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Protein

5-hydroxytryptamine receptor 1F

Gene

HTR1F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.3 Publications

GO - Molecular functioni

  • G-protein coupled serotonin receptor activity Source: UniProtKB
  • neurotransmitter receptor activity Source: GO_Central
  • serotonin binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179097-MONOMER.
ReactomeiR-HSA-390666. Serotonin receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1F
Short name:
5-HT-1F
Short name:
5-HT1F
Alternative name(s):
Serotonin receptor 1F
Gene namesi
Name:HTR1F
Synonyms:HTR1EL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:5292. HTR1F.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 50Helical; Name=1By similarityAdd BLAST21
Topological domaini51 – 60CytoplasmicBy similarity10
Transmembranei61 – 83Helical; Name=2By similarityAdd BLAST23
Topological domaini84 – 97ExtracellularBy similarityAdd BLAST14
Transmembranei98 – 118Helical; Name=3By similarityAdd BLAST21
Topological domaini119 – 140CytoplasmicBy similarityAdd BLAST22
Transmembranei141 – 161Helical; Name=4By similarityAdd BLAST21
Topological domaini162 – 178ExtracellularBy similarityAdd BLAST17
Transmembranei179 – 201Helical; Name=5By similarityAdd BLAST23
Topological domaini202 – 290CytoplasmicBy similarityAdd BLAST89
Transmembranei291 – 311Helical; Name=6By similarityAdd BLAST21
Topological domaini312 – 329ExtracellularBy similarityAdd BLAST18
Transmembranei330 – 350Helical; Name=7By similarityAdd BLAST21
Topological domaini351 – 366CytoplasmicBy similarityAdd BLAST16

GO - Cellular componenti

  • dendrite Source: GO_Central
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3355.
OpenTargetsiENSG00000179097.
PharmGKBiPA29553.

Chemistry databases

ChEMBLiCHEMBL1805.
DrugBankiDB00216. Eletriptan.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB01221. Ketamine.
DB00247. Methysergide.
DB06148. Mianserin.
DB00952. Naratriptan.
DB00953. Rizatriptan.
DB00669. Sumatriptan.
DB00315. Zolmitriptan.
GuidetoPHARMACOLOGYi5.

Polymorphism and mutation databases

BioMutaiHTR1F.
DMDMi398967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689371 – 3665-hydroxytryptamine receptor 1FAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP30939.
PaxDbiP30939.
PRIDEiP30939.

PTM databases

iPTMnetiP30939.
PhosphoSitePlusiP30939.

Expressioni

Gene expression databases

BgeeiENSG00000179097.
CleanExiHS_HTR1F.
GenevisibleiP30939. HS.

Organism-specific databases

HPAiHPA005555.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322924.

Chemistry databases

BindingDBiP30939.

Structurei

3D structure databases

ProteinModelPortaliP30939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 108Agonist bindingBy similarity10
Regioni306 – 310Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi120 – 122DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi343 – 347NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30939.
KOiK04153.
OMAiTPYMLEK.
OrthoDBiEOG091G06VI.
PhylomeDBiP30939.
TreeFamiTF316350.

Family and domain databases

InterProiIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV
60 70 80 90 100
TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL
110 120 130 140 150
SVDITCCTCS ILHLSAIALD RYRAITDAVE YARKRTPKHA GIMITIVWII
160 170 180 190 200
SVFISMPPLF WRHQGTSRDD ECIIKHDHIV STIYSTFGAF YIPLALILIL
210 220 230 240 250
YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS VSTSYVLEKS
260 270 280 290 300
LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG
310 320 330 340 350
AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF
360
NEDFKKAFQK LVRCRC
Length:366
Mass (Da):41,709
Last modified:July 1, 1993 - v1
Checksum:i16EA80344793B54F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05597 Genomic DNA. Translation: AAA36605.1.
L04962 Genomic DNA. Translation: AAA36646.1.
AF498981 mRNA. Translation: AAM21128.1.
AC119733 Genomic DNA. No translation available.
BC069125 mRNA. Translation: AAH69125.1.
CCDSiCCDS2920.1.
PIRiA47321.
RefSeqiNP_000857.1. NM_000866.4.
NP_001309137.1. NM_001322208.1.
NP_001309138.1. NM_001322209.1.
NP_001309139.1. NM_001322210.1.
XP_005264808.1. XM_005264751.3.
XP_011531966.1. XM_011533664.2.
UniGeneiHs.248136.

Genome annotation databases

EnsembliENST00000319595; ENSP00000322924; ENSG00000179097.
GeneIDi3355.
KEGGihsa:3355.
UCSCiuc062lsi.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05597 Genomic DNA. Translation: AAA36605.1.
L04962 Genomic DNA. Translation: AAA36646.1.
AF498981 mRNA. Translation: AAM21128.1.
AC119733 Genomic DNA. No translation available.
BC069125 mRNA. Translation: AAH69125.1.
CCDSiCCDS2920.1.
PIRiA47321.
RefSeqiNP_000857.1. NM_000866.4.
NP_001309137.1. NM_001322208.1.
NP_001309138.1. NM_001322209.1.
NP_001309139.1. NM_001322210.1.
XP_005264808.1. XM_005264751.3.
XP_011531966.1. XM_011533664.2.
UniGeneiHs.248136.

3D structure databases

ProteinModelPortaliP30939.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322924.

Chemistry databases

BindingDBiP30939.
ChEMBLiCHEMBL1805.
DrugBankiDB00216. Eletriptan.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB01221. Ketamine.
DB00247. Methysergide.
DB06148. Mianserin.
DB00952. Naratriptan.
DB00953. Rizatriptan.
DB00669. Sumatriptan.
DB00315. Zolmitriptan.
GuidetoPHARMACOLOGYi5.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP30939.
PhosphoSitePlusiP30939.

Polymorphism and mutation databases

BioMutaiHTR1F.
DMDMi398967.

Proteomic databases

EPDiP30939.
PaxDbiP30939.
PRIDEiP30939.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319595; ENSP00000322924; ENSG00000179097.
GeneIDi3355.
KEGGihsa:3355.
UCSCiuc062lsi.1. human.

Organism-specific databases

CTDi3355.
DisGeNETi3355.
GeneCardsiHTR1F.
H-InvDBHIX0163359.
HGNCiHGNC:5292. HTR1F.
HPAiHPA005555.
MIMi182134. gene.
neXtProtiNX_P30939.
OpenTargetsiENSG00000179097.
PharmGKBiPA29553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30939.
KOiK04153.
OMAiTPYMLEK.
OrthoDBiEOG091G06VI.
PhylomeDBiP30939.
TreeFamiTF316350.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179097-MONOMER.
ReactomeiR-HSA-390666. Serotonin receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii5-HT1F_receptor.
GenomeRNAii3355.
PROiP30939.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179097.
CleanExiHS_HTR1F.
GenevisibleiP30939. HS.

Family and domain databases

InterProiIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT1F_HUMAN
AccessioniPrimary (citable) accession number: P30939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.