Reviewed, UniProtKB/Swiss-Prot P30945 (SCG2_RANRI)

Names and origin

Protein names	Recommended name:     Secretogranin-2 Alternative name(s):     Secretogranin II       Short name=SgII Cleaved into the following chain:     1- Recommended name:             Secretoneurin                 Short name=SN         Alternative name(s):             Brain peptide
Organism	Rana ridibunda (Laughing frog) (Marsh frog)
Taxonomic identifier	8406 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Rana › Pelophylax

Protein attributes

Sequence length	601 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be important in regulation of neurosecretion.
Subcellular location	Secretogranin-2: Cytoplasmic vesicle › secretory vesicle By similarity. Secretoneurin: Secreted By similarity.
Sequence similarities	Belongs to the chromogranin/secretogranin protein family.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Secreted
Domain	Signal
PTM	Cleavage on pair of basic residues Sulfation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW secretory granule Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	By similarity
	Chain	31 – 601	571	Secretogranin-2		PRO_0000005459
	Peptide	183 – 215	33	Secretoneurin		PRO_0000005460
Amino acid modifications
	Modified residue	151	1	Sulfotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30945-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 8D16FDAA1280A712	FASTA	601	69,900
	10 20 30 40 50 60 MSSQRNYCLA GCLSSCILVI LMSFSDAASF QYYQVPQQDQ EYRMKTLQRL PSPDMLKALE 70 80 90 100 110 120 YIENLRKQAS RTESLPDYTS YQGAPFLSEQ KDTQALSTDT AKSPTSDDES EWMRAMLEAL 130 140 150 160 170 180 MQAEKEAKVS PQEKNNLYMD KNIPPELIED YDSNKWSEKR PKAGKFSSRL YDDYSRDNPL 190 200 210 220 230 240 KRTNEIVEGQ YTPQSLATLQ SVFQELGKLK GQANNKRDRM EEDQKLYKDD EDDLYKANNI 250 260 270 280 290 300 AYEDVAGGED WNPIEEKVES QTQEELKESK EEVEKTDDME DEIKRSGLLG LQDEEPEKDT 310 320 330 340 350 360 KEQESENLSN LMNTYLNMWM NRMDKGKQNP DRRSLRFSGK ELDPEAIYQL IDISRNLQIP 370 380 390 400 410 420 PEDLIDMLRD EDGRKFGGRL ESEKEVDVPL DLDEVTETMT DKTNVYKNKQ GFVRQPTSPV 430 440 450 460 470 480 LPNIPEGLTV EDMVNLMGAD KLQNRFKQNN GLQRPYPMLS KIKGHKAIWP KESEKRQIEY 490 500 510 520 530 540 ESRPEKEEEL ADYVVKMLAK YPELLGNNQN KKMPIPYSAG DLQELEKQYE NALRGYVNMR 550 560 570 580 590 600 GYQDLETVSS SNRRLSTREN DDTQNKQYID EDLLMKVLEY LNQEKAEKAR DHSVKRSMEN M

References

[1]	"Molecular cloning of frog secretogranin II reveals the occurrence of several highly conserved potential regulatory peptides." Anouar Y., Jegou S., Alexandre D., Lihrmann I., Conlon J.M., Vaudry H. FEBS Lett. 394:295-299(1996) [PubMed: 8830661] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.
[2]	"Identification of a peptide arising from the specific post-translation processing of secretogranin II." Vaudry H., Conlon J.M. FEBS Lett. 284:31-33(1991) [PubMed: 2060624] [Abstract] Cited for: PROTEIN SEQUENCE OF 183-215. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U68757 mRNA. Translation: AAB17470.1.
PIR	S74239.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P30945.
Family and domain databases
InterPro	IPR018054. Chromogranin_CS. IPR001990. Granin. [Graphical view]
Pfam	PF01271. Granin. 1 hit. [Graphical view]
PROSITE	PS00422. GRANINS_1. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCG2_RANRI

Accession

Primary (citable) accession number: P30945

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)