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Protein

Beta-lactamase

Gene

cblA

Organism
Bacteroides uniformis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Gene namesi
Name:cblA
OrganismiBacteroides uniformis
Taxonomic identifieri820 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001703722 – 296Beta-lactamaseAdd BLAST275

Proteomic databases

PRIDEiP30898

Structurei

3D structure databases

ProteinModelPortaliP30898
SMRiP30898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 237Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
IPR023650 Beta-lactam_class-A_AS
PRINTSiPR00118 BLACTAMASEA
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00146 BETA_LACTAMASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAYFIAILT LFTCIATVVR AQQMSELENR IDSLLNGKKA TVGIAVWTDK
60 70 80 90 100
GDMLRYNDHV HFPLLSVFKF HVALAVLDKM DKQSISLDSI VSIKASQMPP
110 120 130 140 150
NTYSPLRKKF PDQDFTITLR ELMQYSISQS DNNACDILIE YAGGIKHIND
160 170 180 190 200
YIHRLSIDSF NLSETEDGMH SSFEAVYRNW STPSAMVRLL RTADEKELFS
210 220 230 240 250
NKELKDFLWQ TMIDTETGAN KLKGMLPAKT VVGHKTGSSD RNADGMKTAD
260 270 280 290
NDAGLVILPD GRKYYIAAFV MDSYETDEDN ANIIARISRM VYDAMR
Length:296
Mass (Da):33,450
Last modified:July 1, 1993 - v1
Checksum:i87ACA38331207004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08472 Genomic DNA Translation: AAA66962.1
PIRiI40231
RefSeqiWP_005827792.1, NZ_NFHS01000003.1

Genome annotation databases

GeneIDi31505337

Similar proteinsi

Entry informationi

Entry nameiBLAC_BACUN
AccessioniPrimary (citable) accession number: P30898
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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