P30882 (CCL5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 5

Alternative name(s):
MuRantes
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES

Gene names

Name:	Ccl5
Synonyms:	Scya5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	91 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils.
Subcellular location	Secreted.
Tissue specificity	T-cell and macrophage specific.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	MAPK cascade Inferred from electronic annotation. Source: Compara activation of phospholipase D activity Inferred from sequence or structural similarity. Source: BHF-UCL calcium ion transport Inferred from electronic annotation. Source: Compara cell-cell signaling Inferred from sequence or structural similarity. Source: BHF-UCL cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara cellular protein complex assembly Inferred from sequence or structural similarity. Source: BHF-UCL cellular response to fibroblast growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to interferon-gamma Inferred from electronic annotation. Source: Compara cellular response to interleukin-1 Inferred from electronic annotation. Source: Compara cellular response to organic cyclic compound Inferred from electronic annotation. Source: Compara cellular response to tumor necrosis factor Inferred from electronic annotation. Source: Compara eosinophil chemotaxis Inferred from sequence or structural similarity. Source: BHF-UCL exocytosis Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW leukocyte cell-cell adhesion Inferred from sequence or structural similarity. Source: BHF-UCL lipopolysaccharide-mediated signaling pathway Inferred from electronic annotation. Source: Compara negative regulation by host of viral transcription Inferred from electronic annotation. Source: Compara negative regulation of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of T cell apoptotic process Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of macrophage apoptotic process Inferred from mutant phenotype PubMed 16208318. Source: BHF-UCL negative regulation of viral genome replication Inferred from sequence or structural similarity. Source: BHF-UCL neutrophil activation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of T cell apoptotic process Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of T cell chemotaxis Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of calcium ion transport Inferred from electronic annotation. Source: Compara positive regulation of cell-cell adhesion mediated by integrin Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of cellular biosynthetic process Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of chemokine (C-X-C motif) ligand 2 production Non-traceable author statement PubMed 21293018. Source: BHF-UCL positive regulation of defense response to virus by host Inferred by curator PubMed 16208318. Source: BHF-UCL positive regulation of homotypic cell-cell adhesion Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of macrophage chemotaxis Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of monocyte chemotaxis Inferred from direct assay PubMed 19779041. Source: BHF-UCL positive regulation of natural killer cell chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of phosphatidylinositol 3-kinase cascade Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of smooth muscle cell migration Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of smooth muscle cell proliferation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of tyrosine phosphorylation of STAT protein Inferred from sequence or structural similarity. Source: BHF-UCL protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara protein tetramerization Inferred from sequence or structural similarity. Source: BHF-UCL regulation of T cell activation Inferred from sequence or structural similarity. Source: BHF-UCL response to toxin Inferred from electronic annotation. Source: Compara response to tumor necrosis factor Inferred from direct assay Ref.1. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay Ref.1. Source: MGI extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	CCR1 chemokine receptor binding Inferred from direct assay PubMed 15557190. Source: BHF-UCL CCR5 chemokine receptor binding Inferred from sequence or structural similarity. Source: BHF-UCL chemoattractant activity Inferred from electronic annotation. Source: Compara chemokine activity Inferred from sequence or structural similarity. Source: BHF-UCL chemokine receptor antagonist activity Inferred from sequence or structural similarity. Source: BHF-UCL phosphatidylinositol phospholipase C activity Inferred from electronic annotation. Source: Compara phospholipase activator activity Inferred from electronic annotation. Source: Compara protein homodimerization activity Inferred from sequence or structural similarity. Source: BHF-UCL protein kinase activity Inferred from electronic annotation. Source: Compara protein self-association Inferred from sequence or structural similarity. Source: BHF-UCL receptor signaling protein tyrosine kinase activator activity Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 91	68	C-C motif chemokine 5		PRO_0000005179
Amino acid modifications
	Disulfide bond	33 ↔ 57		By similarity
	Disulfide bond	34 ↔ 73		By similarity
Experimental info
	Sequence conflict	19	1	T → A in AAB22330. Ref.2
	Sequence conflict	41	1	A → E in AAA40029. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P30882 [UniParc]. Last modified June 1, 1994. Version 2. Checksum: 5DFD66F4684FE1C8	FASTA	91	10,071
	10 20 30 40 50 60 MKISAAALTI ILTAAALCTP APASPYGSDT TPCCFAYLSL ALPRAHVKEY FYTSSKCSNL 70 80 90 AVVFVTRRNR QVCANPEKKW VQEYINYLEM S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes." Heeger P., Wolf G., Meyers C., Sun M.J., O'Farrell S.C., Krensky A.M., Neilson E.G. Kidney Int. 41:220-225(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man." Schall T.J., Simpson N.J., Mak J.Y. Eur. J. Immunol. 22:1477-1481(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTES." Danoff T.M., Lalley P.A., Chang Y.S., Heeger P.S., Neilson E.G. J. Immunol. 152:1182-1189(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NIH Swiss.
[4]	"Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2." Shin H.S., Drysdale B.E., Shin M.L., Noble P.W., Fisher S.N., Paznekas W.A. Mol. Cell. Biol. 14:2914-2925(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[5]	"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis." Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P. J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: B10.S/J, BALB/cJ, DBA/2J, NOD/LtJ and SJL/J. Tissue: Spleen.
[6]	"Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES." Nomiyama H. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/Sv.
[7]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Pancreas.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M77747 mRNA. Translation: AAA40029.1. S37648 mRNA. Translation: AAB22330.1. U02298 Unassigned DNA. Translation: AAA18302.1. X70675 Genomic DNA. Translation: CAA50011.1. AF065944 mRNA. Translation: AAC17511.1. AF065945 mRNA. Translation: AAC17512.1. AF065946 mRNA. Translation: AAC17513.1. AF065947 mRNA. Translation: AAC17514.1. AF128187 mRNA. Translation: AAF22528.1. AB051897 Genomic DNA. Translation: BAB18731.1. AK003101 mRNA. Translation: BAB22566.1. BC033508 mRNA. Translation: AAH33508.1.
IPI	IPI00382025.
PIR	A46539. I48875.
RefSeq	NP_038681.2. NM_013653.3.
UniGene	Mm.284248.
3D structure databases
ProteinModelPortal	P30882.
SMR	P30882. Positions 28-91.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000039600.
PTM databases
PhosphoSite	P30882.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000035938; ENSMUSP00000039600; ENSMUSG00000035042.
GeneID	20304.
KEGG	mmu:20304.
Organism-specific databases
CTD	6352.
MGI	MGI:98262. Ccl5.
Phylogenomic databases
eggNOG	NOG38896.
HOGENOM	HOG000036685.
HOVERGEN	HBG017871.
InParanoid	P30882.
KO	K12499.
OMA	QEYFYTS.
OrthoDB	EOG4W3SPN.
Gene expression databases
ArrayExpress	P30882.
Bgee	P30882.
CleanEx	MM_CCL5.
Genevestigator	P30882.
GermOnline	ENSMUSG00000035042. Mus musculus.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	298055.
SOURCE	Search...

Entry information

Entry name

CCL5_MOUSE

Accession

Primary (citable) accession number: P30882

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program