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Protein

Olfactory receptor 1E1

Gene

OR1E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Protein family/group databases

TCDBi9.A.14.8.1 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1E1
Alternative name(s):
Olfactory receptor 13-66
Short name:
OR13-66
Olfactory receptor 17-2/17-32
Short name:
OR17-2
Short name:
OR17-32
Olfactory receptor 1E5
Olfactory receptor 1E6
Olfactory receptor 5-85
Short name:
OR5-85
Olfactory receptor OR17-18
Olfactory receptor-like protein HGMP07I
Gene namesi
Name:OR1E1
Synonyms:OR1E5, OR1E6, OR1E9P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000180016.2
HGNCiHGNC:8189 OR1E1
neXtProtiNX_P30953

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8387
PharmGKBiPA32062

Polymorphism and mutation databases

BioMutaiOR1E1
DMDMi400671

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504251 – 314Olfactory receptor 1E1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP30953
PaxDbiP30953
PRIDEiP30953

PTM databases

iPTMnetiP30953
PhosphoSitePlusiP30953

Expressioni

Gene expression databases

BgeeiENSG00000180016
CleanExiHS_OR1E1
GenevisibleiP30953 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000313384

Structurei

3D structure databases

ProteinModelPortaliP30953
SMRiP30953
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9M4 Eukaryota
ENOG41113B1 LUCA
GeneTreeiENSGT00860000133705
HOVERGENiHBG017625
InParanoidiP30953
KOiK04257
OMAiRVICKRQ
OrthoDBiEOG091G0EOH
PhylomeDBiP30953
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR
60 70 80 90 100
LDSHLHTPMY LFLSNLSFSD LCFSSVTIPK LLQNMQNQDP SIPYADCLTQ
110 120 130 140 150
MYFFLLFGDL ESFLLVAMAY DRYVAICFPL HYTAIMSPML CLALVALSWV
160 170 180 190 200
LTTFHAMLHT LLMARLCFCA DNVIPHFFCD MSALLKLAFS DTRVNEWVIF
210 220 230 240 250
IMGGLILVIP FLLILGSYAR IVSSILKVPS SKGICKAFST CGSHLSVVSL
260 270 280 290 300
FYGTVIGLYL CSSANSSTLK DTVMAMMYTV VTPMLNPFIY SLRNRDMKGA
310
LSRVIHQKKT FFSL
Length:314
Mass (Da):35,264
Last modified:July 1, 1993 - v1
Checksum:iBA24A1E6F60A208E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178F → L in AAA17447 (PubMed:8004088).Curated1
Sequence conflicti221I → V in AAC39629 (PubMed:9500546).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053119129P → L. Corresponds to variant dbSNP:rs1735011Ensembl.1
Natural variantiVAR_010226143A → T1 PublicationCorresponds to variant dbSNP:rs150989Ensembl.1
Natural variantiVAR_053120262S → P. Corresponds to variant dbSNP:rs379856Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64994 Genomic DNA Translation: CAA46127.1
AF087916 Genomic DNA Translation: AAF37309.1
AF095725 Genomic DNA Translation: AAF03261.1
U78308 Genomic DNA Translation: AAD00276.1
AF052041 Genomic DNA Translation: AAD17495.1
U04642 Genomic DNA Translation: AAA17447.1
U04682 Genomic DNA Translation: AAA18346.1
AF399550 Genomic DNA Translation: AAK95035.1
U86222 Genomic DNA Translation: AAC39613.1
U86274 Genomic DNA Translation: AAC39629.1
BK004237 Genomic DNA Translation: DAA04635.1
BK004353 Genomic DNA Translation: DAA04751.1
CCDSiCCDS11024.1
PIRiI38470
I38474
S20572
RefSeqiNP_003544.2, NM_003553.2
UniGeneiHs.278485

Genome annotation databases

EnsembliENST00000322608; ENSP00000313384; ENSG00000180016
GeneIDi8387
KEGGihsa:8387
UCSCiuc002fvj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1E1_HUMAN
AccessioniPrimary (citable) accession number: P30953
Secondary accession number(s): O43884
, P47882, P47885, Q6IFA9, Q6IFM5, Q9UBJ1, Q9UM60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: January 31, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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