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P30899 (BLAC_BACVU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Gene names
Name:cfxA
OrganismBacteroides vulgatus
Taxonomic identifier821 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Can hydrolyze cephalosporins, penicillins and also cefoxitin; but at a slow rate.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulation

Inhibited by clavulanic acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 321291Beta-lactamase
PRO_0000017038

Regions

Region233 – 2353Substrate binding By similarity

Sites

Active site831Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P30899 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 6ADD45ED16F0BDFA

FASTA32135,376
        10         20         30         40         50         60 
MEKNRKKQIV VLSIALVCIF ILVFSLFHKS ATKDSANPPL TNVLTDSISQ IVSACPGEIG 

        70         80         90        100        110        120 
VAVIVNNRDT VKVNNKSVYP MMSVFKVHQA LALCNDFDNK GISLDTLVNI NRDKLDPKTW 

       130        140        150        160        170        180 
SPMLKDYSGP VISLTVRDLL RYTLTQSDNN ASNLMFKDMV NVAQTDSFIA TLIPRSSFQI 

       190        200        210        220        230        240 
AYTEEEMSAD HNKAYSNYTS PLGAAMLMNR LFTEGLIDDE KQSFIKNTLK ECKTGVDRIA 

       250        260        270        280        290        300 
APLLDKEGVV IAHKTGSGYV NENGVLAAHN DVAYICLPNN ISYTLAVFVK DFKGNKSQAS 

       310        320 
QYVAHISAVV YSLLMQTSVK S 

« Hide

References

[1]"Genetic and biochemical analysis of a novel Ambler class A beta-lactamase responsible for cefoxitin resistance in Bacteroides species."
Parker A.C., Smith C.J.
Antimicrob. Agents Chemother. 37:1028-1036(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CLA341.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U38243 Genomic DNA. Translation: AAB17891.1.
PIRS27528. I40600.

3D structure databases

ProteinModelPortalP30899.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_BACVU
AccessionPrimary (citable) accession number: P30899
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families