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P30935 (SSR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatostatin receptor type 3

Short name=SS-3-R
Short name=SS3-R
Short name=SS3R
Alternative name(s):
SSR-28
Gene names
Name:Sstr3
Synonyms:Smstr3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. Ref.1

Subunit structure

Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: Internalized into endoplasmic vesicles upon somatostatin-stimulation By similarity.

Tissue specificity

In the brain, primarily observed in the forebrain. Moderate levels found throughout laminae 2-6 of the neocortex and allocortex, and high levels in lamina 2 of the piriform and entorhinal cortices. High levels also present in the cornu ammonis fields of the hippocampus. In the amygdala, highly expressed in the nucleus of the lateral olfactory tract with expression also detected in the rostral portions of the basal magnocellular and lateral nuclei. In the diencephalon, moderate levels observed in the ventromedial and arcuate nuclei of the hypothalamus. In the midbrain, moderate levels found in the lateral portion of the substantia nigra pars reticulata. Ref.1

Post-translational modification

Phosphorylated. Phosphorylation increases upon somatostatin binding By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Somatostatin receptor type 3
PRO_0000070125

Regions

Topological domain1 – 4545Extracellular Potential
Transmembrane46 – 7126Helical; Name=1; Potential
Topological domain72 – 8110Cytoplasmic Potential
Transmembrane82 – 10322Helical; Name=2; Potential
Topological domain104 – 11815Extracellular Potential
Transmembrane119 – 14022Helical; Name=3; Potential
Topological domain141 – 16222Cytoplasmic Potential
Transmembrane163 – 18220Helical; Name=4; Potential
Topological domain183 – 20624Extracellular Potential
Transmembrane207 – 23226Helical; Name=5; Potential
Topological domain233 – 26634Cytoplasmic Potential
Transmembrane267 – 28822Helical; Name=6; Potential
Topological domain289 – 30214Extracellular Potential
Transmembrane303 – 32523Helical; Name=7; Potential
Topological domain326 – 428103Cytoplasmic Potential
Compositional bias358 – 37316Poly-Glu

Amino acid modifications

Modified residue3571Phosphothreonine By similarity
Glycosylation181N-linked (GlcNAc...) Potential
Glycosylation311N-linked (GlcNAc...) Potential
Disulfide bond117 ↔ 192 By similarity

Experimental info

Sequence conflict121T → M in AAA40144. Ref.1
Sequence conflict121T → M in AAI20844. Ref.4
Sequence conflict121T → M in AAI37671. Ref.4
Sequence conflict191A → T in AAA40144. Ref.1
Sequence conflict191A → T in AAI20844. Ref.4
Sequence conflict191A → T in AAI37671. Ref.4
Sequence conflict1661A → R in AAA40144. Ref.1
Sequence conflict2111T → M in AAA40144. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P30935 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 5B1010167AD8780F

FASTA42847,216
        10         20         30         40         50         60 
MATVTYPSSE PTTLDPGNAS STWPLDTTLG NTSAGASLTG LAVSGILISL VYLVVCVVGL 

        70         80         90        100        110        120 
LGNSLVIYVV LRHTSSPSVT SVYILNLALA DELFMLGLPF LAAQNALSYW PFGSLMCRLV 

       130        140        150        160        170        180 
MAVDGINQFT SIFCLTVMSV DRYLAVVHPT RSARWRTAPV ARTVSAAVWV ASAVVVLPVV 

       190        200        210        220        230        240 
VFSGVPRGMS TCHMQWPEPA AAWRTAFIIY TAALGFFGPL LVICLCYLLI VVKVRSTTRR 

       250        260        270        280        290        300 
VRAPSCQWVQ APACQRRRRS ERRVTRMVVA VVALFVLCWM PFYLLNIVNV VCPLPEEPAF 

       310        320        330        340        350        360 
FGLYFLVVAL PYANSCANPI LYGFLSYRFK QGFRRILLRP SRRIRSQEPG SGPPEKTEEE 

       370        380        390        400        410        420 
EDEEEEERRE EEERRMQRGQ EMNGRLSQIA QAGTSGQQPR PCTGTAKEQQ LLPQEATAGD 


KASTLSHL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase."
Yasuda K., Rens-Domiano S., Breder C.D., Law S.F., Saper C.B., Reisine T., Bell G.I.
J. Biol. Chem. 267:20422-20428(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Diencephalon.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M91000 Genomic DNA. Translation: AAA40144.1.
AK136904 mRNA. Translation: BAE23164.1.
AL590144 Genomic DNA. No translation available.
BC120843 mRNA. Translation: AAI20844.1.
BC137670 mRNA. Translation: AAI37671.1.
PIRA44021.
RefSeqNP_033244.2. NM_009218.3.
XP_006520732.1. XM_006520669.1.
XP_006520733.1. XM_006520670.1.
UniGeneMm.211411.

3D structure databases

ProteinModelPortalP30935.
SMRP30935. Positions 37-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP30935. 9 interactions.
STRING10090.ENSMUSP00000058040.

Chemistry

BindingDBP30935.
ChEMBLCHEMBL2238.
GuidetoPHARMACOLOGY357.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30935.

Proteomic databases

PRIDEP30935.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000053239; ENSMUSP00000058040; ENSMUSG00000044933.
GeneID20607.
KEGGmmu:20607.
UCSCuc007wpo.1. mouse.

Organism-specific databases

CTD6753.
MGIMGI:98329. Sstr3.

Phylogenomic databases

eggNOGNOG274661.
GeneTreeENSGT00630000089736.
HOGENOMHOG000230485.
HOVERGENHBG106919.
InParanoidQ3UVV5.
KOK04219.
OMANASSAWP.
OrthoDBEOG7BKCVQ.
TreeFamTF315737.

Gene expression databases

BgeeP30935.
CleanExMM_SSTR3.
GenevestigatorP30935.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001856. Somatstn_rcpt_3.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00589. SOMATOSTTN3R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298955.
PROP30935.
SOURCESearch...

Entry information

Entry nameSSR3_MOUSE
AccessionPrimary (citable) accession number: P30935
Secondary accession number(s): Q0VB04, Q3UVV5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries