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P30887

- PHO2_YARLI

UniProt

P30887 - PHO2_YARLI

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Protein
Acid phosphatase
Gene
PHO2, YALI0D03465g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Probably serves to scavenge phosphorus for growing cells.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi49 – 491Magnesium By similarity
Metal bindingi50 – 501Magnesium By similarity
Metal bindingi81 – 811Magnesium By similarity
Metal bindingi156 – 1561Magnesium By similarity
Active sitei189 – 1891 Reviewed prediction

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acid phosphatase (EC:3.1.3.2)
    Gene namesi
    Name:PHO2
    Ordered Locus Names:YALI0D03465g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome D

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717 Reviewed prediction
    Add
    BLAST
    Chaini18 – 358341Acid phosphatase
    PRO_0000033476Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi27 – 271N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi32 – 321N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi145 – 1451N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi199 – 1991N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi278 – 2781N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP30887.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SurE nucleotidase family.

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0496.
    HOGENOMiHOG000248507.
    OMAiSETASHN.
    OrthoDBiEOG79CZ89.

    Family and domain databases

    Gene3Di3.40.1210.10. 1 hit.
    InterProiIPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view]
    PfamiPF01975. SurE. 1 hit.
    [Graphical view]
    SUPFAMiSSF64167. SSF64167. 1 hit.
    TIGRFAMsiTIGR00087. surE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30887-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFSTIALPL LASAALAQTN SSHSGTNATS HNSTVPNENS KTTIVVTNDD    50
    SWASANIRAF YDELKKEGYN VFMFAPALQQ SGTGGTFVLP KNTTLAKGAE 100
    WGSAPVGAPA WGQDEKDDHI WYFDGTPGAA VTFGFDYALP KFHNNITVDL 150
    VVSGPNEGWN LGPFVYTLSG TEGAMYTSVL RGVPAIAFSG ENKHTYYANA 200
    SNSETASHNI YAKASTAIVK NLLKNAKGRP SVLPYGVGLS VNLPLVGDID 250
    PTGKCTDPKP IFTRQTGRGA ITDKLVFNET TGLFKYGDIK SDATKACLNG 300
    DCFLPDETDV INNWGCYSSI SVVSTDYDAP GALAAEAQFL NRGLVEFAPT 350
    GYGSFPGN 358
    Length:358
    Mass (Da):38,003
    Last modified:October 11, 2004 - v2
    Checksum:i0362F01F892E693B
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti228 – 2281G → V in CAA46331. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65225 Genomic DNA. Translation: CAA46331.1.
    CR382130 Genomic DNA. Translation: CAG80552.1.
    PIRiS19993.
    RefSeqiXP_502364.1. XM_502364.1.

    Genome annotation databases

    EnsemblFungiiCAG80552; CAG80552; YALI0_D03465g.
    GeneIDi2910307.
    KEGGiyli:YALI0D03465g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65225 Genomic DNA. Translation: CAA46331.1 .
    CR382130 Genomic DNA. Translation: CAG80552.1 .
    PIRi S19993.
    RefSeqi XP_502364.1. XM_502364.1.

    3D structure databases

    ProteinModelPortali P30887.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG80552 ; CAG80552 ; YALI0_D03465g .
    GeneIDi 2910307.
    KEGGi yli:YALI0D03465g.

    Phylogenomic databases

    eggNOGi COG0496.
    HOGENOMi HOG000248507.
    OMAi SETASHN.
    OrthoDBi EOG79CZ89.

    Family and domain databases

    Gene3Di 3.40.1210.10. 1 hit.
    InterProi IPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view ]
    Pfami PF01975. SurE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64167. SSF64167. 1 hit.
    TIGRFAMsi TIGR00087. surE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Complementation of Saccharomyces cerevisiae acid phosphatase mutation by a genomic sequence from the yeast Yarrowia lipolytica identifies a new phosphatase."
      Treton B.Y., le Dall M.-T., Gaillardin C.
      Curr. Genet. 22:345-355(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIB 122 / E 150.

    Entry informationi

    Entry nameiPHO2_YARLI
    AccessioniPrimary (citable) accession number: P30887
    Secondary accession number(s): Q6CAE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: October 11, 2004
    Last modified: May 14, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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