P30963 (CCMA_BRAJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA
EC=3.6.3.41

Alternative name(s):
Heme exporter protein A

Gene names

Name:	ccmA
Synonyms:	cycV
Ordered Locus Names:	blr0467

Organism

Bradyrhizobium japonicum

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01707
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01707.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	Cytochrome c biogenesis ATP-binding export protein CcmA HAMAP MF_01707		PRO_0000092173
Regions
	Domain	3 – 199	197	ABC transporter
	Nucleotide binding	35 – 42	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P30963 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 96EC3BB0C0D3141B	FASTA	200	21,132
	10 20 30 40 50 60 MQLSGRRVIC VRGGREVFAG LDFEAVSGEA VAVVGRNGSG KTSLLRLIAG LLIPAGGTIA 70 80 90 100 110 120 LDGGDAELTL PEQCHYLGHR DALKPALSVA ENLSFWADFL GGERLDAHES LATVGLDHAT 130 140 150 160 170 180 HLPAAFLSAG QRRRLSLARL LTVRRPIWLL DEPTTALDVA GQDMFGGLMR DHLARGGLII 190 200 AATHMALGID SRELRIGGVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Discovery and sequence analysis of bacterial genes involved in the biogenesis of c-type cytochromes." Ramseier T.M., Winteler H.V., Hennecke H. J. Biol. Chem. 266:7793-7803(1991) [PubMed: 1850420] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: USDA 110RIF15.
[2]	"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60874 Genomic DNA. Translation: AAA26192.1. BA000040 Genomic DNA. Translation: BAC45732.1.
PIR	A39741.
RefSeq	NP_767107.1. NC_004463.1.
3D structure databases
ProteinModelPortal	P30963.
ModBase	Search...
Protein family/group databases
TCDB	3.A.1.107.1. ATP-binding cassette (ABC) superfamily.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1051912.
GenomeReviews	Gene locus blr0467 in contig BA000040_GR.
KEGG	bja:blr0467.
NMPDR	fig|224911.1.peg.467.
PATRIC	21184399. VBIBraJap65052_0477.
Phylogenomic databases
HOGENOM	HBG758042.
OMA	PFNAIDK.
PhylomeDB	P30963.
ProtClustDB	PRK13539.
Enzyme and pathway databases
BioCyc	BJAP224911:BLR0467-MONOMER.
Family and domain databases
HAMAP	MF_01707. ABC_ATPase_CcmA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K02193.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. CcmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_BRAJA

Accession

Primary (citable) accession number: P30963

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program