P30939 (5HT1F_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 1F
Short name=5-HT-1F
Short name=5-HT1F

Alternative name(s):
Serotonin receptor 1F

Gene names

Name:	HTR1F
Synonyms:	HTR1EL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement Ref.2. Source: ProtInc synaptic transmission Traceable author statement Ref.2. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	serotonin binding Inferred from direct assay Ref.2. Source: MGI serotonin receptor activity Inferred from direct assay Ref.2. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	5-hydroxytryptamine receptor 1F		PRO_0000068937
Regions
	Topological domain	1 – 29	29	Extracellular By similarity
	Transmembrane	30 – 50	21	Helical; Name=1; By similarity
	Topological domain	51 – 64	14	Cytoplasmic By similarity
	Transmembrane	65 – 85	21	Helical; Name=2; By similarity
	Topological domain	86 – 97	12	Extracellular By similarity
	Transmembrane	98 – 118	21	Helical; Name=3; By similarity
	Topological domain	119 – 140	22	Cytoplasmic By similarity
	Transmembrane	141 – 161	21	Helical; Name=4; By similarity
	Topological domain	162 – 178	17	Extracellular By similarity
	Transmembrane	179 – 199	21	Helical; Name=5; By similarity
	Topological domain	200 – 290	91	Cytoplasmic By similarity
	Transmembrane	291 – 311	21	Helical; Name=6; By similarity
	Topological domain	312 – 329	18	Extracellular By similarity
	Transmembrane	330 – 350	21	Helical; Name=7; By similarity
	Topological domain	351 – 366	16	Cytoplasmic By similarity
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 172		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30939 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 16EA80344793B54F	FASTA	366	41,709
	10 20 30 40 50 60 MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV TRKLHHPANY 70 80 90 100 110 120 LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL SVDITCCTCS ILHLSAIALD 130 140 150 160 170 180 RYRAITDAVE YARKRTPKHA GIMITIVWII SVFISMPPLF WRHQGTSRDD ECIIKHDHIV 190 200 210 220 230 240 STIYSTFGAF YIPLALILIL YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS 250 260 270 280 290 300 VSTSYVLEKS LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG 310 320 330 340 350 360 AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF NEDFKKAFQK LVRCRC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes." Lovenberg T.W., Erlander M.G., Baron B.M., Racke M., Slone A.L., Siegel B.W., Craft C.M., Burns J.E., Danielson P.E., Sutcliffe G.J. Proc. Natl. Acad. Sci. U.S.A. 90:2184-2188(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase." Adham N., Kao H.-T., Schechter L.E., Bard J., Olsen M., Urquhart D., Durkin M., Hartig P.R., Winshank R.L., Branchek T.A. Proc. Natl. Acad. Sci. U.S.A. 90:408-412(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L05597 Genomic DNA. Translation: AAA36605.1. L04962 Genomic DNA. Translation: AAA36646.1. AF498981 mRNA. Translation: AAM21128.1. BC069125 mRNA. Translation: AAH69125.1.
IPI	IPI00028093.
PIR	A47321.
RefSeq	NP_000857.1. NM_000866.3.
UniGene	Hs.248136.
3D structure databases
ProteinModelPortal	P30939.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000322924.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P30939.
Polymorphism databases
DMDM	398967.
Proteomic databases
PaxDb	P30939.
PRIDE	P30939.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000319595; ENSP00000322924; ENSG00000179097.
GeneID	3355.
KEGG	hsa:3355.
UCSC	uc003dqr.2. human.
Organism-specific databases
CTD	3355.
GeneCards	GC03P088031.
H-InvDB	HIX0163359.
HGNC	HGNC:5292. HTR1F.
HPA	HPA005555.
MIM	182134. gene.
neXtProt	NX_P30939.
PharmGKB	PA29553.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG249628.
HOGENOM	HOG000239242.
HOVERGEN	HBG106962.
InParanoid	P30939.
KO	K04153.
OMA	VVNVCEK.
OrthoDB	EOG43XV41.
PhylomeDB	P30939.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P30939.
Bgee	P30939.
CleanEx	HS_HTR1F.
Genevestigator	P30939.
GermOnline	ENSG00000179097. Homo sapiens.
Family and domain databases
InterPro	IPR000450. 5HT1F_rcpt. IPR002231. 5HT_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00515. 5HT1FRECEPTR. PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P30939.
ChEMBL	CHEMBL1805.
DrugBank	DB00216. Eletriptan. DB00952. Naratriptan. DB00953. Rizatriptan. DB00669. Sumatriptan. DB00315. Zolmitriptan.
GenomeRNAi	3355.
NextBio	13266.
SOURCE	Search...

Entry information

Entry name

5HT1F_HUMAN

Accession

Primary (citable) accession number: P30939

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.