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P30954 (O10J1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10J1
Alternative name(s):
Olfactory receptor OR1-26
Olfactory receptor-like protein HGMP07J
Gene names
Name:OR10J1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Olfactory receptor 10J1
PRO_0000150707

Regions

Topological domain1 – 3636Extracellular Potential
Transmembrane37 – 5721Helical; Name=1; Potential
Topological domain58 – 658Cytoplasmic Potential
Transmembrane66 – 8621Helical; Name=2; Potential
Topological domain87 – 11024Extracellular Potential
Transmembrane111 – 13121Helical; Name=3; Potential
Topological domain132 – 15019Cytoplasmic Potential
Transmembrane151 – 17121Helical; Name=4; Potential
Topological domain172 – 20736Extracellular Potential
Transmembrane208 – 22720Helical; Name=5; Potential
Topological domain228 – 24720Cytoplasmic Potential
Transmembrane248 – 26821Helical; Name=6; Potential
Topological domain269 – 28113Extracellular Potential
Transmembrane282 – 30221Helical; Name=7; Potential
Topological domain303 – 32018Cytoplasmic Potential

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation161N-linked (GlcNAc...) Potential
Disulfide bond108 ↔ 199 By similarity

Natural variations

Natural variant621M → I. Ref.1 Ref.3 Ref.5
Corresponds to variant rs10908722 [ dbSNP | Ensembl ].
VAR_034292
Natural variant1031I → M. Ref.1 Ref.3 Ref.4 Ref.5
Corresponds to variant rs12048482 [ dbSNP | Ensembl ].
VAR_053281
Natural variant1121M → I.
Corresponds to variant rs12118628 [ dbSNP | Ensembl ].
VAR_034293

Sequences

Sequence LengthMass (Da)Tools
P30954 [UniParc].

Last modified March 23, 2010. Version 2.
Checksum: 1AA1B612519EFD25

FASTA32035,925
        10         20         30         40         50         60 
MLLCFRFGNQ SMKRENFTLI TDFVFQGFSS FHEQQITLFG VFLALYILTL AGNIIIVTII 

        70         80         90        100        110        120 
RMDLHLHTPM YFFLSMLSTS ETVYTLVILP RMLSSLVGMS QPISLAGCAT QMFFFVTFGI 

       130        140        150        160        170        180 
TNCFLLTAMG YDRYVAICNP LRYMVIMNKR LRIQLVLGAC SIGLIVAITQ VTSVFRLPFC 

       190        200        210        220        230        240 
ARKVPHFFCD IRPVMKLSCI DTTVNEILTL IISVLVLVVP MGLVFISYVL IISTILKIAS 

       250        260        270        280        290        300 
VEGRKKAFAT CASHLTVVIV HYSCASIAYL KPKSENTREH DQLISVTYTV ITPLLNPVVY 

       310        320 
TLRNKEVKDA LCRAVGGKFS 

« Hide

References

« Hide 'large scale' references
[1]"Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-62 AND MET-103.
Tissue: Testis.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-62 AND MET-103.
Tissue: Cerebellum.
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-294, VARIANT MET-103.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, VARIANTS ILE-62 AND MET-103.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64995 Genomic DNA. Translation: CAA46128.1.
AL663023 Genomic DNA. Translation: CAH70964.1.
BC069150 mRNA. Translation: AAH69150.1.
BC112290 mRNA. Translation: AAI12291.1.
AF399587 Genomic DNA. Translation: AAK95072.1.
BK004527 Genomic DNA. Translation: DAA04925.1.
CCDSCCDS1185.1.
PIRS20573.
RefSeqNP_036483.2. NM_012351.2.
UniGeneHs.532661.

3D structure databases

ProteinModelPortalP30954.
SMRP30954. Positions 35-237.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000399078.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30954.

Polymorphism databases

DMDM292495022.

Proteomic databases

PRIDEP30954.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000423932; ENSP00000399078; ENSG00000196184.
GeneID26476.
KEGGhsa:26476.
UCSCuc010piv.2. human.

Organism-specific databases

CTD26476.
GeneCardsGC01P159409.
H-InvDBHIX0028779.
HGNCHGNC:8175. OR10J1.
neXtProtNX_P30954.
PharmGKBPA31982.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG84232.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidP30954.
KOK04257.
OMAKRENFTL.
OrthoDBEOG71P2B9.
PhylomeDBP30954.
TreeFamTF337624.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP30954.
CleanExHS_OR10J1.
GenevestigatorP30954.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10J1.
GenomeRNAi26476.
NextBio48736.
PROP30954.

Entry information

Entry nameO10J1_HUMAN
AccessionPrimary (citable) accession number: P30954
Secondary accession number(s): Q2M1M8 expand/collapse secondary AC list , Q5VSV1, Q6IET5, Q96R56
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries