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P30932 (CD9_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CD9 antigen
Alternative name(s):
CD_antigen=CD9
Gene names
Name:CD9
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion By similarity.

Subunit structure

Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Post-translational modification

Phosphorylated on tyrosine following B-cell activation By similarity.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 226225CD9 antigen
PRO_0000219202

Regions

Topological domain2 – 1211Cytoplasmic Potential
Transmembrane13 – 3321Helical; Potential
Topological domain34 – 5320Extracellular Potential
Transmembrane54 – 7421Helical; Potential
Topological domain75 – 8511Cytoplasmic Potential
Transmembrane86 – 10924Helical; Potential
Topological domain110 – 19384Extracellular Potential
Transmembrane194 – 21926Helical; Potential
Topological domain220 – 2267Cytoplasmic Potential

Amino acid modifications

Lipidation91S-palmitoyl cysteine By similarity
Lipidation761S-palmitoyl cysteine By similarity
Lipidation771S-palmitoyl cysteine By similarity
Lipidation851S-palmitoyl cysteine By similarity
Lipidation2161S-palmitoyl cysteine By similarity
Lipidation2171S-palmitoyl cysteine By similarity
Glycosylation501N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P30932 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: C18A778646380BE2

FASTA22625,258
        10         20         30         40         50         60 
MPVKGGTKCI KYLLFGFNFI FWLAGIAVLS VGLWLRFDSQ TKSIFEQENN DSSFYTGVYI 

        70         80         90        100        110        120 
LIGAGALMML VGFLGCCGAV QESQCMLGLF FSFLLVIFAI EVAAAIWGYS HKEEVIKEVQ 

       130        140        150        160        170        180 
KFYEDTYNKL KNKDEPQRET LKAIHIALDC CGLTGVPEQF LTDTCPPKNL IDSLKTRPCP 

       190        200        210        220 
EAIDEIFRSK FHIIGAVGIG IAVVMIFGMV FSMILCCAIR RNRDMV

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the bovine CD9 antigen from ocular ciliary epithelial cells."
Martin-Alonso J.M., Hernando N., Ghosh S., Coca-Prados M.
J. Biochem. 112:63-67(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ocular ciliary epithelium.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M81720 mRNA. Translation: AAA30439.1.
BC147992 mRNA. Translation: AAI47993.1.
IPIIPI00686645.
PIRJX0221.
RefSeqNP_776325.1. NM_173900.2.
UniGeneBt.2573.

3D structure databases

ProteinModelPortalP30932.
ModBaseSearch...

Proteomic databases

PaxDbP30932.
PRIDEP30932.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID280746.
KEGGbta:280746.

Organism-specific databases

CTD928.

Phylogenomic databases

eggNOGNOG242618.
HOGENOMHOG000230651.
HOVERGENHBG002324.
InParanoidP30932.
KOK06460.
OrthoDBEOG402WT9.

Enzyme and pathway databases

BioCycCATTLE:280746-MONOMER.

Gene expression databases

ArrayExpressP30932.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. Tetraspanin. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804915.

Entry information

Entry nameCD9_BOVIN
AccessionPrimary (citable) accession number: P30932
Secondary accession number(s): A6QLK0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: May 29, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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