Olfactory receptor 1E1 - Homo sapiens (Human)

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P30953 (OR1E1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 122. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Olfactory receptor 1E1

Alternative name(s):
Olfactory receptor 13-66
Short name=OR13-66
Olfactory receptor 17-2/17-32
Short name=OR17-2
Short name=OR17-32
Olfactory receptor 1E5
Olfactory receptor 1E6
Olfactory receptor 5-85
Short name=OR5-85
Olfactory receptor OR17-18
Olfactory receptor-like protein HGMP07I

Gene names

Name:	OR1E1
Synonyms:	OR1E5, OR1E6, OR1E9P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 314

314

Olfactory receptor 1E1

PRO_0000150425

Regions

Topological domain

1 – 25

Extracellular Potential

Transmembrane

26 – 49

Helical; Name=1; Potential

Topological domain

50 – 57

Cytoplasmic Potential

Transmembrane

58 – 79

Helical; Name=2; Potential

Topological domain

80 – 100

Extracellular Potential

Transmembrane

101 – 120

Helical; Name=3; Potential

Topological domain

121 – 139

Cytoplasmic Potential

Transmembrane

140 – 158

Helical; Name=4; Potential

Topological domain

159 – 195

Extracellular Potential

Transmembrane

196 – 219

Helical; Name=5; Potential

Topological domain

220 – 236

Cytoplasmic Potential

Transmembrane

237 – 259

Helical; Name=6; Potential

Topological domain

260 – 272

Extracellular Potential

Transmembrane

273 – 292

Helical; Name=7; Potential

Topological domain

293 – 314

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

129

P → L.
Corresponds to variant rs1735011 [ dbSNP | Ensembl ].

VAR_053119

Natural variant

143

A → T. Ref.9

VAR_010226

Natural variant

262

S → P.
Corresponds to variant rs379856 [ dbSNP | Ensembl ].

VAR_053120

Experimental info

Sequence conflict

178

F → L in AAA17447. Ref.6

Sequence conflict

221

I → V in AAC39629. Ref.8

Sequences

Sequence

Length

Mass (Da)

Tools

P30953 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: BA24A1E6F60A208E
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FASTA

314

35,264

        10         20         30         40         50         60 
MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR LDSHLHTPMY 

        70         80         90        100        110        120 
LFLSNLSFSD LCFSSVTIPK LLQNMQNQDP SIPYADCLTQ MYFFLLFGDL ESFLLVAMAY 

       130        140        150        160        170        180 
DRYVAICFPL HYTAIMSPML CLALVALSWV LTTFHAMLHT LLMARLCFCA DNVIPHFFCD 

       190        200        210        220        230        240 
MSALLKLAFS DTRVNEWVIF IMGGLILVIP FLLILGSYAR IVSSILKVPS SKGICKAFST 

       250        260        270        280        290        300 
CGSHLSVVSL FYGTVIGLYL CSSANSSTLK DTVMAMMYTV VTPMLNPFIY SLRNRDMKGA 

       310 
LSRVIHQKKT FFSL

« Hide

References

[1]	"Expression of members of the putative olfactory receptor gene family in mammalian germ cells." Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G. Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Testis.
[2]	"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster." Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D. Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the olfactory receptor gene cluster of human chromosome 17p13.3, containing OR genes 2, 201, 93 and pseudogene 1." Ferraz C., Vidal S., Brun C., Demaille J.G. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Sequence of cosmid ICRF105cE06173 of human chromosome 17p13.3 olfactory receptor gene cluster, containing genes OR17-32 and OR17-201-1, and pseudogene OR17-01." Ferraz C., Demaille J.G. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Sequence of cosmid L53 of human chromosome 17p13.3 olfactory receptor gene cluster, containing the OR17-32 gene and the OR17-01 pseudogene." Ferraz C., Vidal S., Brun C., Demaille J.G. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire." Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A. Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[7]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[8]	"Distribution of olfactory receptor genes in the human genome." Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G., Demaille J.G., Giorgi D. Nat. Genet. 18:243-250(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[9]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, VARIANT THR-143.
[10]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	X64994 Genomic DNA. Translation: CAA46127.1. AF087916 Genomic DNA. Translation: AAF37309.1. AF095725 Genomic DNA. Translation: AAF03261.1. U78308 Genomic DNA. Translation: AAD00276.1. AF052041 Genomic DNA. Translation: AAD17495.1. U04642 Genomic DNA. Translation: AAA17447.1. U04682 Genomic DNA. Translation: AAA18346.1. AF399550 Genomic DNA. Translation: AAK95035.1. U86222 Genomic DNA. Translation: AAC39613.1. U86274 Genomic DNA. Translation: AAC39629.1. BK004237 Genomic DNA. Translation: DAA04635.1. BK004353 Genomic DNA. Translation: DAA04751.1.
IPI	IPI00028117.
PIR	I38470. I38474. S20572.
RefSeq	NP_003544.2. NM_003553.2.
UniGene	Hs.278485.
3D structure databases
ProteinModelPortal	P30953.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000313384.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	400671.
Proteomic databases
PaxDb	P30953.
PRIDE	P30953.
Protocols and materials databases
DNASU	8387.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322608; ENSP00000313384; ENSG00000180016.
GeneID	8387.
KEGG	hsa:8387.
UCSC	uc002fvj.1. human.
Organism-specific databases
CTD	8387.
GeneCards	GC17M003300.
H-InvDB	HIX0039264.
HGNC	HGNC:8189. OR1E1.
neXtProt	NX_P30953.
PharmGKB	PA32062.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44681.
HOVERGEN	HBG017625.
InParanoid	P30953.
KO	K04257.
OMA	HQKKTFF.
OrthoDB	EOG4S1T7R.
PhylomeDB	P30953.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P30953.
CleanEx	HS_OR1E1.
Genevestigator	P30953.
GermOnline	ENSG00000180016. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8387.
NextBio	31396.

Entry information

Entry name

OR1E1_HUMAN

Accession

Primary (citable) accession number: P30953
Secondary accession number(s): O43884

Q9UM60

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 122 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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List of 7-transmembrane G-linked receptor entries

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents