Somatostatin receptor type 3 - Rattus norvegicus (Rat)

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P30936 (SSR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 99. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Somatostatin receptor type 3
Short name=SS-3-R
Short name=SS3-R
Short name=SS3R

Alternative name(s):
SSR-28

Gene names

Name:

Sstr3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Note: Internalized into endoplasmic vesicles upon somatostatin-stimulation. Ref.2
Tissue specificity	Densely expressed in cerebellum and in moderate levels in the amygdala, cortex, striatum, spleen, liver, pituitary.
Post-translational modification	Phosphorylated. Phosphorylation increases upon somatostatin binding. Ref.2
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to estradiol stimulus Inferred from expression pattern PubMed 9564833. Source: RGD cellular response to glucocorticoid stimulus Inferred from expression pattern PubMed 14512709. Source: RGD cerebellum development Inferred from expression pattern PubMed 9166718. Source: RGD forebrain development Inferred from expression pattern PubMed 10805921. Source: RGD response to starvation Inferred from expression pattern PubMed 7956902. Source: RGD somatostatin signaling pathway Inferred from electronic annotation. Source: GOC spermatogenesis Inferred from expression pattern PubMed 9421433. Source: RGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 9322965. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nonmotile primary cilium Inferred from electronic annotation. Source: Compara plasma membrane Inferred from direct assay PubMed 9322965. Source: RGD
Molecular_function	somatostatin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 428

428

Somatostatin receptor type 3

PRO_0000070126

Regions

Topological domain

1 – 45

Extracellular Potential

Transmembrane

46 – 71

Helical; Name=1; Potential

Topological domain

72 – 81

Cytoplasmic Potential

Transmembrane

82 – 103

Helical; Name=2; Potential

Topological domain

104 – 118

Extracellular Potential

Transmembrane

119 – 140

Helical; Name=3; Potential

Topological domain

141 – 162

Cytoplasmic Potential

Transmembrane

163 – 182

Helical; Name=4; Potential

Topological domain

183 – 206

Extracellular Potential

Transmembrane

207 – 232

Helical; Name=5; Potential

Topological domain

233 – 266

Cytoplasmic Potential

Transmembrane

267 – 288

Helical; Name=6; Potential

Topological domain

289 – 302

Extracellular Potential

Transmembrane

303 – 325

Helical; Name=7; Potential

Topological domain

326 – 428

103

Cytoplasmic Potential

Compositional bias

358 – 373

Poly-Glu

Amino acid modifications

Modified residue

341

Phosphoserine Probable

Modified residue

346

Phosphoserine Probable

Modified residue

351

Phosphoserine Probable

Modified residue

357

Phosphothreonine Ref.2

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

117 ↔ 192

By similarity

Experimental info

Mutagenesis

341

S → A: Impaired internalization after somatostatin binding. Ref.2

Mutagenesis

346

S → A: Impaired internalization after somatostatin binding. Ref.2

Mutagenesis

351

S → A: Impaired internalization after somatostatin binding. Ref.2

Mutagenesis

357

T → A: Reduced basal and somatostatin-induced phosphorylation. Impaired internalization after somatostatin binding. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P30936 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: BE0AA948840A9E9D
Show »

FASTA

428

47,151

        10         20         30         40         50         60 
MAAVTYPSSV PTTLDPGNAS SAWPLDTSLG NASAGTSLAG LAVSGILISL VYLVVCVVGL 

        70         80         90        100        110        120 
LGNSLVIYVV LRHTSSPSVT SVYILNLALA DELFMLGLPF LAAQNALSYW PFGSLMCRLV 

       130        140        150        160        170        180 
MAVDGINQFT SIFCLTVMSV DRYLAVVHPT RSARWRTAPV ARMVSAAVWV ASAVVVLPVV 

       190        200        210        220        230        240 
VFSGVPRGMS TCHMQWPEPA AAWRTAFIIY TAALGFFGPL LVICLCYLLI VVKVRSTTRR 

       250        260        270        280        290        300 
VRAPSCQWVQ APACQRRRRS ERRVTRMVVA VVALFVLCWM PFYLLNIVNV VCPLPEEPAF 

       310        320        330        340        350        360 
FGLYFLVVAL PYANSCANPI LYGFLSYRFK QGFRRILLRP SRRVRSQEPG SGPPEKTEEE 

       370        380        390        400        410        420 
EDEEEEERRE EEERRMQRGQ EMNGRLSQIA QPGPSGQQQR PCTGTAKEQQ LLPQEATAGD 


KASTLSHL

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References

[1]	"Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain." Meyerhof W., Wulfsen I., Schoenrock C., Fehr S., Richter D. Proc. Natl. Acad. Sci. U.S.A. 89:10267-10271(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.
[2]	"Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization." Roth A., Kreienkamp H.-J., Meyerhof W., Richter D. J. Biol. Chem. 272:23769-23774(1997) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF SER-341; SER-346; SER-351 AND THR-357, PHOSPHORYLATION AT SER-341; SER-346; SER-351 AND THR-357.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63574 mRNA. Translation: CAA45130.1.
IPI	IPI00213657.
PIR	S30508.
RefSeq	NP_598206.1. NM_133522.1.
UniGene	Rn.10458.
3D structure databases
ProteinModelPortal	P30936.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000009612.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P30936.
Proteomic databases
PaxDb	P30936.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000009612; ENSRNOP00000009612; ENSRNOG00000007332.
GeneID	171044.
KEGG	rno:171044.
UCSC	RGD:620308. rat.
Organism-specific databases
CTD	6753.
RGD	620308. Sstr3.
Phylogenomic databases
eggNOG	NOG274661.
GeneTree	ENSGT00630000089736.
HOGENOM	HOG000230485.
HOVERGEN	HBG106919.
InParanoid	P30936.
KO	K04219.
OMA	NASSAWP.
OrthoDB	EOG4XPQGG.
Gene expression databases
Genevestigator	P30936.
GermOnline	ENSRNOG00000007332. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000586. Somatstn_rcpt. IPR001856. Somatstn_rcpt_3. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00589. SOMATOSTTN3R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P30936.
ChEMBL	CHEMBL3340.
NextBio	621561.

Entry information

Entry name

SSR3_RAT

Accession

Primary (citable) accession number: P30936

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents