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P30873 (SSR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatostatin receptor type 1

Short name=SS-1-R
Short name=SS1-R
Short name=SS1R
Alternative name(s):
SRIF-2
Gene names
Name:Sstr1
Synonyms:Smstr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Jejunum and stomach.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Dlg4Q621083EBI-7665262,EBI-300895

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Somatostatin receptor type 1
PRO_0000070117

Regions

Topological domain1 – 5656Extracellular Potential
Transmembrane57 – 8428Helical; Name=1; Potential
Topological domain85 – 9410Cytoplasmic Potential
Transmembrane95 – 12026Helical; Name=2; Potential
Topological domain121 – 13111Extracellular Potential
Transmembrane132 – 15322Helical; Name=3; Potential
Topological domain154 – 17522Cytoplasmic Potential
Transmembrane176 – 19621Helical; Name=4; Potential
Topological domain197 – 21923Extracellular Potential
Transmembrane220 – 24425Helical; Name=5; Potential
Topological domain245 – 27026Cytoplasmic Potential
Transmembrane271 – 29626Helical; Name=6; Potential
Topological domain297 – 3037Extracellular Potential
Transmembrane304 – 32724Helical; Name=7; Potential
Topological domain328 – 39164Cytoplasmic Potential

Amino acid modifications

Lipidation3391S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation481N-linked (GlcNAc...) Potential
Disulfide bond130 ↔ 208 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30873 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 4461673956F2BD22

FASTA39142,718
        10         20         30         40         50         60 
MFPNGTASSP SSSPSPSPGS CGEGACSRGP GSGAADGMEE PGRNASQNGT LSEGQGSAIL 

        70         80         90        100        110        120 
ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL AIADELLMLS VPFLVTSTLL 

       130        140        150        160        170        180 
RHWPFGALLC RLVLSVDAVN MFTSIYCLTV LSVDRYVAVV HPIKAARYRR PTVAKVVNLG 

       190        200        210        220        230        240 
VWVLSLLVIL PIVVFSRTAA NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC 

       250        260        270        280        290        300 
LCYVLIIAKM RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD 

       310        320        330        340        350        360 
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP VDYYATALKS 

       370        380        390 
RAYSVEDFQP ENLESGGVFR NGTCASRIST L 

« Hide

References

[1]"Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney."
Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.
Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81831 Genomic DNA. Translation: AAA58255.1.
PIRC41795.
RefSeqNP_033242.1. NM_009216.3.
XP_006515697.1. XM_006515634.1.
UniGeneMm.278336.

3D structure databases

ProteinModelPortalP30873.
SMRP30873. Positions 56-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP30873. 2 interactions.
MINTMINT-6504720.
STRING10090.ENSMUSP00000106299.

Chemistry

BindingDBP30873.
ChEMBLCHEMBL2111427.
GuidetoPHARMACOLOGY355.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30873.

Proteomic databases

PRIDEP30873.

Protocols and materials databases

DNASU20605.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044299; ENSMUSP00000037045; ENSMUSG00000035431.
ENSMUST00000110671; ENSMUSP00000106299; ENSMUSG00000035431.
GeneID20605.
KEGGmmu:20605.
UCSCuc007npu.1. mouse.

Organism-specific databases

CTD6751.
MGIMGI:98327. Sstr1.

Phylogenomic databases

eggNOGNOG274661.
HOGENOMHOG000230485.
HOVERGENHBG106919.
InParanoidP30873.
KOK04217.
OMALLHHWPF.
OrthoDBEOG7BKCVQ.
PhylomeDBP30873.
TreeFamTF315737.

Gene expression databases

BgeeP30873.
CleanExMM_SSTR1.
GenevestigatorP30873.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298945.
PROP30873.
SOURCESearch...

Entry information

Entry nameSSR1_MOUSE
AccessionPrimary (citable) accession number: P30873
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries