P30954 (O10J1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10J1

Alternative name(s):
Olfactory receptor OR1-26
Olfactory receptor-like protein HGMP07J

Gene names

Name:

OR10J1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC single fertilization Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Olfactory receptor 10J1		PRO_0000150707
Regions
	Topological domain	1 – 36	36	Extracellular Potential
	Transmembrane	37 – 57	21	Helical; Name=1; Potential
	Topological domain	58 – 65	8	Cytoplasmic Potential
	Transmembrane	66 – 86	21	Helical; Name=2; Potential
	Topological domain	87 – 110	24	Extracellular Potential
	Transmembrane	111 – 131	21	Helical; Name=3; Potential
	Topological domain	132 – 150	19	Cytoplasmic Potential
	Transmembrane	151 – 171	21	Helical; Name=4; Potential
	Topological domain	172 – 207	36	Extracellular Potential
	Transmembrane	208 – 227	20	Helical; Name=5; Potential
	Topological domain	228 – 247	20	Cytoplasmic Potential
	Transmembrane	248 – 268	21	Helical; Name=6; Potential
	Topological domain	269 – 281	13	Extracellular Potential
	Transmembrane	282 – 302	21	Helical; Name=7; Potential
	Topological domain	303 – 320	18	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Glycosylation	16	1	N-linked (GlcNAc...) Potential
	Disulfide bond	108 ↔ 199		By similarity
Natural variations
	Natural variant	62	1	M → I. Ref.1 Ref.3 Ref.5 Corresponds to variant rs10908722 [ dbSNP | Ensembl ].		VAR_034292
	Natural variant	103	1	I → M. Ref.1 Ref.3 Ref.4 Ref.5 Corresponds to variant rs12048482 [ dbSNP | Ensembl ].		VAR_053281
	Natural variant	112	1	M → I. Corresponds to variant rs12118628 [ dbSNP | Ensembl ].		VAR_034293

Sequences

	Sequence		Length	Mass (Da)
	P30954 [UniParc]. Last modified March 23, 2010. Version 2. Checksum: 1AA1B612519EFD25	FASTA	320	35,925
	10 20 30 40 50 60 MLLCFRFGNQ SMKRENFTLI TDFVFQGFSS FHEQQITLFG VFLALYILTL AGNIIIVTII 70 80 90 100 110 120 RMDLHLHTPM YFFLSMLSTS ETVYTLVILP RMLSSLVGMS QPISLAGCAT QMFFFVTFGI 130 140 150 160 170 180 TNCFLLTAMG YDRYVAICNP LRYMVIMNKR LRIQLVLGAC SIGLIVAITQ VTSVFRLPFC 190 200 210 220 230 240 ARKVPHFFCD IRPVMKLSCI DTTVNEILTL IISVLVLVVP MGLVFISYVL IISTILKIAS 250 260 270 280 290 300 VEGRKKAFAT CASHLTVVIV HYSCASIAYL KPKSENTREH DQLISVTYTV ITPLLNPVVY 310 320 TLRNKEVKDA LCRAVGGKFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of members of the putative olfactory receptor gene family in mammalian germ cells." Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G. Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-62 AND MET-103. Tissue: Testis.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-62 AND MET-103. Tissue: Cerebellum.
[4]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-294, VARIANT MET-103.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, VARIANTS ILE-62 AND MET-103.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	X64995 Genomic DNA. Translation: CAA46128.1. AL663023 Genomic DNA. Translation: CAH70964.1. BC069150 mRNA. Translation: AAH69150.1. BC112290 mRNA. Translation: AAI12291.1. AF399587 Genomic DNA. Translation: AAK95072.1. BK004527 Genomic DNA. Translation: DAA04925.1.
IPI	IPI00028118.
PIR	S20573.
RefSeq	NP_036483.2. NM_012351.2.
UniGene	Hs.532661.
3D structure databases
ProteinModelPortal	P30954.
SMR	P30954. Positions 35-237.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000399078.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P30954.
Polymorphism databases
DMDM	292495022.
Proteomic databases
PRIDE	P30954.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000423932; ENSP00000399078; ENSG00000196184.
GeneID	26476.
KEGG	hsa:26476.
UCSC	uc010piv.2. human.
Organism-specific databases
CTD	26476.
GeneCards	GC01P159409.
H-InvDB	HIX0028779.
HGNC	HGNC:8175. OR10J1.
neXtProt	NX_P30954.
PharmGKB	PA31982.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84232.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	P30954.
KO	K04257.
OMA	QSMKREN.
OrthoDB	EOG4KKZ3K.
PhylomeDB	P30954.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P30954.
CleanEx	HS_OR10J1.
Genevestigator	P30954.
GermOnline	ENSG00000196184. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26476.
NextBio	48736.

Entry information

Entry name

O10J1_HUMAN

Accession

Primary (citable) accession number: P30954
Secondary accession number(s): Q2M1M8 , Q5VSV1, Q6IET5, Q96R56

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	March 23, 2010
Last modified:	May 1, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.