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Protein

Olfactory receptor 1E1

Gene

OR1E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. G-protein coupled receptor signaling pathway Source: GO_Central
  3. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Protein family/group databases

TCDBi9.A.14.8.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1E1
Alternative name(s):
Olfactory receptor 13-66
Short name:
OR13-66
Olfactory receptor 17-2/17-32
Short name:
OR17-2
Short name:
OR17-32
Olfactory receptor 1E5
Olfactory receptor 1E6
Olfactory receptor 5-85
Short name:
OR5-85
Olfactory receptor OR17-18
Olfactory receptor-like protein HGMP07I
Gene namesi
Name:OR1E1
Synonyms:OR1E5, OR1E6, OR1E9P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8189. OR1E1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32062.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 1E1PRO_0000150425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP30953.
PRIDEiP30953.

Expressioni

Gene expression databases

BgeeiP30953.
CleanExiHS_OR1E1.
GenevestigatoriP30953.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000313384.

Structurei

3D structure databases

ProteinModelPortaliP30953.
SMRiP30953. Positions 32-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44681.
GeneTreeiENSGT00760000118845.
HOVERGENiHBG017625.
InParanoidiP30953.
KOiK04257.
OMAiVICKKKV.
OrthoDBiEOG7JT6WV.
PhylomeDBiP30953.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR
60 70 80 90 100
LDSHLHTPMY LFLSNLSFSD LCFSSVTIPK LLQNMQNQDP SIPYADCLTQ
110 120 130 140 150
MYFFLLFGDL ESFLLVAMAY DRYVAICFPL HYTAIMSPML CLALVALSWV
160 170 180 190 200
LTTFHAMLHT LLMARLCFCA DNVIPHFFCD MSALLKLAFS DTRVNEWVIF
210 220 230 240 250
IMGGLILVIP FLLILGSYAR IVSSILKVPS SKGICKAFST CGSHLSVVSL
260 270 280 290 300
FYGTVIGLYL CSSANSSTLK DTVMAMMYTV VTPMLNPFIY SLRNRDMKGA
310
LSRVIHQKKT FFSL
Length:314
Mass (Da):35,264
Last modified:July 1, 1993 - v1
Checksum:iBA24A1E6F60A208E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781F → L in AAA17447 (PubMed:8004088).Curated
Sequence conflicti221 – 2211I → V in AAC39629 (PubMed:9500546).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti129 – 1291P → L.
Corresponds to variant rs1735011 [ dbSNP | Ensembl ].
VAR_053119
Natural varianti143 – 1431A → T.1 Publication
Corresponds to variant rs150989 [ dbSNP | Ensembl ].
VAR_010226
Natural varianti262 – 2621S → P.
Corresponds to variant rs379856 [ dbSNP | Ensembl ].
VAR_053120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64994 Genomic DNA. Translation: CAA46127.1.
AF087916 Genomic DNA. Translation: AAF37309.1.
AF095725 Genomic DNA. Translation: AAF03261.1.
U78308 Genomic DNA. Translation: AAD00276.1.
AF052041 Genomic DNA. Translation: AAD17495.1.
U04642 Genomic DNA. Translation: AAA17447.1.
U04682 Genomic DNA. Translation: AAA18346.1.
AF399550 Genomic DNA. Translation: AAK95035.1.
U86222 Genomic DNA. Translation: AAC39613.1.
U86274 Genomic DNA. Translation: AAC39629.1.
BK004237 Genomic DNA. Translation: DAA04635.1.
BK004353 Genomic DNA. Translation: DAA04751.1.
CCDSiCCDS11024.1.
PIRiI38470.
I38474.
S20572.
RefSeqiNP_003544.2. NM_003553.2.
UniGeneiHs.278485.

Genome annotation databases

EnsembliENST00000322608; ENSP00000313384; ENSG00000180016.
GeneIDi8387.
KEGGihsa:8387.
UCSCiuc002fvj.1. human.

Polymorphism databases

DMDMi400671.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64994 Genomic DNA. Translation: CAA46127.1.
AF087916 Genomic DNA. Translation: AAF37309.1.
AF095725 Genomic DNA. Translation: AAF03261.1.
U78308 Genomic DNA. Translation: AAD00276.1.
AF052041 Genomic DNA. Translation: AAD17495.1.
U04642 Genomic DNA. Translation: AAA17447.1.
U04682 Genomic DNA. Translation: AAA18346.1.
AF399550 Genomic DNA. Translation: AAK95035.1.
U86222 Genomic DNA. Translation: AAC39613.1.
U86274 Genomic DNA. Translation: AAC39629.1.
BK004237 Genomic DNA. Translation: DAA04635.1.
BK004353 Genomic DNA. Translation: DAA04751.1.
CCDSiCCDS11024.1.
PIRiI38470.
I38474.
S20572.
RefSeqiNP_003544.2. NM_003553.2.
UniGeneiHs.278485.

3D structure databases

ProteinModelPortaliP30953.
SMRiP30953. Positions 32-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000313384.

Protein family/group databases

TCDBi9.A.14.8.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

Polymorphism databases

DMDMi400671.

Proteomic databases

PaxDbiP30953.
PRIDEiP30953.

Protocols and materials databases

DNASUi8387.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322608; ENSP00000313384; ENSG00000180016.
GeneIDi8387.
KEGGihsa:8387.
UCSCiuc002fvj.1. human.

Organism-specific databases

CTDi8387.
GeneCardsiGC17M003300.
H-InvDBHIX0039264.
HGNCiHGNC:8189. OR1E1.
neXtProtiNX_P30953.
PharmGKBiPA32062.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44681.
GeneTreeiENSGT00760000118845.
HOVERGENiHBG017625.
InParanoidiP30953.
KOiK04257.
OMAiVICKKKV.
OrthoDBiEOG7JT6WV.
PhylomeDBiP30953.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1E1.
GenomeRNAii8387.
NextBioi31396.
PROiP30953.

Gene expression databases

BgeeiP30953.
CleanExiHS_OR1E1.
GenevestigatoriP30953.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Testis.
  2. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
    Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
    Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the olfactory receptor gene cluster of human chromosome 17p13.3, containing OR genes 2, 201, 93 and pseudogene 1."
    Ferraz C., Vidal S., Brun C., Demaille J.G.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Sequence of cosmid ICRF105cE06173 of human chromosome 17p13.3 olfactory receptor gene cluster, containing genes OR17-32 and OR17-201-1, and pseudogene OR17-01."
    Ferraz C., Demaille J.G.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Sequence of cosmid L53 of human chromosome 17p13.3 olfactory receptor gene cluster, containing the OR17-32 gene and the OR17-01 pseudogene."
    Ferraz C., Vidal S., Brun C., Demaille J.G.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
    Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
    Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  9. Cited for: IDENTIFICATION, VARIANT THR-143.
  10. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1E1_HUMAN
AccessioniPrimary (citable) accession number: P30953
Secondary accession number(s): O43884
, P47882, P47885, Q6IFA9, Q6IFM5, Q9UBJ1, Q9UM60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 4, 2015
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.