P30935 (SSR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Somatostatin receptor type 3
Short name=SS-3-R
Short name=SS3-R
Short name=SS3R

Alternative name(s):
SSR-28

Gene names

Name:	Sstr3
Synonyms:	Smstr3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Note: Internalized into endoplasmic vesicles upon somatostatin-stimulation By similarity.
Post-translational modification	Phosphorylated. Phosphorylation increases upon somatostatin binding By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to estradiol stimulus Inferred from electronic annotation. Source: Compara cellular response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara cerebellum development Inferred from electronic annotation. Source: Compara forebrain development Inferred from electronic annotation. Source: Compara response to starvation Inferred from electronic annotation. Source: Compara somatostatin signaling pathway Inferred from electronic annotation. Source: GOC spermatogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cilium membrane Inferred from direct assay PubMed 22179047. Source: MGI cytoplasm Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nonmotile primary cilium Inferred from direct assay PubMed 18334641. Source: BHF-UCL
Molecular_function	somatostatin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Somatostatin receptor type 3		PRO_0000070125
Regions
	Topological domain	1 – 45	45	Extracellular Potential
	Transmembrane	46 – 71	26	Helical; Name=1; Potential
	Topological domain	72 – 81	10	Cytoplasmic Potential
	Transmembrane	82 – 103	22	Helical; Name=2; Potential
	Topological domain	104 – 118	15	Extracellular Potential
	Transmembrane	119 – 140	22	Helical; Name=3; Potential
	Topological domain	141 – 162	22	Cytoplasmic Potential
	Transmembrane	163 – 182	20	Helical; Name=4; Potential
	Topological domain	183 – 206	24	Extracellular Potential
	Transmembrane	207 – 232	26	Helical; Name=5; Potential
	Topological domain	233 – 266	34	Cytoplasmic Potential
	Transmembrane	267 – 288	22	Helical; Name=6; Potential
	Topological domain	289 – 302	14	Extracellular Potential
	Transmembrane	303 – 325	23	Helical; Name=7; Potential
	Topological domain	326 – 428	103	Cytoplasmic Potential
	Compositional bias	358 – 373	16	Poly-Glu
Amino acid modifications
	Modified residue	357	1	Phosphothreonine By similarity
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Glycosylation	31	1	N-linked (GlcNAc...) Potential
	Disulfide bond	117 ↔ 192		By similarity
Experimental info
	Sequence conflict	12	1	T → M in AAA40144. Ref.1
	Sequence conflict	19	1	A → T in AAA40144. Ref.1
	Sequence conflict	166	1	A → R in AAA40144. Ref.1
	Sequence conflict	211	1	T → M in AAA40144. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P30935 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 5B1010167AD8780F	FASTA	428	47,216
	10 20 30 40 50 60 MATVTYPSSE PTTLDPGNAS STWPLDTTLG NTSAGASLTG LAVSGILISL VYLVVCVVGL 70 80 90 100 110 120 LGNSLVIYVV LRHTSSPSVT SVYILNLALA DELFMLGLPF LAAQNALSYW PFGSLMCRLV 130 140 150 160 170 180 MAVDGINQFT SIFCLTVMSV DRYLAVVHPT RSARWRTAPV ARTVSAAVWV ASAVVVLPVV 190 200 210 220 230 240 VFSGVPRGMS TCHMQWPEPA AAWRTAFIIY TAALGFFGPL LVICLCYLLI VVKVRSTTRR 250 260 270 280 290 300 VRAPSCQWVQ APACQRRRRS ERRVTRMVVA VVALFVLCWM PFYLLNIVNV VCPLPEEPAF 310 320 330 340 350 360 FGLYFLVVAL PYANSCANPI LYGFLSYRFK QGFRRILLRP SRRIRSQEPG SGPPEKTEEE 370 380 390 400 410 420 EDEEEEERRE EEERRMQRGQ EMNGRLSQIA QAGTSGQQPR PCTGTAKEQQ LLPQEATAGD KASTLSHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase." Yasuda K., Rens-Domiano S., Breder C.D., Law S.F., Saper C.B., Reisine T., Bell G.I. J. Biol. Chem. 267:20422-20428(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Diencephalon.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M91000 Genomic DNA. Translation: AAA40144.1. AK136904 mRNA. Translation: BAE23164.1. AL590144 Genomic DNA. No translation available.
IPI	IPI00135713.
PIR	A44021.
RefSeq	NP_033244.2. NM_009218.3.
UniGene	Mm.211411.
3D structure databases
ProteinModelPortal	P30935.
SMR	P30935. Positions 37-334.
ModBase	Search...
Protein-protein interaction databases
IntAct	P30935. 9 interactions.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P30935.
Proteomic databases
PRIDE	P30935.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000053239; ENSMUSP00000058040; ENSMUSG00000044933.
GeneID	20607.
KEGG	mmu:20607.
Organism-specific databases
CTD	6753.
MGI	MGI:98329. Sstr3.
Phylogenomic databases
eggNOG	NOG274661.
GeneTree	ENSGT00630000089736.
HOGENOM	HOG000230485.
HOVERGEN	HBG106919.
InParanoid	Q3UVV5.
KO	K04219.
OMA	NASSAWP.
OrthoDB	EOG4XPQGG.
Gene expression databases
Bgee	P30935.
CleanEx	MM_SSTR3.
Genevestigator	P30935.
GermOnline	ENSMUSG00000044933. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000586. Somatstn_rcpt. IPR001856. Somatstn_rcpt_3. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00589. SOMATOSTTN3R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P30935.
ChEMBL	CHEMBL2238.
NextBio	298955.
SOURCE	Search...

Entry information

Entry name

SSR3_MOUSE

Accession

Primary (citable) accession number: P30935
Secondary accession number(s): Q3UVV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program