Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P30940 (5HT1F_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 1F

Short name=5-HT-1F
Short name=5-HT1F
Alternative name(s):
Serotonin receptor 1F
Gene names
Name:Htr1f
Synonyms:5ht1f
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3663665-hydroxytryptamine receptor 1F
PRO_0000068940

Regions

Topological domain1 – 2929Extracellular By similarity
Transmembrane30 – 5021Helical; Name=1; By similarity
Topological domain51 – 6010Cytoplasmic By similarity
Transmembrane61 – 8323Helical; Name=2; By similarity
Topological domain84 – 9714Extracellular By similarity
Transmembrane98 – 11821Helical; Name=3; By similarity
Topological domain119 – 14022Cytoplasmic By similarity
Transmembrane141 – 16121Helical; Name=4; By similarity
Topological domain162 – 17817Extracellular By similarity
Transmembrane179 – 20123Helical; Name=5; By similarity
Topological domain202 – 29089Cytoplasmic By similarity
Transmembrane291 – 31121Helical; Name=6; By similarity
Topological domain312 – 32918Extracellular By similarity
Transmembrane330 – 35021Helical; Name=7; By similarity
Topological domain351 – 36616Cytoplasmic By similarity
Region99 – 10810Agonist binding By similarity
Region306 – 3105Agonist binding By similarity
Motif120 – 1223DRY motif; important for ligand-induced conformation changes By similarity
Motif343 – 3475NPxxY motif; important for ligand-induced conformation changes and signaling By similarity

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 172 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30940 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 0672868A41DFDBFB

FASTA36641,880
        10         20         30         40         50         60 
MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NCLVITAIIV TRKLHHPANY 

        70         80         90        100        110        120 
LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQGLCDLWL SVDIICCTCS ILHLSAIALD 

       130        140        150        160        170        180 
RYRAITDAVE YARKRTPRHA GITITTVWVI SVFISVPPLF WRHQGNSRDD QCIIKHDHIV 

       190        200        210        220        230        240 
STIYSTFGAF YIPLVLILIL YYKIYRAART LYHKRQASRM IKEELNGQVL LESGEKSIKL 

       250        260        270        280        290        300 
VSTSYMLEKS LSDPSTDFDR IHSTVKSPRS ELKHEKSWRR QKISGTRERK AATTLGLILG 

       310        320        330        340        350        360 
AFVICWLPFF VKELVVNICE KCKISEEMSN FLAWLGYLNS LINPLIYTIF NEDFKKAFQK 


LVRCRN 

« Hide

References

[1]"Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes."
Lovenberg T.W., Erlander M.G., Baron B.M., Racke M., Slone A.L., Siegel B.W., Craft C.M., Burns J.E., Danielson P.E., Sutcliffe G.J.
Proc. Natl. Acad. Sci. U.S.A. 90:2184-2188(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05596 Genomic DNA. Translation: AAA42133.1.
PIRA47385.
UniGeneRn.44301.

3D structure databases

ProteinModelPortalP30940.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000000907.

Chemistry

BindingDBP30940.
ChEMBLCHEMBL4646.
GuidetoPHARMACOLOGY5.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30940.

Proteomic databases

PRIDEP30940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:71083. rat.

Organism-specific databases

RGD71083. Htr1f.

Phylogenomic databases

eggNOGNOG249628.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP30940.
PhylomeDBP30940.

Gene expression databases

GenevestigatorP30940.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13949457.
PROP30940.

Entry information

Entry name5HT1F_RAT
AccessionPrimary (citable) accession number: P30940
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries