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P30938 (SSR5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatostatin receptor type 5

Short name=SS-5-R
Short name=SS5-R
Short name=SS5R
Gene names
Name:Sstr5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. Ref.1 Ref.2

Subunit structure

Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Prominent in the pituitary and small intestine. Low levels in islets and spleen. Not detected in kidney, pancreas, cerebellum, or cortex. Ref.1 Ref.2

Post-translational modification

Palmitoylated at Cys-320 by ZDHHC5, but not ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Somatostatin receptor type 5
PRO_0000070132

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 6328Helical; Name=1; Potential
Topological domain64 – 7310Cytoplasmic Potential
Transmembrane74 – 9926Helical; Name=2; Potential
Topological domain100 – 11112Extracellular Potential
Transmembrane112 – 13322Helical; Name=3; Potential
Topological domain134 – 15522Cytoplasmic Potential
Transmembrane156 – 17621Helical; Name=4; Potential
Topological domain177 – 19620Extracellular Potential
Transmembrane197 – 22125Helical; Name=5; Potential
Topological domain222 – 24726Cytoplasmic Potential
Transmembrane248 – 27326Helical; Name=6; Potential
Topological domain274 – 28310Extracellular Potential
Transmembrane284 – 30825Helical; Name=7; Potential
Topological domain309 – 36355Cytoplasmic Potential

Amino acid modifications

Lipidation3201S-palmitoyl cysteine; by ZDHHC5 By similarity
Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 185 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30938 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 4BD4512960613B4A

FASTA36339,971
        10         20         30         40         50         60 
MEPLSLASTP SWNASAASSG NHNWSLVGSA SPMGARAVLV PVLYLLVCTV GLSGNTLVIY 

        70         80         90        100        110        120 
VVLRHAKMKT VTNVYILNLA VADVLFMLGL PFLATQNAVV SYWPFGSFLC RLVMTLDGIN 

       130        140        150        160        170        180 
QFTSIFCLMV MSVDRYLAVV HPLRSARWRR PRVAKMASAA VWVFSLLMSL PLLVFADVQE 

       190        200        210        220        230        240 
GWGTCNLSWP EPVGLWGAAF ITYTSVLGFF GPLLVICLCY LLIVVKVKAA GMRVGSSRRR 

       250        260        270        280        290        300 
RSEPKVTRMV VVVVLVFVGC WLPFFIVNIV NLAFTLPEEP TSAGLYFFVV VLSYANSCAN 

       310        320        330        340        350        360 
PLLYGFLSDN FRQSFRKVLC LRRGYGMEDA DAIEPRPDKS GRPQATLPTR SCEANGLMQT 


SRI 

« Hide

References

[1]"Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28."
O'Carroll A.-M., Lolait S.J., Konig M., Mahan L.C.
Mol. Pharmacol. 42:939-946(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Pituitary.
[2]"Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28."
Panetta R., Greenwood M.T., Warszynska A., Demchyshyn L.L., Day R., Niznik H.B., Srikant C.B., Patel Y.C.
Mol. Pharmacol. 45:417-427(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO C-TERMINUS, FUNCTION, TISSUE SPECIFICITY.
Tissue: Pituitary.
[3]"Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase."
Kokkola T., Kruse C., Roy-Pogodzik E.M., Pekkinen J., Bauch C., Honck H.H., Hennemann H., Kreienkamp H.J.
FEBS Lett. 585:2665-2670(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ZDHHC5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L04535 mRNA. Translation: AAA17029.1.
U01152 mRNA. Translation: AAC09011.1.
X74828 mRNA. Translation: CAA52825.1.
PIRI57940.
UniGeneRn.91342.

3D structure databases

ProteinModelPortalP30938.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP30938. 1 interaction.
MINTMINT-1489396.
STRING10116.ENSRNOP00000025451.

Chemistry

BindingDBP30938.
ChEMBLCHEMBL4318.
GuidetoPHARMACOLOGY359.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30938.

Proteomic databases

PRIDEP30938.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:3765. rat.

Organism-specific databases

RGD3765. Sstr5.

Phylogenomic databases

eggNOGNOG274661.
HOGENOMHOG000230485.
HOVERGENHBG106919.
InParanoidP30938.
PhylomeDBP30938.

Gene expression databases

GenevestigatorP30938.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001184. Somatstn_rcpt_5.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00591. SOMATOSTTN5R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP30938.

Entry information

Entry nameSSR5_RAT
AccessionPrimary (citable) accession number: P30938
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries