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P30953

- OR1E1_HUMAN

UniProt

P30953 - OR1E1_HUMAN

Protein

Olfactory receptor 1E1

Gene

OR1E1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. sensory perception of smell Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Protein family/group databases

    TCDBi9.A.14.8.1. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1E1
    Alternative name(s):
    Olfactory receptor 13-66
    Short name:
    OR13-66
    Olfactory receptor 17-2/17-32
    Short name:
    OR17-2
    Short name:
    OR17-32
    Olfactory receptor 1E5
    Olfactory receptor 1E6
    Olfactory receptor 5-85
    Short name:
    OR5-85
    Olfactory receptor OR17-18
    Olfactory receptor-like protein HGMP07I
    Gene namesi
    Name:OR1E1
    Synonyms:OR1E5, OR1E6, OR1E9P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:8189. OR1E1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32062.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 1E1PRO_0000150425Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP30953.
    PRIDEiP30953.

    Expressioni

    Gene expression databases

    BgeeiP30953.
    CleanExiHS_OR1E1.
    GenevestigatoriP30953.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000313384.

    Structurei

    3D structure databases

    ProteinModelPortaliP30953.
    SMRiP30953. Positions 32-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44681.
    HOVERGENiHBG017625.
    InParanoidiP30953.
    KOiK04257.
    OMAiHQKKTFF.
    OrthoDBiEOG7JT6WV.
    PhylomeDBiP30953.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30953-1 [UniParc]FASTAAdd to Basket

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    MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR    50
    LDSHLHTPMY LFLSNLSFSD LCFSSVTIPK LLQNMQNQDP SIPYADCLTQ 100
    MYFFLLFGDL ESFLLVAMAY DRYVAICFPL HYTAIMSPML CLALVALSWV 150
    LTTFHAMLHT LLMARLCFCA DNVIPHFFCD MSALLKLAFS DTRVNEWVIF 200
    IMGGLILVIP FLLILGSYAR IVSSILKVPS SKGICKAFST CGSHLSVVSL 250
    FYGTVIGLYL CSSANSSTLK DTVMAMMYTV VTPMLNPFIY SLRNRDMKGA 300
    LSRVIHQKKT FFSL 314
    Length:314
    Mass (Da):35,264
    Last modified:July 1, 1993 - v1
    Checksum:iBA24A1E6F60A208E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti178 – 1781F → L in AAA17447. (PubMed:8004088)Curated
    Sequence conflicti221 – 2211I → V in AAC39629. (PubMed:9500546)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti129 – 1291P → L.
    Corresponds to variant rs1735011 [ dbSNP | Ensembl ].
    VAR_053119
    Natural varianti143 – 1431A → T.1 Publication
    Corresponds to variant rs150989 [ dbSNP | Ensembl ].
    VAR_010226
    Natural varianti262 – 2621S → P.
    Corresponds to variant rs379856 [ dbSNP | Ensembl ].
    VAR_053120

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64994 Genomic DNA. Translation: CAA46127.1.
    AF087916 Genomic DNA. Translation: AAF37309.1.
    AF095725 Genomic DNA. Translation: AAF03261.1.
    U78308 Genomic DNA. Translation: AAD00276.1.
    AF052041 Genomic DNA. Translation: AAD17495.1.
    U04642 Genomic DNA. Translation: AAA17447.1.
    U04682 Genomic DNA. Translation: AAA18346.1.
    AF399550 Genomic DNA. Translation: AAK95035.1.
    U86222 Genomic DNA. Translation: AAC39613.1.
    U86274 Genomic DNA. Translation: AAC39629.1.
    BK004237 Genomic DNA. Translation: DAA04635.1.
    BK004353 Genomic DNA. Translation: DAA04751.1.
    CCDSiCCDS11024.1.
    PIRiI38470.
    I38474.
    S20572.
    RefSeqiNP_003544.2. NM_003553.2.
    UniGeneiHs.278485.

    Genome annotation databases

    EnsembliENST00000322608; ENSP00000313384; ENSG00000180016.
    GeneIDi8387.
    KEGGihsa:8387.
    UCSCiuc002fvj.1. human.

    Polymorphism databases

    DMDMi400671.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64994 Genomic DNA. Translation: CAA46127.1 .
    AF087916 Genomic DNA. Translation: AAF37309.1 .
    AF095725 Genomic DNA. Translation: AAF03261.1 .
    U78308 Genomic DNA. Translation: AAD00276.1 .
    AF052041 Genomic DNA. Translation: AAD17495.1 .
    U04642 Genomic DNA. Translation: AAA17447.1 .
    U04682 Genomic DNA. Translation: AAA18346.1 .
    AF399550 Genomic DNA. Translation: AAK95035.1 .
    U86222 Genomic DNA. Translation: AAC39613.1 .
    U86274 Genomic DNA. Translation: AAC39629.1 .
    BK004237 Genomic DNA. Translation: DAA04635.1 .
    BK004353 Genomic DNA. Translation: DAA04751.1 .
    CCDSi CCDS11024.1.
    PIRi I38470.
    I38474.
    S20572.
    RefSeqi NP_003544.2. NM_003553.2.
    UniGenei Hs.278485.

    3D structure databases

    ProteinModelPortali P30953.
    SMRi P30953. Positions 32-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000313384.

    Protein family/group databases

    TCDBi 9.A.14.8.1. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    Polymorphism databases

    DMDMi 400671.

    Proteomic databases

    PaxDbi P30953.
    PRIDEi P30953.

    Protocols and materials databases

    DNASUi 8387.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322608 ; ENSP00000313384 ; ENSG00000180016 .
    GeneIDi 8387.
    KEGGi hsa:8387.
    UCSCi uc002fvj.1. human.

    Organism-specific databases

    CTDi 8387.
    GeneCardsi GC17M003300.
    H-InvDB HIX0039264.
    HGNCi HGNC:8189. OR1E1.
    neXtProti NX_P30953.
    PharmGKBi PA32062.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44681.
    HOVERGENi HBG017625.
    InParanoidi P30953.
    KOi K04257.
    OMAi HQKKTFF.
    OrthoDBi EOG7JT6WV.
    PhylomeDBi P30953.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1E1.
    GenomeRNAii 8387.
    NextBioi 31396.
    PROi P30953.

    Gene expression databases

    Bgeei P30953.
    CleanExi HS_OR1E1.
    Genevestigatori P30953.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
      Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
      Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Testis.
    2. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
      Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
      Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the olfactory receptor gene cluster of human chromosome 17p13.3, containing OR genes 2, 201, 93 and pseudogene 1."
      Ferraz C., Vidal S., Brun C., Demaille J.G.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Sequence of cosmid ICRF105cE06173 of human chromosome 17p13.3 olfactory receptor gene cluster, containing genes OR17-32 and OR17-201-1, and pseudogene OR17-01."
      Ferraz C., Demaille J.G.
      Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Sequence of cosmid L53 of human chromosome 17p13.3 olfactory receptor gene cluster, containing the OR17-32 gene and the OR17-01 pseudogene."
      Ferraz C., Vidal S., Brun C., Demaille J.G.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
      Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
      Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    9. Cited for: IDENTIFICATION, VARIANT THR-143.
    10. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR1E1_HUMAN
    AccessioniPrimary (citable) accession number: P30953
    Secondary accession number(s): O43884
    , P47882, P47885, Q6IFA9, Q6IFM5, Q9UBJ1, Q9UM60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3