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P30935

- SSR3_MOUSE

UniProt

P30935 - SSR3_MOUSE

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Protein

Somatostatin receptor type 3

Gene

Sstr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.1 Publication

GO - Molecular functioni

  1. somatostatin receptor activity Source: InterPro

GO - Biological processi

  1. cellular response to estradiol stimulus Source: Ensembl
  2. cellular response to glucocorticoid stimulus Source: Ensembl
  3. cerebellum development Source: Ensembl
  4. forebrain development Source: Ensembl
  5. response to starvation Source: Ensembl
  6. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 3
Short name:
SS-3-R
Short name:
SS3-R
Short name:
SS3R
Alternative name(s):
SSR-28
Gene namesi
Name:Sstr3
Synonyms:Smstr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:98329. Sstr3.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Internalized into endoplasmic vesicles upon somatostatin-stimulation.By similarity

GO - Cellular componenti

  1. ciliary membrane Source: MGI
  2. cilium Source: MGI
  3. cytoplasm Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. nonmotile primary cilium Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Somatostatin receptor type 3PRO_0000070125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 192PROSITE-ProRule annotation
Modified residuei357 – 3571PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP30935.

PTM databases

PhosphoSiteiP30935.

Expressioni

Tissue specificityi

In the brain, primarily observed in the forebrain. Moderate levels found throughout laminae 2-6 of the neocortex and allocortex, and high levels in lamina 2 of the piriform and entorhinal cortices. High levels also present in the cornu ammonis fields of the hippocampus. In the amygdala, highly expressed in the nucleus of the lateral olfactory tract with expression also detected in the rostral portions of the basal magnocellular and lateral nuclei. In the diencephalon, moderate levels observed in the ventromedial and arcuate nuclei of the hypothalamus. In the midbrain, moderate levels found in the lateral portion of the substantia nigra pars reticulata.1 Publication

Gene expression databases

BgeeiP30935.
CleanExiMM_SSTR3.
GenevestigatoriP30935.

Interactioni

Subunit structurei

Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity).By similarity

Protein-protein interaction databases

IntActiP30935. 9 interactions.
STRINGi10090.ENSMUSP00000058040.

Structurei

3D structure databases

ProteinModelPortaliP30935.
SMRiP30935. Positions 37-334.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
BLAST
Topological domaini72 – 8110CytoplasmicSequence Analysis
Topological domaini104 – 11815ExtracellularSequence AnalysisAdd
BLAST
Topological domaini141 – 16222CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini183 – 20624ExtracellularSequence AnalysisAdd
BLAST
Topological domaini233 – 26634CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini289 – 30214ExtracellularSequence AnalysisAdd
BLAST
Topological domaini326 – 428103CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 7126Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei82 – 10322Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei119 – 14022Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei163 – 18220Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei207 – 23226Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei267 – 28822Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei303 – 32523Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi358 – 37316Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274661.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP30935.
KOiK04219.
OMAiNASSAWP.
OrthoDBiEOG7BKCVQ.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001856. Somatstn_rcpt_3.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00589. SOMATOSTTN3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30935 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATVTYPSSE PTTLDPGNAS STWPLDTTLG NTSAGASLTG LAVSGILISL
60 70 80 90 100
VYLVVCVVGL LGNSLVIYVV LRHTSSPSVT SVYILNLALA DELFMLGLPF
110 120 130 140 150
LAAQNALSYW PFGSLMCRLV MAVDGINQFT SIFCLTVMSV DRYLAVVHPT
160 170 180 190 200
RSARWRTAPV ARTVSAAVWV ASAVVVLPVV VFSGVPRGMS TCHMQWPEPA
210 220 230 240 250
AAWRTAFIIY TAALGFFGPL LVICLCYLLI VVKVRSTTRR VRAPSCQWVQ
260 270 280 290 300
APACQRRRRS ERRVTRMVVA VVALFVLCWM PFYLLNIVNV VCPLPEEPAF
310 320 330 340 350
FGLYFLVVAL PYANSCANPI LYGFLSYRFK QGFRRILLRP SRRIRSQEPG
360 370 380 390 400
SGPPEKTEEE EDEEEEERRE EEERRMQRGQ EMNGRLSQIA QAGTSGQQPR
410 420
PCTGTAKEQQ LLPQEATAGD KASTLSHL
Length:428
Mass (Da):47,216
Last modified:July 27, 2011 - v2
Checksum:i5B1010167AD8780F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121T → M in AAA40144. (PubMed:1328199)Curated
Sequence conflicti12 – 121T → M in AAI20844. (PubMed:15489334)Curated
Sequence conflicti12 – 121T → M in AAI37671. (PubMed:15489334)Curated
Sequence conflicti19 – 191A → T in AAA40144. (PubMed:1328199)Curated
Sequence conflicti19 – 191A → T in AAI20844. (PubMed:15489334)Curated
Sequence conflicti19 – 191A → T in AAI37671. (PubMed:15489334)Curated
Sequence conflicti166 – 1661A → R in AAA40144. (PubMed:1328199)Curated
Sequence conflicti211 – 2111T → M in AAA40144. (PubMed:1328199)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91000 Genomic DNA. Translation: AAA40144.1.
AK136904 mRNA. Translation: BAE23164.1.
AL590144 Genomic DNA. No translation available.
BC120843 mRNA. Translation: AAI20844.1.
BC137670 mRNA. Translation: AAI37671.1.
CCDSiCCDS27617.1.
PIRiA44021.
RefSeqiNP_033244.2. NM_009218.3.
XP_006520732.1. XM_006520669.1.
XP_006520733.1. XM_006520670.1.
UniGeneiMm.211411.

Genome annotation databases

EnsembliENSMUST00000053239; ENSMUSP00000058040; ENSMUSG00000044933.
GeneIDi20607.
KEGGimmu:20607.
UCSCiuc007wpo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91000 Genomic DNA. Translation: AAA40144.1 .
AK136904 mRNA. Translation: BAE23164.1 .
AL590144 Genomic DNA. No translation available.
BC120843 mRNA. Translation: AAI20844.1 .
BC137670 mRNA. Translation: AAI37671.1 .
CCDSi CCDS27617.1.
PIRi A44021.
RefSeqi NP_033244.2. NM_009218.3.
XP_006520732.1. XM_006520669.1.
XP_006520733.1. XM_006520670.1.
UniGenei Mm.211411.

3D structure databases

ProteinModelPortali P30935.
SMRi P30935. Positions 37-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30935. 9 interactions.
STRINGi 10090.ENSMUSP00000058040.

Chemistry

BindingDBi P30935.
ChEMBLi CHEMBL2238.
GuidetoPHARMACOLOGYi 357.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30935.

Proteomic databases

PRIDEi P30935.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053239 ; ENSMUSP00000058040 ; ENSMUSG00000044933 .
GeneIDi 20607.
KEGGi mmu:20607.
UCSCi uc007wpo.1. mouse.

Organism-specific databases

CTDi 6753.
MGIi MGI:98329. Sstr3.

Phylogenomic databases

eggNOGi NOG274661.
GeneTreei ENSGT00760000118797.
HOGENOMi HOG000230485.
HOVERGENi HBG106919.
InParanoidi P30935.
KOi K04219.
OMAi NASSAWP.
OrthoDBi EOG7BKCVQ.
TreeFami TF315737.

Miscellaneous databases

NextBioi 298955.
PROi P30935.
SOURCEi Search...

Gene expression databases

Bgeei P30935.
CleanExi MM_SSTR3.
Genevestigatori P30935.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001856. Somatstn_rcpt_3.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00589. SOMATOSTTN3R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase."
    Yasuda K., Rens-Domiano S., Breder C.D., Law S.F., Saper C.B., Reisine T., Bell G.I.
    J. Biol. Chem. 267:20422-20428(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSSR3_MOUSE
AccessioniPrimary (citable) accession number: P30935
Secondary accession number(s): Q0VB04, Q3UVV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3