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P30899

- BLAC_BACVU

UniProt

P30899 - BLAC_BACVU

Protein

Beta-lactamase

Gene

cfxA

Organism
Bacteroides vulgatus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    • Comment

    Functioni

    Can hydrolyze cephalosporins, penicillins and also cefoxitin; but at a slow rate.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Enzyme regulationi

    Inhibited by clavulanic acid.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei83 – 831Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Gene namesi
    Name:cfxA
    OrganismiBacteroides vulgatus
    Taxonomic identifieri821 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 321291Beta-lactamasePRO_0000017038Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP30899.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni233 – 2353Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30899-1 [UniParc]FASTAAdd to Basket

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    MEKNRKKQIV VLSIALVCIF ILVFSLFHKS ATKDSANPPL TNVLTDSISQ    50
    IVSACPGEIG VAVIVNNRDT VKVNNKSVYP MMSVFKVHQA LALCNDFDNK 100
    GISLDTLVNI NRDKLDPKTW SPMLKDYSGP VISLTVRDLL RYTLTQSDNN 150
    ASNLMFKDMV NVAQTDSFIA TLIPRSSFQI AYTEEEMSAD HNKAYSNYTS 200
    PLGAAMLMNR LFTEGLIDDE KQSFIKNTLK ECKTGVDRIA APLLDKEGVV 250
    IAHKTGSGYV NENGVLAAHN DVAYICLPNN ISYTLAVFVK DFKGNKSQAS 300
    QYVAHISAVV YSLLMQTSVK S 321
    Length:321
    Mass (Da):35,376
    Last modified:July 1, 1993 - v1
    Checksum:i6ADD45ED16F0BDFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38243 Genomic DNA. Translation: AAB17891.1.
    PIRiI40600. S27528.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38243 Genomic DNA. Translation: AAB17891.1 .
    PIRi I40600. S27528.

    3D structure databases

    ProteinModelPortali P30899.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic and biochemical analysis of a novel Ambler class A beta-lactamase responsible for cefoxitin resistance in Bacteroides species."
      Parker A.C., Smith C.J.
      Antimicrob. Agents Chemother. 37:1028-1036(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CLA341.

    Entry informationi

    Entry nameiBLAC_BACVU
    AccessioniPrimary (citable) accession number: P30899
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3