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P30890

- NSP5_ROTGI

UniProt

P30890 - NSP5_ROTGI

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Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 5
Short name:
NSP5
OrganismiRotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Taxonomic identifieri28877 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]

Subcellular locationi

Host cytoplasm
Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 174174Non-structural protein 5PRO_0000149630Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories (By similarity).By similarity

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili118 – 13922Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the rotavirus B NSP5 family.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR020244. Rotavirus_B_NSP5.
[Graphical view]
ProDomiPD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P30890-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEASEFNFN LRRKSRAVTA SRRVKEEVKE KQKMDDSKSQ VVDVDSVSVY
60 70 80 90 100
SHESSRSNYS DAYEKLKREP VVEESNDARY RTFEFSEDEE TFKPANKMSD
110 120 130 140 150
KSQRNSKSKH TEGLECSDTV LEKISELTLE IEKVKQMNQP ITVDAAFNMT
160 170
LRNVDNLTTR QKQALVNSII NSMN
Length:174
Mass (Da):20,057
Last modified:July 1, 1993 - v1
Checksum:i76AE32FD271140DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00912 Genomic RNA. Translation: BAA00758.1.
PIRiJQ1310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00912 Genomic RNA. Translation: BAA00758.1 .
PIRi JQ1310.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR020244. Rotavirus_B_NSP5.
[Graphical view ]
ProDomi PD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of group B rotavirus genes 9 and 11."
    Petric M., Mayur K., Vonderfecht S., Eiden J.J.
    J. Gen. Virol. 72:2801-2804(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP5_ROTGI
AccessioniPrimary (citable) accession number: P30890
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3