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P30966

- 5HT5A_MOUSE

UniProt

P30966 - 5HT5A_MOUSE

Protein

5-hydroxytryptamine receptor 5A

Gene

Htr5a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

    GO - Molecular functioni

    1. serotonin receptor activity Source: MGI

    GO - Biological processi

    1. cAMP-mediated signaling Source: MGI
    2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: Ensembl
    3. hippocampus development Source: Ensembl
    4. response to estradiol Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 5A
    Short name:
    5-HT-5
    Short name:
    5-HT-5A
    Short name:
    5-HT5A
    Alternative name(s):
    Serotonin receptor 5A
    Gene namesi
    Name:Htr5a
    Synonyms:5ht5a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:96283. Htr5a.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. Golgi apparatus Source: Ensembl
    3. integral component of plasma membrane Source: InterPro
    4. perikaryon Source: Ensembl
    5. rough endoplasmic reticulum Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3573575-hydroxytryptamine receptor 5APRO_0000068970Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi120 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP30966.

    PTM databases

    PhosphoSiteiP30966.

    Expressioni

    Tissue specificityi

    Expressed predominantly in the central nervous system; in the cerebral cortex, hippocampus, habenula, olfactory bulb and granular layer of the cerebellum.

    Gene expression databases

    ArrayExpressiP30966.
    BgeeiP30966.
    CleanExiMM_HTR5A.
    GenevestigatoriP30966.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP30966.
    SMRiP30966. Positions 39-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040ExtracellularBy similarityAdd
    BLAST
    Topological domaini64 – 7815CytoplasmicBy similarityAdd
    BLAST
    Topological domaini100 – 11516ExtracellularBy similarityAdd
    BLAST
    Topological domaini138 – 15821CytoplasmicBy similarityAdd
    BLAST
    Topological domaini182 – 19817ExtracellularBy similarityAdd
    BLAST
    Topological domaini220 – 28263CytoplasmicBy similarityAdd
    BLAST
    Topological domaini304 – 32017ExtracellularBy similarityAdd
    BLAST
    Topological domaini342 – 35716CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6323Helical; Name=1By similarityAdd
    BLAST
    Transmembranei79 – 9921Helical; Name=2By similarityAdd
    BLAST
    Transmembranei116 – 13722Helical; Name=3By similarityAdd
    BLAST
    Transmembranei159 – 18123Helical; Name=4By similarityAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5By similarityAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=6By similarityAdd
    BLAST
    Transmembranei321 – 34121Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260742.
    GeneTreeiENSGT00750000117301.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiQ3URB0.
    KOiK04161.
    OMAiNSAFKNF.
    OrthoDBiEOG7SXW3H.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001397. 5HT5A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00518. 5HT5ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30966-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLPVNLTSF SLSTPSSLEP NRSLDTEVLR PSRPFLSAFR VLVLTLLGFL    50
    AAATFTWNLL VLATILKVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH 100
    ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHLEYT 150
    LRTRKRVSNV MILLTWALST VISLAPLLFG WGETYSEPSE ECQVSREPSY 200
    TVFSTVGAFY LPLCVVLFVY WKIYRAAKFR MGSRKTNSVS PVPEAVEVKN 250
    ATQHPQMVFT VRHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP 300
    FFVTELISPL CSWDVPAIWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK 350
    VFFSKQQ 357
    Length:357
    Mass (Da):40,736
    Last modified:July 27, 2011 - v2
    Checksum:iC0F7314A3AB9F75F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti214 – 2152CV → WL in CAA79155. (PubMed:1464308)Curated
    Sequence conflicti261 – 2611V → A in CAA79155. (PubMed:1464308)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18278 Genomic DNA. Translation: CAA79155.1.
    AK141636 mRNA. Translation: BAE24778.1.
    CH466524 Genomic DNA. Translation: EDL37224.1.
    BC115911 mRNA. Translation: AAI15912.1.
    BC116654 mRNA. Translation: AAI16655.1.
    CCDSiCCDS19141.1.
    PIRiS28058.
    RefSeqiNP_032340.2. NM_008314.2.
    UniGeneiMm.4835.

    Genome annotation databases

    EnsembliENSMUST00000036227; ENSMUSP00000038884; ENSMUSG00000039106.
    GeneIDi15563.
    KEGGimmu:15563.
    UCSCiuc008wtt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18278 Genomic DNA. Translation: CAA79155.1 .
    AK141636 mRNA. Translation: BAE24778.1 .
    CH466524 Genomic DNA. Translation: EDL37224.1 .
    BC115911 mRNA. Translation: AAI15912.1 .
    BC116654 mRNA. Translation: AAI16655.1 .
    CCDSi CCDS19141.1.
    PIRi S28058.
    RefSeqi NP_032340.2. NM_008314.2.
    UniGenei Mm.4835.

    3D structure databases

    ProteinModelPortali P30966.
    SMRi P30966. Positions 39-349.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P30966.
    ChEMBLi CHEMBL3597.
    GuidetoPHARMACOLOGYi 10.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30966.

    Proteomic databases

    PaxDbi P30966.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036227 ; ENSMUSP00000038884 ; ENSMUSG00000039106 .
    GeneIDi 15563.
    KEGGi mmu:15563.
    UCSCi uc008wtt.1. mouse.

    Organism-specific databases

    CTDi 3361.
    MGIi MGI:96283. Htr5a.

    Phylogenomic databases

    eggNOGi NOG260742.
    GeneTreei ENSGT00750000117301.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi Q3URB0.
    KOi K04161.
    OMAi NSAFKNF.
    OrthoDBi EOG7SXW3H.
    TreeFami TF316350.

    Miscellaneous databases

    NextBioi 288522.
    PROi P30966.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30966.
    Bgeei P30966.
    CleanExi MM_HTR5A.
    Genevestigatori P30966.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001397. 5HT5A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF14. PTHR24247:SF14. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00518. 5HT5ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family."
      Plassat J.-L., Boschert U., Amlaiky N., Hen R.
      EMBO J. 11:4779-4786(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization."
      Matthes H., Boschert U., Amlaiky N., Grailhe R., Plassat J.-L., Muscatelli F., Mattei M.-G., Hen R.
      Mol. Pharmacol. 43:313-319(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Tissue: Brain.

    Entry informationi

    Entry namei5HT5A_MOUSE
    AccessioniPrimary (citable) accession number: P30966
    Secondary accession number(s): Q3URB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3