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P30890 (NSP5_ROTGI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein 5

Short name=NSP5
OrganismRotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Taxonomic identifier28877 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]

Protein attributes

Sequence length174 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.

Subunit structure

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.

Subcellular location

Host cytoplasm. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

Sequence similarities

Belongs to the rotavirus B NSP5 family.

Ontologies

Keywords
   Cellular componentHost cytoplasm
   DomainCoiled coil
Gene Ontology (GO)
   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 174174Non-structural protein 5
PRO_0000149630

Regions

Coiled coil118 – 13922 Potential

Sequences

Sequence LengthMass (Da)Tools
P30890 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 76AE32FD271140DE

FASTA17420,057
        10         20         30         40         50         60 
MAEASEFNFN LRRKSRAVTA SRRVKEEVKE KQKMDDSKSQ VVDVDSVSVY SHESSRSNYS 

        70         80         90        100        110        120 
DAYEKLKREP VVEESNDARY RTFEFSEDEE TFKPANKMSD KSQRNSKSKH TEGLECSDTV 

       130        140        150        160        170 
LEKISELTLE IEKVKQMNQP ITVDAAFNMT LRNVDNLTTR QKQALVNSII NSMN 

« Hide

References

[1]"Comparison of group B rotavirus genes 9 and 11."
Petric M., Mayur K., Vonderfecht S., Eiden J.J.
J. Gen. Virol. 72:2801-2804(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00912 Genomic RNA. Translation: BAA00758.1.
PIRJQ1310.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR020244. Rotavirus_B_NSP5.
[Graphical view]
ProDomPD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameNSP5_ROTGI
AccessionPrimary (citable) accession number: P30890
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 3, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families