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P30951

- GPR12_RAT

UniProt

P30951 - GPR12_RAT

Protein

G-protein coupled receptor 12

Gene

Gpr12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Receptor with constitutive G(s) signaling activity that activates cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. phosphatidylcholine binding Source: Ensembl

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 12
    Alternative name(s):
    R334
    Gene namesi
    Name:Gpr12
    Synonyms:Gpcr12
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 12

    Organism-specific databases

    RGDi68333. Gpr12.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334G-protein coupled receptor 12PRO_0000069529Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Lipidationi317 – 3171S-palmitoyl cysteineBy similarity
    Modified residuei330 – 3301PhosphoserineSequence Analysis
    Modified residuei332 – 3321PhosphoserineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Expressioni

    Tissue specificityi

    Expressed in the brain, pituitary gland and testis.2 Publications

    Gene expression databases

    GenevestigatoriP30951.

    Structurei

    3D structure databases

    ProteinModelPortaliP30951.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4848ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini70 – 789CytoplasmicSequence Analysis
    Topological domaini100 – 11314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 15824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 19920ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 25232CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 2829ExtracellularSequence Analysis
    Topological domaini304 – 33431CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei49 – 6921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG309471.
    GeneTreeiENSGT00750000117639.
    HOGENOMiHOG000294075.
    HOVERGENiHBG079561.
    KOiK04315.
    OMAiLTYNSER.
    OrthoDBiEOG7966H0.
    PhylomeDBiP30951.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000599. GPR12.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00650. GPR12ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30951-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEDPKVNLS GLPRDCIEAG TPENISAAVP SQGSVVESEP ELVVNPWDIV    50
    LCSSGTLICC ENAVVVLIIF HSPSLRAPMF LLIGSLALAD LLAGLGLIIN 100
    FVFAYLLQSE ATKLVTIGLI VASFSASVCS LLAITVDRYL SLYYALTYHS 150
    ERTVTFTYVM LVMLWGTSTC LGLLPVMGWN CLRDESTCSV VRPLTKNNAA 200
    ILSISFLFMF ALMLQLYIQI CKIVMRHAHQ IALQHHFLAT SHYVTTRKGI 250
    STLALILGTF AACWMPFTLY SLIADYTYPS IYTYATLLPA TYNSIINPVI 300
    YAFRNQEIQK ALCLICCGCI PNTLSQRARS PSDV 334
    Length:334
    Mass (Da):36,704
    Last modified:October 1, 1996 - v3
    Checksum:iDFA50BEA56141E44
    GO

    Sequence cautioni

    The sequence CAA43713.1 differs from that shown. Reason: Frameshift at positions 151, 160, 175, 177, 193, 311 and 325.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61496 mRNA. Translation: CAA43713.1. Frameshift.
    U12184 mRNA. Translation: AAB60518.1.
    BC127447 mRNA. Translation: AAI27448.1.
    PIRiS18444.
    RefSeqiNP_001032372.1. NM_001037295.1.
    NP_110458.1. NM_030831.1.
    XP_006248901.1. XM_006248839.1.
    UniGeneiRn.88417.

    Genome annotation databases

    EnsembliENSRNOT00000061129; ENSRNOP00000057844; ENSRNOG00000039832.
    GeneIDi80840.
    KEGGirno:80840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61496 mRNA. Translation: CAA43713.1 . Frameshift.
    U12184 mRNA. Translation: AAB60518.1 .
    BC127447 mRNA. Translation: AAI27448.1 .
    PIRi S18444.
    RefSeqi NP_001032372.1. NM_001037295.1.
    NP_110458.1. NM_030831.1.
    XP_006248901.1. XM_006248839.1.
    UniGenei Rn.88417.

    3D structure databases

    ProteinModelPortali P30951.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 86.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000061129 ; ENSRNOP00000057844 ; ENSRNOG00000039832 .
    GeneIDi 80840.
    KEGGi rno:80840.

    Organism-specific databases

    CTDi 2835.
    RGDi 68333. Gpr12.

    Phylogenomic databases

    eggNOGi NOG309471.
    GeneTreei ENSGT00750000117639.
    HOGENOMi HOG000294075.
    HOVERGENi HBG079561.
    KOi K04315.
    OMAi LTYNSER.
    OrthoDBi EOG7966H0.
    PhylomeDBi P30951.

    Miscellaneous databases

    NextBioi 614870.
    PROi P30951.

    Gene expression databases

    Genevestigatori P30951.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000599. GPR12.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00650. GPR12ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and tissue distribution of a candidate G protein-coupled receptor from rat pituitary gland."
      Eidne K.A., Zabavnik J., Peters T., Yoshida S., Anderson L., Taylor P.L.
      FEBS Lett. 292:243-248(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Pituitary.
    2. "A putative rat G protein coupled receptor cDNA isolated from cerebral cortex."
      Bonner T.I., Brownstein M.J.
      Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth."
      Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.
      J. Biol. Chem. 282:10506-10515(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGPR12_RAT
    AccessioniPrimary (citable) accession number: P30951
    Secondary accession number(s): A0JPJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3