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Protein

Olfactory receptor 1E1

Gene

OR1E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180016-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Protein family/group databases

TCDBi9.A.14.8.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1E1
Alternative name(s):
Olfactory receptor 13-66
Short name:
OR13-66
Olfactory receptor 17-2/17-32
Short name:
OR17-2
Short name:
OR17-32
Olfactory receptor 1E5
Olfactory receptor 1E6
Olfactory receptor 5-85
Short name:
OR5-85
Olfactory receptor OR17-18
Olfactory receptor-like protein HGMP07I
Gene namesi
Name:OR1E1
Synonyms:OR1E5, OR1E6, OR1E9P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8189. OR1E1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8387.
OpenTargetsiENSG00000180016.
PharmGKBiPA32062.

Polymorphism and mutation databases

BioMutaiOR1E1.
DMDMi400671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504251 – 314Olfactory receptor 1E1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP30953.
PRIDEiP30953.

PTM databases

iPTMnetiP30953.
PhosphoSitePlusiP30953.

Expressioni

Gene expression databases

BgeeiENSG00000180016.
CleanExiHS_OR1E1.
GenevisibleiP30953. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000313384.

Structurei

3D structure databases

ProteinModelPortaliP30953.
SMRiP30953.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9M4. Eukaryota.
ENOG41113B1. LUCA.
GeneTreeiENSGT00860000133705.
HOVERGENiHBG017625.
InParanoidiP30953.
KOiK04257.
OMAiRVICKRQ.
OrthoDBiEOG091G0EOH.
PhylomeDBiP30953.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR
60 70 80 90 100
LDSHLHTPMY LFLSNLSFSD LCFSSVTIPK LLQNMQNQDP SIPYADCLTQ
110 120 130 140 150
MYFFLLFGDL ESFLLVAMAY DRYVAICFPL HYTAIMSPML CLALVALSWV
160 170 180 190 200
LTTFHAMLHT LLMARLCFCA DNVIPHFFCD MSALLKLAFS DTRVNEWVIF
210 220 230 240 250
IMGGLILVIP FLLILGSYAR IVSSILKVPS SKGICKAFST CGSHLSVVSL
260 270 280 290 300
FYGTVIGLYL CSSANSSTLK DTVMAMMYTV VTPMLNPFIY SLRNRDMKGA
310
LSRVIHQKKT FFSL
Length:314
Mass (Da):35,264
Last modified:July 1, 1993 - v1
Checksum:iBA24A1E6F60A208E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178F → L in AAA17447 (PubMed:8004088).Curated1
Sequence conflicti221I → V in AAC39629 (PubMed:9500546).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053119129P → L.Corresponds to variant rs1735011dbSNPEnsembl.1
Natural variantiVAR_010226143A → T.1 PublicationCorresponds to variant rs150989dbSNPEnsembl.1
Natural variantiVAR_053120262S → P.Corresponds to variant rs379856dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64994 Genomic DNA. Translation: CAA46127.1.
AF087916 Genomic DNA. Translation: AAF37309.1.
AF095725 Genomic DNA. Translation: AAF03261.1.
U78308 Genomic DNA. Translation: AAD00276.1.
AF052041 Genomic DNA. Translation: AAD17495.1.
U04642 Genomic DNA. Translation: AAA17447.1.
U04682 Genomic DNA. Translation: AAA18346.1.
AF399550 Genomic DNA. Translation: AAK95035.1.
U86222 Genomic DNA. Translation: AAC39613.1.
U86274 Genomic DNA. Translation: AAC39629.1.
BK004237 Genomic DNA. Translation: DAA04635.1.
BK004353 Genomic DNA. Translation: DAA04751.1.
CCDSiCCDS11024.1.
PIRiI38470.
I38474.
S20572.
RefSeqiNP_003544.2. NM_003553.2.
UniGeneiHs.278485.

Genome annotation databases

EnsembliENST00000322608; ENSP00000313384; ENSG00000180016.
GeneIDi8387.
KEGGihsa:8387.
UCSCiuc002fvj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64994 Genomic DNA. Translation: CAA46127.1.
AF087916 Genomic DNA. Translation: AAF37309.1.
AF095725 Genomic DNA. Translation: AAF03261.1.
U78308 Genomic DNA. Translation: AAD00276.1.
AF052041 Genomic DNA. Translation: AAD17495.1.
U04642 Genomic DNA. Translation: AAA17447.1.
U04682 Genomic DNA. Translation: AAA18346.1.
AF399550 Genomic DNA. Translation: AAK95035.1.
U86222 Genomic DNA. Translation: AAC39613.1.
U86274 Genomic DNA. Translation: AAC39629.1.
BK004237 Genomic DNA. Translation: DAA04635.1.
BK004353 Genomic DNA. Translation: DAA04751.1.
CCDSiCCDS11024.1.
PIRiI38470.
I38474.
S20572.
RefSeqiNP_003544.2. NM_003553.2.
UniGeneiHs.278485.

3D structure databases

ProteinModelPortaliP30953.
SMRiP30953.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000313384.

Protein family/group databases

TCDBi9.A.14.8.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP30953.
PhosphoSitePlusiP30953.

Polymorphism and mutation databases

BioMutaiOR1E1.
DMDMi400671.

Proteomic databases

PaxDbiP30953.
PRIDEiP30953.

Protocols and materials databases

DNASUi8387.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322608; ENSP00000313384; ENSG00000180016.
GeneIDi8387.
KEGGihsa:8387.
UCSCiuc002fvj.2. human.

Organism-specific databases

CTDi8387.
DisGeNETi8387.
GeneCardsiOR1E1.
H-InvDBHIX0039264.
HGNCiHGNC:8189. OR1E1.
neXtProtiNX_P30953.
OpenTargetsiENSG00000180016.
PharmGKBiPA32062.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9M4. Eukaryota.
ENOG41113B1. LUCA.
GeneTreeiENSGT00860000133705.
HOVERGENiHBG017625.
InParanoidiP30953.
KOiK04257.
OMAiRVICKRQ.
OrthoDBiEOG091G0EOH.
PhylomeDBiP30953.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180016-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1E1.
GenomeRNAii8387.
PROiP30953.

Gene expression databases

BgeeiENSG00000180016.
CleanExiHS_OR1E1.
GenevisibleiP30953. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1E1_HUMAN
AccessioniPrimary (citable) accession number: P30953
Secondary accession number(s): O43884
, P47882, P47885, Q6IFA9, Q6IFM5, Q9UBJ1, Q9UM60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.