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P30987 (TA2R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thromboxane A2 receptor

Short name=TXA2-R
Alternative name(s):
Prostanoid TP receptor
Gene names
Name:Tbxa2r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

Subunit structure

Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinflammatory response

Inferred from mutant phenotype PubMed 15834430. Source: MGI

positive regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle contraction

Inferred from direct assay PubMed 12925702. Source: MGI

positive regulation of vasoconstriction

Inferred from electronic annotation. Source: Ensembl

regulation of vasoconstriction

Inferred from genetic interaction PubMed 14627611. Source: MGI

response to drug

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from mutant phenotype PubMed 15834430. Source: MGI

response to nutrient

Inferred from electronic annotation. Source: Ensembl

second-messenger-mediated signaling

Inferred from direct assay Ref.1. Source: MGI

   Cellular_componentacrosomal vesicle

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionthromboxane receptor activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Thromboxane A2 receptor
PRO_0000070139

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5223Helical; Name=1; Potential
Topological domain53 – 6513Cytoplasmic Potential
Transmembrane66 – 8621Helical; Name=2; Potential
Topological domain87 – 10519Extracellular Potential
Transmembrane106 – 12722Helical; Name=3; Potential
Topological domain128 – 14720Cytoplasmic Potential
Transmembrane148 – 17023Helical; Name=4; Potential
Topological domain171 – 19121Extracellular Potential
Transmembrane192 – 21726Helical; Name=5; Potential
Topological domain218 – 24427Cytoplasmic Potential
Transmembrane245 – 26824Helical; Name=6; Potential
Topological domain269 – 28719Extracellular Potential
Transmembrane288 – 30922Helical; Name=7; Potential
Topological domain310 – 34132Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation161N-linked (GlcNAc...) Potential
Disulfide bond104 ↔ 181 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30987 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: F090F027E7D1F234

FASTA34137,098
        10         20         30         40         50         60 
MWPNGTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA GARPGAGPRS 

        70         80         90        100        110        120 
SFLALLCGLV LTDFLGLLVT GAIVASQHAA LLDWRATDPS CRLCYFMGVA MVFFGLCPLL 

       130        140        150        160        170        180 
LGAAMASERF VGITRPFSRP TATSRRAWAT VGLVWVAAGA LGLLPLLGLG RYSVQYPGSW 

       190        200        210        220        230        240 
CFLTLGTQRG DVVFGLIFAL LGSASVGLSL LLNTVSVATL CRVYHTREAT QRPRDCEVEM 

       250        260        270        280        290        300 
MVQLVGIMVV ATVCWMPLLV FIMQTLLQTP PVMSFSGQLL RATEHQLLIY LRVATWNQIL 

       310        320        330        340 
DPWVYILFRR SVLRRLHPRF SSQLQAVSLR RPPAQAMLSG P 

« Hide

References

[1]"Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis."
Namba T., Sugimoto Y., Hirata M., Hayashi Y., Honda A., Watabe A., Negishi M., Ichikawa A., Narumiya S.
Biochem. Biophys. Res. Commun. 184:1197-1203(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ddY.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10849 mRNA. Translation: BAA01622.1.
CCDSCCDS24053.1.
PIRJH0606.
RefSeqNP_001264194.1. NM_001277265.1.
NP_033351.1. NM_009325.4.
XP_006513523.1. XM_006513460.1.
UniGeneMm.4545.

3D structure databases

ProteinModelPortalP30987.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP30987.
ChEMBLCHEMBL1795181.
GuidetoPHARMACOLOGY346.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30987.

Proteomic databases

PRIDEP30987.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105325; ENSMUSP00000100962; ENSMUSG00000034881.
GeneID21390.
KEGGmmu:21390.
UCSCuc007ghg.1. mouse.

Organism-specific databases

CTD6915.
MGIMGI:98496. Tbxa2r.

Phylogenomic databases

eggNOGNOG263172.
HOGENOMHOG000015238.
HOVERGENHBG108543.
InParanoidP30987.
KOK04264.
OMAATLCRVY.
OrthoDBEOG7TBC2R.
PhylomeDBP30987.
TreeFamTF324982.

Gene expression databases

ArrayExpressP30987.
BgeeP30987.
CleanExMM_TBXA2R.
GenevestigatorP30987.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio300644.
PROP30987.
SOURCESearch...

Entry information

Entry nameTA2R_MOUSE
AccessionPrimary (citable) accession number: P30987
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries