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P30953 (OR1E1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1E1
Alternative name(s):
Olfactory receptor 13-66
Short name=OR13-66
Olfactory receptor 17-2/17-32
Short name=OR17-2
Short name=OR17-32
Olfactory receptor 1E5
Olfactory receptor 1E6
Olfactory receptor 5-85
Short name=OR5-85
Olfactory receptor OR17-18
Olfactory receptor-like protein HGMP07I
Gene names
Name:OR1E1
Synonyms:OR1E5, OR1E6, OR1E9P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Olfactory receptor 1E1
PRO_0000150425

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23617Cytoplasmic Potential
Transmembrane237 – 25923Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29220Helical; Name=7; Potential
Topological domain293 – 31422Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential

Natural variations

Natural variant1291P → L.
Corresponds to variant rs1735011 [ dbSNP | Ensembl ].
VAR_053119
Natural variant1431A → T. Ref.9
Corresponds to variant rs150989 [ dbSNP | Ensembl ].
VAR_010226
Natural variant2621S → P.
Corresponds to variant rs379856 [ dbSNP | Ensembl ].
VAR_053120

Experimental info

Sequence conflict1781F → L in AAA17447. Ref.6
Sequence conflict2211I → V in AAC39629. Ref.8

Sequences

Sequence LengthMass (Da)Tools
P30953 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: BA24A1E6F60A208E

FASTA31435,264
        10         20         30         40         50         60 
MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR LDSHLHTPMY 

        70         80         90        100        110        120 
LFLSNLSFSD LCFSSVTIPK LLQNMQNQDP SIPYADCLTQ MYFFLLFGDL ESFLLVAMAY 

       130        140        150        160        170        180 
DRYVAICFPL HYTAIMSPML CLALVALSWV LTTFHAMLHT LLMARLCFCA DNVIPHFFCD 

       190        200        210        220        230        240 
MSALLKLAFS DTRVNEWVIF IMGGLILVIP FLLILGSYAR IVSSILKVPS SKGICKAFST 

       250        260        270        280        290        300 
CGSHLSVVSL FYGTVIGLYL CSSANSSTLK DTVMAMMYTV VTPMLNPFIY SLRNRDMKGA 

       310 
LSRVIHQKKT FFSL 

« Hide

References

[1]"Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Testis.
[2]"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the olfactory receptor gene cluster of human chromosome 17p13.3, containing OR genes 2, 201, 93 and pseudogene 1."
Ferraz C., Vidal S., Brun C., Demaille J.G.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Sequence of cosmid ICRF105cE06173 of human chromosome 17p13.3 olfactory receptor gene cluster, containing genes OR17-32 and OR17-201-1, and pseudogene OR17-01."
Ferraz C., Demaille J.G.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Sequence of cosmid L53 of human chromosome 17p13.3 olfactory receptor gene cluster, containing the OR17-32 gene and the OR17-01 pseudogene."
Ferraz C., Vidal S., Brun C., Demaille J.G.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire."
Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H., Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.
Hum. Mol. Genet. 3:229-235(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[7]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[8]"Distribution of olfactory receptor genes in the human genome."
Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G., Demaille J.G., Giorgi D.
Nat. Genet. 18:243-250(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[9]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, VARIANT THR-143.
[10]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64994 Genomic DNA. Translation: CAA46127.1.
AF087916 Genomic DNA. Translation: AAF37309.1.
AF095725 Genomic DNA. Translation: AAF03261.1.
U78308 Genomic DNA. Translation: AAD00276.1.
AF052041 Genomic DNA. Translation: AAD17495.1.
U04642 Genomic DNA. Translation: AAA17447.1.
U04682 Genomic DNA. Translation: AAA18346.1.
AF399550 Genomic DNA. Translation: AAK95035.1.
U86222 Genomic DNA. Translation: AAC39613.1.
U86274 Genomic DNA. Translation: AAC39629.1.
BK004237 Genomic DNA. Translation: DAA04635.1.
BK004353 Genomic DNA. Translation: DAA04751.1.
CCDSCCDS11024.1.
PIRI38470.
I38474.
S20572.
RefSeqNP_003544.2. NM_003553.2.
UniGeneHs.278485.

3D structure databases

ProteinModelPortalP30953.
SMRP30953. Positions 32-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000313384.

Protein family/group databases

TCDB9.A.14.8.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

Polymorphism databases

DMDM400671.

Proteomic databases

PaxDbP30953.
PRIDEP30953.

Protocols and materials databases

DNASU8387.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322608; ENSP00000313384; ENSG00000180016.
GeneID8387.
KEGGhsa:8387.
UCSCuc002fvj.1. human.

Organism-specific databases

CTD8387.
GeneCardsGC17M003300.
H-InvDBHIX0039264.
HGNCHGNC:8189. OR1E1.
neXtProtNX_P30953.
PharmGKBPA32062.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44681.
HOVERGENHBG017625.
InParanoidP30953.
KOK04257.
OMAHQKKTFF.
OrthoDBEOG7JT6WV.
PhylomeDBP30953.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP30953.
CleanExHS_OR1E1.
GenevestigatorP30953.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1E1.
GenomeRNAi8387.
NextBio31396.
PROP30953.

Entry information

Entry nameOR1E1_HUMAN
AccessionPrimary (citable) accession number: P30953
Secondary accession number(s): O43884 expand/collapse secondary AC list , P47882, P47885, Q6IFA9, Q6IFM5, Q9UBJ1, Q9UM60
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries