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P30935

- SSR3_MOUSE

UniProt

P30935 - SSR3_MOUSE

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Protein

Somatostatin receptor type 3

Gene
Sstr3, Smstr3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.1 Publication

GO - Molecular functioni

  1. somatostatin receptor activity Source: InterPro

GO - Biological processi

  1. cellular response to estradiol stimulus Source: Ensembl
  2. cellular response to glucocorticoid stimulus Source: Ensembl
  3. cerebellum development Source: Ensembl
  4. forebrain development Source: Ensembl
  5. response to starvation Source: Ensembl
  6. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 3
Short name:
SS-3-R
Short name:
SS3-R
Short name:
SS3R
Alternative name(s):
SSR-28
Gene namesi
Name:Sstr3
Synonyms:Smstr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:98329. Sstr3.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity
Note: Internalized into endoplasmic vesicles upon somatostatin-stimulation By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545Extracellular Reviewed predictionAdd
BLAST
Transmembranei46 – 7126Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini72 – 8110Cytoplasmic Reviewed prediction
Transmembranei82 – 10322Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini104 – 11815Extracellular Reviewed predictionAdd
BLAST
Transmembranei119 – 14022Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini141 – 16222Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei163 – 18220Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini183 – 20624Extracellular Reviewed predictionAdd
BLAST
Transmembranei207 – 23226Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini233 – 26634Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei267 – 28822Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini289 – 30214Extracellular Reviewed predictionAdd
BLAST
Transmembranei303 – 32523Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini326 – 428103Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. ciliary membrane Source: MGI
  2. cilium Source: MGI
  3. cytoplasm Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. nonmotile primary cilium Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Somatostatin receptor type 3PRO_0000070125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi31 – 311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi117 ↔ 192 By similarity
Modified residuei357 – 3571Phosphothreonine By similarity

Post-translational modificationi

Phosphorylated. Phosphorylation increases upon somatostatin binding By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP30935.

PTM databases

PhosphoSiteiP30935.

Expressioni

Tissue specificityi

In the brain, primarily observed in the forebrain. Moderate levels found throughout laminae 2-6 of the neocortex and allocortex, and high levels in lamina 2 of the piriform and entorhinal cortices. High levels also present in the cornu ammonis fields of the hippocampus. In the amygdala, highly expressed in the nucleus of the lateral olfactory tract with expression also detected in the rostral portions of the basal magnocellular and lateral nuclei. In the diencephalon, moderate levels observed in the ventromedial and arcuate nuclei of the hypothalamus. In the midbrain, moderate levels found in the lateral portion of the substantia nigra pars reticulata.1 Publication

Gene expression databases

BgeeiP30935.
CleanExiMM_SSTR3.
GenevestigatoriP30935.

Interactioni

Subunit structurei

Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function By similarity.

Protein-protein interaction databases

IntActiP30935. 9 interactions.
STRINGi10090.ENSMUSP00000058040.

Structurei

3D structure databases

ProteinModelPortaliP30935.
SMRiP30935. Positions 37-334.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi358 – 37316Poly-GluAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274661.
GeneTreeiENSGT00630000089736.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiQ3UVV5.
KOiK04219.
OMAiNASSAWP.
OrthoDBiEOG7BKCVQ.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001856. Somatstn_rcpt_3.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00589. SOMATOSTTN3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30935-1 [UniParc]FASTAAdd to Basket

« Hide

MATVTYPSSE PTTLDPGNAS STWPLDTTLG NTSAGASLTG LAVSGILISL    50
VYLVVCVVGL LGNSLVIYVV LRHTSSPSVT SVYILNLALA DELFMLGLPF 100
LAAQNALSYW PFGSLMCRLV MAVDGINQFT SIFCLTVMSV DRYLAVVHPT 150
RSARWRTAPV ARTVSAAVWV ASAVVVLPVV VFSGVPRGMS TCHMQWPEPA 200
AAWRTAFIIY TAALGFFGPL LVICLCYLLI VVKVRSTTRR VRAPSCQWVQ 250
APACQRRRRS ERRVTRMVVA VVALFVLCWM PFYLLNIVNV VCPLPEEPAF 300
FGLYFLVVAL PYANSCANPI LYGFLSYRFK QGFRRILLRP SRRIRSQEPG 350
SGPPEKTEEE EDEEEEERRE EEERRMQRGQ EMNGRLSQIA QAGTSGQQPR 400
PCTGTAKEQQ LLPQEATAGD KASTLSHL 428
Length:428
Mass (Da):47,216
Last modified:July 27, 2011 - v2
Checksum:i5B1010167AD8780F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121T → M in AAA40144. 1 Publication
Sequence conflicti12 – 121T → M in AAI20844. 1 Publication
Sequence conflicti12 – 121T → M in AAI37671. 1 Publication
Sequence conflicti19 – 191A → T in AAA40144. 1 Publication
Sequence conflicti19 – 191A → T in AAI20844. 1 Publication
Sequence conflicti19 – 191A → T in AAI37671. 1 Publication
Sequence conflicti166 – 1661A → R in AAA40144. 1 Publication
Sequence conflicti211 – 2111T → M in AAA40144. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91000 Genomic DNA. Translation: AAA40144.1.
AK136904 mRNA. Translation: BAE23164.1.
AL590144 Genomic DNA. No translation available.
BC120843 mRNA. Translation: AAI20844.1.
BC137670 mRNA. Translation: AAI37671.1.
CCDSiCCDS27617.1.
PIRiA44021.
RefSeqiNP_033244.2. NM_009218.3.
XP_006520732.1. XM_006520669.1.
XP_006520733.1. XM_006520670.1.
UniGeneiMm.211411.

Genome annotation databases

EnsembliENSMUST00000053239; ENSMUSP00000058040; ENSMUSG00000044933.
GeneIDi20607.
KEGGimmu:20607.
UCSCiuc007wpo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91000 Genomic DNA. Translation: AAA40144.1 .
AK136904 mRNA. Translation: BAE23164.1 .
AL590144 Genomic DNA. No translation available.
BC120843 mRNA. Translation: AAI20844.1 .
BC137670 mRNA. Translation: AAI37671.1 .
CCDSi CCDS27617.1.
PIRi A44021.
RefSeqi NP_033244.2. NM_009218.3.
XP_006520732.1. XM_006520669.1.
XP_006520733.1. XM_006520670.1.
UniGenei Mm.211411.

3D structure databases

ProteinModelPortali P30935.
SMRi P30935. Positions 37-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30935. 9 interactions.
STRINGi 10090.ENSMUSP00000058040.

Chemistry

BindingDBi P30935.
ChEMBLi CHEMBL2238.
GuidetoPHARMACOLOGYi 357.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30935.

Proteomic databases

PRIDEi P30935.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053239 ; ENSMUSP00000058040 ; ENSMUSG00000044933 .
GeneIDi 20607.
KEGGi mmu:20607.
UCSCi uc007wpo.1. mouse.

Organism-specific databases

CTDi 6753.
MGIi MGI:98329. Sstr3.

Phylogenomic databases

eggNOGi NOG274661.
GeneTreei ENSGT00630000089736.
HOGENOMi HOG000230485.
HOVERGENi HBG106919.
InParanoidi Q3UVV5.
KOi K04219.
OMAi NASSAWP.
OrthoDBi EOG7BKCVQ.
TreeFami TF315737.

Miscellaneous databases

NextBioi 298955.
PROi P30935.
SOURCEi Search...

Gene expression databases

Bgeei P30935.
CleanExi MM_SSTR3.
Genevestigatori P30935.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001856. Somatstn_rcpt_3.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00589. SOMATOSTTN3R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase."
    Yasuda K., Rens-Domiano S., Breder C.D., Law S.F., Saper C.B., Reisine T., Bell G.I.
    J. Biol. Chem. 267:20422-20428(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSSR3_MOUSE
AccessioniPrimary (citable) accession number: P30935
Secondary accession number(s): Q0VB04, Q3UVV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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