Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Non-structural protein V

Gene

P/V

Organism
Mumps virus (strain Enders) (MuV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I and II interferon signaling pathways by interacting with host STAT1, STAT2 and STAT3, and mediating their ubiquitination and subsequent proteasomal degradation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi170 – 1701Zinc 1By similarity
Metal bindingi189 – 1891Zinc 1By similarity
Metal bindingi193 – 1931Zinc 2By similarity
Metal bindingi205 – 2051Zinc 2By similarity
Metal bindingi207 – 2071Zinc 2By similarity
Metal bindingi210 – 2101Zinc 2By similarity
Metal bindingi214 – 2141Zinc 1By similarity
Metal bindingi217 – 2171Zinc 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host MDA5 by virus, Inhibition of host RLR pathway by virus, Inhibition of host STAT1 by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Viral immunoevasion

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein V
Alternative name(s):
Non-structural protein NS1
Gene namesi
Name:P/V
OrganismiMumps virus (strain Enders) (MuV)
Taxonomic identifieri11167 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Non-structural protein VPRO_0000142819Add
BLAST

Interactioni

Subunit structurei

Interacts with host IFIH1/MDA5 and DHX58/LGP2. Forms with host DDB1, CUL4A, STAT1, STAT2 and STAT3 the mumps virus V-dependent complex (VDC) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DHX58Q96C102EBI-6599165,EBI-744193From a different organism.
IFIH1Q9BYX42EBI-6599165,EBI-6115771From a different organism.

Protein-protein interaction databases

IntActiP30927. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP30927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paramyxoviruses V protein family.Curated

Family and domain databases

InterProiIPR024279. Paramyx_V_Zn-bd.
[Graphical view]
PfamiPF13008. zf-Paramyx-P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQFIKQDET GDLIETGMNV ANHFLSAPIQ GTNSLSKASI IPGVAPVLIG
60 70 80 90 100
NPEQKNIQHP TASHQGSKSK GRGSGVRSII VPPSEAGNGG TQIPEPLFAQ
110 120 130 140 150
TGQGGIVTTV YQDPTIQPTG SYRSVELTKI GKERMINRFV EKPRISTPVT
160 170 180 190 200
EFKRGAGSGC SRPDNPRGGH RREWSLSWVQ GEVRVFEWCN PICSPITAAA
210 220
RFHSCKCGNC PAKCDQCERD YGPP
Length:224
Mass (Da):24,184
Last modified:July 1, 1993 - v1
Checksum:i6A90961E74341373
GO

RNA editingi

Edited at position 155.1 Publication
Partially edited. RNA editing at this position consists of an insertion of two guanine nucleotides. The sequence displayed here is the V protein, derived from the unedited RNA. The edited RNA gives rise to the P protein (AC P16072).

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00351 Genomic RNA. No translation available.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00351 Genomic RNA. No translation available.

3D structure databases

ProteinModelPortaliP30927.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30927. 2 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR024279. Paramyx_V_Zn-bd.
[Graphical view]
PfamiPF13008. zf-Paramyx-P. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV_MUMPE
AccessioniPrimary (citable) accession number: P30927
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.