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Protein

Olfactory receptor 10J1

Gene

OR10J1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of smell Source: GOC
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • sensory perception of chemical stimulus Source: ProtInc
  • sensory perception of smell Source: GO_Central
  • single fertilization Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10J1
Alternative name(s):
Olfactory receptor OR1-26
Olfactory receptor-like protein HGMP07J
Gene namesi
Name:OR10J1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8175. OR10J1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini58 – 658CytoplasmicSequence Analysis
Transmembranei66 – 8621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini87 – 11024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei111 – 13121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini132 – 15019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 20736ExtracellularSequence AnalysisAdd
BLAST
Transmembranei208 – 22720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini228 – 24720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 28113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini303 – 32018CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31982.

Polymorphism and mutation databases

BioMutaiOR10J1.
DMDMi292495022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 10J1PRO_0000150707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi108 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP30954.

PTM databases

PhosphoSiteiP30954.

Expressioni

Gene expression databases

BgeeiP30954.
CleanExiHS_OR10J1.
GenevestigatoriP30954.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000399078.

Structurei

3D structure databases

ProteinModelPortaliP30954.
SMRiP30954. Positions 35-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84232.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP30954.
KOiK04257.
OMAiKRENFTL.
OrthoDBiEOG71P2B9.
PhylomeDBiP30954.
TreeFamiTF337624.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLCFRFGNQ SMKRENFTLI TDFVFQGFSS FHEQQITLFG VFLALYILTL
60 70 80 90 100
AGNIIIVTII RMDLHLHTPM YFFLSMLSTS ETVYTLVILP RMLSSLVGMS
110 120 130 140 150
QPISLAGCAT QMFFFVTFGI TNCFLLTAMG YDRYVAICNP LRYMVIMNKR
160 170 180 190 200
LRIQLVLGAC SIGLIVAITQ VTSVFRLPFC ARKVPHFFCD IRPVMKLSCI
210 220 230 240 250
DTTVNEILTL IISVLVLVVP MGLVFISYVL IISTILKIAS VEGRKKAFAT
260 270 280 290 300
CASHLTVVIV HYSCASIAYL KPKSENTREH DQLISVTYTV ITPLLNPVVY
310 320
TLRNKEVKDA LCRAVGGKFS
Length:320
Mass (Da):35,925
Last modified:March 23, 2010 - v2
Checksum:i1AA1B612519EFD25
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621M → I.3 Publications
Corresponds to variant rs10908722 [ dbSNP | Ensembl ].
VAR_034292
Natural varianti103 – 1031I → M.4 Publications
Corresponds to variant rs12048482 [ dbSNP | Ensembl ].
VAR_053281
Natural varianti112 – 1121M → I.
Corresponds to variant rs12118628 [ dbSNP | Ensembl ].
VAR_034293

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64995 Genomic DNA. Translation: CAA46128.1.
AL663023 Genomic DNA. Translation: CAH70964.1.
BC069150 mRNA. Translation: AAH69150.1.
BC112290 mRNA. Translation: AAI12291.1.
AF399587 Genomic DNA. Translation: AAK95072.1.
BK004527 Genomic DNA. Translation: DAA04925.1.
CCDSiCCDS1185.1.
PIRiS20573.
RefSeqiNP_036483.2. NM_012351.2.
UniGeneiHs.532661.

Genome annotation databases

EnsembliENST00000423932; ENSP00000399078; ENSG00000196184.
GeneIDi26476.
KEGGihsa:26476.
UCSCiuc010piv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64995 Genomic DNA. Translation: CAA46128.1.
AL663023 Genomic DNA. Translation: CAH70964.1.
BC069150 mRNA. Translation: AAH69150.1.
BC112290 mRNA. Translation: AAI12291.1.
AF399587 Genomic DNA. Translation: AAK95072.1.
BK004527 Genomic DNA. Translation: DAA04925.1.
CCDSiCCDS1185.1.
PIRiS20573.
RefSeqiNP_036483.2. NM_012351.2.
UniGeneiHs.532661.

3D structure databases

ProteinModelPortaliP30954.
SMRiP30954. Positions 35-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000399078.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30954.

Polymorphism and mutation databases

BioMutaiOR10J1.
DMDMi292495022.

Proteomic databases

PRIDEiP30954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423932; ENSP00000399078; ENSG00000196184.
GeneIDi26476.
KEGGihsa:26476.
UCSCiuc010piv.2. human.

Organism-specific databases

CTDi26476.
GeneCardsiGC01P159409.
H-InvDBHIX0028779.
HGNCiHGNC:8175. OR10J1.
neXtProtiNX_P30954.
PharmGKBiPA31982.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG84232.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP30954.
KOiK04257.
OMAiKRENFTL.
OrthoDBiEOG71P2B9.
PhylomeDBiP30954.
TreeFamiTF337624.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10J1.
GenomeRNAii26476.
NextBioi48736.
PROiP30954.

Gene expression databases

BgeeiP30954.
CleanExiHS_OR10J1.
GenevestigatoriP30954.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-62 AND MET-103.
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-62 AND MET-103.
    Tissue: Cerebellum.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-294, VARIANT MET-103.
  5. Cited for: IDENTIFICATION, VARIANTS ILE-62 AND MET-103.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10J1_HUMAN
AccessioniPrimary (citable) accession number: P30954
Secondary accession number(s): Q2M1M8
, Q5VSV1, Q6IET5, Q96R56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 23, 2010
Last modified: April 29, 2015
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.