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P30873

- SSR1_MOUSE

UniProt

P30873 - SSR1_MOUSE

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Protein

Somatostatin receptor type 1

Gene

Sstr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

GO - Molecular functioni

  1. somatostatin receptor activity Source: MGI

GO - Biological processi

  1. cellular response to estradiol stimulus Source: Ensembl
  2. cerebellum development Source: Ensembl
  3. forebrain development Source: Ensembl
  4. glutamate receptor signaling pathway Source: MGI
  5. G-protein coupled receptor signaling pathway Source: MGI
  6. neuropeptide signaling pathway Source: MGI
  7. response to starvation Source: Ensembl
  8. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 1
Short name:
SS-1-R
Short name:
SS1-R
Short name:
SS1R
Alternative name(s):
SRIF-2
Gene namesi
Name:Sstr1
Synonyms:Smstr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:98327. Sstr1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Somatostatin receptor type 1PRO_0000070117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi130 ↔ 208PROSITE-ProRule annotation
Lipidationi339 – 3391S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP30873.

PTM databases

PhosphoSiteiP30873.

Expressioni

Tissue specificityi

Jejunum and stomach.

Gene expression databases

BgeeiP30873.
CleanExiMM_SSTR1.
ExpressionAtlasiP30873. baseline.
GenevestigatoriP30873.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621083EBI-7665262,EBI-300895

Protein-protein interaction databases

IntActiP30873. 2 interactions.
MINTiMINT-6504720.
STRINGi10090.ENSMUSP00000106299.

Structurei

3D structure databases

ProteinModelPortaliP30873.
SMRiP30873. Positions 59-340.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
BLAST
Topological domaini85 – 9410CytoplasmicSequence Analysis
Topological domaini121 – 13111ExtracellularSequence AnalysisAdd
BLAST
Topological domaini154 – 17522CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini197 – 21923ExtracellularSequence AnalysisAdd
BLAST
Topological domaini245 – 27026CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini297 – 3037ExtracellularSequence Analysis
Topological domaini328 – 39164CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 8428Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei95 – 12026Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei132 – 15322Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei220 – 24425Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei271 – 29626Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei304 – 32724Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274661.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP30873.
KOiK04217.
OMAiLLHHWPF.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP30873.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30873-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPNGTASSP SSSPSPSPGS CGEGACSRGP GSGAADGMEE PGRNASQNGT
60 70 80 90 100
LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL
110 120 130 140 150
AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV
160 170 180 190 200
LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA
210 220 230 240 250
NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM
260 270 280 290 300
RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD
310 320 330 340 350
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP
360 370 380 390
VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCASRIST L
Length:391
Mass (Da):42,718
Last modified:July 1, 1993 - v1
Checksum:i4461673956F2BD22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81831 Genomic DNA. Translation: AAA58255.1.
CCDSiCCDS36456.1.
PIRiC41795.
RefSeqiNP_033242.1. NM_009216.3.
XP_006515697.1. XM_006515634.1.
UniGeneiMm.278336.

Genome annotation databases

EnsembliENSMUST00000044299; ENSMUSP00000037045; ENSMUSG00000035431.
ENSMUST00000110671; ENSMUSP00000106299; ENSMUSG00000035431.
GeneIDi20605.
KEGGimmu:20605.
UCSCiuc007npu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81831 Genomic DNA. Translation: AAA58255.1 .
CCDSi CCDS36456.1.
PIRi C41795.
RefSeqi NP_033242.1. NM_009216.3.
XP_006515697.1. XM_006515634.1.
UniGenei Mm.278336.

3D structure databases

ProteinModelPortali P30873.
SMRi P30873. Positions 59-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30873. 2 interactions.
MINTi MINT-6504720.
STRINGi 10090.ENSMUSP00000106299.

Chemistry

BindingDBi P30873.
ChEMBLi CHEMBL2111427.
GuidetoPHARMACOLOGYi 355.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30873.

Proteomic databases

PRIDEi P30873.

Protocols and materials databases

DNASUi 20605.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044299 ; ENSMUSP00000037045 ; ENSMUSG00000035431 .
ENSMUST00000110671 ; ENSMUSP00000106299 ; ENSMUSG00000035431 .
GeneIDi 20605.
KEGGi mmu:20605.
UCSCi uc007npu.1. mouse.

Organism-specific databases

CTDi 6751.
MGIi MGI:98327. Sstr1.

Phylogenomic databases

eggNOGi NOG274661.
HOGENOMi HOG000230485.
HOVERGENi HBG106919.
InParanoidi P30873.
KOi K04217.
OMAi LLHHWPF.
OrthoDBi EOG7BKCVQ.
PhylomeDBi P30873.
TreeFami TF315737.

Miscellaneous databases

NextBioi 298945.
PROi P30873.
SOURCEi Search...

Gene expression databases

Bgeei P30873.
CleanExi MM_SSTR1.
ExpressionAtlasi P30873. baseline.
Genevestigatori P30873.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney."
    Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.
    Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSSR1_MOUSE
AccessioniPrimary (citable) accession number: P30873
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3