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P30939

- 5HT1F_HUMAN

UniProt

P30939 - 5HT1F_HUMAN

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Protein

5-hydroxytryptamine receptor 1F

Gene

HTR1F

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.3 Publications

GO - Molecular functioni

  1. serotonin binding Source: MGI
  2. serotonin receptor activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
  2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  3. serotonin receptor signaling pathway Source: GOC
  4. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_17064. Serotonin receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1F
Short name:
5-HT-1F
Short name:
5-HT1F
Alternative name(s):
Serotonin receptor 1F
Gene namesi
Name:HTR1F
Synonyms:HTR1EL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:5292. HTR1F.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularBy similarityAdd
BLAST
Transmembranei30 – 5021Helical; Name=1By similarityAdd
BLAST
Topological domaini51 – 6010CytoplasmicBy similarity
Transmembranei61 – 8323Helical; Name=2By similarityAdd
BLAST
Topological domaini84 – 9714ExtracellularBy similarityAdd
BLAST
Transmembranei98 – 11821Helical; Name=3By similarityAdd
BLAST
Topological domaini119 – 14022CytoplasmicBy similarityAdd
BLAST
Transmembranei141 – 16121Helical; Name=4By similarityAdd
BLAST
Topological domaini162 – 17817ExtracellularBy similarityAdd
BLAST
Transmembranei179 – 20123Helical; Name=5By similarityAdd
BLAST
Topological domaini202 – 29089CytoplasmicBy similarityAdd
BLAST
Transmembranei291 – 31121Helical; Name=6By similarityAdd
BLAST
Topological domaini312 – 32918ExtracellularBy similarityAdd
BLAST
Transmembranei330 – 35021Helical; Name=7By similarityAdd
BLAST
Topological domaini351 – 36616CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3663665-hydroxytryptamine receptor 1FPRO_0000068937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30939.
PRIDEiP30939.

PTM databases

PhosphoSiteiP30939.

Expressioni

Gene expression databases

BgeeiP30939.
CleanExiHS_HTR1F.
ExpressionAtlasiP30939. baseline and differential.
GenevestigatoriP30939.

Organism-specific databases

HPAiHPA005555.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322924.

Structurei

3D structure databases

ProteinModelPortaliP30939.
SMRiP30939. Positions 20-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 10810Agonist bindingBy similarity
Regioni306 – 3105Agonist bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi120 – 1223DRY motif; important for ligand-induced conformation changesBy similarity
Motifi343 – 3475NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30939.
KOiK04153.
OMAiVVNVCEK.
OrthoDBiEOG7NCV3Q.
PhylomeDBiP30939.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30939-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV
60 70 80 90 100
TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL
110 120 130 140 150
SVDITCCTCS ILHLSAIALD RYRAITDAVE YARKRTPKHA GIMITIVWII
160 170 180 190 200
SVFISMPPLF WRHQGTSRDD ECIIKHDHIV STIYSTFGAF YIPLALILIL
210 220 230 240 250
YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS VSTSYVLEKS
260 270 280 290 300
LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG
310 320 330 340 350
AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF
360
NEDFKKAFQK LVRCRC
Length:366
Mass (Da):41,709
Last modified:July 1, 1993 - v1
Checksum:i16EA80344793B54F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05597 Genomic DNA. Translation: AAA36605.1.
L04962 Genomic DNA. Translation: AAA36646.1.
AF498981 mRNA. Translation: AAM21128.1.
AC119733 Genomic DNA. No translation available.
BC069125 mRNA. Translation: AAH69125.1.
CCDSiCCDS2920.1.
PIRiA47321.
RefSeqiNP_000857.1. NM_000866.3.
XP_005264804.1. XM_005264747.1.
XP_005264805.1. XM_005264748.2.
XP_005264806.1. XM_005264749.1.
XP_005264807.1. XM_005264750.1.
XP_005264808.1. XM_005264751.1.
UniGeneiHs.248136.

Genome annotation databases

EnsembliENST00000319595; ENSP00000322924; ENSG00000179097.
GeneIDi3355.
KEGGihsa:3355.
UCSCiuc003dqr.2. human.

Polymorphism databases

DMDMi398967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05597 Genomic DNA. Translation: AAA36605.1 .
L04962 Genomic DNA. Translation: AAA36646.1 .
AF498981 mRNA. Translation: AAM21128.1 .
AC119733 Genomic DNA. No translation available.
BC069125 mRNA. Translation: AAH69125.1 .
CCDSi CCDS2920.1.
PIRi A47321.
RefSeqi NP_000857.1. NM_000866.3.
XP_005264804.1. XM_005264747.1.
XP_005264805.1. XM_005264748.2.
XP_005264806.1. XM_005264749.1.
XP_005264807.1. XM_005264750.1.
XP_005264808.1. XM_005264751.1.
UniGenei Hs.248136.

3D structure databases

ProteinModelPortali P30939.
SMRi P30939. Positions 20-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000322924.

Chemistry

BindingDBi P30939.
ChEMBLi CHEMBL2096904.
DrugBanki DB00216. Eletriptan.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB01221. Ketamine.
DB00247. Methysergide.
DB06148. Mianserin.
DB00952. Naratriptan.
DB00953. Rizatriptan.
DB00669. Sumatriptan.
DB00315. Zolmitriptan.
GuidetoPHARMACOLOGYi 5.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30939.

Polymorphism databases

DMDMi 398967.

Proteomic databases

PaxDbi P30939.
PRIDEi P30939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319595 ; ENSP00000322924 ; ENSG00000179097 .
GeneIDi 3355.
KEGGi hsa:3355.
UCSCi uc003dqr.2. human.

Organism-specific databases

CTDi 3355.
GeneCardsi GC03P088031.
H-InvDB HIX0163359.
HGNCi HGNC:5292. HTR1F.
HPAi HPA005555.
MIMi 182134. gene.
neXtProti NX_P30939.
PharmGKBi PA29553.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249628.
GeneTreei ENSGT00760000118795.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P30939.
KOi K04153.
OMAi VVNVCEK.
OrthoDBi EOG7NCV3Q.
PhylomeDBi P30939.
TreeFami TF316350.

Enzyme and pathway databases

Reactomei REACT_17064. Serotonin receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii 5-HT1F_receptor.
GenomeRNAii 3355.
NextBioi 13266.
PROi P30939.
SOURCEi Search...

Gene expression databases

Bgeei P30939.
CleanExi HS_HTR1F.
ExpressionAtlasi P30939. baseline and differential.
Genevestigatori P30939.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF34. PTHR24247:SF34. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes."
    Lovenberg T.W., Erlander M.G., Baron B.M., Racke M., Slone A.L., Siegel B.W., Craft C.M., Burns J.E., Danielson P.E., Sutcliffe G.J.
    Proc. Natl. Acad. Sci. U.S.A. 90:2184-2188(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase."
    Adham N., Kao H.-T., Schechter L.E., Bard J., Olsen M., Urquhart D., Durkin M., Hartig P.R., Winshank R.L., Branchek T.A.
    Proc. Natl. Acad. Sci. U.S.A. 90:408-412(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: REVIEW.
  7. "Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships."
    Klein M.T., Dukat M., Glennon R.A., Teitler M.
    J. Pharmacol. Exp. Ther. 337:860-867(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Serotonin receptors - from molecular biology to clinical applications."
    Pytliak M., Vargova V., Mechirova V., Felsoci M.
    Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry namei5HT1F_HUMAN
AccessioniPrimary (citable) accession number: P30939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3