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Protein

Gonadotropin-releasing hormone receptor

Gene

Gnrhr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

  • cellular response to gonadotropin-releasing hormone Source: GO_Central
  • circadian rhythm Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: RGD
  • negative regulation of cell proliferation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gonadotropin-releasing hormone receptor
Short name:
GnRH receptor
Short name:
GnRH-R
Gene namesi
Name:Gnrhr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70513. Gnrhr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 5820Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 7719CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9720Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini98 – 11518ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13722Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 16427CytoplasmicSequence analysisAdd
BLAST
Transmembranei165 – 18420Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini185 – 21127ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23120Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini232 – 28049CytoplasmicSequence analysisAdd
BLAST
Transmembranei281 – 29919Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini300 – 3056ExtracellularSequence analysis
Transmembranei306 – 32520Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini326 – 3272CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3066.
GuidetoPHARMACOLOGYi256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Gonadotropin-releasing hormone receptorPRO_0000069491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30969.

Expressioni

Inductioni

Expression oscillates in a diurnal and melatonin-dependent fashion in the preoptic area (POA) region in the hypothalamus, with maximal expression attained during the dark phase of the light/dark cycle.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi249567. 2 interactions.
MINTiMINT-194174.
STRINGi10116.ENSRNOP00000002755.

Chemistry

BindingDBiP30969.

Structurei

3D structure databases

ProteinModelPortaliP30969.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000251590.
HOVERGENiHBG009082.
InParanoidiP30969.
KOiK04280.
PhylomeDBiP30969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001658. GphnRH_fam_rcpt.
IPR027982. GphnRH_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF22. PTHR24241:SF22. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANNASLEQD QNHCSAINNS IPLTQGKLPT LTLSGKIRVT VTFFLFLLST
60 70 80 90 100
AFNASFLVKL QRWTQKRKKG KKLSRMKVLL KHLTLANLLE TLIVMPLDGM
110 120 130 140 150
WNITVQWYAG EFLCKVLSYL KLFSMYAPAF MMVVISLDRS LAVTQPLAVQ
160 170 180 190 200
SKSKLERSMT SLAWILSIVF AGPQLYIFRM IYLADGSGPA VFSQCVTHCS
210 220 230 240 250
FPQWWHEAFY NFFTFSCLFI IPLLIMLICN AKIIFALTRV LHQDPRKLQL
260 270 280 290 300
NQSKNNIPRA RLRTLKMTVA FGTSFVICWT PYYVLGIWYW FDPEMLNRVS
310 320
EPVNHFFFLF AFLNPCFDPL IYGYFSL
Length:327
Mass (Da):37,748
Last modified:February 1, 1994 - v2
Checksum:i86A2CA1A2C9F1BE4
GO

Sequence cautioni

The sequence AAA41265.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841A → V in CAA48776 (PubMed:1338727).Curated
Sequence conflicti184 – 1841A → V in AAB26420 (PubMed:1338727).Curated
Sequence conflicti272 – 2721G → A in AAA41265 (PubMed:7916600).Curated
Sequence conflicti272 – 2721G → A in CAA54083 (PubMed:8185587).Curated
Sequence conflicti272 – 2721G → A in AAC60671 (PubMed:7764374).Curated
Sequence conflicti272 – 2721G → A in AAB58038 (Ref. 7) Curated
Sequence conflicti311 – 3111A → G in CAA48776 (PubMed:1338727).Curated
Sequence conflicti311 – 3111A → G in AAB26420 (PubMed:1338727).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S59525 mRNA. Translation: AAB26420.1.
X68980 mRNA. Translation: CAA48776.1.
U00935 mRNA. Translation: AAC27349.1.
L25053 mRNA. Translation: AAA41265.1. Different initiation.
L07646 mRNA. Translation: AAA41274.1.
X76635 mRNA. Translation: CAA54083.1.
S68578 mRNA. Translation: AAC60671.1.
U92471, U92469, U92470 Genomic DNA. Translation: AAB58038.1.
PIRiI60169.
RefSeqiNP_112300.2. NM_031038.3.
UniGeneiRn.112595.

Genome annotation databases

GeneIDi81668.
KEGGirno:81668.
UCSCiRGD:70513. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S59525 mRNA. Translation: AAB26420.1.
X68980 mRNA. Translation: CAA48776.1.
U00935 mRNA. Translation: AAC27349.1.
L25053 mRNA. Translation: AAA41265.1. Different initiation.
L07646 mRNA. Translation: AAA41274.1.
X76635 mRNA. Translation: CAA54083.1.
S68578 mRNA. Translation: AAC60671.1.
U92471, U92469, U92470 Genomic DNA. Translation: AAB58038.1.
PIRiI60169.
RefSeqiNP_112300.2. NM_031038.3.
UniGeneiRn.112595.

3D structure databases

ProteinModelPortaliP30969.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249567. 2 interactions.
MINTiMINT-194174.
STRINGi10116.ENSRNOP00000002755.

Chemistry

BindingDBiP30969.
ChEMBLiCHEMBL3066.
GuidetoPHARMACOLOGYi256.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP30969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81668.
KEGGirno:81668.
UCSCiRGD:70513. rat.

Organism-specific databases

CTDi2798.
RGDi70513. Gnrhr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000251590.
HOVERGENiHBG009082.
InParanoidiP30969.
KOiK04280.
PhylomeDBiP30969.

Miscellaneous databases

PROiP30969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001658. GphnRH_fam_rcpt.
IPR027982. GphnRH_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF22. PTHR24241:SF22. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterisation of the rat pituitary gonadotropin-releasing hormone (GnRH) receptor."
    Eidne K.A., Sellar R.E., Couper G., Anderson L., Taylor P.L.
    Mol. Cell. Endocrinol. 90:R5-R9(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Pituitary.
  2. "Molecular cloning and regulation of gene expression of rat gonadotropin releasing hormone (GnRH) receptor."
    Kakar S.S., Grantham K., Musgrove L.C., Devor D.C., Sellers J.C., Neill J.D.
    Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Buffalo.
    Tissue: Pituitary.
  3. "Molecular and functional characterization of GnRH receptors cloned from rat pituitary and a mouse pituitary tumor cell line."
    Perrin M.H., Bilezikjian L.M., Hoeger C., Donaldson C.J., Rivier J., Haas Y., Vale W.W.
    Biochem. Biophys. Res. Commun. 191:1139-1144(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  4. "Isolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptor."
    Kaiser U.B., Zhao D., Cardona G.R., Chin W.W.
    Biochem. Biophys. Res. Commun. 189:1645-1652(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Pituitary.
  5. "Nucleotide sequence analysis of mRNAs predicts that rat pituitary and gonadal gonadotropin-releasing hormone receptor proteins have identical primary structure."
    Moumni M., Kottler M.L., Counis R.
    Biochem. Biophys. Res. Commun. 200:1359-1366(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary and Testis.
  6. "Isolation of rat GnRH receptor cDNA having different 5'-noncoding sequence."
    Kudo A., Park M.K., Kawashima S.
    Zool. Sci. 10:863-867(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. Reinhart J., Xiao S., Arora K.K., Catt K.J.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. "Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression."
    Matagne V., Kim J.G., Ryu B.J., Hur M.K., Kim M.S., Kim K., Park B.S., Damante G., Smiley G., Lee B.J., Ojeda S.R.
    J. Neuroendocrinol. 24:916-929(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiGNRHR_RAT
AccessioniPrimary (citable) accession number: P30969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1994
Last modified: July 6, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.