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P30873

- SSR1_MOUSE

UniProt

P30873 - SSR1_MOUSE

Protein

Somatostatin receptor type 1

Gene

Sstr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. somatostatin receptor activity Source: MGI

    GO - Biological processi

    1. cellular response to estradiol stimulus Source: Ensembl
    2. cerebellum development Source: Ensembl
    3. forebrain development Source: Ensembl
    4. glutamate receptor signaling pathway Source: MGI
    5. G-protein coupled receptor signaling pathway Source: MGI
    6. neuropeptide signaling pathway Source: MGI
    7. response to starvation Source: Ensembl
    8. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 1
    Short name:
    SS-1-R
    Short name:
    SS1-R
    Short name:
    SS1R
    Alternative name(s):
    SRIF-2
    Gene namesi
    Name:Sstr1
    Synonyms:Smstr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:98327. Sstr1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: MGI
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Somatostatin receptor type 1PRO_0000070117Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi130 ↔ 208PROSITE-ProRule annotation
    Lipidationi339 – 3391S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP30873.

    PTM databases

    PhosphoSiteiP30873.

    Expressioni

    Tissue specificityi

    Jejunum and stomach.

    Gene expression databases

    BgeeiP30873.
    CleanExiMM_SSTR1.
    GenevestigatoriP30873.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dlg4Q621083EBI-7665262,EBI-300895

    Protein-protein interaction databases

    IntActiP30873. 2 interactions.
    MINTiMINT-6504720.
    STRINGi10090.ENSMUSP00000106299.

    Structurei

    3D structure databases

    ProteinModelPortaliP30873.
    SMRiP30873. Positions 58-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini85 – 9410CytoplasmicSequence Analysis
    Topological domaini121 – 13111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini154 – 17522CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini197 – 21923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini245 – 27026CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 3037ExtracellularSequence Analysis
    Topological domaini328 – 39164CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 8428Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 12026Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei132 – 15322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 24425Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29626Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32724Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274661.
    HOGENOMiHOG000230485.
    HOVERGENiHBG106919.
    InParanoidiP30873.
    KOiK04217.
    OMAiLLHHWPF.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP30873.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001116. Somatstn_rcpt_1.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00587. SOMATOSTTN1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30873-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPNGTASSP SSSPSPSPGS CGEGACSRGP GSGAADGMEE PGRNASQNGT    50
    LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL 100
    AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV 150
    LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA 200
    NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM 250
    RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD 300
    DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP 350
    VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCASRIST L 391
    Length:391
    Mass (Da):42,718
    Last modified:July 1, 1993 - v1
    Checksum:i4461673956F2BD22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81831 Genomic DNA. Translation: AAA58255.1.
    CCDSiCCDS36456.1.
    PIRiC41795.
    RefSeqiNP_033242.1. NM_009216.3.
    XP_006515697.1. XM_006515634.1.
    UniGeneiMm.278336.

    Genome annotation databases

    EnsembliENSMUST00000044299; ENSMUSP00000037045; ENSMUSG00000035431.
    ENSMUST00000110671; ENSMUSP00000106299; ENSMUSG00000035431.
    GeneIDi20605.
    KEGGimmu:20605.
    UCSCiuc007npu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81831 Genomic DNA. Translation: AAA58255.1 .
    CCDSi CCDS36456.1.
    PIRi C41795.
    RefSeqi NP_033242.1. NM_009216.3.
    XP_006515697.1. XM_006515634.1.
    UniGenei Mm.278336.

    3D structure databases

    ProteinModelPortali P30873.
    SMRi P30873. Positions 58-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P30873. 2 interactions.
    MINTi MINT-6504720.
    STRINGi 10090.ENSMUSP00000106299.

    Chemistry

    BindingDBi P30873.
    ChEMBLi CHEMBL2111427.
    GuidetoPHARMACOLOGYi 355.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30873.

    Proteomic databases

    PRIDEi P30873.

    Protocols and materials databases

    DNASUi 20605.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044299 ; ENSMUSP00000037045 ; ENSMUSG00000035431 .
    ENSMUST00000110671 ; ENSMUSP00000106299 ; ENSMUSG00000035431 .
    GeneIDi 20605.
    KEGGi mmu:20605.
    UCSCi uc007npu.1. mouse.

    Organism-specific databases

    CTDi 6751.
    MGIi MGI:98327. Sstr1.

    Phylogenomic databases

    eggNOGi NOG274661.
    HOGENOMi HOG000230485.
    HOVERGENi HBG106919.
    InParanoidi P30873.
    KOi K04217.
    OMAi LLHHWPF.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P30873.
    TreeFami TF315737.

    Miscellaneous databases

    NextBioi 298945.
    PROi P30873.
    SOURCEi Search...

    Gene expression databases

    Bgeei P30873.
    CleanExi MM_SSTR1.
    Genevestigatori P30873.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001116. Somatstn_rcpt_1.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00587. SOMATOSTTN1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney."
      Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.
      Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiSSR1_MOUSE
    AccessioniPrimary (citable) accession number: P30873
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3