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Protein

D-lactate dehydrogenase

Gene
N/A
Organism
Lactobacillus helveticus (Lactobacillus suntoryeus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R)-lactate + NAD+ = pyruvate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei176NAD1 Publication1
Binding sitei213NAD1 Publication1
Active sitei236By similarity1
Binding sitei260NAD1 Publication1
Active sitei265By similarity1
Active sitei297Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi156 – 157NAD1 Publication2
Nucleotide bindingi207 – 208NAD1 Publication2
Nucleotide bindingi234 – 236NAD1 Publication3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

SABIO-RKiP30901

Names & Taxonomyi

Protein namesi
Recommended name:
D-lactate dehydrogenase (EC:1.1.1.28)
Short name:
D-LDH
Alternative name(s):
D-specific 2-hydroxyacid dehydrogenase
OrganismiLactobacillus helveticus (Lactobacillus suntoryeus)
Taxonomic identifieri1587 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Pathology & Biotechi

Chemistry databases

DrugBankiDB03940 Oxamic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000759542 – 337D-lactate dehydrogenaseAdd BLAST336

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Turni11 – 13Combined sources3
Helixi14 – 23Combined sources10
Beta strandi28 – 30Combined sources3
Helixi40 – 43Combined sources4
Beta strandi48 – 52Combined sources5
Helixi60 – 67Combined sources8
Turni68 – 70Combined sources3
Beta strandi73 – 75Combined sources3
Beta strandi77 – 79Combined sources3
Helixi86 – 91Combined sources6
Helixi104 – 120Combined sources17
Helixi122 – 130Combined sources9
Helixi144 – 146Combined sources3
Beta strandi147 – 152Combined sources6
Helixi156 – 167Combined sources12
Beta strandi171 – 175Combined sources5
Helixi183 – 186Combined sources4
Helixi193 – 196Combined sources4
Turni197 – 199Combined sources3
Beta strandi201 – 205Combined sources5
Turni211 – 215Combined sources5
Helixi219 – 222Combined sources4
Beta strandi229 – 233Combined sources5
Helixi237 – 239Combined sources3
Helixi242 – 250Combined sources9
Beta strandi253 – 260Combined sources8
Helixi265 – 268Combined sources4
Helixi281 – 288Combined sources8
Beta strandi292 – 294Combined sources3
Helixi303 – 322Combined sources20
Beta strandi327 – 329Combined sources3
Turni333 – 335Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DLDX-ray2.70A/B1-337[»]
ProteinModelPortaliP30901
SMRiP30901
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30901

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C5I Bacteria
COG1052 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00065 D_2_HYDROXYACID_DH_1, 1 hit
PS00670 D_2_HYDROXYACID_DH_2, 1 hit
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVFAYAIR KDEEPFLNEW KEAHKDIDVD YTDKLLTPET AKLAKGADGV
60 70 80 90 100
VVYQQLDYTA DTLQALADAG VTKMSLRNVG VDNIDMDKAK ELGFQITNVP
110 120 130 140 150
VYSPNAIAEH AAIQAARVLR QDKRMDEKMA KRDLRWAPTI GREVRDQVVG
160 170 180 190 200
VVGTGHIGQV FMRIMEGFGA KVIAYDIFKN PELEKKGYYV DSLDDLYKQA
210 220 230 240 250
DVISLHVPDV PANVHMINDK SIAEMKDGVV IVNCSRGRLV DTDAVIRGLD
260 270 280 290 300
SGKIFGFVMD TYEDEVGVFN KDWEGKEFPD KRLADLIDRP NVLVTPHTAF
310 320 330
YTTHAVRNMV VKAFNNNLKL INGEKPDSPV ALNKNKF
Length:337
Mass (Da):37,779
Last modified:January 23, 2007 - v2
Checksum:iD0561DD82C03B3C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66723 Genomic DNA Translation: CAA47255.1
U07604 Genomic DNA Translation: AAA20464.1
PIRiS29296
RefSeqiWP_003628108.1, NZ_PJRL01000033.1

Similar proteinsi

Entry informationi

Entry nameiLDHD_LACHE
AccessioniPrimary (citable) accession number: P30901
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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