ID   PHO2_YARLI              Reviewed;         358 AA.
AC   P30887; Q6CAE8;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=Acid phosphatase;
DE            EC=3.1.3.2;
DE   Flags: Precursor;
GN   Name=PHO2; OrderedLocusNames=YALI0D03465g;
OS   Yarrowia lipolytica (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=4952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX   MEDLINE=93046805; PubMed=1423722; DOI=10.1007/BF00352435;
RA   Treton B.Y., le Dall M.-T., Gaillardin C.;
RT   "Complementation of Saccharomyces cerevisiae acid phosphatase mutation
RT   by a genomic sequence from the yeast Yarrowia lipolytica identifies a
RT   new phosphatase.";
RL   Curr. Genet. 22:345-355(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Probably serves to scavenge phosphorus for growing
CC       cells.
CC   -!- CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol +
CC       phosphate.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the surE nucleotidase family.
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DR   EMBL; X65225; CAA46331.1; -; Genomic_DNA.
DR   EMBL; CR382130; CAG80552.1; -; Genomic_DNA.
DR   PIR; S19993; S19993.
DR   RefSeq; XP_502364.1; -.
DR   GeneID; 2910307; -.
DR   KEGG; yli:YALI0D03465g; -.
DR   HOGENOM; P30887; -.
DR   BRENDA; 3.1.3.2; 3602.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002828; SurE-like_Pase/nucleotidase.
DR   Gene3D; G3DSA:3.40.1210.10; SurE-like_Pase/nucleotidase; 1.
DR   Pfam; PF01975; SurE; 1.
DR   ProDom; PD005378; SurE; 1.
DR   TIGRFAMs; TIGR00087; surE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Glycoprotein; Hydrolase; Magnesium; Metal-binding;
KW   Secreted; Signal.
FT   SIGNAL        1     17       Potential.
FT   CHAIN        18    358       Acid phosphatase.
FT                                /FTId=PRO_0000033476.
FT   ACT_SITE    189    189       Potential.
FT   METAL        49     49       Magnesium (By similarity).
FT   METAL        50     50       Magnesium (By similarity).
FT   METAL        81     81       Magnesium (By similarity).
FT   METAL       156    156       Magnesium (By similarity).
FT   CARBOHYD     20     20       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     27     27       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     32     32       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     92     92       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    145    145       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    199    199       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    278    278       N-linked (GlcNAc...) (Potential).
FT   CONFLICT    228    228       G -> V (in Ref. 1; CAA46331).
SQ   SEQUENCE   358 AA;  38003 MW;  0362F01F892E693B CRC64;
     MKFSTIALPL LASAALAQTN SSHSGTNATS HNSTVPNENS KTTIVVTNDD SWASANIRAF
     YDELKKEGYN VFMFAPALQQ SGTGGTFVLP KNTTLAKGAE WGSAPVGAPA WGQDEKDDHI
     WYFDGTPGAA VTFGFDYALP KFHNNITVDL VVSGPNEGWN LGPFVYTLSG TEGAMYTSVL
     RGVPAIAFSG ENKHTYYANA SNSETASHNI YAKASTAIVK NLLKNAKGRP SVLPYGVGLS
     VNLPLVGDID PTGKCTDPKP IFTRQTGRGA ITDKLVFNET TGLFKYGDIK SDATKACLNG
     DCFLPDETDV INNWGCYSSI SVVSTDYDAP GALAAEAQFL NRGLVEFAPT GYGSFPGN
//