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P30938

- SSR5_RAT

UniProt

P30938 - SSR5_RAT

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Protein

Somatostatin receptor type 5

Gene

Sstr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.2 Publications

GO - Molecular functioni

  1. somatostatin receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
  2. cellular response to glucocorticoid stimulus Source: RGD
  3. somatostatin signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 5
Short name:
SS-5-R
Short name:
SS5-R
Short name:
SS5R
Gene namesi
Name:Sstr5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3765. Sstr5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Somatostatin receptor type 5PRO_0000070132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi110 ↔ 185PROSITE-ProRule annotation
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Lipidationi320 – 3201S-palmitoyl cysteine; by ZDHHC5By similarity

Post-translational modificationi

Palmitoylated at Cys-320 by ZDHHC5, but not ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP30938.

PTM databases

PhosphoSiteiP30938.

Expressioni

Tissue specificityi

Prominent in the pituitary and small intestine. Low levels in islets and spleen. Not detected in kidney, pancreas, cerebellum, or cortex.2 Publications

Gene expression databases

GenevestigatoriP30938.

Interactioni

Subunit structurei

Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2 (By similarity).By similarity

Protein-protein interaction databases

IntActiP30938. 1 interaction.
MINTiMINT-1489396.
STRINGi10116.ENSRNOP00000025451.

Structurei

3D structure databases

ProteinModelPortaliP30938.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Topological domaini64 – 7310CytoplasmicSequence Analysis
Topological domaini100 – 11112ExtracellularSequence AnalysisAdd
BLAST
Topological domaini134 – 15522CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini177 – 19620ExtracellularSequence AnalysisAdd
BLAST
Topological domaini222 – 24726CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini274 – 28310ExtracellularSequence Analysis
Topological domaini309 – 36355CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 6328Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei74 – 9926Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei197 – 22125Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei248 – 27326Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei284 – 30825Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274661.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP30938.
PhylomeDBiP30938.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001184. Somatstn_rcpt_5.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00591. SOMATOSTTN5R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30938-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPLSLASTP SWNASAASSG NHNWSLVGSA SPMGARAVLV PVLYLLVCTV
60 70 80 90 100
GLSGNTLVIY VVLRHAKMKT VTNVYILNLA VADVLFMLGL PFLATQNAVV
110 120 130 140 150
SYWPFGSFLC RLVMTLDGIN QFTSIFCLMV MSVDRYLAVV HPLRSARWRR
160 170 180 190 200
PRVAKMASAA VWVFSLLMSL PLLVFADVQE GWGTCNLSWP EPVGLWGAAF
210 220 230 240 250
ITYTSVLGFF GPLLVICLCY LLIVVKVKAA GMRVGSSRRR RSEPKVTRMV
260 270 280 290 300
VVVVLVFVGC WLPFFIVNIV NLAFTLPEEP TSAGLYFFVV VLSYANSCAN
310 320 330 340 350
PLLYGFLSDN FRQSFRKVLC LRRGYGMEDA DAIEPRPDKS GRPQATLPTR
360
SCEANGLMQT SRI
Length:363
Mass (Da):39,971
Last modified:February 1, 1995 - v2
Checksum:i4BD4512960613B4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04535 mRNA. Translation: AAA17029.1.
U01152 mRNA. Translation: AAC09011.1.
X74828 mRNA. Translation: CAA52825.1.
PIRiI57940.
UniGeneiRn.91342.

Genome annotation databases

UCSCiRGD:3765. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04535 mRNA. Translation: AAA17029.1 .
U01152 mRNA. Translation: AAC09011.1 .
X74828 mRNA. Translation: CAA52825.1 .
PIRi I57940.
UniGenei Rn.91342.

3D structure databases

ProteinModelPortali P30938.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30938. 1 interaction.
MINTi MINT-1489396.
STRINGi 10116.ENSRNOP00000025451.

Chemistry

BindingDBi P30938.
ChEMBLi CHEMBL4318.
GuidetoPHARMACOLOGYi 359.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30938.

Proteomic databases

PRIDEi P30938.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3765. rat.

Organism-specific databases

RGDi 3765. Sstr5.

Phylogenomic databases

eggNOGi NOG274661.
HOGENOMi HOG000230485.
HOVERGENi HBG106919.
InParanoidi P30938.
PhylomeDBi P30938.

Miscellaneous databases

PROi P30938.

Gene expression databases

Genevestigatori P30938.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001184. Somatstn_rcpt_5.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00591. SOMATOSTTN5R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28."
    O'Carroll A.-M., Lolait S.J., Konig M., Mahan L.C.
    Mol. Pharmacol. 42:939-946(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Pituitary.
  2. "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28."
    Panetta R., Greenwood M.T., Warszynska A., Demchyshyn L.L., Day R., Niznik H.B., Srikant C.B., Patel Y.C.
    Mol. Pharmacol. 45:417-427(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO C-TERMINUS, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Pituitary.
  3. "Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase."
    Kokkola T., Kruse C., Roy-Pogodzik E.M., Pekkinen J., Bauch C., Honck H.H., Hennemann H., Kreienkamp H.J.
    FEBS Lett. 585:2665-2670(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZDHHC5.

Entry informationi

Entry nameiSSR5_RAT
AccessioniPrimary (citable) accession number: P30938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1995
Last modified: October 1, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3