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P30987

- TA2R_MOUSE

UniProt

P30987 - TA2R_MOUSE

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Protein

Thromboxane A2 receptor

Gene
Tbxa2r
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

GO - Molecular functioni

  1. thromboxane receptor activity Source: MGI

GO - Biological processi

  1. inflammatory response Source: MGI
  2. positive regulation of angiogenesis Source: Ensembl
  3. positive regulation of blood pressure Source: Ensembl
  4. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  5. positive regulation of smooth muscle contraction Source: MGI
  6. positive regulation of vasoconstriction Source: Ensembl
  7. regulation of vasoconstriction Source: MGI
  8. response to drug Source: Ensembl
  9. response to lipopolysaccharide Source: MGI
  10. response to nutrient Source: Ensembl
  11. second-messenger-mediated signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane A2 receptor
Short name:
TXA2-R
Alternative name(s):
Prostanoid TP receptor
Gene namesi
Name:Tbxa2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:98496. Tbxa2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929Extracellular Reviewed predictionAdd
BLAST
Transmembranei30 – 5223Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini53 – 6513Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei66 – 8621Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini87 – 10519Extracellular Reviewed predictionAdd
BLAST
Transmembranei106 – 12722Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini128 – 14720Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei148 – 17023Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini171 – 19121Extracellular Reviewed predictionAdd
BLAST
Transmembranei192 – 21726Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini218 – 24427Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei245 – 26824Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini269 – 28719Extracellular Reviewed predictionAdd
BLAST
Transmembranei288 – 30922Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini310 – 34132Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Thromboxane A2 receptorPRO_0000070139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16 – 161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi104 ↔ 181 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP30987.

PTM databases

PhosphoSiteiP30987.

Expressioni

Gene expression databases

ArrayExpressiP30987.
BgeeiP30987.
CleanExiMM_TBXA2R.
GenevestigatoriP30987.

Interactioni

Subunit structurei

Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression By similarity.

Structurei

3D structure databases

ProteinModelPortaliP30987.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263172.
HOGENOMiHOG000015238.
HOVERGENiHBG108543.
InParanoidiP30987.
KOiK04264.
OMAiATLCRVY.
OrthoDBiEOG7TBC2R.
PhylomeDBiP30987.
TreeFamiTF324982.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30987-1 [UniParc]FASTAAdd to Basket

« Hide

MWPNGTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA    50
GARPGAGPRS SFLALLCGLV LTDFLGLLVT GAIVASQHAA LLDWRATDPS 100
CRLCYFMGVA MVFFGLCPLL LGAAMASERF VGITRPFSRP TATSRRAWAT 150
VGLVWVAAGA LGLLPLLGLG RYSVQYPGSW CFLTLGTQRG DVVFGLIFAL 200
LGSASVGLSL LLNTVSVATL CRVYHTREAT QRPRDCEVEM MVQLVGIMVV 250
ATVCWMPLLV FIMQTLLQTP PVMSFSGQLL RATEHQLLIY LRVATWNQIL 300
DPWVYILFRR SVLRRLHPRF SSQLQAVSLR RPPAQAMLSG P 341
Length:341
Mass (Da):37,098
Last modified:July 1, 1993 - v1
Checksum:iF090F027E7D1F234
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10849 mRNA. Translation: BAA01622.1.
CCDSiCCDS24053.1.
PIRiJH0606.
RefSeqiNP_001264194.1. NM_001277265.1.
NP_033351.1. NM_009325.4.
XP_006513523.1. XM_006513460.1.
UniGeneiMm.4545.

Genome annotation databases

EnsembliENSMUST00000105325; ENSMUSP00000100962; ENSMUSG00000034881.
GeneIDi21390.
KEGGimmu:21390.
UCSCiuc007ghg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10849 mRNA. Translation: BAA01622.1 .
CCDSi CCDS24053.1.
PIRi JH0606.
RefSeqi NP_001264194.1. NM_001277265.1.
NP_033351.1. NM_009325.4.
XP_006513523.1. XM_006513460.1.
UniGenei Mm.4545.

3D structure databases

ProteinModelPortali P30987.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P30987.
ChEMBLi CHEMBL1795181.
GuidetoPHARMACOLOGYi 346.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30987.

Proteomic databases

PRIDEi P30987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105325 ; ENSMUSP00000100962 ; ENSMUSG00000034881 .
GeneIDi 21390.
KEGGi mmu:21390.
UCSCi uc007ghg.1. mouse.

Organism-specific databases

CTDi 6915.
MGIi MGI:98496. Tbxa2r.

Phylogenomic databases

eggNOGi NOG263172.
HOGENOMi HOG000015238.
HOVERGENi HBG108543.
InParanoidi P30987.
KOi K04264.
OMAi ATLCRVY.
OrthoDBi EOG7TBC2R.
PhylomeDBi P30987.
TreeFami TF324982.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.
REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 300644.
PROi P30987.
SOURCEi Search...

Gene expression databases

ArrayExpressi P30987.
Bgeei P30987.
CleanExi MM_TBXA2R.
Genevestigatori P30987.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis."
    Namba T., Sugimoto Y., Hirata M., Hayashi Y., Honda A., Watabe A., Negishi M., Ichikawa A., Narumiya S.
    Biochem. Biophys. Res. Commun. 184:1197-1203(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Lung.

Entry informationi

Entry nameiTA2R_MOUSE
AccessioniPrimary (citable) accession number: P30987
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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