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Protein

Somatostatin receptor type 4

Gene

Sstr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.

GO - Molecular functioni

  • neuropeptide binding Source: GO_Central
  • somatostatin receptor activity Source: RGD

GO - Biological processi

  • arachidonic acid metabolic process Source: RGD
  • cell migration Source: RGD
  • cellular response to glucocorticoid stimulus Source: RGD
  • chemical synaptic transmission Source: GO_Central
  • forebrain development Source: RGD
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
  • negative regulation of cAMP metabolic process Source: RGD
  • negative regulation of cell proliferation Source: GO_Central
  • positive regulation of MAPK cascade Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 4
Short name:
SS-4-R
Short name:
SS4-R
Short name:
SS4R
Gene namesi
Name:Sstr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3764. Sstr4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 69Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini70 – 79CytoplasmicSequence analysis10
Transmembranei80 – 105Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini106 – 116ExtracellularSequence analysisAdd BLAST11
Transmembranei117 – 138Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini139 – 160CytoplasmicSequence analysisAdd BLAST22
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 203ExtracellularSequence analysisAdd BLAST22
Transmembranei204 – 228Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini229 – 254CytoplasmicSequence analysisAdd BLAST26
Transmembranei255 – 280Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini281 – 287ExtracellularSequence analysis7
Transmembranei288 – 311Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini312 – 384CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • neuron projection Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2096977.
GuidetoPHARMACOLOGYi358.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701291 – 384Somatostatin receptor type 4Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi115 ↔ 194PROSITE-ProRule annotation
Lipidationi323S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30937.

PTM databases

PhosphoSitePlusiP30937.

Expressioni

Tissue specificityi

Brain, lung, heart and islets. Moderate levels in the hippocampus, cortex and olfactory bulb.

Gene expression databases

BgeeiENSRNOG00000004641.
GenevisibleiP30937. RN.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4P310163EBI-7665959,EBI-375655

Protein-protein interaction databases

IntActiP30937. 1 interactor.
MINTiMINT-6504981.
STRINGi10116.ENSRNOP00000066231.

Chemistry databases

BindingDBiP30937.

Structurei

3D structure databases

ProteinModelPortaliP30937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOVERGENiHBG106919.
InParanoidiP30937.
KOiK04220.
OMAiLIVGKMR.
OrthoDBiEOG091G0HEN.
PhylomeDBiP30937.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPATLPLG GEDTTWTPGI NASWAPDEEE DAVRSDGTGT AGMVTIQCIY
60 70 80 90 100
ALVCLVGLVG NALVIFVILR YAKMKTATNI YLLNLAVADE LFMLSVPFVA
110 120 130 140 150
SAAALRHWPF GAVLCRAVLS VDGLNMFTSV FCLTVLSVDR YVAVVHPLRA
160 170 180 190 200
ATYRRPSVAK LINLGVWLAS LLVTLPIAVF ADTRPARGGE AVACNLHWPH
210 220 230 240 250
PAWSAVFVIY TFLLGFLLPV LAIGLCYLLI VGKMRAVALR AGWQQRRRSE
260 270 280 290 300
KKITRLVLMV VTVFVLCWMP FYVVQLLNLF VTSLDATVNH VSLILSYANS
310 320 330 340 350
CANPILYGFL SDNFRRSFQR VLCLRCCLLE TTGGAEEEPL DYYATALKSR
360 370 380
GGPGCICPPL PCQQEPMQAE PACKRVPFTK TTTF
Length:384
Mass (Da):42,088
Last modified:July 1, 1993 - v1
Checksum:i044542B4922411E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96544 Genomic DNA. Translation: AAA42180.1.
U04738 mRNA. Translation: AAA17519.1.
PIRiA47249.
RefSeqiNP_037168.1. NM_013036.2.
UniGeneiRn.9936.

Genome annotation databases

EnsembliENSRNOT00000006181; ENSRNOP00000066231; ENSRNOG00000004641.
GeneIDi25555.
KEGGirno:25555.
UCSCiRGD:3764. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96544 Genomic DNA. Translation: AAA42180.1.
U04738 mRNA. Translation: AAA17519.1.
PIRiA47249.
RefSeqiNP_037168.1. NM_013036.2.
UniGeneiRn.9936.

3D structure databases

ProteinModelPortaliP30937.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30937. 1 interactor.
MINTiMINT-6504981.
STRINGi10116.ENSRNOP00000066231.

Chemistry databases

BindingDBiP30937.
ChEMBLiCHEMBL2096977.
GuidetoPHARMACOLOGYi358.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP30937.

Proteomic databases

PaxDbiP30937.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006181; ENSRNOP00000066231; ENSRNOG00000004641.
GeneIDi25555.
KEGGirno:25555.
UCSCiRGD:3764. rat.

Organism-specific databases

CTDi6754.
RGDi3764. Sstr4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOVERGENiHBG106919.
InParanoidiP30937.
KOiK04220.
OMAiLIVGKMR.
OrthoDBiEOG091G0HEN.
PhylomeDBiP30937.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP30937.

Gene expression databases

BgeeiENSRNOG00000004641.
GenevisibleiP30937. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSR4_RAT
AccessioniPrimary (citable) accession number: P30937
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.