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Protein

Somatostatin receptor type 3

Gene

Sstr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events
R-MMU-5620922 BBSome-mediated cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 3
Short name:
SS-3-R
Short name:
SS3-R
Short name:
SS3R
Alternative name(s):
SSR-28
Gene namesi
Name:Sstr3
Synonyms:Smstr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98329 Sstr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 71Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini72 – 81CytoplasmicSequence analysis10
Transmembranei82 – 103Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini104 – 118ExtracellularSequence analysisAdd BLAST15
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini141 – 162CytoplasmicSequence analysisAdd BLAST22
Transmembranei163 – 182Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini183 – 206ExtracellularSequence analysisAdd BLAST24
Transmembranei207 – 232Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini233 – 266CytoplasmicSequence analysisAdd BLAST34
Transmembranei267 – 288Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini289 – 302ExtracellularSequence analysisAdd BLAST14
Transmembranei303 – 325Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini326 – 428CytoplasmicSequence analysisAdd BLAST103

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2238
GuidetoPHARMACOLOGYi357

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701251 – 428Somatostatin receptor type 3Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 192PROSITE-ProRule annotation
Modified residuei341PhosphoserineBy similarity1
Modified residuei346PhosphoserineBy similarity1
Modified residuei351PhosphoserineBy similarity1
Modified residuei357PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP30935
PaxDbiP30935
PRIDEiP30935

PTM databases

iPTMnetiP30935
PhosphoSitePlusiP30935

Expressioni

Tissue specificityi

In the brain, primarily observed in the forebrain. Moderate levels found throughout laminae 2-6 of the neocortex and allocortex, and high levels in lamina 2 of the piriform and entorhinal cortices. High levels also present in the cornu ammonis fields of the hippocampus. In the amygdala, highly expressed in the nucleus of the lateral olfactory tract with expression also detected in the rostral portions of the basal magnocellular and lateral nuclei. In the diencephalon, moderate levels observed in the ventromedial and arcuate nuclei of the hypothalamus. In the midbrain, moderate levels found in the lateral portion of the substantia nigra pars reticulata.1 Publication

Gene expression databases

BgeeiENSMUSG00000044933
CleanExiMM_SSTR3
GenevisibleiP30935 MM

Interactioni

Subunit structurei

Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity).By similarity

GO - Molecular functioni

  • signaling receptor binding Source: MGI

Protein-protein interaction databases

IntActiP30935, 9 interactors
STRINGi10090.ENSMUSP00000058040

Chemistry databases

BindingDBiP30935

Structurei

3D structure databases

ProteinModelPortaliP30935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi358 – 373Poly-GluAdd BLAST16

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230485
HOVERGENiHBG106919
InParanoidiP30935
KOiK04219
OMAiPYANSCA
OrthoDBiEOG091G0HEN
TreeFamiTF315737

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000586 Somatstn_rcpt
IPR001856 Somatstn_rcpt_3
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00246 SOMATOSTATNR
PR00589 SOMATOSTTN3R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVTYPSSE PTTLDPGNAS STWPLDTTLG NTSAGASLTG LAVSGILISL
60 70 80 90 100
VYLVVCVVGL LGNSLVIYVV LRHTSSPSVT SVYILNLALA DELFMLGLPF
110 120 130 140 150
LAAQNALSYW PFGSLMCRLV MAVDGINQFT SIFCLTVMSV DRYLAVVHPT
160 170 180 190 200
RSARWRTAPV ARTVSAAVWV ASAVVVLPVV VFSGVPRGMS TCHMQWPEPA
210 220 230 240 250
AAWRTAFIIY TAALGFFGPL LVICLCYLLI VVKVRSTTRR VRAPSCQWVQ
260 270 280 290 300
APACQRRRRS ERRVTRMVVA VVALFVLCWM PFYLLNIVNV VCPLPEEPAF
310 320 330 340 350
FGLYFLVVAL PYANSCANPI LYGFLSYRFK QGFRRILLRP SRRIRSQEPG
360 370 380 390 400
SGPPEKTEEE EDEEEEERRE EEERRMQRGQ EMNGRLSQIA QAGTSGQQPR
410 420
PCTGTAKEQQ LLPQEATAGD KASTLSHL
Length:428
Mass (Da):47,216
Last modified:July 27, 2011 - v2
Checksum:i5B1010167AD8780F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12T → M in AAA40144 (PubMed:1328199).Curated1
Sequence conflicti12T → M in AAI20844 (PubMed:15489334).Curated1
Sequence conflicti12T → M in AAI37671 (PubMed:15489334).Curated1
Sequence conflicti19A → T in AAA40144 (PubMed:1328199).Curated1
Sequence conflicti19A → T in AAI20844 (PubMed:15489334).Curated1
Sequence conflicti19A → T in AAI37671 (PubMed:15489334).Curated1
Sequence conflicti166A → R in AAA40144 (PubMed:1328199).Curated1
Sequence conflicti211T → M in AAA40144 (PubMed:1328199).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91000 Genomic DNA Translation: AAA40144.1
AK136904 mRNA Translation: BAE23164.1
AL590144 Genomic DNA No translation available.
BC120843 mRNA Translation: AAI20844.1
BC137670 mRNA Translation: AAI37671.1
CCDSiCCDS27617.1
PIRiA44021
RefSeqiNP_033244.2, NM_009218.3
XP_006520732.1, XM_006520669.3
XP_006520733.1, XM_006520670.3
XP_011243833.1, XM_011245531.1
UniGeneiMm.211411

Genome annotation databases

EnsembliENSMUST00000053239; ENSMUSP00000058040; ENSMUSG00000044933
GeneIDi20607
KEGGimmu:20607
UCSCiuc007wpo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSSR3_MOUSE
AccessioniPrimary (citable) accession number: P30935
Secondary accession number(s): Q0VB04, Q3UVV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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