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P30951

- GPR12_RAT

UniProt

P30951 - GPR12_RAT

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Protein

G-protein coupled receptor 12

Gene

Gpr12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor with constitutive G(s) signaling activity that activates cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. phosphatidylcholine binding Source: Ensembl

GO - Biological processi

  1. cellular calcium ion homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 12
Alternative name(s):
R334
Gene namesi
Name:Gpr12
Synonyms:Gpcr12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 12

Organism-specific databases

RGDi68333. Gpr12.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334G-protein coupled receptor 12PRO_0000069529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Lipidationi317 – 3171S-palmitoyl cysteineBy similarity
Modified residuei330 – 3301PhosphoserineSequence Analysis
Modified residuei332 – 3321PhosphoserineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Expressioni

Tissue specificityi

Expressed in the brain, pituitary gland and testis.2 Publications

Gene expression databases

GenevestigatoriP30951.

Structurei

3D structure databases

ProteinModelPortaliP30951.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848ExtracellularSequence AnalysisAdd
BLAST
Topological domaini70 – 789CytoplasmicSequence Analysis
Topological domaini100 – 11314ExtracellularSequence AnalysisAdd
BLAST
Topological domaini135 – 15824CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini180 – 19920ExtracellularSequence AnalysisAdd
BLAST
Topological domaini221 – 25232CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini274 – 2829ExtracellularSequence Analysis
Topological domaini304 – 33431CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei79 – 9921Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei114 – 13421Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei283 – 30321Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG309471.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiP30951.
KOiK04315.
OMAiLTYNSER.
OrthoDBiEOG7966H0.
PhylomeDBiP30951.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000599. GPR12.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00650. GPR12ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30951-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEDPKVNLS GLPRDCIEAG TPENISAAVP SQGSVVESEP ELVVNPWDIV
60 70 80 90 100
LCSSGTLICC ENAVVVLIIF HSPSLRAPMF LLIGSLALAD LLAGLGLIIN
110 120 130 140 150
FVFAYLLQSE ATKLVTIGLI VASFSASVCS LLAITVDRYL SLYYALTYHS
160 170 180 190 200
ERTVTFTYVM LVMLWGTSTC LGLLPVMGWN CLRDESTCSV VRPLTKNNAA
210 220 230 240 250
ILSISFLFMF ALMLQLYIQI CKIVMRHAHQ IALQHHFLAT SHYVTTRKGI
260 270 280 290 300
STLALILGTF AACWMPFTLY SLIADYTYPS IYTYATLLPA TYNSIINPVI
310 320 330
YAFRNQEIQK ALCLICCGCI PNTLSQRARS PSDV
Length:334
Mass (Da):36,704
Last modified:October 1, 1996 - v3
Checksum:iDFA50BEA56141E44
GO

Sequence cautioni

The sequence CAA43713.1 differs from that shown. Reason: Frameshift at positions 151, 160, 175, 177, 193, 311 and 325.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61496 mRNA. Translation: CAA43713.1. Frameshift.
U12184 mRNA. Translation: AAB60518.1.
BC127447 mRNA. Translation: AAI27448.1.
PIRiS18444.
RefSeqiNP_001032372.1. NM_001037295.1.
NP_110458.1. NM_030831.1.
UniGeneiRn.88417.

Genome annotation databases

EnsembliENSRNOT00000061129; ENSRNOP00000057844; ENSRNOG00000039832.
GeneIDi80840.
KEGGirno:80840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61496 mRNA. Translation: CAA43713.1 . Frameshift.
U12184 mRNA. Translation: AAB60518.1 .
BC127447 mRNA. Translation: AAI27448.1 .
PIRi S18444.
RefSeqi NP_001032372.1. NM_001037295.1.
NP_110458.1. NM_030831.1.
UniGenei Rn.88417.

3D structure databases

ProteinModelPortali P30951.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 86.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000061129 ; ENSRNOP00000057844 ; ENSRNOG00000039832 .
GeneIDi 80840.
KEGGi rno:80840.

Organism-specific databases

CTDi 2835.
RGDi 68333. Gpr12.

Phylogenomic databases

eggNOGi NOG309471.
GeneTreei ENSGT00760000118804.
HOGENOMi HOG000294075.
HOVERGENi HBG079561.
InParanoidi P30951.
KOi K04315.
OMAi LTYNSER.
OrthoDBi EOG7966H0.
PhylomeDBi P30951.

Miscellaneous databases

NextBioi 614870.
PROi P30951.

Gene expression databases

Genevestigatori P30951.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000599. GPR12.
IPR000723. GPR_3/6/12_orphan.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00650. GPR12ORPHANR.
PR00644. GPRORPHANR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and tissue distribution of a candidate G protein-coupled receptor from rat pituitary gland."
    Eidne K.A., Zabavnik J., Peters T., Yoshida S., Anderson L., Taylor P.L.
    FEBS Lett. 292:243-248(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Pituitary.
  2. "A putative rat G protein coupled receptor cDNA isolated from cerebral cortex."
    Bonner T.I., Brownstein M.J.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth."
    Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.
    J. Biol. Chem. 282:10506-10515(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR12_RAT
AccessioniPrimary (citable) accession number: P30951
Secondary accession number(s): A0JPJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3