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P30874

- SSR2_HUMAN

UniProt

P30874 - SSR2_HUMAN

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Protein

Somatostatin receptor type 2

Gene
SSTR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.5 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei89 – 891Important for ligand binding

GO - Molecular functioni

  1. PDZ domain binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. somatostatin receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  2. cell-cell signaling Source: ProtInc
  3. cellular response to estradiol stimulus Source: Ensembl
  4. cellular response to glucocorticoid stimulus Source: Ensembl
  5. cerebellum development Source: Ensembl
  6. digestion Source: ProtInc
  7. forebrain development Source: Ensembl
  8. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  9. negative regulation of cell proliferation Source: ProtInc
  10. peristalsis Source: Ensembl
  11. regulation of muscle contraction Source: Ensembl
  12. response to nutrient Source: ProtInc
  13. response to starvation Source: Ensembl
  14. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP30874.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 2
Short name:
SS-2-R
Short name:
SS2-R
Short name:
SS2R
Alternative name(s):
SRIF-1
Gene namesi
Name:SSTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:11331. SSTR2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Cytoplasm
Note: Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343Extracellular Reviewed predictionAdd
BLAST
Transmembranei44 – 6724Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini68 – 7811Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei79 – 10325Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini104 – 11815Extracellular Reviewed predictionAdd
BLAST
Transmembranei119 – 13820Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini139 – 16123Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei162 – 18120Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini182 – 20726Extracellular Reviewed predictionAdd
BLAST
Transmembranei208 – 22922Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini230 – 25324Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei254 – 27825Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini279 – 28810Extracellular Reviewed prediction
Transmembranei289 – 30315Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini304 – 36966Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi89 – 891D → A: Expression levels reduced by 60%. 1 Publication
Mutagenesisi89 – 891D → L: Expression levels reduced by 80%. 1 Publication
Mutagenesisi89 – 891D → R: Slightly reduced expression levels. Remains localized in membrane. Abolishes ligand binding and G protein-mediated calcium release. 1 Publication
Mutagenesisi139 – 1391D → A: Expression levels reduced by 50%. Significantly reduced ligand binding capacity but increased affinity. Reduced G protein-mediated cAMP release but no effect on G-protein mediated calcium release. 1 Publication
Mutagenesisi139 – 1391D → N: Expression levels reduced by 40%. No significant change in ligand binding capacity or affinity. Reduced G protein-mediated cAMP signaling but no effect on G protein-mediated calcium release. 1 Publication
Mutagenesisi140 – 1401R → A: Slightly reduced expression levels. No significant change in ligand binding capacity or affinity. No significant change in G protein-mediated cAMP or calcium release. 1 Publication
Mutagenesisi140 – 1401R → E: Almost abolishes expression. Abolishes membrane localization. 1 Publication
Mutagenesisi140 – 1401R → L: Slightly reduced expression levels. Significantly reduced ligand binding capacity but increased affinity. Reduced G protein-mediated cAMP release but no effect on G protein-mediated calcium release. 1 Publication

Organism-specific databases

PharmGKBiPA36155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Somatostatin receptor type 2PRO_0000070120Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Glycosylationi22 – 221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi32 – 321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi115 ↔ 193 By similarity
Lipidationi328 – 3281S-palmitoyl cysteine Reviewed prediction
Modified residuei341 – 3411Phosphoserine By similarity
Modified residuei343 – 3431Phosphoserine By similarity
Modified residuei348 – 3481Phosphoserine By similarity
Modified residuei353 – 3531Phosphothreonine By similarity
Modified residuei354 – 3541Phosphothreonine By similarity

Post-translational modificationi

Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP30874.
PRIDEiP30874.

PTM databases

PhosphoSiteiP30874.

Expressioni

Tissue specificityi

Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.2 Publications

Gene expression databases

BgeeiP30874.
CleanExiHS_SSTR2.
GenevestigatoriP30874.

Organism-specific databases

HPAiHPA007264.

Interactioni

Subunit structurei

Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PIK3R1P279865EBI-6266898,EBI-79464
SSTR3P327453EBI-6266898,EBI-6266935

Protein-protein interaction databases

BioGridi112630. 5 interactions.
IntActiP30874. 2 interactions.
MINTiMINT-3340293.
STRINGi9606.ENSP00000350198.

Structurei

3D structure databases

ProteinModelPortaliP30874.
SMRiP30874. Positions 46-328.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274661.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP30874.
KOiK04218.
OMAiVIMPIMI.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP30874.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR002074. Somatstn_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00588. SOMATOSTTN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P30874-1) [UniParc]FASTAAdd to Basket

Also known as: SSTR2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDMADEPLNG SHTWLSIPFD LNGSVVSTNT SNQTEPYYDL TSNAVLTFIY    50
FVVCIIGLCG NTLVIYVILR YAKMKTITNI YILNLAIADE LFMLGLPFLA 100
MQVALVHWPF GKAICRVVMT VDGINQFTSI FCLTVMSIDR YLAVVHPIKS 150
AKWRRPRTAK MITMAVWGVS LLVILPIMIY AGLRSNQWGR SSCTINWPGE 200
SGAWYTGFII YTFILGFLVP LTIICLCYLF IIIKVKSSGI RVGSSKRKKS 250
EKKVTRMVSI VVAVFIFCWL PFYIFNVSSV SMAISPTPAL KGMFDFVVVL 300
TYANSCANPI LYAFLSDNFK KSFQNVLCLV KVSGTDDGER SDSKQDKSRL 350
NETTETQRTL LNGDLQTSI 369
Length:369
Mass (Da):41,333
Last modified:July 1, 1993 - v1
Checksum:i3B5D7D8A9AC246C6
GO
Isoform B (identifier: P30874-2) [UniParc]FASTAAdd to Basket

Also known as: SSTR2B

The sequence of this isoform differs from the canonical sequence as follows:
     332-369: VSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI → VDNSKSGEEGSCLDMIFRNNKNRKK

Show »
Length:356
Mass (Da):40,007
Checksum:iD10FA237FAED61F3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei332 – 36938VSGTD…LQTSI → VDNSKSGEEGSCLDMIFRNN KNRKK in isoform B. VSP_001922Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771I → T in BAG36594. 1 Publication
Sequence conflicti122 – 1221D → N in BAG36594. 1 Publication
Sequence conflicti356 – 3561T → A in BAG36594. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81830 Genomic DNA. Translation: AAA58248.1.
AY236542 Genomic DNA. Translation: AAO92064.1.
AF184174 Genomic DNA. Translation: AAF42809.1.
AF184174 Genomic DNA. Translation: AAF42810.1.
AB065911 Genomic DNA. Translation: BAC06126.1.
AK290745 mRNA. Translation: BAF83434.1.
AK313866 mRNA. Translation: BAG36594.1.
BT019926 mRNA. Translation: AAV38729.1.
BC000256 mRNA. Translation: AAH00256.1.
BC009522 mRNA. Translation: AAH09522.1.
BC019610 mRNA. Translation: AAH19610.1.
BC095495 mRNA. Translation: AAH95495.1.
CCDSiCCDS11691.1. [P30874-1]
PIRiB41795.
RefSeqiNP_001041.1. NM_001050.2. [P30874-1]
UniGeneiHs.514451.

Genome annotation databases

EnsembliENST00000315332; ENSP00000326616; ENSG00000180616. [P30874-2]
ENST00000357585; ENSP00000350198; ENSG00000180616. [P30874-1]
GeneIDi6752.
KEGGihsa:6752.
UCSCiuc002jje.3. human. [P30874-1]

Polymorphism databases

DMDMi401126.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81830 Genomic DNA. Translation: AAA58248.1 .
AY236542 Genomic DNA. Translation: AAO92064.1 .
AF184174 Genomic DNA. Translation: AAF42809.1 .
AF184174 Genomic DNA. Translation: AAF42810.1 .
AB065911 Genomic DNA. Translation: BAC06126.1 .
AK290745 mRNA. Translation: BAF83434.1 .
AK313866 mRNA. Translation: BAG36594.1 .
BT019926 mRNA. Translation: AAV38729.1 .
BC000256 mRNA. Translation: AAH00256.1 .
BC009522 mRNA. Translation: AAH09522.1 .
BC019610 mRNA. Translation: AAH19610.1 .
BC095495 mRNA. Translation: AAH95495.1 .
CCDSi CCDS11691.1. [P30874-1 ]
PIRi B41795.
RefSeqi NP_001041.1. NM_001050.2. [P30874-1 ]
UniGenei Hs.514451.

3D structure databases

ProteinModelPortali P30874.
SMRi P30874. Positions 46-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112630. 5 interactions.
IntActi P30874. 2 interactions.
MINTi MINT-3340293.
STRINGi 9606.ENSP00000350198.

Chemistry

BindingDBi P30874.
ChEMBLi CHEMBL2111436.
GuidetoPHARMACOLOGYi 356.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30874.

Polymorphism databases

DMDMi 401126.

Proteomic databases

PaxDbi P30874.
PRIDEi P30874.

Protocols and materials databases

DNASUi 6752.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315332 ; ENSP00000326616 ; ENSG00000180616 . [P30874-2 ]
ENST00000357585 ; ENSP00000350198 ; ENSG00000180616 . [P30874-1 ]
GeneIDi 6752.
KEGGi hsa:6752.
UCSCi uc002jje.3. human. [P30874-1 ]

Organism-specific databases

CTDi 6752.
GeneCardsi GC17P071161.
HGNCi HGNC:11331. SSTR2.
HPAi HPA007264.
MIMi 182452. gene.
neXtProti NX_P30874.
PharmGKBi PA36155.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG274661.
HOGENOMi HOG000230485.
HOVERGENi HBG106919.
InParanoidi P30874.
KOi K04218.
OMAi VIMPIMI.
OrthoDBi EOG7BKCVQ.
PhylomeDBi P30874.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinki P30874.

Miscellaneous databases

GeneWikii Somatostatin_receptor_2.
GenomeRNAii 6752.
NextBioi 26340.
PROi P30874.
SOURCEi Search...

Gene expression databases

Bgeei P30874.
CleanExi HS_SSTR2.
Genevestigatori P30874.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR002074. Somatstn_rcpt_2.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00588. SOMATOSTTN2R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney."
    Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.
    Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
  2. "Genomic structure and transcriptional regulation of the human somatostatin receptor type 2."
    Petersenn S., Rasch A.C., Presch S., Beil F.U., Schulte H.M.
    Mol. Cell. Endocrinol. 157:75-85(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B).
  3. "Isolation of complete coding sequence for somatostatin receptor 2 (SSTR2)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Eye.
  8. "Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation."
    Patel Y.C., Greenwood M., Kent G., Panetta R., Srikant C.B.
    Biochem. Biophys. Res. Commun. 192:288-294(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS A AND B).
  9. "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
    Zitzer H., Hoenck H.-H., Baechner D., Richter D., Kreienkamp H.-J.
    J. Biol. Chem. 274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHANK1.
  10. "Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking."
    Grant M., Collier B., Kumar U.
    J. Biol. Chem. 279:36179-36183(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
  11. "Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization."
    Grant M., Alturaihi H., Jaquet P., Collier B., Kumar U.
    Mol. Endocrinol. 22:2278-2292(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH BETA-ARRESTIN, SUBCELLULAR LOCATION.
  12. "The somatostatin 2A receptor is enriched in migrating neurons during rat and human brain development and stimulates migration and axonal outgrowth."
    Le Verche V., Kaindl A.M., Verney C., Csaba Z., Peineau S., Olivier P., Adle-Biassette H., Leterrier C., Vitalis T., Renaud J., Dargent B., Gressens P., Dournaud P.
    PLoS ONE 4:E5509-E5509(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  13. "SSTR2 is the functionally dominant somatostatin receptor in human pancreatic beta- and alpha-cells."
    Kailey B., van de Bunt M., Cheley S., Johnson P.R., MacDonald P.E., Gloyn A.L., Rorsman P., Braun M.
    Am. J. Physiol. 303:E1107-E1116(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  14. "Identification of critical residues involved in ligand binding and G protein signaling in human somatostatin receptor subtype 2."
    Parry J.J., Chen R., Andrews R., Lears K.A., Rogers B.E.
    Endocrinology 153:2747-2755(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ASP-89; ASP-139 AND ARG-140.

Entry informationi

Entry nameiSSR2_HUMAN
AccessioniPrimary (citable) accession number: P30874
Secondary accession number(s): A8K3Y0
, B2R9P7, Q4VBP0, Q96GE0, Q96TF2, Q9BWH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 3, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi