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P30935

- SSR3_MOUSE

UniProt

P30935 - SSR3_MOUSE

Protein

Somatostatin receptor type 3

Gene

Sstr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.1 Publication

    GO - Molecular functioni

    1. somatostatin receptor activity Source: InterPro

    GO - Biological processi

    1. cellular response to estradiol stimulus Source: Ensembl
    2. cellular response to glucocorticoid stimulus Source: Ensembl
    3. cerebellum development Source: Ensembl
    4. forebrain development Source: Ensembl
    5. response to starvation Source: Ensembl
    6. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 3
    Short name:
    SS-3-R
    Short name:
    SS3-R
    Short name:
    SS3R
    Alternative name(s):
    SSR-28
    Gene namesi
    Name:Sstr3
    Synonyms:Smstr3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:98329. Sstr3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Internalized into endoplasmic vesicles upon somatostatin-stimulation.By similarity

    GO - Cellular componenti

    1. ciliary membrane Source: MGI
    2. cilium Source: MGI
    3. cytoplasm Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. nonmotile primary cilium Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Somatostatin receptor type 3PRO_0000070125Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 192PROSITE-ProRule annotation
    Modified residuei357 – 3571PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated. Phosphorylation increases upon somatostatin binding By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP30935.

    PTM databases

    PhosphoSiteiP30935.

    Expressioni

    Tissue specificityi

    In the brain, primarily observed in the forebrain. Moderate levels found throughout laminae 2-6 of the neocortex and allocortex, and high levels in lamina 2 of the piriform and entorhinal cortices. High levels also present in the cornu ammonis fields of the hippocampus. In the amygdala, highly expressed in the nucleus of the lateral olfactory tract with expression also detected in the rostral portions of the basal magnocellular and lateral nuclei. In the diencephalon, moderate levels observed in the ventromedial and arcuate nuclei of the hypothalamus. In the midbrain, moderate levels found in the lateral portion of the substantia nigra pars reticulata.1 Publication

    Gene expression databases

    BgeeiP30935.
    CleanExiMM_SSTR3.
    GenevestigatoriP30935.

    Interactioni

    Subunit structurei

    Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function By similarity.By similarity

    Protein-protein interaction databases

    IntActiP30935. 9 interactions.
    STRINGi10090.ENSMUSP00000058040.

    Structurei

    3D structure databases

    ProteinModelPortaliP30935.
    SMRiP30935. Positions 37-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 8110CytoplasmicSequence Analysis
    Topological domaini104 – 11815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 16222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 20624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini233 – 26634CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 30214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini326 – 428103CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 7126Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei119 – 14022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei207 – 23226Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28822Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32523Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi358 – 37316Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274661.
    GeneTreeiENSGT00630000089736.
    HOGENOMiHOG000230485.
    HOVERGENiHBG106919.
    InParanoidiQ3UVV5.
    KOiK04219.
    OMAiNASSAWP.
    OrthoDBiEOG7BKCVQ.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001856. Somatstn_rcpt_3.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00589. SOMATOSTTN3R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30935-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATVTYPSSE PTTLDPGNAS STWPLDTTLG NTSAGASLTG LAVSGILISL    50
    VYLVVCVVGL LGNSLVIYVV LRHTSSPSVT SVYILNLALA DELFMLGLPF 100
    LAAQNALSYW PFGSLMCRLV MAVDGINQFT SIFCLTVMSV DRYLAVVHPT 150
    RSARWRTAPV ARTVSAAVWV ASAVVVLPVV VFSGVPRGMS TCHMQWPEPA 200
    AAWRTAFIIY TAALGFFGPL LVICLCYLLI VVKVRSTTRR VRAPSCQWVQ 250
    APACQRRRRS ERRVTRMVVA VVALFVLCWM PFYLLNIVNV VCPLPEEPAF 300
    FGLYFLVVAL PYANSCANPI LYGFLSYRFK QGFRRILLRP SRRIRSQEPG 350
    SGPPEKTEEE EDEEEEERRE EEERRMQRGQ EMNGRLSQIA QAGTSGQQPR 400
    PCTGTAKEQQ LLPQEATAGD KASTLSHL 428
    Length:428
    Mass (Da):47,216
    Last modified:July 27, 2011 - v2
    Checksum:i5B1010167AD8780F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121T → M in AAA40144. (PubMed:1328199)Curated
    Sequence conflicti12 – 121T → M in AAI20844. (PubMed:15489334)Curated
    Sequence conflicti12 – 121T → M in AAI37671. (PubMed:15489334)Curated
    Sequence conflicti19 – 191A → T in AAA40144. (PubMed:1328199)Curated
    Sequence conflicti19 – 191A → T in AAI20844. (PubMed:15489334)Curated
    Sequence conflicti19 – 191A → T in AAI37671. (PubMed:15489334)Curated
    Sequence conflicti166 – 1661A → R in AAA40144. (PubMed:1328199)Curated
    Sequence conflicti211 – 2111T → M in AAA40144. (PubMed:1328199)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91000 Genomic DNA. Translation: AAA40144.1.
    AK136904 mRNA. Translation: BAE23164.1.
    AL590144 Genomic DNA. No translation available.
    BC120843 mRNA. Translation: AAI20844.1.
    BC137670 mRNA. Translation: AAI37671.1.
    CCDSiCCDS27617.1.
    PIRiA44021.
    RefSeqiNP_033244.2. NM_009218.3.
    XP_006520732.1. XM_006520669.1.
    XP_006520733.1. XM_006520670.1.
    UniGeneiMm.211411.

    Genome annotation databases

    EnsembliENSMUST00000053239; ENSMUSP00000058040; ENSMUSG00000044933.
    GeneIDi20607.
    KEGGimmu:20607.
    UCSCiuc007wpo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91000 Genomic DNA. Translation: AAA40144.1 .
    AK136904 mRNA. Translation: BAE23164.1 .
    AL590144 Genomic DNA. No translation available.
    BC120843 mRNA. Translation: AAI20844.1 .
    BC137670 mRNA. Translation: AAI37671.1 .
    CCDSi CCDS27617.1.
    PIRi A44021.
    RefSeqi NP_033244.2. NM_009218.3.
    XP_006520732.1. XM_006520669.1.
    XP_006520733.1. XM_006520670.1.
    UniGenei Mm.211411.

    3D structure databases

    ProteinModelPortali P30935.
    SMRi P30935. Positions 37-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P30935. 9 interactions.
    STRINGi 10090.ENSMUSP00000058040.

    Chemistry

    BindingDBi P30935.
    ChEMBLi CHEMBL2238.
    GuidetoPHARMACOLOGYi 357.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30935.

    Proteomic databases

    PRIDEi P30935.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053239 ; ENSMUSP00000058040 ; ENSMUSG00000044933 .
    GeneIDi 20607.
    KEGGi mmu:20607.
    UCSCi uc007wpo.1. mouse.

    Organism-specific databases

    CTDi 6753.
    MGIi MGI:98329. Sstr3.

    Phylogenomic databases

    eggNOGi NOG274661.
    GeneTreei ENSGT00630000089736.
    HOGENOMi HOG000230485.
    HOVERGENi HBG106919.
    InParanoidi Q3UVV5.
    KOi K04219.
    OMAi NASSAWP.
    OrthoDBi EOG7BKCVQ.
    TreeFami TF315737.

    Miscellaneous databases

    NextBioi 298955.
    PROi P30935.
    SOURCEi Search...

    Gene expression databases

    Bgeei P30935.
    CleanExi MM_SSTR3.
    Genevestigatori P30935.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001856. Somatstn_rcpt_3.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00589. SOMATOSTTN3R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase."
      Yasuda K., Rens-Domiano S., Breder C.D., Law S.F., Saper C.B., Reisine T., Bell G.I.
      J. Biol. Chem. 267:20422-20428(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Diencephalon.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiSSR3_MOUSE
    AccessioniPrimary (citable) accession number: P30935
    Secondary accession number(s): Q0VB04, Q3UVV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3