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P30937 (SSR4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatostatin receptor type 4

Short name=SS-4-R
Short name=SS4-R
Short name=SS4R
Gene names
Name:Sstr4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Brain, lung, heart and islets. Moderate levels in the hippocampus, cortex and olfactory bulb.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Dlg4P310163EBI-7665959,EBI-375655

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Somatostatin receptor type 4
PRO_0000070129

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6928Helical; Name=1; Potential
Topological domain70 – 7910Cytoplasmic Potential
Transmembrane80 – 10526Helical; Name=2; Potential
Topological domain106 – 11611Extracellular Potential
Transmembrane117 – 13822Helical; Name=3; Potential
Topological domain139 – 16022Cytoplasmic Potential
Transmembrane161 – 18121Helical; Name=4; Potential
Topological domain182 – 20322Extracellular Potential
Transmembrane204 – 22825Helical; Name=5; Potential
Topological domain229 – 25426Cytoplasmic Potential
Transmembrane255 – 28026Helical; Name=6; Potential
Topological domain281 – 2877Extracellular Potential
Transmembrane288 – 31124Helical; Name=7; Potential
Topological domain312 – 38473Cytoplasmic Potential

Amino acid modifications

Lipidation3231S-palmitoyl cysteine Potential
Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond115 ↔ 194 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30937 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 044542B4922411E5

FASTA38442,088
        10         20         30         40         50         60 
MNTPATLPLG GEDTTWTPGI NASWAPDEEE DAVRSDGTGT AGMVTIQCIY ALVCLVGLVG 

        70         80         90        100        110        120 
NALVIFVILR YAKMKTATNI YLLNLAVADE LFMLSVPFVA SAAALRHWPF GAVLCRAVLS 

       130        140        150        160        170        180 
VDGLNMFTSV FCLTVLSVDR YVAVVHPLRA ATYRRPSVAK LINLGVWLAS LLVTLPIAVF 

       190        200        210        220        230        240 
ADTRPARGGE AVACNLHWPH PAWSAVFVIY TFLLGFLLPV LAIGLCYLLI VGKMRAVALR 

       250        260        270        280        290        300 
AGWQQRRRSE KKITRLVLMV VTVFVLCWMP FYVVQLLNLF VTSLDATVNH VSLILSYANS 

       310        320        330        340        350        360 
CANPILYGFL SDNFRRSFQR VLCLRCCLLE TTGGAEEEPL DYYATALKSR GGPGCICPPL 

       370        380 
PCQQEPMQAE PACKRVPFTK TTTF 

« Hide

References

[1]"Molecular cloning and functional expression of a brain-specific somatostatin receptor."
Bruno J.F., Xu Y., Song J., Berelowitz M.
Proc. Natl. Acad. Sci. U.S.A. 89:11151-11155(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[2]"Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade."
Bito H., Mori M., Sakanaka C., Takano T., Honda Z., Gotoh Y., Nishida E., Shimizu T.
J. Biol. Chem. 269:12722-12730(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M96544 Genomic DNA. Translation: AAA42180.1.
U04738 mRNA. Translation: AAA17519.1.
PIRA47249.
RefSeqNP_037168.1. NM_013036.2.
UniGeneRn.9936.

3D structure databases

ProteinModelPortalP30937.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP30937. 1 interaction.
MINTMINT-6504981.

Chemistry

BindingDBP30937.
ChEMBLCHEMBL2096977.
GuidetoPHARMACOLOGY358.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30937.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006181; ENSRNOP00000066231; ENSRNOG00000004641.
GeneID25555.
KEGGrno:25555.
UCSCRGD:3764. rat.

Organism-specific databases

CTD6754.
RGD3764. Sstr4.

Phylogenomic databases

GeneTreeENSGT00630000089736.
HOVERGENHBG106919.
KOK04220.
OMAFYVVQLL.
OrthoDBEOG7BKCVQ.
PhylomeDBP30937.

Gene expression databases

GenevestigatorP30937.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607121.
PROP30937.

Entry information

Entry nameSSR4_RAT
AccessionPrimary (citable) accession number: P30937
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries