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Protein

Olfactory receptor 10J1

Gene

OR10J1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • olfactory receptor activity Source: InterPro

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • sensory perception of chemical stimulus Source: ProtInc
  • single fertilization Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10J1
Alternative name(s):
Olfactory receptor OR1-26
Olfactory receptor-like protein HGMP07J
Gene namesi
Name:OR10J1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8175. OR10J1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 65CytoplasmicSequence analysis8
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 110ExtracellularSequence analysisAdd BLAST24
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini132 – 150CytoplasmicSequence analysisAdd BLAST19
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 207ExtracellularSequence analysisAdd BLAST36
Transmembranei208 – 227Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini228 – 247CytoplasmicSequence analysisAdd BLAST20
Transmembranei248 – 268Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini269 – 281ExtracellularSequence analysisAdd BLAST13
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 320CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26476.
OpenTargetsiENSG00000196184.
PharmGKBiPA31982.

Polymorphism and mutation databases

BioMutaiOR10J1.
DMDMi292495022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507071 – 320Olfactory receptor 10J1Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi108 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30954.
PRIDEiP30954.

PTM databases

iPTMnetiP30954.
PhosphoSitePlusiP30954.

Expressioni

Gene expression databases

BgeeiENSG00000196184.
CleanExiHS_OR10J1.
GenevisibleiP30954. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000399078.

Structurei

3D structure databases

ProteinModelPortaliP30954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBT. Eukaryota.
ENOG4111C5X. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP30954.
KOiK04257.
OMAiQSMKREN.
OrthoDBiEOG091G0AZH.
PhylomeDBiP30954.
TreeFamiTF337624.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLCFRFGNQ SMKRENFTLI TDFVFQGFSS FHEQQITLFG VFLALYILTL
60 70 80 90 100
AGNIIIVTII RMDLHLHTPM YFFLSMLSTS ETVYTLVILP RMLSSLVGMS
110 120 130 140 150
QPISLAGCAT QMFFFVTFGI TNCFLLTAMG YDRYVAICNP LRYMVIMNKR
160 170 180 190 200
LRIQLVLGAC SIGLIVAITQ VTSVFRLPFC ARKVPHFFCD IRPVMKLSCI
210 220 230 240 250
DTTVNEILTL IISVLVLVVP MGLVFISYVL IISTILKIAS VEGRKKAFAT
260 270 280 290 300
CASHLTVVIV HYSCASIAYL KPKSENTREH DQLISVTYTV ITPLLNPVVY
310 320
TLRNKEVKDA LCRAVGGKFS
Length:320
Mass (Da):35,925
Last modified:March 23, 2010 - v2
Checksum:i1AA1B612519EFD25
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03429262M → I.3 PublicationsCorresponds to variant rs10908722dbSNPEnsembl.1
Natural variantiVAR_053281103I → M.4 PublicationsCorresponds to variant rs12048482dbSNPEnsembl.1
Natural variantiVAR_034293112M → I.Corresponds to variant rs12118628dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64995 Genomic DNA. Translation: CAA46128.1.
AL663023 Genomic DNA. Translation: CAH70964.1.
BC069150 mRNA. Translation: AAH69150.1.
BC112290 mRNA. Translation: AAI12291.1.
AF399587 Genomic DNA. Translation: AAK95072.1.
BK004527 Genomic DNA. Translation: DAA04925.1.
CCDSiCCDS1185.1.
PIRiS20573.
RefSeqiNP_036483.2. NM_012351.2.
UniGeneiHs.532661.

Genome annotation databases

EnsembliENST00000423932; ENSP00000399078; ENSG00000196184.
GeneIDi26476.
KEGGihsa:26476.
UCSCiuc010piv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64995 Genomic DNA. Translation: CAA46128.1.
AL663023 Genomic DNA. Translation: CAH70964.1.
BC069150 mRNA. Translation: AAH69150.1.
BC112290 mRNA. Translation: AAI12291.1.
AF399587 Genomic DNA. Translation: AAK95072.1.
BK004527 Genomic DNA. Translation: DAA04925.1.
CCDSiCCDS1185.1.
PIRiS20573.
RefSeqiNP_036483.2. NM_012351.2.
UniGeneiHs.532661.

3D structure databases

ProteinModelPortaliP30954.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000399078.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP30954.
PhosphoSitePlusiP30954.

Polymorphism and mutation databases

BioMutaiOR10J1.
DMDMi292495022.

Proteomic databases

PaxDbiP30954.
PRIDEiP30954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423932; ENSP00000399078; ENSG00000196184.
GeneIDi26476.
KEGGihsa:26476.
UCSCiuc010piv.3. human.

Organism-specific databases

CTDi26476.
DisGeNETi26476.
GeneCardsiOR10J1.
H-InvDBHIX0028779.
HGNCiHGNC:8175. OR10J1.
neXtProtiNX_P30954.
OpenTargetsiENSG00000196184.
PharmGKBiPA31982.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFBT. Eukaryota.
ENOG4111C5X. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP30954.
KOiK04257.
OMAiQSMKREN.
OrthoDBiEOG091G0AZH.
PhylomeDBiP30954.
TreeFamiTF337624.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10J1.
GenomeRNAii26476.
PROiP30954.

Gene expression databases

BgeeiENSG00000196184.
CleanExiHS_OR10J1.
GenevisibleiP30954. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10J1_HUMAN
AccessioniPrimary (citable) accession number: P30954
Secondary accession number(s): Q2M1M8
, Q5VSV1, Q6IET5, Q96R56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 23, 2010
Last modified: November 2, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.