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P30882

- CCL5_MOUSE

UniProt

P30882 - CCL5_MOUSE

Protein

C-C motif chemokine 5

Gene

Ccl5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils.

    GO - Molecular functioni

    1. CCR1 chemokine receptor binding Source: BHF-UCL
    2. CCR5 chemokine receptor binding Source: BHF-UCL
    3. chemoattractant activity Source: Ensembl
    4. chemokine activity Source: BHF-UCL
    5. chemokine receptor antagonist activity Source: BHF-UCL
    6. phosphatidylinositol phospholipase C activity Source: Ensembl
    7. phospholipase activator activity Source: Ensembl
    8. protein homodimerization activity Source: BHF-UCL
    9. protein kinase activity Source: Ensembl
    10. protein self-association Source: BHF-UCL
    11. receptor signaling protein tyrosine kinase activator activity Source: BHF-UCL

    GO - Biological processi

    1. activation of phospholipase D activity Source: BHF-UCL
    2. calcium ion transport Source: Ensembl
    3. cell-cell signaling Source: BHF-UCL
    4. cellular calcium ion homeostasis Source: Ensembl
    5. cellular protein complex assembly Source: BHF-UCL
    6. cellular response to fibroblast growth factor stimulus Source: Ensembl
    7. cellular response to interferon-gamma Source: Ensembl
    8. cellular response to interleukin-1 Source: Ensembl
    9. cellular response to organic cyclic compound Source: Ensembl
    10. cellular response to tumor necrosis factor Source: Ensembl
    11. eosinophil chemotaxis Source: BHF-UCL
    12. exocytosis Source: Ensembl
    13. inflammatory response Source: MGI
    14. leukocyte cell-cell adhesion Source: BHF-UCL
    15. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    16. MAPK cascade Source: Ensembl
    17. negative regulation by host of viral transcription Source: Ensembl
    18. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    19. negative regulation of macrophage apoptotic process Source: BHF-UCL
    20. negative regulation of T cell apoptotic process Source: BHF-UCL
    21. negative regulation of viral genome replication Source: BHF-UCL
    22. neutrophil activation Source: BHF-UCL
    23. positive regulation of calcium ion transport Source: Ensembl
    24. positive regulation of cell adhesion Source: BHF-UCL
    25. positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
    26. positive regulation of cellular biosynthetic process Source: BHF-UCL
    27. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL
    28. positive regulation of defense response to virus by host Source: BHF-UCL
    29. positive regulation of epithelial cell proliferation Source: MGI
    30. positive regulation of homotypic cell-cell adhesion Source: BHF-UCL
    31. positive regulation of macrophage chemotaxis Source: BHF-UCL
    32. positive regulation of monocyte chemotaxis Source: BHF-UCL
    33. positive regulation of natural killer cell chemotaxis Source: Ensembl
    34. positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
    35. positive regulation of phosphorylation Source: BHF-UCL
    36. positive regulation of protein tyrosine kinase activity Source: GOC
    37. positive regulation of smooth muscle cell migration Source: BHF-UCL
    38. positive regulation of smooth muscle cell proliferation Source: BHF-UCL
    39. positive regulation of T cell apoptotic process Source: BHF-UCL
    40. positive regulation of T cell chemotaxis Source: BHF-UCL
    41. positive regulation of T cell migration Source: MGI
    42. positive regulation of T cell proliferation Source: Ensembl
    43. positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
    44. protein kinase B signaling Source: Ensembl
    45. protein tetramerization Source: BHF-UCL
    46. regulation of T cell activation Source: BHF-UCL
    47. response to cytokine Source: MGI
    48. response to toxic substance Source: Ensembl
    49. response to tumor necrosis factor Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 5
    Alternative name(s):
    MuRantes
    SIS-delta
    Small-inducible cytokine A5
    T-cell-specific protein RANTES
    Gene namesi
    Name:Ccl5
    Synonyms:Scya5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98262. Ccl5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9168C-C motif chemokine 5PRO_0000005179Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    PTM databases

    PhosphoSiteiP30882.

    Expressioni

    Tissue specificityi

    T-cell and macrophage specific.

    Gene expression databases

    ArrayExpressiP30882.
    BgeeiP30882.
    CleanExiMM_CCL5.
    GenevestigatoriP30882.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000039600.

    Structurei

    3D structure databases

    ProteinModelPortaliP30882.
    SMRiP30882. Positions 28-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38896.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiP30882.
    KOiK12499.
    OMAiCSIPAVV.
    OrthoDBiEOG7CVQ1F.
    PhylomeDBiP30882.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30882-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKISAAALTI ILTAAALCTP APASPYGSDT TPCCFAYLSL ALPRAHVKEY   50
    FYTSSKCSNL AVVFVTRRNR QVCANPEKKW VQEYINYLEM S 91
    Length:91
    Mass (Da):10,071
    Last modified:June 1, 1994 - v2
    Checksum:i5DFD66F4684FE1C8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191T → A in AAB22330. (PubMed:1376260)Curated
    Sequence conflicti41 – 411A → E in AAA40029. (PubMed:1375672)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77747 mRNA. Translation: AAA40029.1.
    S37648 mRNA. Translation: AAB22330.1.
    U02298 Unassigned DNA. Translation: AAA18302.1.
    X70675 Genomic DNA. Translation: CAA50011.1.
    AF065944 mRNA. Translation: AAC17511.1.
    AF065945 mRNA. Translation: AAC17512.1.
    AF065946 mRNA. Translation: AAC17513.1.
    AF065947 mRNA. Translation: AAC17514.1.
    AF128187 mRNA. Translation: AAF22528.1.
    AB051897 Genomic DNA. Translation: BAB18731.1.
    AK003101 mRNA. Translation: BAB22566.1.
    BC033508 mRNA. Translation: AAH33508.1.
    CCDSiCCDS36254.1.
    PIRiI48875. A46539.
    RefSeqiNP_038681.2. NM_013653.3.
    UniGeneiMm.284248.

    Genome annotation databases

    EnsembliENSMUST00000035938; ENSMUSP00000039600; ENSMUSG00000035042.
    GeneIDi20304.
    KEGGimmu:20304.
    UCSCiuc007kpi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77747 mRNA. Translation: AAA40029.1 .
    S37648 mRNA. Translation: AAB22330.1 .
    U02298 Unassigned DNA. Translation: AAA18302.1 .
    X70675 Genomic DNA. Translation: CAA50011.1 .
    AF065944 mRNA. Translation: AAC17511.1 .
    AF065945 mRNA. Translation: AAC17512.1 .
    AF065946 mRNA. Translation: AAC17513.1 .
    AF065947 mRNA. Translation: AAC17514.1 .
    AF128187 mRNA. Translation: AAF22528.1 .
    AB051897 Genomic DNA. Translation: BAB18731.1 .
    AK003101 mRNA. Translation: BAB22566.1 .
    BC033508 mRNA. Translation: AAH33508.1 .
    CCDSi CCDS36254.1.
    PIRi I48875. A46539.
    RefSeqi NP_038681.2. NM_013653.3.
    UniGenei Mm.284248.

    3D structure databases

    ProteinModelPortali P30882.
    SMRi P30882. Positions 28-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000039600.

    PTM databases

    PhosphoSitei P30882.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035938 ; ENSMUSP00000039600 ; ENSMUSG00000035042 .
    GeneIDi 20304.
    KEGGi mmu:20304.
    UCSCi uc007kpi.2. mouse.

    Organism-specific databases

    CTDi 6352.
    MGIi MGI:98262. Ccl5.

    Phylogenomic databases

    eggNOGi NOG38896.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi P30882.
    KOi K12499.
    OMAi CSIPAVV.
    OrthoDBi EOG7CVQ1F.
    PhylomeDBi P30882.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 298055.
    PROi P30882.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30882.
    Bgeei P30882.
    CleanExi MM_CCL5.
    Genevestigatori P30882.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes."
      Heeger P., Wolf G., Meyers C., Sun M.J., O'Farrell S.C., Krensky A.M., Neilson E.G.
      Kidney Int. 41:220-225(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man."
      Schall T.J., Simpson N.J., Mak J.Y.
      Eur. J. Immunol. 22:1477-1481(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTES."
      Danoff T.M., Lalley P.A., Chang Y.S., Heeger P.S., Neilson E.G.
      J. Immunol. 152:1182-1189(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NIH Swiss.
    4. "Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2."
      Shin H.S., Drysdale B.E., Shin M.L., Noble P.W., Fisher S.N., Paznekas W.A.
      Mol. Cell. Biol. 14:2914-2925(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    5. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
      J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B10.S/J, BALB/cJ, DBA/2J, NOD/LtJ and SJL/J.
      Tissue: Spleen.
    6. "Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES."
      Nomiyama H.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/Sv.
    7. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pancreas.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCCL5_MOUSE
    AccessioniPrimary (citable) accession number: P30882
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3