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P30938

- SSR5_RAT

UniProt

P30938 - SSR5_RAT

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Protein

Somatostatin receptor type 5

Gene
Sstr5
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.2 Publications

GO - Molecular functioni

  1. somatostatin receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
  2. cellular response to glucocorticoid stimulus Source: RGD
  3. somatostatin signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 5
Short name:
SS-5-R
Short name:
SS5-R
Short name:
SS5R
Gene namesi
Name:Sstr5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3765. Sstr5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Extracellular Reviewed predictionAdd
BLAST
Transmembranei36 – 6328Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini64 – 7310Cytoplasmic Reviewed prediction
Transmembranei74 – 9926Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini100 – 11112Extracellular Reviewed predictionAdd
BLAST
Transmembranei112 – 13322Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini134 – 15522Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei156 – 17621Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini177 – 19620Extracellular Reviewed predictionAdd
BLAST
Transmembranei197 – 22125Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini222 – 24726Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei248 – 27326Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini274 – 28310Extracellular Reviewed prediction
Transmembranei284 – 30825Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini309 – 36355Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Somatostatin receptor type 5PRO_0000070132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi110 ↔ 185 By similarity
Glycosylationi186 – 1861N-linked (GlcNAc...) Reviewed prediction
Lipidationi320 – 3201S-palmitoyl cysteine; by ZDHHC5 By similarity

Post-translational modificationi

Palmitoylated at Cys-320 by ZDHHC5, but not ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP30938.

PTM databases

PhosphoSiteiP30938.

Expressioni

Tissue specificityi

Prominent in the pituitary and small intestine. Low levels in islets and spleen. Not detected in kidney, pancreas, cerebellum, or cortex.2 Publications

Gene expression databases

GenevestigatoriP30938.

Interactioni

Subunit structurei

Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2 By similarity.

Protein-protein interaction databases

IntActiP30938. 1 interaction.
MINTiMINT-1489396.
STRINGi10116.ENSRNOP00000025451.

Structurei

3D structure databases

ProteinModelPortaliP30938.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274661.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP30938.
PhylomeDBiP30938.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001184. Somatstn_rcpt_5.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00591. SOMATOSTTN5R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30938-1 [UniParc]FASTAAdd to Basket

« Hide

MEPLSLASTP SWNASAASSG NHNWSLVGSA SPMGARAVLV PVLYLLVCTV    50
GLSGNTLVIY VVLRHAKMKT VTNVYILNLA VADVLFMLGL PFLATQNAVV 100
SYWPFGSFLC RLVMTLDGIN QFTSIFCLMV MSVDRYLAVV HPLRSARWRR 150
PRVAKMASAA VWVFSLLMSL PLLVFADVQE GWGTCNLSWP EPVGLWGAAF 200
ITYTSVLGFF GPLLVICLCY LLIVVKVKAA GMRVGSSRRR RSEPKVTRMV 250
VVVVLVFVGC WLPFFIVNIV NLAFTLPEEP TSAGLYFFVV VLSYANSCAN 300
PLLYGFLSDN FRQSFRKVLC LRRGYGMEDA DAIEPRPDKS GRPQATLPTR 350
SCEANGLMQT SRI 363
Length:363
Mass (Da):39,971
Last modified:February 1, 1995 - v2
Checksum:i4BD4512960613B4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04535 mRNA. Translation: AAA17029.1.
U01152 mRNA. Translation: AAC09011.1.
X74828 mRNA. Translation: CAA52825.1.
PIRiI57940.
UniGeneiRn.91342.

Genome annotation databases

UCSCiRGD:3765. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04535 mRNA. Translation: AAA17029.1 .
U01152 mRNA. Translation: AAC09011.1 .
X74828 mRNA. Translation: CAA52825.1 .
PIRi I57940.
UniGenei Rn.91342.

3D structure databases

ProteinModelPortali P30938.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30938. 1 interaction.
MINTi MINT-1489396.
STRINGi 10116.ENSRNOP00000025451.

Chemistry

BindingDBi P30938.
ChEMBLi CHEMBL4318.
GuidetoPHARMACOLOGYi 359.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30938.

Proteomic databases

PRIDEi P30938.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3765. rat.

Organism-specific databases

RGDi 3765. Sstr5.

Phylogenomic databases

eggNOGi NOG274661.
HOGENOMi HOG000230485.
HOVERGENi HBG106919.
InParanoidi P30938.
PhylomeDBi P30938.

Miscellaneous databases

PROi P30938.

Gene expression databases

Genevestigatori P30938.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001184. Somatstn_rcpt_5.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00591. SOMATOSTTN5R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28."
    O'Carroll A.-M., Lolait S.J., Konig M., Mahan L.C.
    Mol. Pharmacol. 42:939-946(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Pituitary.
  2. "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28."
    Panetta R., Greenwood M.T., Warszynska A., Demchyshyn L.L., Day R., Niznik H.B., Srikant C.B., Patel Y.C.
    Mol. Pharmacol. 45:417-427(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO C-TERMINUS, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Pituitary.
  3. "Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase."
    Kokkola T., Kruse C., Roy-Pogodzik E.M., Pekkinen J., Bauch C., Honck H.H., Hennemann H., Kreienkamp H.J.
    FEBS Lett. 585:2665-2670(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZDHHC5.

Entry informationi

Entry nameiSSR5_RAT
AccessioniPrimary (citable) accession number: P30938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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