ID   OR1E1_HUMAN             Reviewed;         314 AA.
AC   P30953; O43884; P47882; P47885; Q6IFA9; Q6IFM5; Q9UBJ1; Q9UM60;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   27-MAR-2024, entry version 191.
DE   RecName: Full=Olfactory receptor 1E1;
DE   AltName: Full=Olfactory receptor 13-66;
DE            Short=OR13-66;
DE   AltName: Full=Olfactory receptor 17-2/17-32;
DE            Short=OR17-2;
DE            Short=OR17-32;
DE   AltName: Full=Olfactory receptor 1E5;
DE   AltName: Full=Olfactory receptor 1E6;
DE   AltName: Full=Olfactory receptor 5-85;
DE            Short=OR5-85;
DE   AltName: Full=Olfactory receptor OR17-18;
DE   AltName: Full=Olfactory receptor-like protein HGMP07I;
GN   Name=OR1E1; Synonyms=OR1E5, OR1E6, OR1E9P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Testis;
RX   PubMed=1370859; DOI=10.1038/355453a0;
RA   Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA   Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA   Vassart G.;
RT   "Expression of members of the putative olfactory receptor gene family in
RT   mammalian germ cells.";
RL   Nature 355:453-455(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA   Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA   Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT   "Sequence, structure, and evolution of a complete human olfactory receptor
RT   gene cluster.";
RL   Genomics 63:227-245(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ferraz C., Vidal S., Brun C., Demaille J.G.;
RT   "DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the olfactory
RT   receptor gene cluster of human chromosome 17p13.3, containing OR genes 2,
RT   201, 93 and pseudogene 1.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ferraz C., Demaille J.G.;
RT   "Sequence of cosmid ICRF105cE06173 of human chromosome 17p13.3 olfactory
RT   receptor gene cluster, containing genes OR17-32 and OR17-201-1, and
RT   pseudogene OR17-01.";
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ferraz C., Vidal S., Brun C., Demaille J.G.;
RT   "Sequence of cosmid L53 of human chromosome 17p13.3 olfactory receptor gene
RT   cluster, containing the OR17-32 gene and the OR17-01 pseudogene.";
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA   Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA   Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT   "Olfactory receptor gene cluster on human chromosome 17: possible
RT   duplication of an ancestral receptor repertoire.";
RL   Hum. Mol. Genet. 3:229-235(1994).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=9500546; DOI=10.1038/ng0398-243;
RA   Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
RA   Demaille J.G., Giorgi D.;
RT   "Distribution of olfactory receptor genes in the human genome.";
RL   Nat. Genet. 18:243-250(1998).
RN   [9]
RP   IDENTIFICATION, AND VARIANT THR-143.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [10]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1E1";
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DR   EMBL; X64994; CAA46127.1; -; Genomic_DNA.
DR   EMBL; AF087916; AAF37309.1; -; Genomic_DNA.
DR   EMBL; AF095725; AAF03261.1; -; Genomic_DNA.
DR   EMBL; U78308; AAD00276.1; -; Genomic_DNA.
DR   EMBL; AF052041; AAD17495.1; -; Genomic_DNA.
DR   EMBL; U04642; AAA17447.1; -; Genomic_DNA.
DR   EMBL; U04682; AAA18346.1; -; Genomic_DNA.
DR   EMBL; AF399550; AAK95035.1; -; Genomic_DNA.
DR   EMBL; U86222; AAC39613.1; -; Genomic_DNA.
DR   EMBL; U86274; AAC39629.1; -; Genomic_DNA.
DR   EMBL; BK004237; DAA04635.1; -; Genomic_DNA.
DR   EMBL; BK004353; DAA04751.1; -; Genomic_DNA.
DR   CCDS; CCDS11024.1; -.
DR   PIR; I38470; I38470.
DR   PIR; I38474; I38474.
DR   PIR; S20572; S20572.
DR   RefSeq; NP_003544.2; NM_003553.2.
DR   AlphaFoldDB; P30953; -.
DR   SMR; P30953; -.
DR   BioGRID; 113977; 5.
DR   STRING; 9606.ENSP00000313384; -.
DR   TCDB; 9.A.14.8.1; the g-protein-coupled receptor (gpcr) family.
DR   GlyCosmos; P30953; 1 site, No reported glycans.
DR   GlyGen; P30953; 1 site.
DR   iPTMnet; P30953; -.
DR   PhosphoSitePlus; P30953; -.
DR   BioMuta; OR1E1; -.
DR   DMDM; 400671; -.
DR   MassIVE; P30953; -.
DR   PaxDb; 9606-ENSP00000313384; -.
DR   Antibodypedia; 23007; 15 antibodies from 10 providers.
DR   DNASU; 8387; -.
DR   Ensembl; ENST00000322608.2; ENSP00000313384.2; ENSG00000180016.2.
DR   GeneID; 8387; -.
DR   KEGG; hsa:8387; -.
DR   MANE-Select; ENST00000322608.2; ENSP00000313384.2; NM_003553.3; NP_003544.2.
DR   UCSC; uc002fvj.2; human.
DR   AGR; HGNC:8189; -.
DR   CTD; 8387; -.
DR   GeneCards; OR1E1; -.
DR   HGNC; HGNC:8189; OR1E1.
DR   HPA; ENSG00000180016; Not detected.
DR   neXtProt; NX_P30953; -.
DR   PharmGKB; PA32062; -.
DR   VEuPathDB; HostDB:ENSG00000180016; -.
DR   eggNOG; ENOG502SI5J; Eukaryota.
DR   GeneTree; ENSGT00940000165283; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; P30953; -.
DR   OMA; QEPSIPY; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; P30953; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; P30953; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 8387; 10 hits in 712 CRISPR screens.
DR   GeneWiki; OR1E1; -.
DR   GenomeRNAi; 8387; -.
DR   Pharos; P30953; Tdark.
DR   PRO; PR:P30953; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P30953; Protein.
DR   Bgee; ENSG00000180016; Expressed in hindlimb stylopod muscle and 24 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15236; 7tmA_OR1E-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF130; OLFACTORY RECEPTOR 1E1-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P30953; HS.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 1E1"
FT                   /id="PRO_0000150425"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         129
FT                   /note="P -> L (in dbSNP:rs1735011)"
FT                   /id="VAR_053119"
FT   VARIANT         143
FT                   /note="A -> T (in dbSNP:rs150989)"
FT                   /evidence="ECO:0000269|PubMed:14983052"
FT                   /id="VAR_010226"
FT   VARIANT         262
FT                   /note="S -> P (in dbSNP:rs379856)"
FT                   /id="VAR_053120"
FT   CONFLICT        178
FT                   /note="F -> L (in Ref. 6; AAA17447)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        221
FT                   /note="I -> V (in Ref. 8; AAC39629)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   314 AA;  35264 MW;  BA24A1E6F60A208E CRC64;
     MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR LDSHLHTPMY
     LFLSNLSFSD LCFSSVTIPK LLQNMQNQDP SIPYADCLTQ MYFFLLFGDL ESFLLVAMAY
     DRYVAICFPL HYTAIMSPML CLALVALSWV LTTFHAMLHT LLMARLCFCA DNVIPHFFCD
     MSALLKLAFS DTRVNEWVIF IMGGLILVIP FLLILGSYAR IVSSILKVPS SKGICKAFST
     CGSHLSVVSL FYGTVIGLYL CSSANSSTLK DTVMAMMYTV VTPMLNPFIY SLRNRDMKGA
     LSRVIHQKKT FFSL
//