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P30940

- 5HT1F_RAT

UniProt

P30940 - 5HT1F_RAT

Protein

5-hydroxytryptamine receptor 1F

Gene

Htr1f

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

    GO - Molecular functioni

    1. serotonin receptor activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
    2. serotonin receptor signaling pathway Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 1F
    Short name:
    5-HT-1F
    Short name:
    5-HT1F
    Alternative name(s):
    Serotonin receptor 1F
    Gene namesi
    Name:Htr1f
    Synonyms:5ht1f
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi71083. Htr1f.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3663665-hydroxytryptamine receptor 1FPRO_0000068940Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 172PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP30940.

    PTM databases

    PhosphoSiteiP30940.

    Expressioni

    Gene expression databases

    GenevestigatoriP30940.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000907.

    Structurei

    3D structure databases

    ProteinModelPortaliP30940.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularBy similarityAdd
    BLAST
    Topological domaini51 – 6010CytoplasmicBy similarity
    Topological domaini84 – 9714ExtracellularBy similarityAdd
    BLAST
    Topological domaini119 – 14022CytoplasmicBy similarityAdd
    BLAST
    Topological domaini162 – 17817ExtracellularBy similarityAdd
    BLAST
    Topological domaini202 – 29089CytoplasmicBy similarityAdd
    BLAST
    Topological domaini312 – 32918ExtracellularBy similarityAdd
    BLAST
    Topological domaini351 – 36616CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1By similarityAdd
    BLAST
    Transmembranei61 – 8323Helical; Name=2By similarityAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3By similarityAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4By similarityAdd
    BLAST
    Transmembranei179 – 20123Helical; Name=5By similarityAdd
    BLAST
    Transmembranei291 – 31121Helical; Name=6By similarityAdd
    BLAST
    Transmembranei330 – 35021Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni99 – 10810Agonist bindingBy similarity
    Regioni306 – 3105Agonist bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi120 – 1223DRY motif; important for ligand-induced conformation changesBy similarity
    Motifi343 – 3475NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP30940.
    PhylomeDBiP30940.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000450. 5HT1F_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00515. 5HT1FRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30940-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NCLVITAIIV    50
    TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQGLCDLWL 100
    SVDIICCTCS ILHLSAIALD RYRAITDAVE YARKRTPRHA GITITTVWVI 150
    SVFISVPPLF WRHQGNSRDD QCIIKHDHIV STIYSTFGAF YIPLVLILIL 200
    YYKIYRAART LYHKRQASRM IKEELNGQVL LESGEKSIKL VSTSYMLEKS 250
    LSDPSTDFDR IHSTVKSPRS ELKHEKSWRR QKISGTRERK AATTLGLILG 300
    AFVICWLPFF VKELVVNICE KCKISEEMSN FLAWLGYLNS LINPLIYTIF 350
    NEDFKKAFQK LVRCRN 366
    Length:366
    Mass (Da):41,880
    Last modified:July 1, 1993 - v1
    Checksum:i0672868A41DFDBFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05596 Genomic DNA. Translation: AAA42133.1.
    PIRiA47385.
    UniGeneiRn.44301.

    Genome annotation databases

    UCSCiRGD:71083. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05596 Genomic DNA. Translation: AAA42133.1 .
    PIRi A47385.
    UniGenei Rn.44301.

    3D structure databases

    ProteinModelPortali P30940.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000907.

    Chemistry

    BindingDBi P30940.
    ChEMBLi CHEMBL4646.
    GuidetoPHARMACOLOGYi 5.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30940.

    Proteomic databases

    PRIDEi P30940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:71083. rat.

    Organism-specific databases

    RGDi 71083. Htr1f.

    Phylogenomic databases

    eggNOGi NOG249628.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P30940.
    PhylomeDBi P30940.

    Miscellaneous databases

    NextBioi 13949457.
    PROi P30940.

    Gene expression databases

    Genevestigatori P30940.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000450. 5HT1F_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF34. PTHR24247:SF34. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00515. 5HT1FRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes."
      Lovenberg T.W., Erlander M.G., Baron B.M., Racke M., Slone A.L., Siegel B.W., Craft C.M., Burns J.E., Danielson P.E., Sutcliffe G.J.
      Proc. Natl. Acad. Sci. U.S.A. 90:2184-2188(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry namei5HT1F_RAT
    AccessioniPrimary (citable) accession number: P30940
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3