI
    8. response to drug Source: Ensembl
    9. response to lipopolysaccharide Source: MGI
    10. response to nutrient Source: Ensembl
    11. second-messenger-mediated signaling Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_204733. G alpha (12/13) signalling events.
    REACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thromboxane A2 receptor
    Short name:
    TXA2-R
    Alternative name(s):
    Prostanoid TP receptor
    Gene namesi
    Name:Tbxa2r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:98496. Tbxa2r.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Thromboxane A2 receptorPRO_0000070139Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 181PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP30987.

    PTM databases

    PhosphoSiteiP30987.

    Expressioni

    Gene expression databases

    ArrayExpressiP30987.
    BgeeiP30987.
    CleanExiMM_TBXA2R.
    GenevestigatoriP30987.

    Interactioni

    Subunit structurei

    Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP30987.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 6513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini87 – 10519ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 14720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 19121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 24427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 28719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 34132CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5223Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei106 – 12722Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei148 – 17023Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei192 – 21726Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26824Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30922Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263172.
    HOGENOMiHOG000015238.
    HOVERGENiHBG108543.
    InParanoidiP30987.
    KOiK04264.
    OMAiATLCRVY.
    OrthoDBiEOG7TBC2R.
    PhylomeDBiP30987.
    TreeFamiTF324982.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001105. Thbox_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01788. PROSTANOIDR.
    PR00429. THROMBOXANER.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30987-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWPNGTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA    50
    GARPGAGPRS SFLALLCGLV LTDFLGLLVT GAIVASQHAA LLDWRATDPS 100
    CRLCYFMGVA MVFFGLCPLL LGAAMASERF VGITRPFSRP TATSRRAWAT 150
    VGLVWVAAGA LGLLPLLGLG RYSVQYPGSW CFLTLGTQRG DVVFGLIFAL 200
    LGSASVGLSL LLNTVSVATL CRVYHTREAT QRPRDCEVEM MVQLVGIMVV 250
    ATVCWMPLLV FIMQTLLQTP PVMSFSGQLL RATEHQLLIY LRVATWNQIL 300
    DPWVYILFRR SVLRRLHPRF SSQLQAVSLR RPPAQAMLSG P 341
    Length:341
    Mass (Da):37,098
    Last modified:July 1, 1993 - v1
    Checksum:iF090F027E7D1F234
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10849 mRNA. Translation: BAA01622.1.
    CCDSiCCDS24053.1.
    PIRiJH0606.
    RefSeqiNP_001264194.1. NM_001277265.1.
    NP_033351.1. NM_009325.4.
    XP_006513523.1. XM_006513460.1.
    UniGeneiMm.4545.

    Genome annotation databases

    EnsembliENSMUST00000105325; ENSMUSP00000100962; ENSMUSG00000034881.
    GeneIDi21390.
    KEGGimmu:21390.
    UCSCiuc007ghg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10849 mRNA. Translation: BAA01622.1 .
    CCDSi CCDS24053.1.
    PIRi JH0606.
    RefSeqi NP_001264194.1. NM_001277265.1.
    NP_033351.1. NM_009325.4.
    XP_006513523.1. XM_006513460.1.
    UniGenei Mm.4545.

    3D structure databases

    ProteinModelPortali P30987.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P30987.
    ChEMBLi CHEMBL1795181.
    GuidetoPHARMACOLOGYi 346.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30987.

    Proteomic databases

    PRIDEi P30987.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105325 ; ENSMUSP00000100962 ; ENSMUSG00000034881 .
    GeneIDi 21390.
    KEGGi mmu:21390.
    UCSCi uc007ghg.1. mouse.

    Organism-specific databases

    CTDi 6915.
    MGIi MGI:98496. Tbxa2r.

    Phylogenomic databases

    eggNOGi NOG263172.
    HOGENOMi HOG000015238.
    HOVERGENi HBG108543.
    InParanoidi P30987.
    KOi K04264.
    OMAi ATLCRVY.
    OrthoDBi EOG7TBC2R.
    PhylomeDBi P30987.
    TreeFami TF324982.

    Enzyme and pathway databases

    Reactomei REACT_204733. G alpha (12/13) signalling events.
    REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 300644.
    PROi P30987.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30987.
    Bgeei P30987.
    CleanExi MM_TBXA2R.
    Genevestigatori P30987.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001105. Thbox_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01788. PROSTANOIDR.
    PR00429. THROMBOXANER.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis."
      Namba T., Sugimoto Y., Hirata M., Hayashi Y., Honda A., Watabe A., Negishi M., Ichikawa A., Narumiya S.
      Biochem. Biophys. Res. Commun. 184:1197-1203(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ddY.
      Tissue: Lung.

    Entry informationi

    Entry nameiTA2R_MOUSE
    AccessioniPrimary (citable) accession number: P30987
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3