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P30936

- SSR3_RAT

UniProt

P30936 - SSR3_RAT

Protein

Somatostatin receptor type 3

Gene

Sstr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.2 Publications

    GO - Molecular functioni

    1. somatostatin receptor activity Source: InterPro

    GO - Biological processi

    1. cellular response to estradiol stimulus Source: RGD
    2. cellular response to glucocorticoid stimulus Source: RGD
    3. cerebellum development Source: RGD
    4. forebrain development Source: RGD
    5. response to starvation Source: RGD
    6. spermatogenesis Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 3
    Short name:
    SS-3-R
    Short name:
    SS3-R
    Short name:
    SS3R
    Alternative name(s):
    SSR-28
    Gene namesi
    Name:Sstr3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi620308. Sstr3.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
    Note: Internalized into endoplasmic vesicles upon somatostatin-stimulation.

    GO - Cellular componenti

    1. ciliary membrane Source: Ensembl
    2. cytoplasm Source: RGD
    3. integral component of membrane Source: UniProtKB-KW
    4. nonmotile primary cilium Source: Ensembl
    5. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi341 – 3411S → A: Impaired internalization after somatostatin binding. 1 Publication
    Mutagenesisi346 – 3461S → A: Impaired internalization after somatostatin binding. 1 Publication
    Mutagenesisi351 – 3511S → A: Impaired internalization after somatostatin binding. 1 Publication
    Mutagenesisi357 – 3571T → A: Reduced basal and somatostatin-induced phosphorylation. Impaired internalization after somatostatin binding. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Somatostatin receptor type 3PRO_0000070126Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 192PROSITE-ProRule annotation
    Modified residuei341 – 3411Phosphoserine1 Publication
    Modified residuei346 – 3461Phosphoserine1 Publication
    Modified residuei351 – 3511Phosphoserine1 Publication
    Modified residuei357 – 3571Phosphothreonine1 Publication

    Post-translational modificationi

    Phosphorylated. Phosphorylation increases upon somatostatin binding.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP30936.

    PTM databases

    PhosphoSiteiP30936.

    Expressioni

    Tissue specificityi

    Densely expressed in cerebellum and at moderate levels in the amygdala, cortex, striatum, spleen, liver and pituitary.1 Publication

    Gene expression databases

    GenevestigatoriP30936.

    Interactioni

    Subunit structurei

    Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function.1 Publication

    Protein-protein interaction databases

    BioGridi251061. 1 interaction.
    STRINGi10116.ENSRNOP00000009612.

    Structurei

    3D structure databases

    ProteinModelPortaliP30936.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 8110CytoplasmicSequence Analysis
    Topological domaini104 – 11815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 16222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 20624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini233 – 26634CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 30214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini326 – 428103CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 7126Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei119 – 14022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei207 – 23226Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28822Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32523Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi358 – 37316Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274661.
    GeneTreeiENSGT00630000089736.
    HOGENOMiHOG000230485.
    HOVERGENiHBG106919.
    InParanoidiP30936.
    KOiK04219.
    OMAiNASSAWP.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP30936.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001856. Somatstn_rcpt_3.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00589. SOMATOSTTN3R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30936-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVTYPSSV PTTLDPGNAS SAWPLDTSLG NASAGTSLAG LAVSGILISL    50
    VYLVVCVVGL LGNSLVIYVV LRHTSSPSVT SVYILNLALA DELFMLGLPF 100
    LAAQNALSYW PFGSLMCRLV MAVDGINQFT SIFCLTVMSV DRYLAVVHPT 150
    RSARWRTAPV ARMVSAAVWV ASAVVVLPVV VFSGVPRGMS TCHMQWPEPA 200
    AAWRTAFIIY TAALGFFGPL LVICLCYLLI VVKVRSTTRR VRAPSCQWVQ 250
    APACQRRRRS ERRVTRMVVA VVALFVLCWM PFYLLNIVNV VCPLPEEPAF 300
    FGLYFLVVAL PYANSCANPI LYGFLSYRFK QGFRRILLRP SRRVRSQEPG 350
    SGPPEKTEEE EDEEEEERRE EEERRMQRGQ EMNGRLSQIA QPGPSGQQQR 400
    PCTGTAKEQQ LLPQEATAGD KASTLSHL 428
    Length:428
    Mass (Da):47,151
    Last modified:July 1, 1993 - v1
    Checksum:iBE0AA948840A9E9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63574 mRNA. Translation: CAA45130.1.
    PIRiS30508.
    RefSeqiNP_598206.1. NM_133522.1.
    XP_006242028.1. XM_006241966.1.
    UniGeneiRn.10458.

    Genome annotation databases

    EnsembliENSRNOT00000009612; ENSRNOP00000009612; ENSRNOG00000007332.
    GeneIDi171044.
    KEGGirno:171044.
    UCSCiRGD:620308. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63574 mRNA. Translation: CAA45130.1 .
    PIRi S30508.
    RefSeqi NP_598206.1. NM_133522.1.
    XP_006242028.1. XM_006241966.1.
    UniGenei Rn.10458.

    3D structure databases

    ProteinModelPortali P30936.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 251061. 1 interaction.
    STRINGi 10116.ENSRNOP00000009612.

    Chemistry

    BindingDBi P30936.
    ChEMBLi CHEMBL2096977.
    GuidetoPHARMACOLOGYi 357.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30936.

    Proteomic databases

    PaxDbi P30936.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009612 ; ENSRNOP00000009612 ; ENSRNOG00000007332 .
    GeneIDi 171044.
    KEGGi rno:171044.
    UCSCi RGD:620308. rat.

    Organism-specific databases

    CTDi 6753.
    RGDi 620308. Sstr3.

    Phylogenomic databases

    eggNOGi NOG274661.
    GeneTreei ENSGT00630000089736.
    HOGENOMi HOG000230485.
    HOVERGENi HBG106919.
    InParanoidi P30936.
    KOi K04219.
    OMAi NASSAWP.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P30936.
    TreeFami TF315737.

    Miscellaneous databases

    NextBioi 621561.
    PROi P30936.

    Gene expression databases

    Genevestigatori P30936.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001856. Somatstn_rcpt_3.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00589. SOMATOSTTN3R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain."
      Meyerhof W., Wulfsen I., Schoenrock C., Fehr S., Richter D.
      Proc. Natl. Acad. Sci. U.S.A. 89:10267-10271(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: Wistar.
      Tissue: Brain.
    2. "Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization."
      Roth A., Kreienkamp H.-J., Meyerhof W., Richter D.
      J. Biol. Chem. 272:23769-23774(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF SER-341; SER-346; SER-351 AND THR-357, PHOSPHORYLATION AT SER-341; SER-346; SER-351 AND THR-357.
    3. "Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A)."
      Pfeiffer M., Koch T., Schroder H., Klutzny M., Kirscht S., Kreienkamp H.J., Hollt V., Schulz S.
      J. Biol. Chem. 276:14027-14036(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSSR3_RAT
    AccessioniPrimary (citable) accession number: P30936
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3