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Protein

Aldehyde dehydrogenase, dimeric NADP-preferring

Gene

ALDH3A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).By similarityCurated

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei30PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, dimeric NADP-preferring (EC:1.2.1.5)
Alternative name(s):
Aldehyde dehydrogenase 3
Aldehyde dehydrogenase family 3 member A1
Corneal 15.8 kDa protein
Corneal protein 54
Short name:
bCP54
Transparentin
Gene namesi
Name:ALDH3A1
Synonyms:ALDH3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000056469‹1 – ›239Aldehyde dehydrogenase, dimeric NADP-preferringAdd BLAST›239

Proteomic databases

PaxDbiP30907.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028125.

Structurei

3D structure databases

ProteinModelPortaliP30907.
SMRiP30907.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiP30907.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
PfamiView protein in Pfam
PF00171. Aldedh. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiView protein in PROSITE
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.

Sequencei

Sequence statusi: Fragment.

P30907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NPHYVDKDRD LDIACRRIAW GKFMNSGQTC VAPDYILCDP SIQSQVVEKL
60 70 80 90 100
KKSLKEFYGE DAKKSRDYGR IINSRHFQRV MGLLEGQKVA YGGTGDATTR
110 120 130 140 150
YIAPTILTDV DPESPVMQEE VFGPVLPIMC VRSLEEAIQF ITQREKPLAL
160 170 180 190 200
YVFSPNDKVI KKMIAETSSG GVTANDVVVH ISVHSLPYGG VGDSGMGSYH
210 220 230
GRKSFETFSH RRSCLVRPLL NEETLKARYP RARPICPDT
Length:239
Mass (Da):26,743
Last modified:November 1, 1997 - v2
Checksum:i16BD07206287716C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2391

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51969 mRNA. Translation: AAB24736.2.
M37384 mRNA. Translation: AAA30468.1.
PIRiPS0412.
T01406.
UniGeneiBt.13116.

Entry informationi

Entry nameiAL3A1_BOVIN
AccessioniPrimary (citable) accession number: P30907
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: February 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome