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Protein

5-hydroxytryptamine receptor 1F

Gene

Htr1f

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1F
Short name:
5-HT-1F
Short name:
5-HT1F
Alternative name(s):
Serotonin receptor 1F
Gene namesi
Name:Htr1f
Synonyms:5ht1f
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71083. Htr1f.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 50Helical; Name=1By similarityAdd BLAST21
Topological domaini51 – 60CytoplasmicBy similarity10
Transmembranei61 – 83Helical; Name=2By similarityAdd BLAST23
Topological domaini84 – 97ExtracellularBy similarityAdd BLAST14
Transmembranei98 – 118Helical; Name=3By similarityAdd BLAST21
Topological domaini119 – 140CytoplasmicBy similarityAdd BLAST22
Transmembranei141 – 161Helical; Name=4By similarityAdd BLAST21
Topological domaini162 – 178ExtracellularBy similarityAdd BLAST17
Transmembranei179 – 201Helical; Name=5By similarityAdd BLAST23
Topological domaini202 – 290CytoplasmicBy similarityAdd BLAST89
Transmembranei291 – 311Helical; Name=6By similarityAdd BLAST21
Topological domaini312 – 329ExtracellularBy similarityAdd BLAST18
Transmembranei330 – 350Helical; Name=7By similarityAdd BLAST21
Topological domaini351 – 366CytoplasmicBy similarityAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4646.
GuidetoPHARMACOLOGYi5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689401 – 3665-hydroxytryptamine receptor 1FAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30940.
PRIDEiP30940.

PTM databases

PhosphoSitePlusiP30940.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000907.

Chemistry databases

BindingDBiP30940.

Structurei

3D structure databases

ProteinModelPortaliP30940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 108Agonist bindingBy similarity10
Regioni306 – 310Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi120 – 122DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi343 – 347NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30940.
PhylomeDBiP30940.

Family and domain databases

InterProiIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NCLVITAIIV
60 70 80 90 100
TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQGLCDLWL
110 120 130 140 150
SVDIICCTCS ILHLSAIALD RYRAITDAVE YARKRTPRHA GITITTVWVI
160 170 180 190 200
SVFISVPPLF WRHQGNSRDD QCIIKHDHIV STIYSTFGAF YIPLVLILIL
210 220 230 240 250
YYKIYRAART LYHKRQASRM IKEELNGQVL LESGEKSIKL VSTSYMLEKS
260 270 280 290 300
LSDPSTDFDR IHSTVKSPRS ELKHEKSWRR QKISGTRERK AATTLGLILG
310 320 330 340 350
AFVICWLPFF VKELVVNICE KCKISEEMSN FLAWLGYLNS LINPLIYTIF
360
NEDFKKAFQK LVRCRN
Length:366
Mass (Da):41,880
Last modified:July 1, 1993 - v1
Checksum:i0672868A41DFDBFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05596 Genomic DNA. Translation: AAA42133.1.
PIRiA47385.
UniGeneiRn.44301.

Genome annotation databases

UCSCiRGD:71083. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05596 Genomic DNA. Translation: AAA42133.1.
PIRiA47385.
UniGeneiRn.44301.

3D structure databases

ProteinModelPortaliP30940.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000907.

Chemistry databases

BindingDBiP30940.
ChEMBLiCHEMBL4646.
GuidetoPHARMACOLOGYi5.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP30940.

Proteomic databases

PaxDbiP30940.
PRIDEiP30940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:71083. rat.

Organism-specific databases

RGDi71083. Htr1f.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30940.
PhylomeDBiP30940.

Miscellaneous databases

PROiP30940.

Family and domain databases

InterProiIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT1F_RAT
AccessioniPrimary (citable) accession number: P30940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.