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P30897 (BLAC_PROMI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Carbenicillinase
Gene names
Name:blaP
OrganismProteus mirabilis
Taxonomic identifier584 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes carbenicillin.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 298270Beta-lactamase
PRO_0000017007

Regions

Region237 – 2393Substrate binding By similarity

Sites

Active site721Acyl-ester intermediate By similarity

Amino acid modifications

Disulfide bond79 ↔ 126 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30897 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: A3710003B728BD5F

FASTA29832,765
        10         20         30         40         50         60 
MNVRQHKASF FSVVITFLCL TLSLNANATD SVLEAVTNAE TELGARIGLA AHDLETGKRW 

        70         80         90        100        110        120 
EHKSNERFPL SSTFKTLACA NVLQRVDLGK ERIDRVVRFS ESNLVTYSPV TEKHVGKKGM 

       130        140        150        160        170        180 
SLAELCQATL STSDNSAANF ILQAIGGPKA LTKFLRSIGD DTTRLDRWEP ELNEAVPGDK 

       190        200        210        220        230        240 
RDTTTPIAMV TTLEKLLIDE TLSIKSRQQL ESWLKGNEVG DALFRKGVPS DWIVADRTGA 

       250        260        270        280        290 
GGYGSRAITA VMWPPNRKPI VAALYITETD ASFEERNAVI AKIGEQIAKT VLMENSRN 

« Hide

References

[1]"Nucleotide sequence and characterization of a carbenicillin-hydrolyzing penicillinase gene from Proteus mirabilis."
Sakurai Y., Tsukamoto K., Sawai T.
J. Bacteriol. 173:7038-7041(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 29-37.
Strain: GN79.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13209 Genomic DNA. Translation: BAA02496.1.
PIRA41381.

3D structure databases

ProteinModelPortalP30897.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL5744.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_PROMI
AccessionPrimary (citable) accession number: P30897
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 16, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families