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Protein

ATP synthase subunit d, mitochondrial

Gene

ATP7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

Miscellaneous

Present with 6820 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31825-MONOMER

Protein family/group databases

TCDBi3.A.2.1.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit d, mitochondrial
Gene namesi
Name:ATP7
Ordered Locus Names:YKL016C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL016C
SGDiS000001499 ATP7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000716812 – 174ATP synthase subunit d, mitochondrialAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP30902
PaxDbiP30902
PRIDEiP30902

PTM databases

iPTMnetiP30902

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.

Protein-protein interaction databases

BioGridi34116, 246 interactors
DIPiDIP-3039N
IntActiP30902, 10 interactors
MINTiP30902
STRINGi4932.YKL016C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6B2Zelectron microscopy3.60O/d2-174[»]
6B8Helectron microscopy3.60d/r2-174[»]
6CP3electron microscopy3.8072-174[»]
6CP5electron microscopy4.2072-174[»]
6CP6electron microscopy3.6072-174[»]
6CP7electron microscopy4.1072-174[»]
ProteinModelPortaliP30902
SMRiP30902
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase d subunit family.Curated

Phylogenomic databases

HOGENOMiHOG000201694
InParanoidiP30902
KOiK02138
OMAiKWTVPGY
OrthoDBiEOG092C57O4

Family and domain databases

Gene3Di1.20.58.880, 1 hit
InterProiView protein in InterPro
IPR008689 ATP_synth_F0_dsu_mt
IPR036228 ATP_synth_F0_dsu_sf_mt
PANTHERiPTHR12700 PTHR12700, 1 hit
PfamiView protein in Pfam
PF05873 Mt_ATP-synt_D, 1 hit
PIRSFiPIRSF005514 ATPase_F0_D_mt, 1 hit
SUPFAMiSSF161065 SSF161065, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAKSAANK LDWAKVISSL RITGSTATQL SSFKKRNDEA RRQLLELQSQ
60 70 80 90 100
PTEVDFSHYR SVLKNTSVID KIESYVKQYK PVKIDASKQL QVIESFEKHA
110 120 130 140 150
MTNAKETESL VSKELKDLQS TLDNIQSARP FDELTVDDLT KIKPEIDAKV
160 170
EEMVKKGKWD VPGYKDRFGN LNVM
Length:174
Mass (Da):19,810
Last modified:January 23, 2007 - v2
Checksum:iC6420CBEDF1BB45E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74048 Genomic DNA Translation: AAA34445.1
X74152 Genomic DNA Translation: CAA52265.1
Z28016 Genomic DNA Translation: CAA81851.1
AY558349 Genomic DNA Translation: AAS56675.1
BK006944 Genomic DNA Translation: DAA09140.1
PIRiA41168
RefSeqiNP_012909.3, NM_001179582.3

Genome annotation databases

EnsemblFungiiYKL016C; YKL016C; YKL016C
GeneIDi853853
KEGGisce:YKL016C

Similar proteinsi

Entry informationi

Entry nameiATP7_YEAST
AccessioniPrimary (citable) accession number: P30902
Secondary accession number(s): D6VXS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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