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Protein

Somatostatin receptor type 4

Gene

Sstr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.

GO - Molecular functioni

  1. neuropeptide binding Source: GO_Central
  2. somatostatin receptor activity Source: RGD

GO - Biological processi

  1. arachidonic acid metabolic process Source: RGD
  2. cell migration Source: RGD
  3. cellular response to glucocorticoid stimulus Source: RGD
  4. forebrain development Source: RGD
  5. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
  6. negative regulation of cAMP metabolic process Source: RGD
  7. negative regulation of cell proliferation Source: GO_Central
  8. neuropeptide signaling pathway Source: GO_Central
  9. positive regulation of MAPK cascade Source: RGD
  10. somatostatin signaling pathway Source: GOC
  11. synaptic transmission Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_306851. Peptide ligand-binding receptors.
REACT_339234. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 4
Short name:
SS-4-R
Short name:
SS4-R
Short name:
SS4R
Gene namesi
Name:Sstr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3764. Sstr4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei42 – 6928Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini70 – 7910CytoplasmicSequence Analysis
Transmembranei80 – 10526Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini106 – 11611ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini139 – 16022CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini182 – 20322ExtracellularSequence AnalysisAdd
BLAST
Transmembranei204 – 22825Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini229 – 25426CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei255 – 28026Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini281 – 2877ExtracellularSequence Analysis
Transmembranei288 – 31124Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini312 – 38473CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. integral component of plasma membrane Source: GO_Central
  3. neuron projection Source: GO_Central
  4. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Somatostatin receptor type 4PRO_0000070129Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 194PROSITE-ProRule annotation
Lipidationi323 – 3231S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiP30937.

Expressioni

Tissue specificityi

Brain, lung, heart and islets. Moderate levels in the hippocampus, cortex and olfactory bulb.

Gene expression databases

GenevestigatoriP30937.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4P310163EBI-7665959,EBI-375655

Protein-protein interaction databases

IntActiP30937. 1 interaction.
MINTiMINT-6504981.

Structurei

3D structure databases

ProteinModelPortaliP30937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118797.
HOVERGENiHBG106919.
InParanoidiP30937.
KOiK04220.
OMAiVDGLNMF.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP30937.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPATLPLG GEDTTWTPGI NASWAPDEEE DAVRSDGTGT AGMVTIQCIY
60 70 80 90 100
ALVCLVGLVG NALVIFVILR YAKMKTATNI YLLNLAVADE LFMLSVPFVA
110 120 130 140 150
SAAALRHWPF GAVLCRAVLS VDGLNMFTSV FCLTVLSVDR YVAVVHPLRA
160 170 180 190 200
ATYRRPSVAK LINLGVWLAS LLVTLPIAVF ADTRPARGGE AVACNLHWPH
210 220 230 240 250
PAWSAVFVIY TFLLGFLLPV LAIGLCYLLI VGKMRAVALR AGWQQRRRSE
260 270 280 290 300
KKITRLVLMV VTVFVLCWMP FYVVQLLNLF VTSLDATVNH VSLILSYANS
310 320 330 340 350
CANPILYGFL SDNFRRSFQR VLCLRCCLLE TTGGAEEEPL DYYATALKSR
360 370 380
GGPGCICPPL PCQQEPMQAE PACKRVPFTK TTTF
Length:384
Mass (Da):42,088
Last modified:June 30, 1993 - v1
Checksum:i044542B4922411E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96544 Genomic DNA. Translation: AAA42180.1.
U04738 mRNA. Translation: AAA17519.1.
PIRiA47249.
RefSeqiNP_037168.1. NM_013036.2.
UniGeneiRn.9936.

Genome annotation databases

EnsembliENSRNOT00000006181; ENSRNOP00000066231; ENSRNOG00000004641.
GeneIDi25555.
KEGGirno:25555.
UCSCiRGD:3764. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96544 Genomic DNA. Translation: AAA42180.1.
U04738 mRNA. Translation: AAA17519.1.
PIRiA47249.
RefSeqiNP_037168.1. NM_013036.2.
UniGeneiRn.9936.

3D structure databases

ProteinModelPortaliP30937.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30937. 1 interaction.
MINTiMINT-6504981.

Chemistry

BindingDBiP30937.
ChEMBLiCHEMBL2096977.
GuidetoPHARMACOLOGYi358.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30937.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006181; ENSRNOP00000066231; ENSRNOG00000004641.
GeneIDi25555.
KEGGirno:25555.
UCSCiRGD:3764. rat.

Organism-specific databases

CTDi6754.
RGDi3764. Sstr4.

Phylogenomic databases

GeneTreeiENSGT00760000118797.
HOVERGENiHBG106919.
InParanoidiP30937.
KOiK04220.
OMAiVDGLNMF.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP30937.

Enzyme and pathway databases

ReactomeiREACT_306851. Peptide ligand-binding receptors.
REACT_339234. G alpha (i) signalling events.

Miscellaneous databases

NextBioi607121.
PROiP30937.

Gene expression databases

GenevestigatoriP30937.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and functional expression of a brain-specific somatostatin receptor."
    Bruno J.F., Xu Y., Song J., Berelowitz M.
    Proc. Natl. Acad. Sci. U.S.A. 89:11151-11155(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade."
    Bito H., Mori M., Sakanaka C., Takano T., Honda Z., Gotoh Y., Nishida E., Shimizu T.
    J. Biol. Chem. 269:12722-12730(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiSSR4_RAT
AccessioniPrimary (citable) accession number: P30937
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 1993
Last sequence update: June 30, 1993
Last modified: March 31, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.