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P30872

- SSR1_HUMAN

UniProt

P30872 - SSR1_HUMAN

Protein

Somatostatin receptor type 1

Gene

SSTR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

    GO - Molecular functioni

    1. somatostatin receptor activity Source: MGI

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell surface receptor signaling pathway Source: ProtInc
    3. cellular response to estradiol stimulus Source: Ensembl
    4. cerebellum development Source: Ensembl
    5. digestion Source: ProtInc
    6. forebrain development Source: Ensembl
    7. glutamate receptor signaling pathway Source: Ensembl
    8. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    9. negative regulation of cell proliferation Source: ProtInc
    10. response to nutrient Source: ProtInc
    11. response to starvation Source: Ensembl
    12. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 1
    Short name:
    SS-1-R
    Short name:
    SS1-R
    Short name:
    SS1R
    Alternative name(s):
    SRIF-2
    Gene namesi
    Name:SSTR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:11330. SSTR1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36154.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Somatostatin receptor type 1PRO_0000070116Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi130 ↔ 208PROSITE-ProRule annotation
    Lipidationi339 – 3391S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP30872.
    PRIDEiP30872.

    PTM databases

    PhosphoSiteiP30872.

    Expressioni

    Tissue specificityi

    Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.

    Gene expression databases

    BgeeiP30872.
    CleanExiHS_SSTR1.
    GenevestigatoriP30872.

    Organism-specific databases

    HPAiHPA031506.

    Interactioni

    Subunit structurei

    Interacts with SKB1.1 Publication

    Protein-protein interaction databases

    BioGridi112629. 3 interactions.
    STRINGi9606.ENSP00000267377.

    Structurei

    3D structure databases

    ProteinModelPortaliP30872.
    SMRiP30872. Positions 58-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini85 – 9410CytoplasmicSequence Analysis
    Topological domaini121 – 13111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini154 – 17522CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini197 – 21923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini245 – 27026CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 3037ExtracellularSequence Analysis
    Topological domaini328 – 39164CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 8428Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 12026Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei132 – 15322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 24425Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29626Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32724Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274661.
    HOGENOMiHOG000230485.
    HOVERGENiHBG106919.
    InParanoidiP30872.
    KOiK04217.
    OMAiLLHHWPF.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP30872.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001116. Somatstn_rcpt_1.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00587. SOMATOSTTN1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30872-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPNGTASSP SSSPSPSPGS CGEGGGSRGP GAGAADGMEE PGRNASQNGT    50
    LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL 100
    AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV 150
    LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA 200
    NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM 250
    RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD 300
    DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP 350
    VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCTSRITT L 391
    Length:391
    Mass (Da):42,686
    Last modified:July 1, 1993 - v1
    Checksum:i85C99AFFF339A43D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81829 Genomic DNA. Translation: AAA58247.1.
    AY322536 Genomic DNA. Translation: AAP84349.1.
    BC035618 mRNA. Translation: AAH35618.1.
    CCDSiCCDS9666.1.
    PIRiA41795.
    RefSeqiNP_001040.1. NM_001049.2.
    UniGeneiHs.248160.

    Genome annotation databases

    EnsembliENST00000267377; ENSP00000267377; ENSG00000139874.
    GeneIDi6751.
    KEGGihsa:6751.
    UCSCiuc001wul.1. human.

    Polymorphism databases

    DMDMi401124.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81829 Genomic DNA. Translation: AAA58247.1 .
    AY322536 Genomic DNA. Translation: AAP84349.1 .
    BC035618 mRNA. Translation: AAH35618.1 .
    CCDSi CCDS9666.1.
    PIRi A41795.
    RefSeqi NP_001040.1. NM_001049.2.
    UniGenei Hs.248160.

    3D structure databases

    ProteinModelPortali P30872.
    SMRi P30872. Positions 58-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112629. 3 interactions.
    STRINGi 9606.ENSP00000267377.

    Chemistry

    BindingDBi P30872.
    ChEMBLi CHEMBL1917.
    DrugBanki DB00104. Octreotide.
    GuidetoPHARMACOLOGYi 355.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30872.

    Polymorphism databases

    DMDMi 401124.

    Proteomic databases

    PaxDbi P30872.
    PRIDEi P30872.

    Protocols and materials databases

    DNASUi 6751.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267377 ; ENSP00000267377 ; ENSG00000139874 .
    GeneIDi 6751.
    KEGGi hsa:6751.
    UCSCi uc001wul.1. human.

    Organism-specific databases

    CTDi 6751.
    GeneCardsi GC14P038677.
    HGNCi HGNC:11330. SSTR1.
    HPAi HPA031506.
    MIMi 182451. gene.
    neXtProti NX_P30872.
    PharmGKBi PA36154.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274661.
    HOGENOMi HOG000230485.
    HOVERGENi HBG106919.
    InParanoidi P30872.
    KOi K04217.
    OMAi LLHHWPF.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P30872.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Somatostatin_receptor_1.
    GenomeRNAii 6751.
    NextBioi 26336.
    PROi P30872.
    SOURCEi Search...

    Gene expression databases

    Bgeei P30872.
    CleanExi HS_SSTR1.
    Genevestigatori P30872.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001116. Somatstn_rcpt_1.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00587. SOMATOSTTN1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney."
      Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.
      Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast."
      Schwaerzler A., Kreienkamp H.-J., Richter D.
      J. Biol. Chem. 275:9557-9562(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SKB1.

    Entry informationi

    Entry nameiSSR1_HUMAN
    AccessioniPrimary (citable) accession number: P30872
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3