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P30898

- BLAC_BACUN

UniProt

P30898 - BLAC_BACUN

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Protein

Beta-lactamase

Gene

cblA

Organism
Bacteroides uniformis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Gene namesi
Name:cblA
OrganismiBacteroides uniformis
Taxonomic identifieri820 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 296275Beta-lactamasePRO_0000017037Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP30898.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni235 – 2373Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30898-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAYFIAILT LFTCIATVVR AQQMSELENR IDSLLNGKKA TVGIAVWTDK
60 70 80 90 100
GDMLRYNDHV HFPLLSVFKF HVALAVLDKM DKQSISLDSI VSIKASQMPP
110 120 130 140 150
NTYSPLRKKF PDQDFTITLR ELMQYSISQS DNNACDILIE YAGGIKHIND
160 170 180 190 200
YIHRLSIDSF NLSETEDGMH SSFEAVYRNW STPSAMVRLL RTADEKELFS
210 220 230 240 250
NKELKDFLWQ TMIDTETGAN KLKGMLPAKT VVGHKTGSSD RNADGMKTAD
260 270 280 290
NDAGLVILPD GRKYYIAAFV MDSYETDEDN ANIIARISRM VYDAMR
Length:296
Mass (Da):33,450
Last modified:July 1, 1993 - v1
Checksum:i87ACA38331207004
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08472 Genomic DNA. Translation: AAA66962.1.
PIRiI40231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08472 Genomic DNA. Translation: AAA66962.1 .
PIRi I40231.

3D structure databases

ProteinModelPortali P30898.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cblA, encoding the species-specific beta-lactamase."
    Smith C.J., Bennett T.K., Parker A.C.
    Antimicrob. Agents Chemother. 38:1711-1715(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WAL-7088.

Entry informationi

Entry nameiBLAC_BACUN
AccessioniPrimary (citable) accession number: P30898
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3