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Protein

C-C motif chemokine 5

Gene

Ccl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Molecular functioni

  1. CCR1 chemokine receptor binding Source: BHF-UCL
  2. CCR5 chemokine receptor binding Source: BHF-UCL
  3. chemoattractant activity Source: MGI
  4. chemokine activity Source: BHF-UCL
  5. chemokine receptor antagonist activity Source: BHF-UCL
  6. chemokine receptor binding Source: MGI
  7. phosphatidylinositol phospholipase C activity Source: MGI
  8. phospholipase activator activity Source: MGI
  9. protein homodimerization activity Source: BHF-UCL
  10. protein kinase activity Source: MGI
  11. protein self-association Source: BHF-UCL
  12. receptor signaling protein tyrosine kinase activator activity Source: BHF-UCL

GO - Biological processi

  1. activation of phospholipase D activity Source: BHF-UCL
  2. calcium ion transport Source: MGI
  3. cell-cell signaling Source: BHF-UCL
  4. cellular calcium ion homeostasis Source: MGI
  5. cellular protein complex assembly Source: BHF-UCL
  6. cellular response to fibroblast growth factor stimulus Source: Ensembl
  7. cellular response to interferon-gamma Source: Ensembl
  8. cellular response to interleukin-1 Source: Ensembl
  9. cellular response to organic cyclic compound Source: MGI
  10. cellular response to tumor necrosis factor Source: Ensembl
  11. chemokine-mediated signaling pathway Source: UniProtKB
  12. eosinophil chemotaxis Source: BHF-UCL
  13. exocytosis Source: MGI
  14. G-protein coupled receptor signaling pathway Source: UniProtKB
  15. inflammatory response Source: MGI
  16. leukocyte cell-cell adhesion Source: BHF-UCL
  17. lipopolysaccharide-mediated signaling pathway Source: MGI
  18. MAPK cascade Source: MGI
  19. negative regulation by host of viral transcription Source: MGI
  20. negative regulation of chemokine-mediated signaling pathway Source: MGI
  21. negative regulation of G-protein coupled receptor protein signaling pathway Source: MGI
  22. negative regulation of macrophage apoptotic process Source: BHF-UCL
  23. negative regulation of T cell apoptotic process Source: BHF-UCL
  24. negative regulation of viral genome replication Source: BHF-UCL
  25. neutrophil activation Source: BHF-UCL
  26. positive chemotaxis Source: MGI
  27. positive regulation of calcium ion transport Source: MGI
  28. positive regulation of cell adhesion Source: BHF-UCL
  29. positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
  30. positive regulation of cell migration Source: MGI
  31. positive regulation of cellular biosynthetic process Source: BHF-UCL
  32. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL
  33. positive regulation of defense response to virus by host Source: BHF-UCL
  34. positive regulation of epithelial cell proliferation Source: MGI
  35. positive regulation of homotypic cell-cell adhesion Source: BHF-UCL
  36. positive regulation of macrophage chemotaxis Source: BHF-UCL
  37. positive regulation of monocyte chemotaxis Source: BHF-UCL
  38. positive regulation of natural killer cell chemotaxis Source: MGI
  39. positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
  40. positive regulation of phosphorylation Source: BHF-UCL
  41. positive regulation of protein tyrosine kinase activity Source: MGI
  42. positive regulation of smooth muscle cell migration Source: BHF-UCL
  43. positive regulation of smooth muscle cell proliferation Source: BHF-UCL
  44. positive regulation of T cell apoptotic process Source: BHF-UCL
  45. positive regulation of T cell chemotaxis Source: BHF-UCL
  46. positive regulation of T cell migration Source: MGI
  47. positive regulation of T cell proliferation Source: MGI
  48. positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
  49. protein kinase B signaling Source: MGI
  50. protein phosphorylation Source: MGI
  51. protein tetramerization Source: BHF-UCL
  52. regulation of insulin secretion Source: UniProtKB
  53. regulation of neuron death Source: UniProtKB
  54. regulation of T cell activation Source: BHF-UCL
  55. response to cytokine Source: MGI
  56. response to toxic substance Source: MGI
  57. response to tumor necrosis factor Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_230248. Chemokine receptors bind chemokines.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
MuRantes
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:Ccl5
Synonyms:Scya5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98262. Ccl5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9168C-C motif chemokine 5PRO_0000005179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

PTM databases

PhosphoSiteiP30882.

Expressioni

Tissue specificityi

T-cell and macrophage specific.

Gene expression databases

BgeeiP30882.
CleanExiMM_CCL5.
ExpressionAtlasiP30882. baseline and differential.
GenevestigatoriP30882.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039600.

Structurei

3D structure databases

ProteinModelPortaliP30882.
SMRiP30882. Positions 28-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP30882.
KOiK12499.
OMAiQEYFYTS.
OrthoDBiEOG7CVQ1F.
PhylomeDBiP30882.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30882-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKISAAALTI ILTAAALCTP APASPYGSDT TPCCFAYLSL ALPRAHVKEY
60 70 80 90
FYTSSKCSNL AVVFVTRRNR QVCANPEKKW VQEYINYLEM S
Length:91
Mass (Da):10,071
Last modified:June 1, 1994 - v2
Checksum:i5DFD66F4684FE1C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191T → A in AAB22330. (PubMed:1376260)Curated
Sequence conflicti41 – 411A → E in AAA40029. (PubMed:1375672)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77747 mRNA. Translation: AAA40029.1.
S37648 mRNA. Translation: AAB22330.1.
U02298 Unassigned DNA. Translation: AAA18302.1.
X70675 Genomic DNA. Translation: CAA50011.1.
AF065944 mRNA. Translation: AAC17511.1.
AF065945 mRNA. Translation: AAC17512.1.
AF065946 mRNA. Translation: AAC17513.1.
AF065947 mRNA. Translation: AAC17514.1.
AF128187 mRNA. Translation: AAF22528.1.
AB051897 Genomic DNA. Translation: BAB18731.1.
AK003101 mRNA. Translation: BAB22566.1.
BC033508 mRNA. Translation: AAH33508.1.
CCDSiCCDS36254.1.
PIRiI48875. A46539.
RefSeqiNP_038681.2. NM_013653.3.
UniGeneiMm.284248.

Genome annotation databases

EnsembliENSMUST00000035938; ENSMUSP00000039600; ENSMUSG00000035042.
GeneIDi20304.
KEGGimmu:20304.
UCSCiuc007kpi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77747 mRNA. Translation: AAA40029.1.
S37648 mRNA. Translation: AAB22330.1.
U02298 Unassigned DNA. Translation: AAA18302.1.
X70675 Genomic DNA. Translation: CAA50011.1.
AF065944 mRNA. Translation: AAC17511.1.
AF065945 mRNA. Translation: AAC17512.1.
AF065946 mRNA. Translation: AAC17513.1.
AF065947 mRNA. Translation: AAC17514.1.
AF128187 mRNA. Translation: AAF22528.1.
AB051897 Genomic DNA. Translation: BAB18731.1.
AK003101 mRNA. Translation: BAB22566.1.
BC033508 mRNA. Translation: AAH33508.1.
CCDSiCCDS36254.1.
PIRiI48875. A46539.
RefSeqiNP_038681.2. NM_013653.3.
UniGeneiMm.284248.

3D structure databases

ProteinModelPortaliP30882.
SMRiP30882. Positions 28-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039600.

PTM databases

PhosphoSiteiP30882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035938; ENSMUSP00000039600; ENSMUSG00000035042.
GeneIDi20304.
KEGGimmu:20304.
UCSCiuc007kpi.2. mouse.

Organism-specific databases

CTDi6352.
MGIiMGI:98262. Ccl5.

Phylogenomic databases

eggNOGiNOG38896.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP30882.
KOiK12499.
OMAiQEYFYTS.
OrthoDBiEOG7CVQ1F.
PhylomeDBiP30882.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_230248. Chemokine receptors bind chemokines.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi298055.
PROiP30882.
SOURCEiSearch...

Gene expression databases

BgeeiP30882.
CleanExiMM_CCL5.
ExpressionAtlasiP30882. baseline and differential.
GenevestigatoriP30882.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes."
    Heeger P., Wolf G., Meyers C., Sun M.J., O'Farrell S.C., Krensky A.M., Neilson E.G.
    Kidney Int. 41:220-225(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man."
    Schall T.J., Simpson N.J., Mak J.Y.
    Eur. J. Immunol. 22:1477-1481(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTES."
    Danoff T.M., Lalley P.A., Chang Y.S., Heeger P.S., Neilson E.G.
    J. Immunol. 152:1182-1189(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NIH Swiss.
  4. "Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2."
    Shin H.S., Drysdale B.E., Shin M.L., Noble P.W., Fisher S.N., Paznekas W.A.
    Mol. Cell. Biol. 14:2914-2925(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  5. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.S/J, BALB/cJ, DBA/2J, NOD/LtJ and SJL/J.
    Tissue: Spleen.
  6. "Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES."
    Nomiyama H.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
  7. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiCCL5_MOUSE
AccessioniPrimary (citable) accession number: P30882
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 1, 1994
Last modified: February 4, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.