Reviewed, UniProtKB/Swiss-Prot P30898 (BLAC_BACUN)

Names and origin

Protein names

Recommended name:
    Beta-lactamase
    EC=3.5.2.6

Gene names

Name:

cblA

Organism

Bacteroides uniformis

Taxonomic identifier

820 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	A beta-lactam + H2O = a substituted beta-amino acid.
Sequence similarities	Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Domain	Signal
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	beta-lactam antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	beta-lactamase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 296	275	Beta-lactamase		PRO_0000017037
Regions
	Region	235 – 237	3	Substrate binding By similarity
Sites
	Active site	66	1	Acyl-ester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30898-1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 87ACA38331207004	FASTA	296	33,450
	10 20 30 40 50 60 MKAYFIAILT LFTCIATVVR AQQMSELENR IDSLLNGKKA TVGIAVWTDK GDMLRYNDHV 70 80 90 100 110 120 HFPLLSVFKF HVALAVLDKM DKQSISLDSI VSIKASQMPP NTYSPLRKKF PDQDFTITLR 130 140 150 160 170 180 ELMQYSISQS DNNACDILIE YAGGIKHIND YIHRLSIDSF NLSETEDGMH SSFEAVYRNW 190 200 210 220 230 240 STPSAMVRLL RTADEKELFS NKELKDFLWQ TMIDTETGAN KLKGMLPAKT VVGHKTGSSD 250 260 270 280 290 RNADGMKTAD NDAGLVILPD GRKYYIAAFV MDSYETDEDN ANIIARISRM VYDAMR

References

[1]

"Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cblA, encoding the species-specific beta-lactamase." Smith C.J., Bennett T.K., Parker A.C. Antimicrob. Agents Chemother. 38:1711-1715(1994) [PubMed: 7985999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WAL-7088.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L08472 Genomic DNA. Translation: AAA66962.1.
PIR	I40231.
3D structure databases
HSSP	HSSP built from PDB template 1E25 based on UniProtKB P37321.
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.5.2.6. 141800.
Family and domain databases
InterPro	IPR001466. Beta_lactamase-related. IPR000871. Beta_lactamase_A/D. [Graphical view]
Pfam	PF00144. Beta-lactamase. 1 hit. [Graphical view]
PRINTS	PR00118. BLACTAMASEA.
PROSITE	PS00146. BETA_LACTAMASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BLAC_BACUN

Accession

Primary (citable) accession number: P30898

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)