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P30926

- ACHB4_HUMAN

UniProt

P30926 - ACHB4_HUMAN

Protein

Neuronal acetylcholine receptor subunit beta-4

Gene

CHRNB4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: UniProtKB
    2. acetylcholine receptor activity Source: UniProtKB
    3. ligand-gated ion channel activity Source: DFLAT

    GO - Biological processi

    1. action potential Source: Ensembl
    2. behavioral response to nicotine Source: Ensembl
    3. cation transport Source: GOC
    4. ion transmembrane transport Source: GOC
    5. ion transport Source: UniProtKB
    6. locomotory behavior Source: Ensembl
    7. regulation of neurotransmitter secretion Source: UniProtKB
    8. regulation of smooth muscle contraction Source: Ensembl
    9. signal transduction Source: UniProtKB
    10. smooth muscle contraction Source: Ensembl
    11. synaptic transmission Source: Reactome
    12. synaptic transmission, cholinergic Source: ProtInc
    13. synaptic transmission involved in micturition Source: UniProtKB

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22223. Highly sodium permeable acetylcholine nicotinic receptors.
    REACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
    REACT_22352. Highly calcium permeable nicotinic acetylcholine receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal acetylcholine receptor subunit beta-4
    Gene namesi
    Name:CHRNB4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:1964. CHRNB4.

    Subcellular locationi

    GO - Cellular componenti

    1. acetylcholine-gated channel complex Source: UniProtKB
    2. cell junction Source: UniProtKB-KW
    3. integral component of membrane Source: UniProtKB
    4. integral component of plasma membrane Source: UniProtKB
    5. plasma membrane Source: Reactome
    6. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26496.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 498477Neuronal acetylcholine receptor subunit beta-4PRO_0000000389Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi153 ↔ 167By similarity
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP30926.
    PRIDEiP30926.

    PTM databases

    PhosphoSiteiP30926.

    Expressioni

    Gene expression databases

    ArrayExpressiP30926.
    BgeeiP30926.
    CleanExiHS_CHRNB4.
    GenevestigatoriP30926.

    Interactioni

    Subunit structurei

    Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.1 Publication

    Protein-protein interaction databases

    BioGridi107565. 1 interaction.
    STRINGi9606.ENSP00000261751.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ASGmodel-B/D/E262-284[»]
    ProteinModelPortaliP30926.
    SMRiP30926. Positions 25-328, 458-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 236215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini258 – 2658CytoplasmicSequence Analysis
    Topological domaini287 – 29812ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini320 – 460141CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini482 – 49817ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei461 – 48121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290206.
    HOGENOMiHOG000006757.
    HOVERGENiHBG003756.
    InParanoidiP30926.
    KOiK04815.
    OMAiMTPTASM.
    OrthoDBiEOG72JWGV.
    PhylomeDBiP30926.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P30926-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRRAPSLVLF FLVALCGRGN CRVANAEEKL MDDLLNKTRY NNLIRPATSS    50
    SQLISIKLQL SLAQLISVNE REQIMTTNVW LKQEWTDYRL TWNSSRYEGV 100
    NILRIPAKRI WLPDIVLYNN ADGTYEVSVY TNLIVRSNGS VLWLPPAIYK 150
    SACKIEVKYF PFDQQNCTLK FRSWTYDHTE IDMVLMTPTA SMDDFTPSGE 200
    WDIVALPGRR TVNPQDPSYV DVTYDFIIKR KPLFYTINLI IPCVLTTLLA 250
    ILVFYLPSDC GEKMTLCISV LLALTFFLLL ISKIVPPTSL DVPLIGKYLM 300
    FTMVLVTFSI VTSVCVLNVH HRSPSTHTMA PWVKRCFLHK LPTFLFMKRP 350
    GPDSSPARAF PPSKSCVTKP EATATSTSPS NFYGNSMYFV NPASAASKSP 400
    AGSTPVAIPR DFWLRSSGRF RQDVQEALEG VSFIAQHMKN DDEDQSVVED 450
    WKYVAMVVDR LFLWVFMFVC VLGTVGLFLP PLFQTHAASE GPYAAQRD 498
    Length:498
    Mass (Da):56,380
    Last modified:November 1, 1997 - v2
    Checksum:i0D48AB203F3FD03E
    GO
    Isoform 2 (identifier: P30926-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         120-217: NADGTYEVSV...GRRTVNPQDP → KSLRTGSTWL...GKDGGLGCPL
         218-498: Missing.

    Show »
    Length:231
    Mass (Da):25,862
    Checksum:i4182D0886DD041BE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti72 – 732EQ → DE in CAA48336. (PubMed:1330682)Curated
    Sequence conflicti121 – 1211Missing in CAC34819. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti91 – 911T → I.
    Corresponds to variant rs12914008 [ dbSNP | Ensembl ].
    VAR_048174
    Natural varianti136 – 1361R → W.1 Publication
    Corresponds to variant rs141876090 [ dbSNP | Ensembl ].
    VAR_013241
    Natural varianti140 – 1401S → G.1 Publication
    Corresponds to variant rs56218866 [ dbSNP | Ensembl ].
    VAR_013242
    Natural varianti467 – 4671M → V.1 Publication
    Corresponds to variant rs61737502 [ dbSNP | Ensembl ].
    VAR_013243

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei120 – 21798NADGT…NPQDP → KSLRTGSTWLWWWTGCSCGC SCLCASWALWGSSYRPSSRP MQLLRGPTLPSVTEGPLGCG VRGCEWPGGHFAASFWVVAD EALSKYVSIGHQPHQTSHSR GTGKDGGLGCPL in isoform 2. 1 PublicationVSP_046674Add
    BLAST
    Alternative sequencei218 – 498281Missing in isoform 2. 1 PublicationVSP_046675Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62439 mRNA. Translation: AAB40117.1.
    U48861 mRNA. Translation: AAA92123.1.
    Y08416 mRNA. Translation: CAA69693.1.
    AJ306454
    , AJ306455, AJ306456, AJ306457, AJ306458, AJ306459 Genomic DNA. Translation: CAC34819.1.
    AF306329
    , AF306325, AF306326, AF306327, AF306328 Genomic DNA. Translation: AAL02062.1.
    AC022748 Genomic DNA. No translation available.
    AC067863 Genomic DNA. No translation available.
    BC096080 mRNA. Translation: AAH96080.1.
    BC096081 mRNA. Translation: AAH96081.1.
    BC096083 mRNA. Translation: AAH96083.1.
    BC096082 mRNA. Translation: AAH96082.1.
    AF453877 Genomic DNA. Translation: AAL57840.1.
    X68275 mRNA. Translation: CAA48336.1.
    CCDSiCCDS10306.1. [P30926-1]
    CCDS58392.1. [P30926-2]
    PIRiG02421.
    RefSeqiNP_000741.1. NM_000750.3. [P30926-1]
    NP_001243496.1. NM_001256567.1. [P30926-2]
    UniGeneiHs.624178.

    Genome annotation databases

    EnsembliENST00000261751; ENSP00000261751; ENSG00000117971. [P30926-1]
    ENST00000412074; ENSP00000416386; ENSG00000117971. [P30926-2]
    GeneIDi1143.
    KEGGihsa:1143.
    UCSCiuc002bed.1. human. [P30926-1]

    Polymorphism databases

    DMDMi2506129.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62439 mRNA. Translation: AAB40117.1 .
    U48861 mRNA. Translation: AAA92123.1 .
    Y08416 mRNA. Translation: CAA69693.1 .
    AJ306454
    , AJ306455 , AJ306456 , AJ306457 , AJ306458 , AJ306459 Genomic DNA. Translation: CAC34819.1 .
    AF306329
    , AF306325 , AF306326 , AF306327 , AF306328 Genomic DNA. Translation: AAL02062.1 .
    AC022748 Genomic DNA. No translation available.
    AC067863 Genomic DNA. No translation available.
    BC096080 mRNA. Translation: AAH96080.1 .
    BC096081 mRNA. Translation: AAH96081.1 .
    BC096083 mRNA. Translation: AAH96083.1 .
    BC096082 mRNA. Translation: AAH96082.1 .
    AF453877 Genomic DNA. Translation: AAL57840.1 .
    X68275 mRNA. Translation: CAA48336.1 .
    CCDSi CCDS10306.1. [P30926-1 ]
    CCDS58392.1. [P30926-2 ]
    PIRi G02421.
    RefSeqi NP_000741.1. NM_000750.3. [P30926-1 ]
    NP_001243496.1. NM_001256567.1. [P30926-2 ]
    UniGenei Hs.624178.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ASG model - B/D/E 262-284 [» ]
    ProteinModelPortali P30926.
    SMRi P30926. Positions 25-328, 458-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107565. 1 interaction.
    STRINGi 9606.ENSP00000261751.

    Chemistry

    BindingDBi P30926.
    ChEMBLi CHEMBL2111384.
    DrugBanki DB00514. Dextromethorphan.
    DB00674. Galantamine.
    DB01227. Levomethadyl Acetate.
    DB00184. Nicotine.
    DB01090. Pentolinium.
    GuidetoPHARMACOLOGYi 474.

    PTM databases

    PhosphoSitei P30926.

    Polymorphism databases

    DMDMi 2506129.

    Proteomic databases

    PaxDbi P30926.
    PRIDEi P30926.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261751 ; ENSP00000261751 ; ENSG00000117971 . [P30926-1 ]
    ENST00000412074 ; ENSP00000416386 ; ENSG00000117971 . [P30926-2 ]
    GeneIDi 1143.
    KEGGi hsa:1143.
    UCSCi uc002bed.1. human. [P30926-1 ]

    Organism-specific databases

    CTDi 1143.
    GeneCardsi GC15M078916.
    HGNCi HGNC:1964. CHRNB4.
    MIMi 118509. gene.
    neXtProti NX_P30926.
    PharmGKBi PA26496.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290206.
    HOGENOMi HOG000006757.
    HOVERGENi HBG003756.
    InParanoidi P30926.
    KOi K04815.
    OMAi MTPTASM.
    OrthoDBi EOG72JWGV.
    PhylomeDBi P30926.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_22223. Highly sodium permeable acetylcholine nicotinic receptors.
    REACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
    REACT_22352. Highly calcium permeable nicotinic acetylcholine receptors.

    Miscellaneous databases

    GeneWikii CHRNB4.
    GenomeRNAii 1143.
    NextBioi 4756.
    PROi P30926.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30926.
    Bgeei P30926.
    CleanExi HS_CHRNB4.
    Genevestigatori P30926.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
      Elliott K.J., Ellis S.B., Berckhan K.J., Urrutia A., Chavez-Noriega L.E., Johnson E.C., Velicelebi G., Harpold M.M.
      J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "'Orphan' alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor."
      Gerzanich V., Kuryatov A., Anand R., Lindstrom J.
      Mol. Pharmacol. 51:320-327(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
      Groot Kormelink P.J., Luyten W.H.M.L.
      FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Characterization of the genomic structure of human nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: identification of two novel introns in the 3' untranslated region of CHRNA3 and of a tail-to-tail overlap between CHRNA3 and CHRNA5."
      Duga S., Solda G., Asselta R., Bonati M.T., Dalpra L., Malcovati M., Tenchini M.L.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    5. "Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4."
      Lev-Lehman E., Bercovich D., Xu W., Stockton D.W., Beaudet A.L.
      J. Hum. Genet. 46:362-366(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS TRP-136; GLY-140 AND VAL-467.
    6. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-198 (ISOFORM 2).
    8. "Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes."
      Valor L.M., Campos-Caro A., Carrasco-Serrano C., Ortiz J.A., Ballesta J.J., Criado M.
      J. Biol. Chem. 277:8866-8876(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
    9. "Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines."
      Tarroni P., Rubboli F., Chini B., Zwart R., Oortgiesen M., Sher E., Clementi F.
      FEBS Lett. 312:66-70(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-498.
    10. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
      Lansdell S.J., Gee V.J., Harkness P.C., Doward A.I., Baker E.R., Gibb A.J., Millar N.S.
      Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIC3.

    Entry informationi

    Entry nameiACHB4_HUMAN
    AccessioniPrimary (citable) accession number: P30926
    Secondary accession number(s): A4FTX5
    , E9PHE8, Q16607, Q4VBA5, Q8WXC8, Q9BQR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 149 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3