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P30939 (5HT1F_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 1F

Short name=5-HT-1F
Short name=5-HT1F
Alternative name(s):
Serotonin receptor 1F
Gene names
Name:HTR1F
Synonyms:HTR1EL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Ref.1 Ref.2 Ref.7

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1 Ref.2.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3663665-hydroxytryptamine receptor 1F
PRO_0000068937

Regions

Topological domain1 – 2929Extracellular By similarity
Transmembrane30 – 5021Helical; Name=1; By similarity
Topological domain51 – 6010Cytoplasmic By similarity
Transmembrane61 – 8323Helical; Name=2; By similarity
Topological domain84 – 9714Extracellular By similarity
Transmembrane98 – 11821Helical; Name=3; By similarity
Topological domain119 – 14022Cytoplasmic By similarity
Transmembrane141 – 16121Helical; Name=4; By similarity
Topological domain162 – 17817Extracellular By similarity
Transmembrane179 – 20123Helical; Name=5; By similarity
Topological domain202 – 29089Cytoplasmic By similarity
Transmembrane291 – 31121Helical; Name=6; By similarity
Topological domain312 – 32918Extracellular By similarity
Transmembrane330 – 35021Helical; Name=7; By similarity
Topological domain351 – 36616Cytoplasmic By similarity
Region99 – 10810Agonist binding By similarity
Region306 – 3105Agonist binding By similarity
Motif120 – 1223DRY motif; important for ligand-induced conformation changes By similarity
Motif343 – 3475NPxxY motif; important for ligand-induced conformation changes and signaling By similarity

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 172 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30939 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 16EA80344793B54F

FASTA36641,709
        10         20         30         40         50         60 
MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV TRKLHHPANY 

        70         80         90        100        110        120 
LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL SVDITCCTCS ILHLSAIALD 

       130        140        150        160        170        180 
RYRAITDAVE YARKRTPKHA GIMITIVWII SVFISMPPLF WRHQGTSRDD ECIIKHDHIV 

       190        200        210        220        230        240 
STIYSTFGAF YIPLALILIL YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS 

       250        260        270        280        290        300 
VSTSYVLEKS LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG 

       310        320        330        340        350        360 
AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF NEDFKKAFQK 


LVRCRC 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes."
Lovenberg T.W., Erlander M.G., Baron B.M., Racke M., Slone A.L., Siegel B.W., Craft C.M., Burns J.E., Danielson P.E., Sutcliffe G.J.
Proc. Natl. Acad. Sci. U.S.A. 90:2184-2188(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
[2]"Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase."
Adham N., Kao H.-T., Schechter L.E., Bard J., Olsen M., Urquhart D., Durkin M., Hartig P.R., Winshank R.L., Branchek T.A.
Proc. Natl. Acad. Sci. U.S.A. 90:408-412(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Serotonin receptors."
Nichols D.E., Nichols C.D.
Chem. Rev. 108:1614-1641(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships."
Klein M.T., Dukat M., Glennon R.A., Teitler M.
J. Pharmacol. Exp. Ther. 337:860-867(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Serotonin receptors - from molecular biology to clinical applications."
Pytliak M., Vargova V., Mechirova V., Felsoci M.
Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05597 Genomic DNA. Translation: AAA36605.1.
L04962 Genomic DNA. Translation: AAA36646.1.
AF498981 mRNA. Translation: AAM21128.1.
AC119733 Genomic DNA. No translation available.
BC069125 mRNA. Translation: AAH69125.1.
PIRA47321.
RefSeqNP_000857.1. NM_000866.3.
XP_005264804.1. XM_005264747.1.
XP_005264805.1. XM_005264748.2.
XP_005264806.1. XM_005264749.1.
XP_005264807.1. XM_005264750.1.
XP_005264808.1. XM_005264751.1.
UniGeneHs.248136.

3D structure databases

ProteinModelPortalP30939.
SMRP30939. Positions 20-363.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000322924.

Chemistry

BindingDBP30939.
ChEMBLCHEMBL1805.
DrugBankDB00216. Eletriptan.
DB00952. Naratriptan.
DB00953. Rizatriptan.
DB00669. Sumatriptan.
DB00315. Zolmitriptan.
GuidetoPHARMACOLOGY5.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30939.

Polymorphism databases

DMDM398967.

Proteomic databases

PaxDbP30939.
PRIDEP30939.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000319595; ENSP00000322924; ENSG00000179097.
GeneID3355.
KEGGhsa:3355.
UCSCuc003dqr.2. human.

Organism-specific databases

CTD3355.
GeneCardsGC03P088031.
H-InvDBHIX0163359.
HGNCHGNC:5292. HTR1F.
HPAHPA005555.
MIM182134. gene.
neXtProtNX_P30939.
PharmGKBPA29553.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG249628.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP30939.
KOK04153.
OMAVVNVCEK.
OrthoDBEOG7NCV3Q.
PhylomeDBP30939.
TreeFamTF316350.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP30939.
BgeeP30939.
CleanExHS_HTR1F.
GenevestigatorP30939.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWiki5-HT1F_receptor.
GenomeRNAi3355.
NextBio13266.
PROP30939.
SOURCESearch...

Entry information

Entry name5HT1F_HUMAN
AccessionPrimary (citable) accession number: P30939
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries