P30987 (TA2R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thromboxane A2 receptor
Short name=TXA2-R

Alternative name(s):
Prostanoid TP receptor

Gene names

Name:

Tbxa2r

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.
Subunit structure	Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara inflammatory response Inferred from mutant phenotype PubMed 15834430. Source: MGI positive regulation of angiogenesis Inferred from electronic annotation. Source: Compara positive regulation of blood pressure Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle contraction Inferred from direct assay PubMed 12925702. Source: MGI positive regulation of vasoconstriction Inferred from electronic annotation. Source: Compara regulation of vasoconstriction Inferred from genetic interaction PubMed 14627611. Source: MGI response to drug Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from mutant phenotype PubMed 15834430. Source: MGI response to nutrient Inferred from electronic annotation. Source: Compara second-messenger-mediated signaling Inferred from direct assay Ref.1. Source: MGI
Cellular_component	acrosomal vesicle Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	thromboxane receptor activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Thromboxane A2 receptor		PRO_0000070139
Regions
	Topological domain	1 – 29	29	Extracellular Potential
	Transmembrane	30 – 52	23	Helical; Name=1; Potential
	Topological domain	53 – 65	13	Cytoplasmic Potential
	Transmembrane	66 – 86	21	Helical; Name=2; Potential
	Topological domain	87 – 105	19	Extracellular Potential
	Transmembrane	106 – 127	22	Helical; Name=3; Potential
	Topological domain	128 – 147	20	Cytoplasmic Potential
	Transmembrane	148 – 170	23	Helical; Name=4; Potential
	Topological domain	171 – 191	21	Extracellular Potential
	Transmembrane	192 – 217	26	Helical; Name=5; Potential
	Topological domain	218 – 244	27	Cytoplasmic Potential
	Transmembrane	245 – 268	24	Helical; Name=6; Potential
	Topological domain	269 – 287	19	Extracellular Potential
	Transmembrane	288 – 309	22	Helical; Name=7; Potential
	Topological domain	310 – 341	32	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	16	1	N-linked (GlcNAc...) Potential
	Disulfide bond	104 ↔ 181		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30987 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: F090F027E7D1F234	FASTA	341	37,098
	10 20 30 40 50 60 MWPNGTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA GARPGAGPRS 70 80 90 100 110 120 SFLALLCGLV LTDFLGLLVT GAIVASQHAA LLDWRATDPS CRLCYFMGVA MVFFGLCPLL 130 140 150 160 170 180 LGAAMASERF VGITRPFSRP TATSRRAWAT VGLVWVAAGA LGLLPLLGLG RYSVQYPGSW 190 200 210 220 230 240 CFLTLGTQRG DVVFGLIFAL LGSASVGLSL LLNTVSVATL CRVYHTREAT QRPRDCEVEM 250 260 270 280 290 300 MVQLVGIMVV ATVCWMPLLV FIMQTLLQTP PVMSFSGQLL RATEHQLLIY LRVATWNQIL 310 320 330 340 DPWVYILFRR SVLRRLHPRF SSQLQAVSLR RPPAQAMLSG P

References

[1]	"Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis." Namba T., Sugimoto Y., Hirata M., Hayashi Y., Honda A., Watabe A., Negishi M., Ichikawa A., Narumiya S. Biochem. Biophys. Res. Commun. 184:1197-1203(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ddY. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D10849 mRNA. Translation: BAA01622.1.
IPI	IPI00135858.
PIR	JH0606.
RefSeq	NP_001264194.1. NM_001277265.1. NP_033351.1. NM_009325.4.
UniGene	Mm.4545.
3D structure databases
ProteinModelPortal	P30987.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P30987.
Proteomic databases
PRIDE	P30987.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000105325; ENSMUSP00000100962; ENSMUSG00000034881.
GeneID	21390.
KEGG	mmu:21390.
UCSC	uc007ghg.1. mouse.
Organism-specific databases
CTD	6915.
MGI	MGI:98496. Tbxa2r.
Phylogenomic databases
eggNOG	NOG263172.
HOGENOM	HOG000015238.
HOVERGEN	HBG108543.
InParanoid	P30987.
KO	K04264.
OMA	EMMVQLL.
OrthoDB	EOG49S674.
Gene expression databases
ArrayExpress	P30987.
Bgee	P30987.
CleanEx	MM_TBXA2R.
Genevestigator	P30987.
GermOnline	ENSMUSG00000034881. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR008365. Prostanoid_rcpt. IPR001105. Thbox_rcpt. [Graphical view]
PANTHER	PTHR11866. PTHR11866. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01788. PROSTANOIDR. PR00429. THROMBOXANER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P30987.
ChEMBL	CHEMBL1795181.
NextBio	300644.
SOURCE	Search...

Entry information

Entry name

TA2R_MOUSE

Accession

Primary (citable) accession number: P30987

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 29, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program