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P30889

- VP7_ROTGI

UniProt

P30889 - VP7_ROTGI

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Protein
Outer capsid glycoprotein VP7
Gene
N/A
Organism
Rotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors By similarity.

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Outer capsid glycoprotein VP7
OrganismiRotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Taxonomic identifieri28877 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]

Subcellular locationi

Virion Reviewed prediction. Host rough endoplasmic reticulum membrane; Single-pass membrane protein; Lumenal side Reviewed prediction
Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2317Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. T=13 icosahedral viral capsid Source: UniProtKB-KW
  2. host cell rough endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral outer capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host endoplasmic reticulum, Host membrane, Membrane, Outer capsid protein, T=13 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Outer capsid glycoprotein VP7
PRO_0000041132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi129 – 1291N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotrimer; in the presence of calcium By similarity. Acquisition of the capsid outer layer requires a high calcium concentration inside the endoplasmic reticulum. Following cell entry, the low calcium concentration in the cytoplasm is probably responsible for the solubilization of the outer layer By similarity.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 84Poly-Leu

Sequence similaritiesi

Belongs to the rotavirus VP7 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR008818. Rotavirus_VP7.
[Graphical view]
PfamiPF05868. Rotavirus_VP7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30889-1 [UniParc]FASTAAdd to Basket

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MTTMLLLLVV AALANGQLTI LPHEESQICF LQPDNPGFDF DGNFTNIFRD    50
YASVKISSFT YKAQDADIVE ILNVDRDRSC TILAIYIADS TLDFNTFLQS 100
ENECVKYAAS KKHYIKLPRD REYFALAKNL SFCPLNDDLI GIYCDTQLET 150
TYFSVARSSN YDVTDIPEFT ELGYVFHSND HFYICERKSE GNWIDYQLFY 200
QNDAPLGTVS QRVNWGNVWS NVKTVAQMVY KILDIFFGKR NIEPRA 246
Length:246
Mass (Da):28,319
Last modified:July 1, 1993 - v1
Checksum:iBF28CC5BF9A169A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00911 Genomic RNA. Translation: BAA00757.1.
PIRiJQ1311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00911 Genomic RNA. Translation: BAA00757.1 .
PIRi JQ1311.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008818. Rotavirus_VP7.
[Graphical view ]
Pfami PF05868. Rotavirus_VP7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of group B rotavirus genes 9 and 11."
    Petric M., Mayur K., Vonderfecht S., Eiden J.J.
    J. Gen. Virol. 72:2801-2804(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP7_ROTGI
AccessioniPrimary (citable) accession number: P30889
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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