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P30953

- OR1E1_HUMAN

UniProt

P30953 - OR1E1_HUMAN

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Protein
Olfactory receptor 1E1
Gene
OR1E1, OR1E5, OR1E6, OR1E9P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Protein family/group databases

TCDBi9.A.14.8.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1E1
Alternative name(s):
Olfactory receptor 13-66
Short name:
OR13-66
Olfactory receptor 17-2/17-32
Short name:
OR17-2
Short name:
OR17-32
Olfactory receptor 1E5
Olfactory receptor 1E6
Olfactory receptor 5-85
Short name:
OR5-85
Olfactory receptor OR17-18
Olfactory receptor-like protein HGMP07I
Gene namesi
Name:OR1E1
Synonyms:OR1E5, OR1E6, OR1E9P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8189. OR1E1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed prediction
Add
BLAST
Transmembranei26 – 4924Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini50 – 578Cytoplasmic Reviewed prediction
Transmembranei58 – 7922Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini80 – 10021Extracellular Reviewed prediction
Add
BLAST
Transmembranei101 – 12020Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 15819Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini159 – 19537Extracellular Reviewed prediction
Add
BLAST
Transmembranei196 – 21924Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini220 – 23617Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei237 – 25923Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini260 – 27213Extracellular Reviewed prediction
Add
BLAST
Transmembranei273 – 29220Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini293 – 31422Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32062.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 1E1
PRO_0000150425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP30953.
PRIDEiP30953.

Expressioni

Gene expression databases

BgeeiP30953.
CleanExiHS_OR1E1.
GenevestigatoriP30953.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000313384.

Structurei

3D structure databases

ProteinModelPortaliP30953.
SMRiP30953. Positions 32-305.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44681.
HOVERGENiHBG017625.
InParanoidiP30953.
KOiK04257.
OMAiHQKKTFF.
OrthoDBiEOG7JT6WV.
PhylomeDBiP30953.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30953-1 [UniParc]FASTAAdd to Basket

« Hide

MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR    50
LDSHLHTPMY LFLSNLSFSD LCFSSVTIPK LLQNMQNQDP SIPYADCLTQ 100
MYFFLLFGDL ESFLLVAMAY DRYVAICFPL HYTAIMSPML CLALVALSWV 150
LTTFHAMLHT LLMARLCFCA DNVIPHFFCD MSALLKLAFS DTRVNEWVIF 200
IMGGLILVIP FLLILGSYAR IVSSILKVPS SKGICKAFST CGSHLSVVSL 250
FYGTVIGLYL CSSANSSTLK DTVMAMMYTV VTPMLNPFIY SLRNRDMKGA 300
LSRVIHQKKT FFSL 314
Length:314
Mass (Da):35,264
Last modified:July 1, 1993 - v1
Checksum:iBA24A1E6F60A208E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti129 – 1291P → L.
Corresponds to variant rs1735011 [ dbSNP | Ensembl ].
VAR_053119
Natural varianti143 – 1431A → T.1 Publication
Corresponds to variant rs150989 [ dbSNP | Ensembl ].
VAR_010226
Natural varianti262 – 2621S → P.
Corresponds to variant rs379856 [ dbSNP | Ensembl ].
VAR_053120

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781F → L in AAA17447. 1 Publication
Sequence conflicti221 – 2211I → V in AAC39629. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64994 Genomic DNA. Translation: CAA46127.1.
AF087916 Genomic DNA. Translation: AAF37309.1.
AF095725 Genomic DNA. Translation: AAF03261.1.
U78308 Genomic DNA. Translation: AAD00276.1.
AF052041 Genomic DNA. Translation: AAD17495.1.
U04642 Genomic DNA. Translation: AAA17447.1.
U04682 Genomic DNA. Translation: AAA18346.1.
AF399550 Genomic DNA. Translation: AAK95035.1.
U86222 Genomic DNA. Translation: AAC39613.1.
U86274 Genomic DNA. Translation: AAC39629.1.
BK004237 Genomic DNA. Translation: DAA04635.1.
BK004353 Genomic DNA. Translation: DAA04751.1.
CCDSiCCDS11024.1.
PIRiI38470.
I38474.
S20572.
RefSeqiNP_003544.2. NM_003553.2.
UniGeneiHs.278485.

Genome annotation databases

EnsembliENST00000322608; ENSP00000313384; ENSG00000180016.
GeneIDi8387.
KEGGihsa:8387.
UCSCiuc002fvj.1. human.

Polymorphism databases

DMDMi400671.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64994 Genomic DNA. Translation: CAA46127.1 .
AF087916 Genomic DNA. Translation: AAF37309.1 .
AF095725 Genomic DNA. Translation: AAF03261.1 .
U78308 Genomic DNA. Translation: AAD00276.1 .
AF052041 Genomic DNA. Translation: AAD17495.1 .
U04642 Genomic DNA. Translation: AAA17447.1 .
U04682 Genomic DNA. Translation: AAA18346.1 .
AF399550 Genomic DNA. Translation: AAK95035.1 .
U86222 Genomic DNA. Translation: AAC39613.1 .
U86274 Genomic DNA. Translation: AAC39629.1 .
BK004237 Genomic DNA. Translation: DAA04635.1 .
BK004353 Genomic DNA. Translation: DAA04751.1 .
CCDSi CCDS11024.1.
PIRi I38470.
I38474.
S20572.
RefSeqi NP_003544.2. NM_003553.2.
UniGenei Hs.278485.

3D structure databases

ProteinModelPortali P30953.
SMRi P30953. Positions 32-305.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000313384.

Protein family/group databases

TCDBi 9.A.14.8.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

Polymorphism databases

DMDMi 400671.

Proteomic databases

PaxDbi P30953.
PRIDEi P30953.

Protocols and materials databases

DNASUi 8387.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322608 ; ENSP00000313384 ; ENSG00000180016 .
GeneIDi 8387.
KEGGi hsa:8387.
UCSCi uc002fvj.1. human.

Organism-specific databases

CTDi 8387.
GeneCardsi GC17M003300.
H-InvDB HIX0039264.
HGNCi HGNC:8189. OR1E1.
neXtProti NX_P30953.
PharmGKBi PA32062.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44681.
HOVERGENi HBG017625.
InParanoidi P30953.
KOi K04257.
OMAi HQKKTFF.
OrthoDBi EOG7JT6WV.
PhylomeDBi P30953.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1E1.
GenomeRNAii 8387.
NextBioi 31396.
PROi P30953.

Gene expression databases

Bgeei P30953.
CleanExi HS_OR1E1.
Genevestigatori P30953.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Testis.
  2. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
    Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
    Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the olfactory receptor gene cluster of human chromosome 17p13.3, containing OR genes 2, 201, 93 and pseudogene 1."
    Ferraz C., Vidal S., Brun C., Demaille J.G.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Sequence of cosmid ICRF105cE06173 of human chromosome 17p13.3 olfactory receptor gene cluster, containing genes OR17-32 and OR17-201-1, and pseudogene OR17-01."
    Ferraz C., Demaille J.G.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Sequence of cosmid L53 of human chromosome 17p13.3 olfactory receptor gene cluster, containing the OR17-32 gene and the OR17-01 pseudogene."
    Ferraz C., Vidal S., Brun C., Demaille J.G.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
    Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
    Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  9. Cited for: IDENTIFICATION, VARIANT THR-143.
  10. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1E1_HUMAN
AccessioniPrimary (citable) accession number: P30953
Secondary accession number(s): O43884
, P47882, P47885, Q6IFA9, Q6IFM5, Q9UBJ1, Q9UM60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 3, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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