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P30937

- SSR4_RAT

UniProt

P30937 - SSR4_RAT

Protein

Somatostatin receptor type 4

Gene

Sstr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. somatostatin receptor activity Source: RGD

    GO - Biological processi

    1. arachidonic acid metabolic process Source: RGD
    2. cell migration Source: RGD
    3. cellular response to glucocorticoid stimulus Source: RGD
    4. forebrain development Source: RGD
    5. negative regulation of cAMP metabolic process Source: RGD
    6. positive regulation of MAPK cascade Source: RGD
    7. somatostatin signaling pathway Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 4
    Short name:
    SS-4-R
    Short name:
    SS4-R
    Short name:
    SS4R
    Gene namesi
    Name:Sstr4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi3764. Sstr4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Somatostatin receptor type 4PRO_0000070129Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 194PROSITE-ProRule annotation
    Lipidationi323 – 3231S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    PTM databases

    PhosphoSiteiP30937.

    Expressioni

    Tissue specificityi

    Brain, lung, heart and islets. Moderate levels in the hippocampus, cortex and olfactory bulb.

    Gene expression databases

    GenevestigatoriP30937.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dlg4P310163EBI-7665959,EBI-375655

    Protein-protein interaction databases

    IntActiP30937. 1 interaction.
    MINTiMINT-6504981.

    Structurei

    3D structure databases

    ProteinModelPortaliP30937.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini70 – 7910CytoplasmicSequence Analysis
    Topological domaini106 – 11611ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 16022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini182 – 20322ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini229 – 25426CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini281 – 2877ExtracellularSequence Analysis
    Topological domaini312 – 38473CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6928Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei80 – 10526Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22825Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 28026Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 31124Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00630000089736.
    HOVERGENiHBG106919.
    KOiK04220.
    OMAiWPHPAWS.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP30937.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001512. Somatstn_rcpt_4.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00590. SOMATOSTTN4R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30937-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTPATLPLG GEDTTWTPGI NASWAPDEEE DAVRSDGTGT AGMVTIQCIY    50
    ALVCLVGLVG NALVIFVILR YAKMKTATNI YLLNLAVADE LFMLSVPFVA 100
    SAAALRHWPF GAVLCRAVLS VDGLNMFTSV FCLTVLSVDR YVAVVHPLRA 150
    ATYRRPSVAK LINLGVWLAS LLVTLPIAVF ADTRPARGGE AVACNLHWPH 200
    PAWSAVFVIY TFLLGFLLPV LAIGLCYLLI VGKMRAVALR AGWQQRRRSE 250
    KKITRLVLMV VTVFVLCWMP FYVVQLLNLF VTSLDATVNH VSLILSYANS 300
    CANPILYGFL SDNFRRSFQR VLCLRCCLLE TTGGAEEEPL DYYATALKSR 350
    GGPGCICPPL PCQQEPMQAE PACKRVPFTK TTTF 384
    Length:384
    Mass (Da):42,088
    Last modified:July 1, 1993 - v1
    Checksum:i044542B4922411E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96544 Genomic DNA. Translation: AAA42180.1.
    U04738 mRNA. Translation: AAA17519.1.
    PIRiA47249.
    RefSeqiNP_037168.1. NM_013036.2.
    UniGeneiRn.9936.

    Genome annotation databases

    EnsembliENSRNOT00000006181; ENSRNOP00000066231; ENSRNOG00000004641.
    GeneIDi25555.
    KEGGirno:25555.
    UCSCiRGD:3764. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96544 Genomic DNA. Translation: AAA42180.1 .
    U04738 mRNA. Translation: AAA17519.1 .
    PIRi A47249.
    RefSeqi NP_037168.1. NM_013036.2.
    UniGenei Rn.9936.

    3D structure databases

    ProteinModelPortali P30937.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P30937. 1 interaction.
    MINTi MINT-6504981.

    Chemistry

    BindingDBi P30937.
    ChEMBLi CHEMBL2096977.
    GuidetoPHARMACOLOGYi 358.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30937.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006181 ; ENSRNOP00000066231 ; ENSRNOG00000004641 .
    GeneIDi 25555.
    KEGGi rno:25555.
    UCSCi RGD:3764. rat.

    Organism-specific databases

    CTDi 6754.
    RGDi 3764. Sstr4.

    Phylogenomic databases

    GeneTreei ENSGT00630000089736.
    HOVERGENi HBG106919.
    KOi K04220.
    OMAi WPHPAWS.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P30937.

    Miscellaneous databases

    NextBioi 607121.
    PROi P30937.

    Gene expression databases

    Genevestigatori P30937.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001512. Somatstn_rcpt_4.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00590. SOMATOSTTN4R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of a brain-specific somatostatin receptor."
      Bruno J.F., Xu Y., Song J., Berelowitz M.
      Proc. Natl. Acad. Sci. U.S.A. 89:11151-11155(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. "Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade."
      Bito H., Mori M., Sakanaka C., Takano T., Honda Z., Gotoh Y., Nishida E., Shimizu T.
      J. Biol. Chem. 269:12722-12730(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiSSR4_RAT
    AccessioniPrimary (citable) accession number: P30937
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3