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P30987

- TA2R_MOUSE

UniProt

P30987 - TA2R_MOUSE

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Protein

Thromboxane A2 receptor

Gene

Tbxa2r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

GO - Molecular functioni

  1. thromboxane receptor activity Source: MGI

GO - Biological processi

  1. inflammatory response Source: MGI
  2. positive regulation of angiogenesis Source: Ensembl
  3. positive regulation of blood pressure Source: Ensembl
  4. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  5. positive regulation of smooth muscle contraction Source: MGI
  6. positive regulation of vasoconstriction Source: Ensembl
  7. regulation of vasoconstriction Source: MGI
  8. response to drug Source: Ensembl
  9. response to lipopolysaccharide Source: MGI
  10. response to nutrient Source: Ensembl
  11. second-messenger-mediated signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_207651. G alpha (q) signalling events.
REACT_230556. Prostanoid ligand receptors.
REACT_233922. Thromboxane signalling through TP receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane A2 receptor
Short name:
TXA2-R
Alternative name(s):
Prostanoid TP receptor
Gene namesi
Name:Tbxa2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:98496. Tbxa2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei30 – 5223Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 6513CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini87 – 10519ExtracellularSequence AnalysisAdd
BLAST
Transmembranei106 – 12722Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini128 – 14720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei148 – 17023Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini171 – 19121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei192 – 21726Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 24427CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 26824Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 28719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30922Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini310 – 34132CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Thromboxane A2 receptorPRO_0000070139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP30987.

PTM databases

PhosphoSiteiP30987.

Expressioni

Gene expression databases

BgeeiP30987.
CleanExiMM_TBXA2R.
ExpressionAtlasiP30987. baseline.
GenevestigatoriP30987.

Interactioni

Subunit structurei

Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP30987.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263172.
HOGENOMiHOG000015238.
HOVERGENiHBG108543.
InParanoidiP30987.
KOiK04264.
OMAiATLCRVY.
OrthoDBiEOG7TBC2R.
PhylomeDBiP30987.
TreeFamiTF324982.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30987-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWPNGTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA
60 70 80 90 100
GARPGAGPRS SFLALLCGLV LTDFLGLLVT GAIVASQHAA LLDWRATDPS
110 120 130 140 150
CRLCYFMGVA MVFFGLCPLL LGAAMASERF VGITRPFSRP TATSRRAWAT
160 170 180 190 200
VGLVWVAAGA LGLLPLLGLG RYSVQYPGSW CFLTLGTQRG DVVFGLIFAL
210 220 230 240 250
LGSASVGLSL LLNTVSVATL CRVYHTREAT QRPRDCEVEM MVQLVGIMVV
260 270 280 290 300
ATVCWMPLLV FIMQTLLQTP PVMSFSGQLL RATEHQLLIY LRVATWNQIL
310 320 330 340
DPWVYILFRR SVLRRLHPRF SSQLQAVSLR RPPAQAMLSG P
Length:341
Mass (Da):37,098
Last modified:July 1, 1993 - v1
Checksum:iF090F027E7D1F234
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10849 mRNA. Translation: BAA01622.1.
CCDSiCCDS24053.1.
PIRiJH0606.
RefSeqiNP_001264194.1. NM_001277265.1.
NP_033351.1. NM_009325.4.
XP_006513523.1. XM_006513460.1.
UniGeneiMm.4545.

Genome annotation databases

EnsembliENSMUST00000105325; ENSMUSP00000100962; ENSMUSG00000034881.
GeneIDi21390.
KEGGimmu:21390.
UCSCiuc007ghg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10849 mRNA. Translation: BAA01622.1 .
CCDSi CCDS24053.1.
PIRi JH0606.
RefSeqi NP_001264194.1. NM_001277265.1.
NP_033351.1. NM_009325.4.
XP_006513523.1. XM_006513460.1.
UniGenei Mm.4545.

3D structure databases

ProteinModelPortali P30987.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P30987.
ChEMBLi CHEMBL1795181.
GuidetoPHARMACOLOGYi 346.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30987.

Proteomic databases

PRIDEi P30987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105325 ; ENSMUSP00000100962 ; ENSMUSG00000034881 .
GeneIDi 21390.
KEGGi mmu:21390.
UCSCi uc007ghg.1. mouse.

Organism-specific databases

CTDi 6915.
MGIi MGI:98496. Tbxa2r.

Phylogenomic databases

eggNOGi NOG263172.
HOGENOMi HOG000015238.
HOVERGENi HBG108543.
InParanoidi P30987.
KOi K04264.
OMAi ATLCRVY.
OrthoDBi EOG7TBC2R.
PhylomeDBi P30987.
TreeFami TF324982.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.
REACT_207651. G alpha (q) signalling events.
REACT_230556. Prostanoid ligand receptors.
REACT_233922. Thromboxane signalling through TP receptor.

Miscellaneous databases

NextBioi 300644.
PROi P30987.
SOURCEi Search...

Gene expression databases

Bgeei P30987.
CleanExi MM_TBXA2R.
ExpressionAtlasi P30987. baseline.
Genevestigatori P30987.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis."
    Namba T., Sugimoto Y., Hirata M., Hayashi Y., Honda A., Watabe A., Negishi M., Ichikawa A., Narumiya S.
    Biochem. Biophys. Res. Commun. 184:1197-1203(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Lung.

Entry informationi

Entry nameiTA2R_MOUSE
AccessioniPrimary (citable) accession number: P30987
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 26, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3