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P30898

- BLAC_BACUN

UniProt

P30898 - BLAC_BACUN

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Protein

Beta-lactamase

Gene
cblA
Organism
Bacteroides uniformis
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Gene namesi
Name:cblA
OrganismiBacteroides uniformis
Taxonomic identifieri820 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 296275Beta-lactamasePRO_0000017037Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP30898.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni235 – 2373Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30898-1 [UniParc]FASTAAdd to Basket

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MKAYFIAILT LFTCIATVVR AQQMSELENR IDSLLNGKKA TVGIAVWTDK    50
GDMLRYNDHV HFPLLSVFKF HVALAVLDKM DKQSISLDSI VSIKASQMPP 100
NTYSPLRKKF PDQDFTITLR ELMQYSISQS DNNACDILIE YAGGIKHIND 150
YIHRLSIDSF NLSETEDGMH SSFEAVYRNW STPSAMVRLL RTADEKELFS 200
NKELKDFLWQ TMIDTETGAN KLKGMLPAKT VVGHKTGSSD RNADGMKTAD 250
NDAGLVILPD GRKYYIAAFV MDSYETDEDN ANIIARISRM VYDAMR 296
Length:296
Mass (Da):33,450
Last modified:July 1, 1993 - v1
Checksum:i87ACA38331207004
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08472 Genomic DNA. Translation: AAA66962.1.
PIRiI40231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08472 Genomic DNA. Translation: AAA66962.1 .
PIRi I40231.

3D structure databases

ProteinModelPortali P30898.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cblA, encoding the species-specific beta-lactamase."
    Smith C.J., Bennett T.K., Parker A.C.
    Antimicrob. Agents Chemother. 38:1711-1715(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WAL-7088.

Entry informationi

Entry nameiBLAC_BACUN
AccessioniPrimary (citable) accession number: P30898
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi