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Protein

G-protein coupled receptor 12

Gene

Gpr12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor with constitutive G(s) signaling activity that activates cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 12
Alternative name(s):
R334
Gene namesi
Name:Gpr12
Synonyms:Gpcr12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi68333. Gpr12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 69Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini70 – 78CytoplasmicSequence analysis9
Transmembranei79 – 99Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini100 – 113ExtracellularSequence analysisAdd BLAST14
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 158CytoplasmicSequence analysisAdd BLAST24
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 199ExtracellularSequence analysisAdd BLAST20
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 252CytoplasmicSequence analysisAdd BLAST32
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 282ExtracellularSequence analysis9
Transmembranei283 – 303Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini304 – 334CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695291 – 334G-protein coupled receptor 12Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Lipidationi317S-palmitoyl cysteineBy similarity1
Modified residuei330PhosphoserineSequence analysis1
Modified residuei332PhosphoserineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP30951.

PTM databases

PhosphoSitePlusiP30951.

Expressioni

Tissue specificityi

Expressed in the brain, pituitary gland and testis.2 Publications

Gene expression databases

BgeeiENSRNOG00000039832.
GenevisibleiP30951. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057844.

Structurei

3D structure databases

ProteinModelPortaliP30951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiP30951.
KOiK04315.
OMAiICCENAV.
OrthoDBiEOG091G0CNB.
PhylomeDBiP30951.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000599. GPR12.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00650. GPR12ORPHANR.
PR00644. GPRORPHANR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEDPKVNLS GLPRDCIEAG TPENISAAVP SQGSVVESEP ELVVNPWDIV
60 70 80 90 100
LCSSGTLICC ENAVVVLIIF HSPSLRAPMF LLIGSLALAD LLAGLGLIIN
110 120 130 140 150
FVFAYLLQSE ATKLVTIGLI VASFSASVCS LLAITVDRYL SLYYALTYHS
160 170 180 190 200
ERTVTFTYVM LVMLWGTSTC LGLLPVMGWN CLRDESTCSV VRPLTKNNAA
210 220 230 240 250
ILSISFLFMF ALMLQLYIQI CKIVMRHAHQ IALQHHFLAT SHYVTTRKGI
260 270 280 290 300
STLALILGTF AACWMPFTLY SLIADYTYPS IYTYATLLPA TYNSIINPVI
310 320 330
YAFRNQEIQK ALCLICCGCI PNTLSQRARS PSDV
Length:334
Mass (Da):36,704
Last modified:October 1, 1996 - v3
Checksum:iDFA50BEA56141E44
GO

Sequence cautioni

The sequence CAA43713 differs from that shown. Reason: Frameshift at positions 151, 160, 175, 177, 193, 311 and 325.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61496 mRNA. Translation: CAA43713.1. Frameshift.
U12184 mRNA. Translation: AAB60518.1.
BC127447 mRNA. Translation: AAI27448.1.
PIRiS18444.
RefSeqiNP_001032372.1. NM_001037295.1.
NP_110458.1. NM_030831.1.
XP_017453953.1. XM_017598464.1.
UniGeneiRn.88417.

Genome annotation databases

EnsembliENSRNOT00000061129; ENSRNOP00000057844; ENSRNOG00000039832.
ENSRNOT00000092720; ENSRNOP00000075912; ENSRNOG00000039832.
GeneIDi80840.
KEGGirno:80840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61496 mRNA. Translation: CAA43713.1. Frameshift.
U12184 mRNA. Translation: AAB60518.1.
BC127447 mRNA. Translation: AAI27448.1.
PIRiS18444.
RefSeqiNP_001032372.1. NM_001037295.1.
NP_110458.1. NM_030831.1.
XP_017453953.1. XM_017598464.1.
UniGeneiRn.88417.

3D structure databases

ProteinModelPortaliP30951.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057844.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP30951.

Proteomic databases

PaxDbiP30951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000061129; ENSRNOP00000057844; ENSRNOG00000039832.
ENSRNOT00000092720; ENSRNOP00000075912; ENSRNOG00000039832.
GeneIDi80840.
KEGGirno:80840.

Organism-specific databases

CTDi2835.
RGDi68333. Gpr12.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiP30951.
KOiK04315.
OMAiICCENAV.
OrthoDBiEOG091G0CNB.
PhylomeDBiP30951.

Miscellaneous databases

PROiP30951.

Gene expression databases

BgeeiENSRNOG00000039832.
GenevisibleiP30951. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000599. GPR12.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00650. GPR12ORPHANR.
PR00644. GPRORPHANR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR12_RAT
AccessioniPrimary (citable) accession number: P30951
Secondary accession number(s): A0JPJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.