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P30938

- SSR5_RAT

UniProt

P30938 - SSR5_RAT

Protein

Somatostatin receptor type 5

Gene

Sstr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.2 Publications

    GO - Molecular functioni

    1. somatostatin receptor activity Source: RGD

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
    2. cellular response to glucocorticoid stimulus Source: RGD
    3. somatostatin signaling pathway Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 5
    Short name:
    SS-5-R
    Short name:
    SS5-R
    Short name:
    SS5R
    Gene namesi
    Name:Sstr5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3765. Sstr5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Somatostatin receptor type 5PRO_0000070132Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 185PROSITE-ProRule annotation
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Lipidationi320 – 3201S-palmitoyl cysteine; by ZDHHC5By similarity

    Post-translational modificationi

    Palmitoylated at Cys-320 by ZDHHC5, but not ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP30938.

    PTM databases

    PhosphoSiteiP30938.

    Expressioni

    Tissue specificityi

    Prominent in the pituitary and small intestine. Low levels in islets and spleen. Not detected in kidney, pancreas, cerebellum, or cortex.2 Publications

    Gene expression databases

    GenevestigatoriP30938.

    Interactioni

    Subunit structurei

    Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2 By similarity.By similarity

    Protein-protein interaction databases

    IntActiP30938. 1 interaction.
    MINTiMINT-1489396.
    STRINGi10116.ENSRNOP00000025451.

    Structurei

    3D structure databases

    ProteinModelPortaliP30938.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7310CytoplasmicSequence Analysis
    Topological domaini100 – 11112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15522CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 19620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini222 – 24726CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28310ExtracellularSequence Analysis
    Topological domaini309 – 36355CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 6328Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9926Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 22125Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 27326Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30825Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274661.
    HOGENOMiHOG000230485.
    HOVERGENiHBG106919.
    InParanoidiP30938.
    PhylomeDBiP30938.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001184. Somatstn_rcpt_5.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00591. SOMATOSTTN5R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30938-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPLSLASTP SWNASAASSG NHNWSLVGSA SPMGARAVLV PVLYLLVCTV    50
    GLSGNTLVIY VVLRHAKMKT VTNVYILNLA VADVLFMLGL PFLATQNAVV 100
    SYWPFGSFLC RLVMTLDGIN QFTSIFCLMV MSVDRYLAVV HPLRSARWRR 150
    PRVAKMASAA VWVFSLLMSL PLLVFADVQE GWGTCNLSWP EPVGLWGAAF 200
    ITYTSVLGFF GPLLVICLCY LLIVVKVKAA GMRVGSSRRR RSEPKVTRMV 250
    VVVVLVFVGC WLPFFIVNIV NLAFTLPEEP TSAGLYFFVV VLSYANSCAN 300
    PLLYGFLSDN FRQSFRKVLC LRRGYGMEDA DAIEPRPDKS GRPQATLPTR 350
    SCEANGLMQT SRI 363
    Length:363
    Mass (Da):39,971
    Last modified:February 1, 1995 - v2
    Checksum:i4BD4512960613B4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04535 mRNA. Translation: AAA17029.1.
    U01152 mRNA. Translation: AAC09011.1.
    X74828 mRNA. Translation: CAA52825.1.
    PIRiI57940.
    UniGeneiRn.91342.

    Genome annotation databases

    UCSCiRGD:3765. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04535 mRNA. Translation: AAA17029.1 .
    U01152 mRNA. Translation: AAC09011.1 .
    X74828 mRNA. Translation: CAA52825.1 .
    PIRi I57940.
    UniGenei Rn.91342.

    3D structure databases

    ProteinModelPortali P30938.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P30938. 1 interaction.
    MINTi MINT-1489396.
    STRINGi 10116.ENSRNOP00000025451.

    Chemistry

    BindingDBi P30938.
    ChEMBLi CHEMBL4318.
    GuidetoPHARMACOLOGYi 359.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30938.

    Proteomic databases

    PRIDEi P30938.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3765. rat.

    Organism-specific databases

    RGDi 3765. Sstr5.

    Phylogenomic databases

    eggNOGi NOG274661.
    HOGENOMi HOG000230485.
    HOVERGENi HBG106919.
    InParanoidi P30938.
    PhylomeDBi P30938.

    Miscellaneous databases

    PROi P30938.

    Gene expression databases

    Genevestigatori P30938.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001184. Somatstn_rcpt_5.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00591. SOMATOSTTN5R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28."
      O'Carroll A.-M., Lolait S.J., Konig M., Mahan L.C.
      Mol. Pharmacol. 42:939-946(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Pituitary.
    2. "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28."
      Panetta R., Greenwood M.T., Warszynska A., Demchyshyn L.L., Day R., Niznik H.B., Srikant C.B., Patel Y.C.
      Mol. Pharmacol. 45:417-427(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO C-TERMINUS, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Pituitary.
    3. "Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase."
      Kokkola T., Kruse C., Roy-Pogodzik E.M., Pekkinen J., Bauch C., Honck H.H., Hennemann H., Kreienkamp H.J.
      FEBS Lett. 585:2665-2670(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZDHHC5.

    Entry informationi

    Entry nameiSSR5_RAT
    AccessioniPrimary (citable) accession number: P30938
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3