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P30937

- SSR4_RAT

UniProt

P30937 - SSR4_RAT

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Protein

Somatostatin receptor type 4

Gene

Sstr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.

GO - Molecular functioni

  1. somatostatin receptor activity Source: RGD

GO - Biological processi

  1. arachidonic acid metabolic process Source: RGD
  2. cell migration Source: RGD
  3. cellular response to glucocorticoid stimulus Source: RGD
  4. forebrain development Source: RGD
  5. negative regulation of cAMP metabolic process Source: RGD
  6. positive regulation of MAPK cascade Source: RGD
  7. somatostatin signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 4
Short name:
SS-4-R
Short name:
SS4-R
Short name:
SS4R
Gene namesi
Name:Sstr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi3764. Sstr4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Somatostatin receptor type 4PRO_0000070129Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 194PROSITE-ProRule annotation
Lipidationi323 – 3231S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiP30937.

Expressioni

Tissue specificityi

Brain, lung, heart and islets. Moderate levels in the hippocampus, cortex and olfactory bulb.

Gene expression databases

GenevestigatoriP30937.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4P310163EBI-7665959,EBI-375655

Protein-protein interaction databases

IntActiP30937. 1 interaction.
MINTiMINT-6504981.

Structurei

3D structure databases

ProteinModelPortaliP30937.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Topological domaini70 – 7910CytoplasmicSequence Analysis
Topological domaini106 – 11611ExtracellularSequence AnalysisAdd
BLAST
Topological domaini139 – 16022CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini182 – 20322ExtracellularSequence AnalysisAdd
BLAST
Topological domaini229 – 25426CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini281 – 2877ExtracellularSequence Analysis
Topological domaini312 – 38473CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6928Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei80 – 10526Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei117 – 13822Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei204 – 22825Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei255 – 28026Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei288 – 31124Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118797.
HOVERGENiHBG106919.
InParanoidiP30937.
KOiK04220.
OMAiWPHPAWS.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP30937.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30937-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTPATLPLG GEDTTWTPGI NASWAPDEEE DAVRSDGTGT AGMVTIQCIY
60 70 80 90 100
ALVCLVGLVG NALVIFVILR YAKMKTATNI YLLNLAVADE LFMLSVPFVA
110 120 130 140 150
SAAALRHWPF GAVLCRAVLS VDGLNMFTSV FCLTVLSVDR YVAVVHPLRA
160 170 180 190 200
ATYRRPSVAK LINLGVWLAS LLVTLPIAVF ADTRPARGGE AVACNLHWPH
210 220 230 240 250
PAWSAVFVIY TFLLGFLLPV LAIGLCYLLI VGKMRAVALR AGWQQRRRSE
260 270 280 290 300
KKITRLVLMV VTVFVLCWMP FYVVQLLNLF VTSLDATVNH VSLILSYANS
310 320 330 340 350
CANPILYGFL SDNFRRSFQR VLCLRCCLLE TTGGAEEEPL DYYATALKSR
360 370 380
GGPGCICPPL PCQQEPMQAE PACKRVPFTK TTTF
Length:384
Mass (Da):42,088
Last modified:July 1, 1993 - v1
Checksum:i044542B4922411E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96544 Genomic DNA. Translation: AAA42180.1.
U04738 mRNA. Translation: AAA17519.1.
PIRiA47249.
RefSeqiNP_037168.1. NM_013036.2.
UniGeneiRn.9936.

Genome annotation databases

EnsembliENSRNOT00000006181; ENSRNOP00000066231; ENSRNOG00000004641.
GeneIDi25555.
KEGGirno:25555.
UCSCiRGD:3764. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96544 Genomic DNA. Translation: AAA42180.1 .
U04738 mRNA. Translation: AAA17519.1 .
PIRi A47249.
RefSeqi NP_037168.1. NM_013036.2.
UniGenei Rn.9936.

3D structure databases

ProteinModelPortali P30937.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30937. 1 interaction.
MINTi MINT-6504981.

Chemistry

BindingDBi P30937.
ChEMBLi CHEMBL2096977.
GuidetoPHARMACOLOGYi 358.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30937.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006181 ; ENSRNOP00000066231 ; ENSRNOG00000004641 .
GeneIDi 25555.
KEGGi rno:25555.
UCSCi RGD:3764. rat.

Organism-specific databases

CTDi 6754.
RGDi 3764. Sstr4.

Phylogenomic databases

GeneTreei ENSGT00760000118797.
HOVERGENi HBG106919.
InParanoidi P30937.
KOi K04220.
OMAi WPHPAWS.
OrthoDBi EOG7BKCVQ.
PhylomeDBi P30937.

Miscellaneous databases

NextBioi 607121.
PROi P30937.

Gene expression databases

Genevestigatori P30937.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and functional expression of a brain-specific somatostatin receptor."
    Bruno J.F., Xu Y., Song J., Berelowitz M.
    Proc. Natl. Acad. Sci. U.S.A. 89:11151-11155(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade."
    Bito H., Mori M., Sakanaka C., Takano T., Honda Z., Gotoh Y., Nishida E., Shimizu T.
    J. Biol. Chem. 269:12722-12730(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiSSR4_RAT
AccessioniPrimary (citable) accession number: P30937
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3