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P30882

- CCL5_MOUSE

UniProt

P30882 - CCL5_MOUSE

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Protein
C-C motif chemokine 5
Gene
Ccl5, Scya5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils.

GO - Molecular functioni

  1. CCR1 chemokine receptor binding Source: BHF-UCL
  2. CCR5 chemokine receptor binding Source: BHF-UCL
  3. chemoattractant activity Source: Ensembl
  4. chemokine activity Source: BHF-UCL
  5. chemokine receptor antagonist activity Source: BHF-UCL
  6. phosphatidylinositol phospholipase C activity Source: Ensembl
  7. phospholipase activator activity Source: Ensembl
  8. protein homodimerization activity Source: BHF-UCL
  9. protein kinase activity Source: Ensembl
  10. protein self-association Source: BHF-UCL
  11. receptor signaling protein tyrosine kinase activator activity Source: BHF-UCL

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. activation of phospholipase D activity Source: BHF-UCL
  3. calcium ion transport Source: Ensembl
  4. cell-cell signaling Source: BHF-UCL
  5. cellular calcium ion homeostasis Source: Ensembl
  6. cellular protein complex assembly Source: BHF-UCL
  7. cellular response to fibroblast growth factor stimulus Source: Ensembl
  8. cellular response to interferon-gamma Source: Ensembl
  9. cellular response to interleukin-1 Source: Ensembl
  10. cellular response to organic cyclic compound Source: Ensembl
  11. cellular response to tumor necrosis factor Source: Ensembl
  12. eosinophil chemotaxis Source: BHF-UCL
  13. exocytosis Source: Ensembl
  14. inflammatory response Source: MGI
  15. leukocyte cell-cell adhesion Source: BHF-UCL
  16. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  17. negative regulation by host of viral transcription Source: Ensembl
  18. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  19. negative regulation of T cell apoptotic process Source: BHF-UCL
  20. negative regulation of macrophage apoptotic process Source: BHF-UCL
  21. negative regulation of viral genome replication Source: BHF-UCL
  22. neutrophil activation Source: BHF-UCL
  23. positive regulation of T cell apoptotic process Source: BHF-UCL
  24. positive regulation of T cell chemotaxis Source: BHF-UCL
  25. positive regulation of T cell migration Source: MGI
  26. positive regulation of T cell proliferation Source: Ensembl
  27. positive regulation of calcium ion transport Source: Ensembl
  28. positive regulation of cell adhesion Source: BHF-UCL
  29. positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
  30. positive regulation of cellular biosynthetic process Source: BHF-UCL
  31. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL
  32. positive regulation of defense response to virus by host Source: BHF-UCL
  33. positive regulation of epithelial cell proliferation Source: MGI
  34. positive regulation of homotypic cell-cell adhesion Source: BHF-UCL
  35. positive regulation of macrophage chemotaxis Source: BHF-UCL
  36. positive regulation of monocyte chemotaxis Source: BHF-UCL
  37. positive regulation of natural killer cell chemotaxis Source: Ensembl
  38. positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
  39. positive regulation of phosphorylation Source: BHF-UCL
  40. positive regulation of protein tyrosine kinase activity Source: GOC
  41. positive regulation of smooth muscle cell migration Source: BHF-UCL
  42. positive regulation of smooth muscle cell proliferation Source: BHF-UCL
  43. positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
  44. protein kinase B signaling Source: Ensembl
  45. protein tetramerization Source: BHF-UCL
  46. regulation of T cell activation Source: BHF-UCL
  47. response to cytokine Source: MGI
  48. response to toxic substance Source: Ensembl
  49. response to tumor necrosis factor Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
MuRantes
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:Ccl5
Synonyms:Scya5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98262. Ccl5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 9168C-C motif chemokine 5
PRO_0000005179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57 By similarity
Disulfide bondi34 ↔ 73 By similarity

Keywords - PTMi

Disulfide bond

PTM databases

PhosphoSiteiP30882.

Expressioni

Tissue specificityi

T-cell and macrophage specific.

Gene expression databases

ArrayExpressiP30882.
BgeeiP30882.
CleanExiMM_CCL5.
GenevestigatoriP30882.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039600.

Structurei

3D structure databases

ProteinModelPortaliP30882.
SMRiP30882. Positions 28-91.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP30882.
KOiK12499.
OMAiCSIPAVV.
OrthoDBiEOG7CVQ1F.
PhylomeDBiP30882.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30882-1 [UniParc]FASTAAdd to Basket

« Hide

MKISAAALTI ILTAAALCTP APASPYGSDT TPCCFAYLSL ALPRAHVKEY   50
FYTSSKCSNL AVVFVTRRNR QVCANPEKKW VQEYINYLEM S 91
Length:91
Mass (Da):10,071
Last modified:June 1, 1994 - v2
Checksum:i5DFD66F4684FE1C8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191T → A in AAB22330. 1 Publication
Sequence conflicti41 – 411A → E in AAA40029. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M77747 mRNA. Translation: AAA40029.1.
S37648 mRNA. Translation: AAB22330.1.
U02298 Unassigned DNA. Translation: AAA18302.1.
X70675 Genomic DNA. Translation: CAA50011.1.
AF065944 mRNA. Translation: AAC17511.1.
AF065945 mRNA. Translation: AAC17512.1.
AF065946 mRNA. Translation: AAC17513.1.
AF065947 mRNA. Translation: AAC17514.1.
AF128187 mRNA. Translation: AAF22528.1.
AB051897 Genomic DNA. Translation: BAB18731.1.
AK003101 mRNA. Translation: BAB22566.1.
BC033508 mRNA. Translation: AAH33508.1.
CCDSiCCDS36254.1.
PIRiI48875. A46539.
RefSeqiNP_038681.2. NM_013653.3.
UniGeneiMm.284248.

Genome annotation databases

EnsembliENSMUST00000035938; ENSMUSP00000039600; ENSMUSG00000035042.
GeneIDi20304.
KEGGimmu:20304.
UCSCiuc007kpi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M77747 mRNA. Translation: AAA40029.1 .
S37648 mRNA. Translation: AAB22330.1 .
U02298 Unassigned DNA. Translation: AAA18302.1 .
X70675 Genomic DNA. Translation: CAA50011.1 .
AF065944 mRNA. Translation: AAC17511.1 .
AF065945 mRNA. Translation: AAC17512.1 .
AF065946 mRNA. Translation: AAC17513.1 .
AF065947 mRNA. Translation: AAC17514.1 .
AF128187 mRNA. Translation: AAF22528.1 .
AB051897 Genomic DNA. Translation: BAB18731.1 .
AK003101 mRNA. Translation: BAB22566.1 .
BC033508 mRNA. Translation: AAH33508.1 .
CCDSi CCDS36254.1.
PIRi I48875. A46539.
RefSeqi NP_038681.2. NM_013653.3.
UniGenei Mm.284248.

3D structure databases

ProteinModelPortali P30882.
SMRi P30882. Positions 28-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000039600.

PTM databases

PhosphoSitei P30882.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035938 ; ENSMUSP00000039600 ; ENSMUSG00000035042 .
GeneIDi 20304.
KEGGi mmu:20304.
UCSCi uc007kpi.2. mouse.

Organism-specific databases

CTDi 6352.
MGIi MGI:98262. Ccl5.

Phylogenomic databases

eggNOGi NOG38896.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi P30882.
KOi K12499.
OMAi CSIPAVV.
OrthoDBi EOG7CVQ1F.
PhylomeDBi P30882.
TreeFami TF334888.

Miscellaneous databases

NextBioi 298055.
PROi P30882.
SOURCEi Search...

Gene expression databases

ArrayExpressi P30882.
Bgeei P30882.
CleanExi MM_CCL5.
Genevestigatori P30882.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes."
    Heeger P., Wolf G., Meyers C., Sun M.J., O'Farrell S.C., Krensky A.M., Neilson E.G.
    Kidney Int. 41:220-225(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man."
    Schall T.J., Simpson N.J., Mak J.Y.
    Eur. J. Immunol. 22:1477-1481(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTES."
    Danoff T.M., Lalley P.A., Chang Y.S., Heeger P.S., Neilson E.G.
    J. Immunol. 152:1182-1189(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NIH Swiss.
  4. "Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2."
    Shin H.S., Drysdale B.E., Shin M.L., Noble P.W., Fisher S.N., Paznekas W.A.
    Mol. Cell. Biol. 14:2914-2925(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  5. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.S/J, BALB/cJ, DBA/2J, NOD/LtJ and SJL/J.
    Tissue: Spleen.
  6. "Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES."
    Nomiyama H.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
  7. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiCCL5_MOUSE
AccessioniPrimary (citable) accession number: P30882
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi