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P30966 (5HT5A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 5A

Short name=5-HT-5
Short name=5-HT-5A
Short name=5-HT5A
Alternative name(s):
Serotonin receptor 5A
Gene names
Name:Htr5a
Synonyms:5ht5a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed predominantly in the central nervous system; in the cerebral cortex, hippocampus, habenula, olfactory bulb and granular layer of the cerebellum.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3573575-hydroxytryptamine receptor 5A
PRO_0000068970

Regions

Topological domain1 – 4040Extracellular By similarity
Transmembrane41 – 6323Helical; Name=1; By similarity
Topological domain64 – 7815Cytoplasmic By similarity
Transmembrane79 – 9921Helical; Name=2; By similarity
Topological domain100 – 11516Extracellular By similarity
Transmembrane116 – 13722Helical; Name=3; By similarity
Topological domain138 – 15821Cytoplasmic By similarity
Transmembrane159 – 18123Helical; Name=4; By similarity
Topological domain182 – 19817Extracellular By similarity
Transmembrane199 – 21921Helical; Name=5; By similarity
Topological domain220 – 28263Cytoplasmic By similarity
Transmembrane283 – 30321Helical; Name=6; By similarity
Topological domain304 – 32017Extracellular By similarity
Transmembrane321 – 34121Helical; Name=7; By similarity
Topological domain342 – 35716Cytoplasmic By similarity

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond120 ↔ 192 By similarity

Experimental info

Sequence conflict214 – 2152CV → WL in CAA79155. Ref.1
Sequence conflict2611V → A in CAA79155. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P30966 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: C0F7314A3AB9F75F

FASTA35740,736
        10         20         30         40         50         60 
MDLPVNLTSF SLSTPSSLEP NRSLDTEVLR PSRPFLSAFR VLVLTLLGFL AAATFTWNLL 

        70         80         90        100        110        120 
VLATILKVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH ELSGRRWQLG RRLCQLWIAC 

       130        140        150        160        170        180 
DVLCCTASIW NVTAIALDRY WSITRHLEYT LRTRKRVSNV MILLTWALST VISLAPLLFG 

       190        200        210        220        230        240 
WGETYSEPSE ECQVSREPSY TVFSTVGAFY LPLCVVLFVY WKIYRAAKFR MGSRKTNSVS 

       250        260        270        280        290        300 
PVPEAVEVKN ATQHPQMVFT VRHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP 

       310        320        330        340        350 
FFVTELISPL CSWDVPAIWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK VFFSKQQ 

« Hide

References

« Hide 'large scale' references
[1]"The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family."
Plassat J.-L., Boschert U., Amlaiky N., Hen R.
EMBO J. 11:4779-4786(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hippocampus.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization."
Matthes H., Boschert U., Amlaiky N., Grailhe R., Plassat J.-L., Muscatelli F., Mattei M.-G., Hen R.
Mol. Pharmacol. 43:313-319(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z18278 Genomic DNA. Translation: CAA79155.1.
AK141636 mRNA. Translation: BAE24778.1.
CH466524 Genomic DNA. Translation: EDL37224.1.
BC115911 mRNA. Translation: AAI15912.1.
BC116654 mRNA. Translation: AAI16655.1.
PIRS28058.
RefSeqNP_032340.2. NM_008314.2.
UniGeneMm.4835.

3D structure databases

ProteinModelPortalP30966.
SMRP30966. Positions 39-349.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP30966.
ChEMBLCHEMBL3597.
GuidetoPHARMACOLOGY10.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30966.

Proteomic databases

PaxDbP30966.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036227; ENSMUSP00000038884; ENSMUSG00000039106.
GeneID15563.
KEGGmmu:15563.
UCSCuc008wtt.1. mouse.

Organism-specific databases

CTD3361.
MGIMGI:96283. Htr5a.

Phylogenomic databases

eggNOGNOG260742.
GeneTreeENSGT00750000117301.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidQ3URB0.
KOK04161.
OMANSAFKNF.
OrthoDBEOG7SXW3H.
TreeFamTF316350.

Gene expression databases

ArrayExpressP30966.
BgeeP30966.
CleanExMM_HTR5A.
GenevestigatorP30966.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288522.
PROP30966.
SOURCESearch...

Entry information

Entry name5HT5A_MOUSE
AccessionPrimary (citable) accession number: P30966
Secondary accession number(s): Q3URB0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries