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Protein

Beta-lactamase

Gene

cfxA

Organism
Bacteroides vulgatus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Can hydrolyze cephalosporins, penicillins and also cefoxitin; but at a slow rate.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by clavulanic acid.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Gene namesi
Name:cfxA
OrganismiBacteroides vulgatus
Taxonomic identifieri821 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001703831 – 321Beta-lactamaseAdd BLAST291

Structurei

3D structure databases

ProteinModelPortaliP30899.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni233 – 235Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKNRKKQIV VLSIALVCIF ILVFSLFHKS ATKDSANPPL TNVLTDSISQ
60 70 80 90 100
IVSACPGEIG VAVIVNNRDT VKVNNKSVYP MMSVFKVHQA LALCNDFDNK
110 120 130 140 150
GISLDTLVNI NRDKLDPKTW SPMLKDYSGP VISLTVRDLL RYTLTQSDNN
160 170 180 190 200
ASNLMFKDMV NVAQTDSFIA TLIPRSSFQI AYTEEEMSAD HNKAYSNYTS
210 220 230 240 250
PLGAAMLMNR LFTEGLIDDE KQSFIKNTLK ECKTGVDRIA APLLDKEGVV
260 270 280 290 300
IAHKTGSGYV NENGVLAAHN DVAYICLPNN ISYTLAVFVK DFKGNKSQAS
310 320
QYVAHISAVV YSLLMQTSVK S
Length:321
Mass (Da):35,376
Last modified:July 1, 1993 - v1
Checksum:i6ADD45ED16F0BDFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38243 Genomic DNA. Translation: AAB17891.1.
PIRiI40600. S27528.
RefSeqiWP_063843237.1. NG_047633.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38243 Genomic DNA. Translation: AAB17891.1.
PIRiI40600. S27528.
RefSeqiWP_063843237.1. NG_047633.1.

3D structure databases

ProteinModelPortaliP30899.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBLAC_BACVU
AccessioniPrimary (citable) accession number: P30899
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 5, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.