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P30899

- BLAC_BACVU

UniProt

P30899 - BLAC_BACVU

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Protein

Beta-lactamase

Gene
cfxA
Organism
Bacteroides vulgatus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Can hydrolyze cephalosporins, penicillins and also cefoxitin; but at a slow rate.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulationi

Inhibited by clavulanic acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Gene namesi
Name:cfxA
OrganismiBacteroides vulgatus
Taxonomic identifieri821 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed predictionAdd
BLAST
Chaini31 – 321291Beta-lactamasePRO_0000017038Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP30899.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni233 – 2353Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30899-1 [UniParc]FASTAAdd to Basket

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MEKNRKKQIV VLSIALVCIF ILVFSLFHKS ATKDSANPPL TNVLTDSISQ    50
IVSACPGEIG VAVIVNNRDT VKVNNKSVYP MMSVFKVHQA LALCNDFDNK 100
GISLDTLVNI NRDKLDPKTW SPMLKDYSGP VISLTVRDLL RYTLTQSDNN 150
ASNLMFKDMV NVAQTDSFIA TLIPRSSFQI AYTEEEMSAD HNKAYSNYTS 200
PLGAAMLMNR LFTEGLIDDE KQSFIKNTLK ECKTGVDRIA APLLDKEGVV 250
IAHKTGSGYV NENGVLAAHN DVAYICLPNN ISYTLAVFVK DFKGNKSQAS 300
QYVAHISAVV YSLLMQTSVK S 321
Length:321
Mass (Da):35,376
Last modified:July 1, 1993 - v1
Checksum:i6ADD45ED16F0BDFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38243 Genomic DNA. Translation: AAB17891.1.
PIRiI40600. S27528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38243 Genomic DNA. Translation: AAB17891.1 .
PIRi I40600. S27528.

3D structure databases

ProteinModelPortali P30899.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic and biochemical analysis of a novel Ambler class A beta-lactamase responsible for cefoxitin resistance in Bacteroides species."
    Parker A.C., Smith C.J.
    Antimicrob. Agents Chemother. 37:1028-1036(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CLA341.

Entry informationi

Entry nameiBLAC_BACVU
AccessioniPrimary (citable) accession number: P30899
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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