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Protein

Thromboxane A2 receptor

Gene

Tbxa2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

GO - Molecular functioni

  • thromboxane A2 receptor activity Source: GO_Central
  • thromboxane receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-391908 Prostanoid ligand receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-428930 Thromboxane signalling through TP receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane A2 receptor
Short name:
TXA2-R
Alternative name(s):
Prostanoid TP receptor
Gene namesi
Name:Tbxa2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:98496 Tbxa2r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 52Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini53 – 65CytoplasmicSequence analysisAdd BLAST13
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 105ExtracellularSequence analysisAdd BLAST19
Transmembranei106 – 127Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini128 – 147CytoplasmicSequence analysisAdd BLAST20
Transmembranei148 – 170Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini171 – 191ExtracellularSequence analysisAdd BLAST21
Transmembranei192 – 217Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini218 – 244CytoplasmicSequence analysisAdd BLAST27
Transmembranei245 – 268Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini269 – 287ExtracellularSequence analysisAdd BLAST19
Transmembranei288 – 309Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini310 – 341CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1795181
GuidetoPHARMACOLOGYi346

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701391 – 341Thromboxane A2 receptorAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation
Modified residuei328PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP30987
PRIDEiP30987

PTM databases

iPTMnetiP30987
PhosphoSitePlusiP30987

Expressioni

Gene expression databases

BgeeiENSMUSG00000034881
CleanExiMM_TBXA2R
ExpressionAtlasiP30987 baseline and differential
GenevisibleiP30987 MM

Interactioni

Subunit structurei

Interacts with RPGRIP1L. Interacts with RACK1; the interaction regulates TBXA2R cell surface expression (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100962

Chemistry databases

BindingDBiP30987

Structurei

3D structure databases

ProteinModelPortaliP30987
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000015238
HOVERGENiHBG108543
InParanoidiP30987
KOiK04264
OMAiRVYHDRE
OrthoDBiEOG091G0DNT
PhylomeDBiP30987
TreeFamiTF324982

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR001105 Thbox_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01788 PROSTANOIDR
PR00429 THROMBOXANER
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30987-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPNGTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA
60 70 80 90 100
GARPGAGPRS SFLALLCGLV LTDFLGLLVT GAIVASQHAA LLDWRATDPS
110 120 130 140 150
CRLCYFMGVA MVFFGLCPLL LGAAMASERF VGITRPFSRP TATSRRAWAT
160 170 180 190 200
VGLVWVAAGA LGLLPLLGLG RYSVQYPGSW CFLTLGTQRG DVVFGLIFAL
210 220 230 240 250
LGSASVGLSL LLNTVSVATL CRVYHTREAT QRPRDCEVEM MVQLVGIMVV
260 270 280 290 300
ATVCWMPLLV FIMQTLLQTP PVMSFSGQLL RATEHQLLIY LRVATWNQIL
310 320 330 340
DPWVYILFRR SVLRRLHPRF SSQLQAVSLR RPPAQAMLSG P
Length:341
Mass (Da):37,098
Last modified:July 1, 1993 - v1
Checksum:iF090F027E7D1F234
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10849 mRNA Translation: BAA01622.1
CCDSiCCDS24053.1
PIRiJH0606
RefSeqiNP_001264194.1, NM_001277265.1
NP_033351.1, NM_009325.4
XP_006513523.1, XM_006513460.3
UniGeneiMm.4545

Genome annotation databases

EnsembliENSMUST00000105325; ENSMUSP00000100962; ENSMUSG00000034881
ENSMUST00000220312; ENSMUSP00000151447; ENSMUSG00000034881
GeneIDi21390
KEGGimmu:21390
UCSCiuc007ghg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTA2R_MOUSE
AccessioniPrimary (citable) accession number: P30987
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome