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P30954

- O10J1_HUMAN

UniProt

P30954 - O10J1_HUMAN

Protein

Olfactory receptor 10J1

Gene

OR10J1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. olfactory receptor activity Source: InterPro

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc
    2. sensory perception of chemical stimulus Source: ProtInc
    3. single fertilization Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10J1
    Alternative name(s):
    Olfactory receptor OR1-26
    Olfactory receptor-like protein HGMP07J
    Gene namesi
    Name:OR10J1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8175. OR10J1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31982.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Olfactory receptor 10J1PRO_0000150707Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi108 ↔ 199PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP30954.

    PTM databases

    PhosphoSiteiP30954.

    Expressioni

    Gene expression databases

    BgeeiP30954.
    CleanExiHS_OR10J1.
    GenevestigatoriP30954.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000399078.

    Structurei

    3D structure databases

    ProteinModelPortaliP30954.
    SMRiP30954. Positions 35-237.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini58 – 658CytoplasmicSequence Analysis
    Topological domaini87 – 11024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 15019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 20736ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 24720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 28113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini303 – 32018CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei208 – 22720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84232.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiP30954.
    KOiK04257.
    OMAiKRENFTL.
    OrthoDBiEOG71P2B9.
    PhylomeDBiP30954.
    TreeFamiTF337624.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30954-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLCFRFGNQ SMKRENFTLI TDFVFQGFSS FHEQQITLFG VFLALYILTL    50
    AGNIIIVTII RMDLHLHTPM YFFLSMLSTS ETVYTLVILP RMLSSLVGMS 100
    QPISLAGCAT QMFFFVTFGI TNCFLLTAMG YDRYVAICNP LRYMVIMNKR 150
    LRIQLVLGAC SIGLIVAITQ VTSVFRLPFC ARKVPHFFCD IRPVMKLSCI 200
    DTTVNEILTL IISVLVLVVP MGLVFISYVL IISTILKIAS VEGRKKAFAT 250
    CASHLTVVIV HYSCASIAYL KPKSENTREH DQLISVTYTV ITPLLNPVVY 300
    TLRNKEVKDA LCRAVGGKFS 320
    Length:320
    Mass (Da):35,925
    Last modified:March 23, 2010 - v2
    Checksum:i1AA1B612519EFD25
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti62 – 621M → I.3 Publications
    Corresponds to variant rs10908722 [ dbSNP | Ensembl ].
    VAR_034292
    Natural varianti103 – 1031I → M.4 Publications
    Corresponds to variant rs12048482 [ dbSNP | Ensembl ].
    VAR_053281
    Natural varianti112 – 1121M → I.
    Corresponds to variant rs12118628 [ dbSNP | Ensembl ].
    VAR_034293

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64995 Genomic DNA. Translation: CAA46128.1.
    AL663023 Genomic DNA. Translation: CAH70964.1.
    BC069150 mRNA. Translation: AAH69150.1.
    BC112290 mRNA. Translation: AAI12291.1.
    AF399587 Genomic DNA. Translation: AAK95072.1.
    BK004527 Genomic DNA. Translation: DAA04925.1.
    CCDSiCCDS1185.1.
    PIRiS20573.
    RefSeqiNP_036483.2. NM_012351.2.
    UniGeneiHs.532661.

    Genome annotation databases

    EnsembliENST00000423932; ENSP00000399078; ENSG00000196184.
    GeneIDi26476.
    KEGGihsa:26476.
    UCSCiuc010piv.2. human.

    Polymorphism databases

    DMDMi292495022.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64995 Genomic DNA. Translation: CAA46128.1 .
    AL663023 Genomic DNA. Translation: CAH70964.1 .
    BC069150 mRNA. Translation: AAH69150.1 .
    BC112290 mRNA. Translation: AAI12291.1 .
    AF399587 Genomic DNA. Translation: AAK95072.1 .
    BK004527 Genomic DNA. Translation: DAA04925.1 .
    CCDSi CCDS1185.1.
    PIRi S20573.
    RefSeqi NP_036483.2. NM_012351.2.
    UniGenei Hs.532661.

    3D structure databases

    ProteinModelPortali P30954.
    SMRi P30954. Positions 35-237.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000399078.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30954.

    Polymorphism databases

    DMDMi 292495022.

    Proteomic databases

    PRIDEi P30954.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000423932 ; ENSP00000399078 ; ENSG00000196184 .
    GeneIDi 26476.
    KEGGi hsa:26476.
    UCSCi uc010piv.2. human.

    Organism-specific databases

    CTDi 26476.
    GeneCardsi GC01P159409.
    H-InvDB HIX0028779.
    HGNCi HGNC:8175. OR10J1.
    neXtProti NX_P30954.
    PharmGKBi PA31982.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84232.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi P30954.
    KOi K04257.
    OMAi KRENFTL.
    OrthoDBi EOG71P2B9.
    PhylomeDBi P30954.
    TreeFami TF337624.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10J1.
    GenomeRNAii 26476.
    NextBioi 48736.
    PROi P30954.

    Gene expression databases

    Bgeei P30954.
    CleanExi HS_OR10J1.
    Genevestigatori P30954.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
      Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
      Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-62 AND MET-103.
      Tissue: Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-62 AND MET-103.
      Tissue: Cerebellum.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-294, VARIANT MET-103.
    5. Cited for: IDENTIFICATION, VARIANTS ILE-62 AND MET-103.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10J1_HUMAN
    AccessioniPrimary (citable) accession number: P30954
    Secondary accession number(s): Q2M1M8
    , Q5VSV1, Q6IET5, Q96R56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3