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P30890

- NSP5_ROTGI

UniProt

P30890 - NSP5_ROTGI

Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein 5
    Short name:
    NSP5
    OrganismiRotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
    Taxonomic identifieri28877 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Rattus norvegicus (Rat) [TaxID: 10116]

    Subcellular locationi

    Host cytoplasm
    Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 174174Non-structural protein 5PRO_0000149630Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.By similarity

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili118 – 13922Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rotavirus B NSP5 family.Curated

    Keywords - Domaini

    Coiled coil

    Family and domain databases

    InterProiIPR020244. Rotavirus_B_NSP5.
    [Graphical view]
    ProDomiPD035122. Rotavirus_B_NSP5. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P30890-1 [UniParc]FASTAAdd to Basket

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    MAEASEFNFN LRRKSRAVTA SRRVKEEVKE KQKMDDSKSQ VVDVDSVSVY    50
    SHESSRSNYS DAYEKLKREP VVEESNDARY RTFEFSEDEE TFKPANKMSD 100
    KSQRNSKSKH TEGLECSDTV LEKISELTLE IEKVKQMNQP ITVDAAFNMT 150
    LRNVDNLTTR QKQALVNSII NSMN 174
    Length:174
    Mass (Da):20,057
    Last modified:July 1, 1993 - v1
    Checksum:i76AE32FD271140DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00912 Genomic RNA. Translation: BAA00758.1.
    PIRiJQ1310.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00912 Genomic RNA. Translation: BAA00758.1 .
    PIRi JQ1310.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR020244. Rotavirus_B_NSP5.
    [Graphical view ]
    ProDomi PD035122. Rotavirus_B_NSP5. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of group B rotavirus genes 9 and 11."
      Petric M., Mayur K., Vonderfecht S., Eiden J.J.
      J. Gen. Virol. 72:2801-2804(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNSP5_ROTGI
    AccessioniPrimary (citable) accession number: P30890
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3