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Protein

5-hydroxytryptamine receptor 1F

Gene

HTR1F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.3 Publications

GO - Molecular functioni

  • serotonin binding Source: MGI
  • serotonin receptor activity Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • serotonin receptor signaling pathway Source: GOC
  • synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_17064. Serotonin receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1F
Short name:
5-HT-1F
Short name:
5-HT1F
Alternative name(s):
Serotonin receptor 1F
Gene namesi
Name:HTR1F
Synonyms:HTR1EL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:5292. HTR1F.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularBy similarityAdd
BLAST
Transmembranei30 – 5021Helical; Name=1By similarityAdd
BLAST
Topological domaini51 – 6010CytoplasmicBy similarity
Transmembranei61 – 8323Helical; Name=2By similarityAdd
BLAST
Topological domaini84 – 9714ExtracellularBy similarityAdd
BLAST
Transmembranei98 – 11821Helical; Name=3By similarityAdd
BLAST
Topological domaini119 – 14022CytoplasmicBy similarityAdd
BLAST
Transmembranei141 – 16121Helical; Name=4By similarityAdd
BLAST
Topological domaini162 – 17817ExtracellularBy similarityAdd
BLAST
Transmembranei179 – 20123Helical; Name=5By similarityAdd
BLAST
Topological domaini202 – 29089CytoplasmicBy similarityAdd
BLAST
Transmembranei291 – 31121Helical; Name=6By similarityAdd
BLAST
Topological domaini312 – 32918ExtracellularBy similarityAdd
BLAST
Transmembranei330 – 35021Helical; Name=7By similarityAdd
BLAST
Topological domaini351 – 36616CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29553.

Chemistry

DrugBankiDB00216. Eletriptan.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB01221. Ketamine.
DB00247. Methysergide.
DB06148. Mianserin.
DB00952. Naratriptan.
DB00953. Rizatriptan.
DB00669. Sumatriptan.
DB00315. Zolmitriptan.

Polymorphism and mutation databases

BioMutaiHTR1F.
DMDMi398967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3663665-hydroxytryptamine receptor 1FPRO_0000068937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30939.
PRIDEiP30939.

PTM databases

PhosphoSiteiP30939.

Expressioni

Gene expression databases

BgeeiP30939.
CleanExiHS_HTR1F.
GenevisibleiP30939. HS.

Organism-specific databases

HPAiHPA005555.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322924.

Structurei

3D structure databases

ProteinModelPortaliP30939.
SMRiP30939. Positions 20-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 10810Agonist bindingBy similarity
Regioni306 – 3105Agonist bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi120 – 1223DRY motif; important for ligand-induced conformation changesBy similarity
Motifi343 – 3475NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30939.
KOiK04153.
OMAiVVNVCEK.
OrthoDBiEOG7NCV3Q.
PhylomeDBiP30939.
TreeFamiTF316350.

Family and domain databases

InterProiIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV
60 70 80 90 100
TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL
110 120 130 140 150
SVDITCCTCS ILHLSAIALD RYRAITDAVE YARKRTPKHA GIMITIVWII
160 170 180 190 200
SVFISMPPLF WRHQGTSRDD ECIIKHDHIV STIYSTFGAF YIPLALILIL
210 220 230 240 250
YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS VSTSYVLEKS
260 270 280 290 300
LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG
310 320 330 340 350
AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF
360
NEDFKKAFQK LVRCRC
Length:366
Mass (Da):41,709
Last modified:July 1, 1993 - v1
Checksum:i16EA80344793B54F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05597 Genomic DNA. Translation: AAA36605.1.
L04962 Genomic DNA. Translation: AAA36646.1.
AF498981 mRNA. Translation: AAM21128.1.
AC119733 Genomic DNA. No translation available.
BC069125 mRNA. Translation: AAH69125.1.
CCDSiCCDS2920.1.
PIRiA47321.
RefSeqiNP_000857.1. NM_000866.3.
XP_005264804.1. XM_005264747.2.
XP_005264805.1. XM_005264748.3.
XP_005264806.1. XM_005264749.2.
XP_005264807.1. XM_005264750.2.
XP_005264808.1. XM_005264751.2.
UniGeneiHs.248136.

Genome annotation databases

EnsembliENST00000319595; ENSP00000322924; ENSG00000179097.
GeneIDi3355.
KEGGihsa:3355.
UCSCiuc003dqr.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05597 Genomic DNA. Translation: AAA36605.1.
L04962 Genomic DNA. Translation: AAA36646.1.
AF498981 mRNA. Translation: AAM21128.1.
AC119733 Genomic DNA. No translation available.
BC069125 mRNA. Translation: AAH69125.1.
CCDSiCCDS2920.1.
PIRiA47321.
RefSeqiNP_000857.1. NM_000866.3.
XP_005264804.1. XM_005264747.2.
XP_005264805.1. XM_005264748.3.
XP_005264806.1. XM_005264749.2.
XP_005264807.1. XM_005264750.2.
XP_005264808.1. XM_005264751.2.
UniGeneiHs.248136.

3D structure databases

ProteinModelPortaliP30939.
SMRiP30939. Positions 20-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322924.

Chemistry

BindingDBiP30939.
ChEMBLiCHEMBL2096904.
DrugBankiDB00216. Eletriptan.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB01221. Ketamine.
DB00247. Methysergide.
DB06148. Mianserin.
DB00952. Naratriptan.
DB00953. Rizatriptan.
DB00669. Sumatriptan.
DB00315. Zolmitriptan.
GuidetoPHARMACOLOGYi5.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30939.

Polymorphism and mutation databases

BioMutaiHTR1F.
DMDMi398967.

Proteomic databases

PaxDbiP30939.
PRIDEiP30939.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319595; ENSP00000322924; ENSG00000179097.
GeneIDi3355.
KEGGihsa:3355.
UCSCiuc003dqr.2. human.

Organism-specific databases

CTDi3355.
GeneCardsiGC03P088031.
H-InvDBHIX0163359.
HGNCiHGNC:5292. HTR1F.
HPAiHPA005555.
MIMi182134. gene.
neXtProtiNX_P30939.
PharmGKBiPA29553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30939.
KOiK04153.
OMAiVVNVCEK.
OrthoDBiEOG7NCV3Q.
PhylomeDBiP30939.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiREACT_17064. Serotonin receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii5-HT1F_receptor.
GenomeRNAii3355.
NextBioi13266.
PROiP30939.
SOURCEiSearch...

Gene expression databases

BgeeiP30939.
CleanExiHS_HTR1F.
GenevisibleiP30939. HS.

Family and domain databases

InterProiIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes."
    Lovenberg T.W., Erlander M.G., Baron B.M., Racke M., Slone A.L., Siegel B.W., Craft C.M., Burns J.E., Danielson P.E., Sutcliffe G.J.
    Proc. Natl. Acad. Sci. U.S.A. 90:2184-2188(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase."
    Adham N., Kao H.-T., Schechter L.E., Bard J., Olsen M., Urquhart D., Durkin M., Hartig P.R., Winshank R.L., Branchek T.A.
    Proc. Natl. Acad. Sci. U.S.A. 90:408-412(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: REVIEW.
  7. "Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships."
    Klein M.T., Dukat M., Glennon R.A., Teitler M.
    J. Pharmacol. Exp. Ther. 337:860-867(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Serotonin receptors - from molecular biology to clinical applications."
    Pytliak M., Vargova V., Mechirova V., Felsoci M.
    Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry namei5HT1F_HUMAN
AccessioniPrimary (citable) accession number: P30939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 24, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.