P30940 (5HT1F_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 1F
Short name=5-HT-1F
Short name=5-HT1F

Alternative name(s):
Serotonin receptor 1F

Gene names

Name:	Htr1f
Synonyms:	5ht1f

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	serotonin receptor signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serotonin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	5-hydroxytryptamine receptor 1F		PRO_0000068940
Regions
	Topological domain	1 – 29	29	Extracellular By similarity
	Transmembrane	30 – 50	21	Helical; Name=1; By similarity
	Topological domain	51 – 64	14	Cytoplasmic By similarity
	Transmembrane	65 – 85	21	Helical; Name=2; By similarity
	Topological domain	86 – 97	12	Extracellular By similarity
	Transmembrane	98 – 118	21	Helical; Name=3; By similarity
	Topological domain	119 – 140	22	Cytoplasmic By similarity
	Transmembrane	141 – 161	21	Helical; Name=4; By similarity
	Topological domain	162 – 178	17	Extracellular By similarity
	Transmembrane	179 – 199	21	Helical; Name=5; By similarity
	Topological domain	200 – 290	91	Cytoplasmic By similarity
	Transmembrane	291 – 311	21	Helical; Name=6; By similarity
	Topological domain	312 – 329	18	Extracellular By similarity
	Transmembrane	330 – 350	21	Helical; Name=7; By similarity
	Topological domain	351 – 366	16	Cytoplasmic By similarity
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 172		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30940 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 0672868A41DFDBFB	FASTA	366	41,880
	10 20 30 40 50 60 MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NCLVITAIIV TRKLHHPANY 70 80 90 100 110 120 LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQGLCDLWL SVDIICCTCS ILHLSAIALD 130 140 150 160 170 180 RYRAITDAVE YARKRTPRHA GITITTVWVI SVFISVPPLF WRHQGNSRDD QCIIKHDHIV 190 200 210 220 230 240 STIYSTFGAF YIPLVLILIL YYKIYRAART LYHKRQASRM IKEELNGQVL LESGEKSIKL 250 260 270 280 290 300 VSTSYMLEKS LSDPSTDFDR IHSTVKSPRS ELKHEKSWRR QKISGTRERK AATTLGLILG 310 320 330 340 350 360 AFVICWLPFF VKELVVNICE KCKISEEMSN FLAWLGYLNS LINPLIYTIF NEDFKKAFQK LVRCRN

References

[1]	"Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes." Lovenberg T.W., Erlander M.G., Baron B.M., Racke M., Slone A.L., Siegel B.W., Craft C.M., Burns J.E., Danielson P.E., Sutcliffe G.J. Proc. Natl. Acad. Sci. U.S.A. 90:2184-2188(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L05596 Genomic DNA. Translation: AAA42133.1.
IPI	IPI00213681.
PIR	A47385.
3D structure databases
ProteinModelPortal	P30940.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000000907.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P30940.
Proteomic databases
PRIDE	P30940.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:71083. rat.
Organism-specific databases
RGD	71083. Htr1f.
Phylogenomic databases
eggNOG	NOG249628.
HOGENOM	HOG000239242.
HOVERGEN	HBG106962.
InParanoid	P30940.
OrthoDB	EOG43XV41.
Gene expression databases
Genevestigator	P30940.
GermOnline	ENSRNOG00000000716. Rattus norvegicus.
Family and domain databases
InterPro	IPR000450. 5HT1F_rcpt. IPR002231. 5HT_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00515. 5HT1FRECEPTR. PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P30940.
ChEMBL	CHEMBL4646.
NextBio	13949457.

Entry information

Entry name

5HT1F_RAT

Accession

Primary (citable) accession number: P30940

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program