Reviewed,
UniProtKB/Swiss-Prot P30872 (SSR1_HUMAN)
Last modified
June 16, 2009.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Somatostatin receptor type 1 Alternative name(s): SS1R SRIF-2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 391 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins. |
| Subunit structure | Interacts with SKB1. Ref.4 |
| Subcellular location | |
| Tissue specificity | Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach. |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Disulfide bond Glycoprotein Lipoprotein Palmitate |
| Gene Ontology (GO) | |
| Biological process | G-protein signaling, coupled to cyclic nucleotide second messenger Traceable author statement. Source: ProtInc cell-cell signaling Ref.1Traceable author statement. Source: ProtInc digestion Ref.1Traceable author statement. Source: ProtInc negative regulation of cell proliferationTraceable author statement. Source: ProtInc response to nutrient Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | somatostatin receptor activity Ref.1 Inferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 391 | 391 | Somatostatin receptor type 1 | PRO_0000070116 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 56 | 56 | Extracellular Potential | ||||||||
| Transmembrane | 57 – 84 | 28 | 1 Potential | ||||||||
| Topological domain | 85 – 94 | 10 | Cytoplasmic Potential | ||||||||
| Transmembrane | 95 – 120 | 26 | 2 Potential | ||||||||
| Topological domain | 121 – 131 | 11 | Extracellular Potential | ||||||||
| Transmembrane | 132 – 153 | 22 | 3 Potential | ||||||||
| Topological domain | 154 – 175 | 22 | Cytoplasmic Potential | ||||||||
| Transmembrane | 176 – 196 | 21 | 4 Potential | ||||||||
| Topological domain | 197 – 219 | 23 | Extracellular Potential | ||||||||
| Transmembrane | 220 – 244 | 25 | 5 Potential | ||||||||
| Topological domain | 245 – 270 | 26 | Cytoplasmic Potential | ||||||||
| Transmembrane | 271 – 296 | 26 | 6 Potential | ||||||||
| Topological domain | 297 – 303 | 7 | Extracellular Potential | ||||||||
| Transmembrane | 304 – 327 | 24 | 7 Potential | ||||||||
| Topological domain | 328 – 391 | 64 | Cytoplasmic Potential | ||||||||
Amino acid modifications | |||||||||||
| Lipidation | 339 | 1 | S-palmitoyl cysteine Potential | ||||||||
| Glycosylation | 4 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 44 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 48 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 130 ↔ 208 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney." Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S. Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992) [PubMed: 1346068] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | "Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast." Schwaerzler A., Kreienkamp H.-J., Richter D. J. Biol. Chem. 275:9557-9562(2000) [PubMed: 10734105] [Abstract] Cited for: INTERACTION WITH SKB1. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M81829 Genomic DNA. Translation: AAA58247.1. AY322536 Genomic DNA. Translation: AAP84349.1. BC035618 mRNA. Translation: AAH35618.1. | |
| IPI | IPI00027804. |
| PIR | A41795. |
| RefSeq | NP_001040.1. |
| UniGene | Hs.248160 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| GPCRDB | Search... |
Proteomic databases | |
| PRIDE | P30872. |
Genome annotation databases | |
| Ensembl | ENSG00000139874. Homo sapiens. [Contig view] |
| GeneID | 6751. |
| KEGG | hsa:6751. |
Organism-specific databases | |
| GeneCards | GC14P037746. |
| H-InvDB | HIX0026752. |
| HGNC | HGNC:11330. SSTR1. |
| HPA | CAB009773. |
| MIM | 182451. gene. |
| PharmGKB | PA36154. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P30872. |
| HOVERGEN | P30872. |
| OMA | P30872. CTSRITT. |
Enzyme and pathway databases | |
| Reactome | REACT_14797. Signaling by GPCR. |
Gene expression databases | |
| ArrayExpress | P30872. |
| Bgee | P30872. |
| CleanEx | HS_SSTR1. |
| GermOnline | ENSG00000139874. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000586. Somatstn_rcpt. IPR001116. Somatstn_rcpt_1. [Graphical view] |
| PANTHER | PTHR19264:SF272. Somatstn_rcpt_1. 1 hit. |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00587. SOMATOSTTN1R. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00104. Octreotide. |
| NextBio | 26336. |
| SOURCE | Search... |
Entry information
| Entry name | SSR1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P30872 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


