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P30966

- 5HT5A_MOUSE

UniProt

P30966 - 5HT5A_MOUSE

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Protein

5-hydroxytryptamine receptor 5A

Gene

Htr5a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

GO - Molecular functioni

  1. serotonin receptor activity Source: MGI

GO - Biological processi

  1. cAMP-mediated signaling Source: MGI
  2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: Ensembl
  3. hippocampus development Source: Ensembl
  4. response to estradiol Source: Ensembl
  5. serotonin receptor signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5A
Short name:
5-HT-5
Short name:
5-HT-5A
Short name:
5-HT5A
Alternative name(s):
Serotonin receptor 5A
Gene namesi
Name:Htr5a
Synonyms:5ht5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:96283. Htr5a.

Subcellular locationi

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. integral component of plasma membrane Source: InterPro
  4. perikaryon Source: Ensembl
  5. rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3573575-hydroxytryptamine receptor 5APRO_0000068970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi120 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30966.

PTM databases

PhosphoSiteiP30966.

Expressioni

Tissue specificityi

Expressed predominantly in the central nervous system; in the cerebral cortex, hippocampus, habenula, olfactory bulb and granular layer of the cerebellum.

Gene expression databases

BgeeiP30966.
CleanExiMM_HTR5A.
ExpressionAtlasiP30966. baseline.
GenevestigatoriP30966.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP30966.
SMRiP30966. Positions 39-349.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularBy similarityAdd
BLAST
Topological domaini64 – 7815CytoplasmicBy similarityAdd
BLAST
Topological domaini100 – 11516ExtracellularBy similarityAdd
BLAST
Topological domaini138 – 15821CytoplasmicBy similarityAdd
BLAST
Topological domaini182 – 19817ExtracellularBy similarityAdd
BLAST
Topological domaini220 – 28263CytoplasmicBy similarityAdd
BLAST
Topological domaini304 – 32017ExtracellularBy similarityAdd
BLAST
Topological domaini342 – 35716CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6323Helical; Name=1By similarityAdd
BLAST
Transmembranei79 – 9921Helical; Name=2By similarityAdd
BLAST
Transmembranei116 – 13722Helical; Name=3By similarityAdd
BLAST
Transmembranei159 – 18123Helical; Name=4By similarityAdd
BLAST
Transmembranei199 – 21921Helical; Name=5By similarityAdd
BLAST
Transmembranei283 – 30321Helical; Name=6By similarityAdd
BLAST
Transmembranei321 – 34121Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260742.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30966.
KOiK04161.
OMAiNSAFKNF.
OrthoDBiEOG7SXW3H.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30966-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLPVNLTSF SLSTPSSLEP NRSLDTEVLR PSRPFLSAFR VLVLTLLGFL
60 70 80 90 100
AAATFTWNLL VLATILKVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH
110 120 130 140 150
ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHLEYT
160 170 180 190 200
LRTRKRVSNV MILLTWALST VISLAPLLFG WGETYSEPSE ECQVSREPSY
210 220 230 240 250
TVFSTVGAFY LPLCVVLFVY WKIYRAAKFR MGSRKTNSVS PVPEAVEVKN
260 270 280 290 300
ATQHPQMVFT VRHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP
310 320 330 340 350
FFVTELISPL CSWDVPAIWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK

VFFSKQQ
Length:357
Mass (Da):40,736
Last modified:July 27, 2011 - v2
Checksum:iC0F7314A3AB9F75F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti214 – 2152CV → WL in CAA79155. (PubMed:1464308)Curated
Sequence conflicti261 – 2611V → A in CAA79155. (PubMed:1464308)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z18278 Genomic DNA. Translation: CAA79155.1.
AK141636 mRNA. Translation: BAE24778.1.
CH466524 Genomic DNA. Translation: EDL37224.1.
BC115911 mRNA. Translation: AAI15912.1.
BC116654 mRNA. Translation: AAI16655.1.
CCDSiCCDS19141.1.
PIRiS28058.
RefSeqiNP_032340.2. NM_008314.2.
UniGeneiMm.4835.

Genome annotation databases

EnsembliENSMUST00000036227; ENSMUSP00000038884; ENSMUSG00000039106.
GeneIDi15563.
KEGGimmu:15563.
UCSCiuc008wtt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z18278 Genomic DNA. Translation: CAA79155.1 .
AK141636 mRNA. Translation: BAE24778.1 .
CH466524 Genomic DNA. Translation: EDL37224.1 .
BC115911 mRNA. Translation: AAI15912.1 .
BC116654 mRNA. Translation: AAI16655.1 .
CCDSi CCDS19141.1.
PIRi S28058.
RefSeqi NP_032340.2. NM_008314.2.
UniGenei Mm.4835.

3D structure databases

ProteinModelPortali P30966.
SMRi P30966. Positions 39-349.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P30966.
ChEMBLi CHEMBL3597.
GuidetoPHARMACOLOGYi 10.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30966.

Proteomic databases

PaxDbi P30966.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036227 ; ENSMUSP00000038884 ; ENSMUSG00000039106 .
GeneIDi 15563.
KEGGi mmu:15563.
UCSCi uc008wtt.1. mouse.

Organism-specific databases

CTDi 3361.
MGIi MGI:96283. Htr5a.

Phylogenomic databases

eggNOGi NOG260742.
GeneTreei ENSGT00760000118795.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P30966.
KOi K04161.
OMAi NSAFKNF.
OrthoDBi EOG7SXW3H.
TreeFami TF316350.

Miscellaneous databases

NextBioi 288522.
PROi P30966.
SOURCEi Search...

Gene expression databases

Bgeei P30966.
CleanExi MM_HTR5A.
ExpressionAtlasi P30966. baseline.
Genevestigatori P30966.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF14. PTHR24247:SF14. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family."
    Plassat J.-L., Boschert U., Amlaiky N., Hen R.
    EMBO J. 11:4779-4786(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization."
    Matthes H., Boschert U., Amlaiky N., Grailhe R., Plassat J.-L., Muscatelli F., Mattei M.-G., Hen R.
    Mol. Pharmacol. 43:313-319(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Tissue: Brain.

Entry informationi

Entry namei5HT5A_MOUSE
AccessioniPrimary (citable) accession number: P30966
Secondary accession number(s): Q3URB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3