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Protein

ATP synthase subunit d, mitochondrial

Gene

ATP7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled proton transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31825-MONOMER.

Protein family/group databases

TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit d, mitochondrial
Gene namesi
Name:ATP7
Ordered Locus Names:YKL016C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL016C.
SGDiS000001499. ATP7.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial proton-transporting ATP synthase, stator stalk Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 174173ATP synthase subunit d, mitochondrialPRO_0000071681Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP30902.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.

Protein-protein interaction databases

BioGridi34116. 61 interactions.
DIPiDIP-3039N.
IntActiP30902. 9 interactions.
MINTiMINT-687011.

Structurei

3D structure databases

ProteinModelPortaliP30902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase d subunit family.Curated

Phylogenomic databases

HOGENOMiHOG000201694.
InParanoidiP30902.
KOiK02138.
OMAiKWTVPGY.
OrthoDBiEOG79W9HQ.

Family and domain databases

InterProiIPR008689. ATPase_F0-cplx_dsu_mt.
[Graphical view]
PANTHERiPTHR12700. PTHR12700. 1 hit.
PIRSFiPIRSF005514. ATPase_F0_D_mt. 1 hit.
SUPFAMiSSF161065. SSF161065. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAKSAANK LDWAKVISSL RITGSTATQL SSFKKRNDEA RRQLLELQSQ
60 70 80 90 100
PTEVDFSHYR SVLKNTSVID KIESYVKQYK PVKIDASKQL QVIESFEKHA
110 120 130 140 150
MTNAKETESL VSKELKDLQS TLDNIQSARP FDELTVDDLT KIKPEIDAKV
160 170
EEMVKKGKWD VPGYKDRFGN LNVM
Length:174
Mass (Da):19,810
Last modified:January 23, 2007 - v2
Checksum:iC6420CBEDF1BB45E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74048 Genomic DNA. Translation: AAA34445.1.
X74152 Genomic DNA. Translation: CAA52265.1.
Z28016 Genomic DNA. Translation: CAA81851.1.
AY558349 Genomic DNA. Translation: AAS56675.1.
BK006944 Genomic DNA. Translation: DAA09140.1.
PIRiA41168.
RefSeqiNP_012909.3. NM_001179582.3.

Genome annotation databases

EnsemblFungiiYKL016C; YKL016C; YKL016C.
GeneIDi853853.
KEGGisce:YKL016C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74048 Genomic DNA. Translation: AAA34445.1.
X74152 Genomic DNA. Translation: CAA52265.1.
Z28016 Genomic DNA. Translation: CAA81851.1.
AY558349 Genomic DNA. Translation: AAS56675.1.
BK006944 Genomic DNA. Translation: DAA09140.1.
PIRiA41168.
RefSeqiNP_012909.3. NM_001179582.3.

3D structure databases

ProteinModelPortaliP30902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34116. 61 interactions.
DIPiDIP-3039N.
IntActiP30902. 9 interactions.
MINTiMINT-687011.

Protein family/group databases

TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Proteomic databases

MaxQBiP30902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL016C; YKL016C; YKL016C.
GeneIDi853853.
KEGGisce:YKL016C.

Organism-specific databases

EuPathDBiFungiDB:YKL016C.
SGDiS000001499. ATP7.

Phylogenomic databases

HOGENOMiHOG000201694.
InParanoidiP30902.
KOiK02138.
OMAiKWTVPGY.
OrthoDBiEOG79W9HQ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31825-MONOMER.

Miscellaneous databases

PROiP30902.

Family and domain databases

InterProiIPR008689. ATPase_F0-cplx_dsu_mt.
[Graphical view]
PANTHERiPTHR12700. PTHR12700. 1 hit.
PIRSFiPIRSF005514. ATPase_F0_D_mt. 1 hit.
SUPFAMiSSF161065. SSF161065. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ATP synthase of yeast mitochondria. Characterization of subunit d and sequence analysis of the structural gene ATP7."
    Norais N., Prome D., Velours J.
    J. Biol. Chem. 266:16541-16549(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, PARTIAL PROTEIN SEQUENCE.
  2. "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene."
    Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W.
    Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATP7_YEAST
AccessioniPrimary (citable) accession number: P30902
Secondary accession number(s): D6VXS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6820 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.