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P30939

- 5HT1F_HUMAN

UniProt

P30939 - 5HT1F_HUMAN

Protein

5-hydroxytryptamine receptor 1F

Gene

HTR1F

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.3 Publications

    GO - Molecular functioni

    1. serotonin binding Source: MGI
    2. serotonin receptor activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
    2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    3. serotonin receptor signaling pathway Source: GOC
    4. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_17064. Serotonin receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 1F
    Short name:
    5-HT-1F
    Short name:
    5-HT1F
    Alternative name(s):
    Serotonin receptor 1F
    Gene namesi
    Name:HTR1F
    Synonyms:HTR1EL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:5292. HTR1F.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29553.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3663665-hydroxytryptamine receptor 1FPRO_0000068937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 172PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP30939.
    PRIDEiP30939.

    PTM databases

    PhosphoSiteiP30939.

    Expressioni

    Gene expression databases

    ArrayExpressiP30939.
    BgeeiP30939.
    CleanExiHS_HTR1F.
    GenevestigatoriP30939.

    Organism-specific databases

    HPAiHPA005555.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000322924.

    Structurei

    3D structure databases

    ProteinModelPortaliP30939.
    SMRiP30939. Positions 20-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularBy similarityAdd
    BLAST
    Topological domaini51 – 6010CytoplasmicBy similarity
    Topological domaini84 – 9714ExtracellularBy similarityAdd
    BLAST
    Topological domaini119 – 14022CytoplasmicBy similarityAdd
    BLAST
    Topological domaini162 – 17817ExtracellularBy similarityAdd
    BLAST
    Topological domaini202 – 29089CytoplasmicBy similarityAdd
    BLAST
    Topological domaini312 – 32918ExtracellularBy similarityAdd
    BLAST
    Topological domaini351 – 36616CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1By similarityAdd
    BLAST
    Transmembranei61 – 8323Helical; Name=2By similarityAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3By similarityAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4By similarityAdd
    BLAST
    Transmembranei179 – 20123Helical; Name=5By similarityAdd
    BLAST
    Transmembranei291 – 31121Helical; Name=6By similarityAdd
    BLAST
    Transmembranei330 – 35021Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni99 – 10810Agonist bindingBy similarity
    Regioni306 – 3105Agonist bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi120 – 1223DRY motif; important for ligand-induced conformation changesBy similarity
    Motifi343 – 3475NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP30939.
    KOiK04153.
    OMAiVVNVCEK.
    OrthoDBiEOG7NCV3Q.
    PhylomeDBiP30939.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000450. 5HT1F_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00515. 5HT1FRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30939-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV    50
    TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL 100
    SVDITCCTCS ILHLSAIALD RYRAITDAVE YARKRTPKHA GIMITIVWII 150
    SVFISMPPLF WRHQGTSRDD ECIIKHDHIV STIYSTFGAF YIPLALILIL 200
    YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS VSTSYVLEKS 250
    LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG 300
    AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF 350
    NEDFKKAFQK LVRCRC 366
    Length:366
    Mass (Da):41,709
    Last modified:July 1, 1993 - v1
    Checksum:i16EA80344793B54F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05597 Genomic DNA. Translation: AAA36605.1.
    L04962 Genomic DNA. Translation: AAA36646.1.
    AF498981 mRNA. Translation: AAM21128.1.
    AC119733 Genomic DNA. No translation available.
    BC069125 mRNA. Translation: AAH69125.1.
    CCDSiCCDS2920.1.
    PIRiA47321.
    RefSeqiNP_000857.1. NM_000866.3.
    XP_005264804.1. XM_005264747.1.
    XP_005264805.1. XM_005264748.2.
    XP_005264806.1. XM_005264749.1.
    XP_005264807.1. XM_005264750.1.
    XP_005264808.1. XM_005264751.1.
    UniGeneiHs.248136.

    Genome annotation databases

    EnsembliENST00000319595; ENSP00000322924; ENSG00000179097.
    GeneIDi3355.
    KEGGihsa:3355.
    UCSCiuc003dqr.2. human.

    Polymorphism databases

    DMDMi398967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05597 Genomic DNA. Translation: AAA36605.1 .
    L04962 Genomic DNA. Translation: AAA36646.1 .
    AF498981 mRNA. Translation: AAM21128.1 .
    AC119733 Genomic DNA. No translation available.
    BC069125 mRNA. Translation: AAH69125.1 .
    CCDSi CCDS2920.1.
    PIRi A47321.
    RefSeqi NP_000857.1. NM_000866.3.
    XP_005264804.1. XM_005264747.1.
    XP_005264805.1. XM_005264748.2.
    XP_005264806.1. XM_005264749.1.
    XP_005264807.1. XM_005264750.1.
    XP_005264808.1. XM_005264751.1.
    UniGenei Hs.248136.

    3D structure databases

    ProteinModelPortali P30939.
    SMRi P30939. Positions 20-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000322924.

    Chemistry

    BindingDBi P30939.
    ChEMBLi CHEMBL1805.
    DrugBanki DB00216. Eletriptan.
    DB00952. Naratriptan.
    DB00953. Rizatriptan.
    DB00669. Sumatriptan.
    DB00315. Zolmitriptan.
    GuidetoPHARMACOLOGYi 5.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30939.

    Polymorphism databases

    DMDMi 398967.

    Proteomic databases

    PaxDbi P30939.
    PRIDEi P30939.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319595 ; ENSP00000322924 ; ENSG00000179097 .
    GeneIDi 3355.
    KEGGi hsa:3355.
    UCSCi uc003dqr.2. human.

    Organism-specific databases

    CTDi 3355.
    GeneCardsi GC03P088031.
    H-InvDB HIX0163359.
    HGNCi HGNC:5292. HTR1F.
    HPAi HPA005555.
    MIMi 182134. gene.
    neXtProti NX_P30939.
    PharmGKBi PA29553.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249628.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P30939.
    KOi K04153.
    OMAi VVNVCEK.
    OrthoDBi EOG7NCV3Q.
    PhylomeDBi P30939.
    TreeFami TF316350.

    Enzyme and pathway databases

    Reactomei REACT_17064. Serotonin receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii 5-HT1F_receptor.
    GenomeRNAii 3355.
    NextBioi 13266.
    PROi P30939.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30939.
    Bgeei P30939.
    CleanExi HS_HTR1F.
    Genevestigatori P30939.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000450. 5HT1F_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF34. PTHR24247:SF34. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00515. 5HT1FRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes."
      Lovenberg T.W., Erlander M.G., Baron B.M., Racke M., Slone A.L., Siegel B.W., Craft C.M., Burns J.E., Danielson P.E., Sutcliffe G.J.
      Proc. Natl. Acad. Sci. U.S.A. 90:2184-2188(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
    2. "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase."
      Adham N., Kao H.-T., Schechter L.E., Bard J., Olsen M., Urquhart D., Durkin M., Hartig P.R., Winshank R.L., Branchek T.A.
      Proc. Natl. Acad. Sci. U.S.A. 90:408-412(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: REVIEW.
    7. "Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships."
      Klein M.T., Dukat M., Glennon R.A., Teitler M.
      J. Pharmacol. Exp. Ther. 337:860-867(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Serotonin receptors - from molecular biology to clinical applications."
      Pytliak M., Vargova V., Mechirova V., Felsoci M.
      Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry namei5HT1F_HUMAN
    AccessioniPrimary (citable) accession number: P30939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3