P30890 (NSP5_ROTGI) Reviewed, UniProtKB/Swiss-Prot
Last modified April 3, 2013. Version 30. History...
Names and origin
|Protein names||Recommended name:|
Non-structural protein 5
|Organism||Rotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))|
|Taxonomic identifier||28877 [NCBI]|
|Taxonomic lineage||Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Rotavirus ›|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
Rattus norvegicus (Rat) [TaxID: 10116]
|Sequence length||174 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.
Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.
Host cytoplasm. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.
Belongs to the rotavirus B NSP5 family.
Sequence annotation (Features)
|D00912 Genomic RNA. Translation: BAA00758.1.|
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR020244. Rotavirus_B_NSP5. |
|ProDom||PD035122. Rotavirus_B_NSP5. 1 hit. |
[Graphical view] [Entries sharing at least one domain]
|Accession||Primary (citable) accession number: P30890|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families