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Protein

Acid phosphatase

Gene

PHO2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably serves to scavenge phosphorus for growing cells.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49MagnesiumBy similarity1
Metal bindingi50MagnesiumBy similarity1
Metal bindingi81MagnesiumBy similarity1
Metal bindingi156MagnesiumBy similarity1
Active sitei189Sequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:PHO2
Ordered Locus Names:YALI0D03465g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome D

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000003347618 – 358Acid phosphataseAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP30887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000248507.
InParanoidiP30887.
OMAiHRSFTTN.
OrthoDBiEOG092C3KHM.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
InterProiIPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSTIALPL LASAALAQTN SSHSGTNATS HNSTVPNENS KTTIVVTNDD
60 70 80 90 100
SWASANIRAF YDELKKEGYN VFMFAPALQQ SGTGGTFVLP KNTTLAKGAE
110 120 130 140 150
WGSAPVGAPA WGQDEKDDHI WYFDGTPGAA VTFGFDYALP KFHNNITVDL
160 170 180 190 200
VVSGPNEGWN LGPFVYTLSG TEGAMYTSVL RGVPAIAFSG ENKHTYYANA
210 220 230 240 250
SNSETASHNI YAKASTAIVK NLLKNAKGRP SVLPYGVGLS VNLPLVGDID
260 270 280 290 300
PTGKCTDPKP IFTRQTGRGA ITDKLVFNET TGLFKYGDIK SDATKACLNG
310 320 330 340 350
DCFLPDETDV INNWGCYSSI SVVSTDYDAP GALAAEAQFL NRGLVEFAPT

GYGSFPGN
Length:358
Mass (Da):38,003
Last modified:October 11, 2004 - v2
Checksum:i0362F01F892E693B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228G → V in CAA46331 (PubMed:1423722).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65225 Genomic DNA. Translation: CAA46331.1.
CR382130 Genomic DNA. Translation: CAG80552.1.
PIRiS19993.
RefSeqiXP_502364.1. XM_502364.1.

Genome annotation databases

EnsemblFungiiCAG80552; CAG80552; YALI0_D03465g.
GeneIDi2910307.
KEGGiyli:YALI0D03465g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65225 Genomic DNA. Translation: CAA46331.1.
CR382130 Genomic DNA. Translation: CAG80552.1.
PIRiS19993.
RefSeqiXP_502364.1. XM_502364.1.

3D structure databases

ProteinModelPortaliP30887.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG80552; CAG80552; YALI0_D03465g.
GeneIDi2910307.
KEGGiyli:YALI0D03465g.

Phylogenomic databases

HOGENOMiHOG000248507.
InParanoidiP30887.
OMAiHRSFTTN.
OrthoDBiEOG092C3KHM.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
InterProiIPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHO2_YARLI
AccessioniPrimary (citable) accession number: P30887
Secondary accession number(s): Q6CAE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.