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P30887

- PHO2_YARLI

UniProt

P30887 - PHO2_YARLI

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Protein

Acid phosphatase

Gene

PHO2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Probably serves to scavenge phosphorus for growing cells.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi49 – 491MagnesiumBy similarity
Metal bindingi50 – 501MagnesiumBy similarity
Metal bindingi81 – 811MagnesiumBy similarity
Metal bindingi156 – 1561MagnesiumBy similarity
Active sitei189 – 1891Sequence Analysis

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:PHO2
Ordered Locus Names:YALI0D03465g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome D

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 358341Acid phosphatasePRO_0000033476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP30887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0496.
HOGENOMiHOG000248507.
InParanoidiP30887.
OMAiSETASHN.
OrthoDBiEOG79CZ89.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
InterProiIPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30887-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFSTIALPL LASAALAQTN SSHSGTNATS HNSTVPNENS KTTIVVTNDD
60 70 80 90 100
SWASANIRAF YDELKKEGYN VFMFAPALQQ SGTGGTFVLP KNTTLAKGAE
110 120 130 140 150
WGSAPVGAPA WGQDEKDDHI WYFDGTPGAA VTFGFDYALP KFHNNITVDL
160 170 180 190 200
VVSGPNEGWN LGPFVYTLSG TEGAMYTSVL RGVPAIAFSG ENKHTYYANA
210 220 230 240 250
SNSETASHNI YAKASTAIVK NLLKNAKGRP SVLPYGVGLS VNLPLVGDID
260 270 280 290 300
PTGKCTDPKP IFTRQTGRGA ITDKLVFNET TGLFKYGDIK SDATKACLNG
310 320 330 340 350
DCFLPDETDV INNWGCYSSI SVVSTDYDAP GALAAEAQFL NRGLVEFAPT

GYGSFPGN
Length:358
Mass (Da):38,003
Last modified:October 11, 2004 - v2
Checksum:i0362F01F892E693B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281G → V in CAA46331. (PubMed:1423722)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65225 Genomic DNA. Translation: CAA46331.1.
CR382130 Genomic DNA. Translation: CAG80552.1.
PIRiS19993.
RefSeqiXP_502364.1. XM_502364.1.

Genome annotation databases

EnsemblFungiiCAG80552; CAG80552; YALI0_D03465g.
GeneIDi2910307.
KEGGiyli:YALI0D03465g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65225 Genomic DNA. Translation: CAA46331.1 .
CR382130 Genomic DNA. Translation: CAG80552.1 .
PIRi S19993.
RefSeqi XP_502364.1. XM_502364.1.

3D structure databases

ProteinModelPortali P30887.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG80552 ; CAG80552 ; YALI0_D03465g .
GeneIDi 2910307.
KEGGi yli:YALI0D03465g.

Phylogenomic databases

eggNOGi COG0496.
HOGENOMi HOG000248507.
InParanoidi P30887.
OMAi SETASHN.
OrthoDBi EOG79CZ89.

Family and domain databases

Gene3Di 3.40.1210.10. 1 hit.
InterProi IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view ]
Pfami PF01975. SurE. 1 hit.
[Graphical view ]
SUPFAMi SSF64167. SSF64167. 1 hit.
TIGRFAMsi TIGR00087. surE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complementation of Saccharomyces cerevisiae acid phosphatase mutation by a genomic sequence from the yeast Yarrowia lipolytica identifies a new phosphatase."
    Treton B.Y., le Dall M.-T., Gaillardin C.
    Curr. Genet. 22:345-355(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiPHO2_YARLI
AccessioniPrimary (citable) accession number: P30887
Secondary accession number(s): Q6CAE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3