SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P30954

- O10J1_HUMAN

UniProt

P30954 - O10J1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Olfactory receptor 10J1
Gene
OR10J1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. sensory perception of chemical stimulus Source: ProtInc
  3. single fertilization Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10J1
Alternative name(s):
Olfactory receptor OR1-26
Olfactory receptor-like protein HGMP07J
Gene namesi
Name:OR10J1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8175. OR10J1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Extracellular Reviewed prediction
Add
BLAST
Transmembranei37 – 5721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini58 – 658Cytoplasmic Reviewed prediction
Transmembranei66 – 8621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini87 – 11024Extracellular Reviewed prediction
Add
BLAST
Transmembranei111 – 13121Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini132 – 15019Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei151 – 17121Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini172 – 20736Extracellular Reviewed prediction
Add
BLAST
Transmembranei208 – 22720Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini228 – 24720Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini269 – 28113Extracellular Reviewed prediction
Add
BLAST
Transmembranei282 – 30221Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini303 – 32018Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 10J1
PRO_0000150707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16 – 161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi108 ↔ 199 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP30954.

PTM databases

PhosphoSiteiP30954.

Expressioni

Gene expression databases

BgeeiP30954.
CleanExiHS_OR10J1.
GenevestigatoriP30954.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000399078.

Structurei

3D structure databases

ProteinModelPortaliP30954.
SMRiP30954. Positions 35-237.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84232.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiP30954.
KOiK04257.
OMAiKRENFTL.
OrthoDBiEOG71P2B9.
PhylomeDBiP30954.
TreeFamiTF337624.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30954-1 [UniParc]FASTAAdd to Basket

« Hide

MLLCFRFGNQ SMKRENFTLI TDFVFQGFSS FHEQQITLFG VFLALYILTL    50
AGNIIIVTII RMDLHLHTPM YFFLSMLSTS ETVYTLVILP RMLSSLVGMS 100
QPISLAGCAT QMFFFVTFGI TNCFLLTAMG YDRYVAICNP LRYMVIMNKR 150
LRIQLVLGAC SIGLIVAITQ VTSVFRLPFC ARKVPHFFCD IRPVMKLSCI 200
DTTVNEILTL IISVLVLVVP MGLVFISYVL IISTILKIAS VEGRKKAFAT 250
CASHLTVVIV HYSCASIAYL KPKSENTREH DQLISVTYTV ITPLLNPVVY 300
TLRNKEVKDA LCRAVGGKFS 320
Length:320
Mass (Da):35,925
Last modified:March 23, 2010 - v2
Checksum:i1AA1B612519EFD25
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621M → I.3 Publications
Corresponds to variant rs10908722 [ dbSNP | Ensembl ].
VAR_034292
Natural varianti103 – 1031I → M.4 Publications
Corresponds to variant rs12048482 [ dbSNP | Ensembl ].
VAR_053281
Natural varianti112 – 1121M → I.
Corresponds to variant rs12118628 [ dbSNP | Ensembl ].
VAR_034293

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64995 Genomic DNA. Translation: CAA46128.1.
AL663023 Genomic DNA. Translation: CAH70964.1.
BC069150 mRNA. Translation: AAH69150.1.
BC112290 mRNA. Translation: AAI12291.1.
AF399587 Genomic DNA. Translation: AAK95072.1.
BK004527 Genomic DNA. Translation: DAA04925.1.
CCDSiCCDS1185.1.
PIRiS20573.
RefSeqiNP_036483.2. NM_012351.2.
UniGeneiHs.532661.

Genome annotation databases

EnsembliENST00000423932; ENSP00000399078; ENSG00000196184.
GeneIDi26476.
KEGGihsa:26476.
UCSCiuc010piv.2. human.

Polymorphism databases

DMDMi292495022.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64995 Genomic DNA. Translation: CAA46128.1 .
AL663023 Genomic DNA. Translation: CAH70964.1 .
BC069150 mRNA. Translation: AAH69150.1 .
BC112290 mRNA. Translation: AAI12291.1 .
AF399587 Genomic DNA. Translation: AAK95072.1 .
BK004527 Genomic DNA. Translation: DAA04925.1 .
CCDSi CCDS1185.1.
PIRi S20573.
RefSeqi NP_036483.2. NM_012351.2.
UniGenei Hs.532661.

3D structure databases

ProteinModelPortali P30954.
SMRi P30954. Positions 35-237.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000399078.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30954.

Polymorphism databases

DMDMi 292495022.

Proteomic databases

PRIDEi P30954.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000423932 ; ENSP00000399078 ; ENSG00000196184 .
GeneIDi 26476.
KEGGi hsa:26476.
UCSCi uc010piv.2. human.

Organism-specific databases

CTDi 26476.
GeneCardsi GC01P159409.
H-InvDB HIX0028779.
HGNCi HGNC:8175. OR10J1.
neXtProti NX_P30954.
PharmGKBi PA31982.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84232.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi P30954.
KOi K04257.
OMAi KRENFTL.
OrthoDBi EOG71P2B9.
PhylomeDBi P30954.
TreeFami TF337624.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10J1.
GenomeRNAii 26476.
NextBioi 48736.
PROi P30954.

Gene expression databases

Bgeei P30954.
CleanExi HS_OR10J1.
Genevestigatori P30954.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-62 AND MET-103.
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-62 AND MET-103.
    Tissue: Cerebellum.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-294, VARIANT MET-103.
  5. Cited for: IDENTIFICATION, VARIANTS ILE-62 AND MET-103.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10J1_HUMAN
AccessioniPrimary (citable) accession number: P30954
Secondary accession number(s): Q2M1M8
, Q5VSV1, Q6IET5, Q96R56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi