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P30897

- BLAC_PROMI

UniProt

P30897 - BLAC_PROMI

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Protein
Beta-lactamase
Gene
blaP
Organism
Proteus mirabilis
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes carbenicillin.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1222-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Carbenicillinase
Gene namesi
Name:blaP
OrganismiProteus mirabilis
Taxonomic identifieri584 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 298270Beta-lactamase
PRO_0000017007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi79 ↔ 126 By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP30897.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni237 – 2393Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30897-1 [UniParc]FASTAAdd to Basket

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MNVRQHKASF FSVVITFLCL TLSLNANATD SVLEAVTNAE TELGARIGLA    50
AHDLETGKRW EHKSNERFPL SSTFKTLACA NVLQRVDLGK ERIDRVVRFS 100
ESNLVTYSPV TEKHVGKKGM SLAELCQATL STSDNSAANF ILQAIGGPKA 150
LTKFLRSIGD DTTRLDRWEP ELNEAVPGDK RDTTTPIAMV TTLEKLLIDE 200
TLSIKSRQQL ESWLKGNEVG DALFRKGVPS DWIVADRTGA GGYGSRAITA 250
VMWPPNRKPI VAALYITETD ASFEERNAVI AKIGEQIAKT VLMENSRN 298
Length:298
Mass (Da):32,765
Last modified:July 1, 1993 - v1
Checksum:iA3710003B728BD5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13209 Genomic DNA. Translation: BAA02496.1.
PIRiA41381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13209 Genomic DNA. Translation: BAA02496.1 .
PIRi A41381.

3D structure databases

ProteinModelPortali P30897.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL5744.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-1222-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and characterization of a carbenicillin-hydrolyzing penicillinase gene from Proteus mirabilis."
    Sakurai Y., Tsukamoto K., Sawai T.
    J. Bacteriol. 173:7038-7041(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 29-37.
    Strain: GN79.

Entry informationi

Entry nameiBLAC_PROMI
AccessioniPrimary (citable) accession number: P30897
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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