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Protein

Thromboxane A2 receptor

Gene

Tbxa2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

GO - Molecular functioni

  • thromboxane A2 receptor activity Source: GO_Central
  • thromboxane receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-391908. Prostanoid ligand receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-428930. Thromboxane signalling through TP receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane A2 receptor
Short name:
TXA2-R
Alternative name(s):
Prostanoid TP receptor
Gene namesi
Name:Tbxa2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:98496. Tbxa2r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 52Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini53 – 65CytoplasmicSequence analysisAdd BLAST13
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 105ExtracellularSequence analysisAdd BLAST19
Transmembranei106 – 127Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini128 – 147CytoplasmicSequence analysisAdd BLAST20
Transmembranei148 – 170Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini171 – 191ExtracellularSequence analysisAdd BLAST21
Transmembranei192 – 217Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini218 – 244CytoplasmicSequence analysisAdd BLAST27
Transmembranei245 – 268Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini269 – 287ExtracellularSequence analysisAdd BLAST19
Transmembranei288 – 309Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini310 – 341CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1795181.
GuidetoPHARMACOLOGYi346.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701391 – 341Thromboxane A2 receptorAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation
Modified residuei328PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP30987.
PRIDEiP30987.

PTM databases

iPTMnetiP30987.
PhosphoSitePlusiP30987.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034881.
CleanExiMM_TBXA2R.
ExpressionAtlasiP30987. baseline and differential.
GenevisibleiP30987. MM.

Interactioni

Subunit structurei

Interacts with RPGRIP1L. Interacts with RACK1; the interaction regulates TBXA2R cell surface expression (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100962.

Chemistry databases

BindingDBiP30987.

Structurei

3D structure databases

ProteinModelPortaliP30987.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG108543.
InParanoidiP30987.
KOiK04264.
OMAiLCHFMGV.
OrthoDBiEOG091G0DNT.
PhylomeDBiP30987.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30987-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPNGTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA
60 70 80 90 100
GARPGAGPRS SFLALLCGLV LTDFLGLLVT GAIVASQHAA LLDWRATDPS
110 120 130 140 150
CRLCYFMGVA MVFFGLCPLL LGAAMASERF VGITRPFSRP TATSRRAWAT
160 170 180 190 200
VGLVWVAAGA LGLLPLLGLG RYSVQYPGSW CFLTLGTQRG DVVFGLIFAL
210 220 230 240 250
LGSASVGLSL LLNTVSVATL CRVYHTREAT QRPRDCEVEM MVQLVGIMVV
260 270 280 290 300
ATVCWMPLLV FIMQTLLQTP PVMSFSGQLL RATEHQLLIY LRVATWNQIL
310 320 330 340
DPWVYILFRR SVLRRLHPRF SSQLQAVSLR RPPAQAMLSG P
Length:341
Mass (Da):37,098
Last modified:July 1, 1993 - v1
Checksum:iF090F027E7D1F234
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10849 mRNA. Translation: BAA01622.1.
CCDSiCCDS24053.1.
PIRiJH0606.
RefSeqiNP_001264194.1. NM_001277265.1.
NP_033351.1. NM_009325.4.
XP_006513523.1. XM_006513460.3.
UniGeneiMm.4545.

Genome annotation databases

EnsembliENSMUST00000105325; ENSMUSP00000100962; ENSMUSG00000034881.
GeneIDi21390.
KEGGimmu:21390.
UCSCiuc007ghg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10849 mRNA. Translation: BAA01622.1.
CCDSiCCDS24053.1.
PIRiJH0606.
RefSeqiNP_001264194.1. NM_001277265.1.
NP_033351.1. NM_009325.4.
XP_006513523.1. XM_006513460.3.
UniGeneiMm.4545.

3D structure databases

ProteinModelPortaliP30987.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100962.

Chemistry databases

BindingDBiP30987.
ChEMBLiCHEMBL1795181.
GuidetoPHARMACOLOGYi346.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP30987.
PhosphoSitePlusiP30987.

Proteomic databases

PaxDbiP30987.
PRIDEiP30987.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105325; ENSMUSP00000100962; ENSMUSG00000034881.
GeneIDi21390.
KEGGimmu:21390.
UCSCiuc007ghg.2. mouse.

Organism-specific databases

CTDi6915.
MGIiMGI:98496. Tbxa2r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG108543.
InParanoidiP30987.
KOiK04264.
OMAiLCHFMGV.
OrthoDBiEOG091G0DNT.
PhylomeDBiP30987.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiR-MMU-391908. Prostanoid ligand receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-428930. Thromboxane signalling through TP receptor.

Miscellaneous databases

PROiP30987.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034881.
CleanExiMM_TBXA2R.
ExpressionAtlasiP30987. baseline and differential.
GenevisibleiP30987. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTA2R_MOUSE
AccessioniPrimary (citable) accession number: P30987
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.