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P30872 (SSR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatostatin receptor type 1

Short name=SS-1-R
Short name=SS1-R
Short name=SS1R
Alternative name(s):
SRIF-2
Gene names
Name:SSTR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

Subunit structure

Interacts with SKB1. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Traceable author statement PubMed 8405411. Source: ProtInc

cell surface receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

cell-cell signaling

Traceable author statement Ref.1. Source: ProtInc

cellular response to estradiol stimulus

Inferred from electronic annotation. Source: Ensembl

cerebellum development

Inferred from electronic annotation. Source: Ensembl

digestion

Traceable author statement Ref.1. Source: ProtInc

forebrain development

Inferred from electronic annotation. Source: Ensembl

glutamate receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Traceable author statement PubMed 9886848. Source: ProtInc

response to nutrient

Traceable author statement Ref.1. Source: ProtInc

response to starvation

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionsomatostatin receptor activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Somatostatin receptor type 1
PRO_0000070116

Regions

Topological domain1 – 5656Extracellular Potential
Transmembrane57 – 8428Helical; Name=1; Potential
Topological domain85 – 9410Cytoplasmic Potential
Transmembrane95 – 12026Helical; Name=2; Potential
Topological domain121 – 13111Extracellular Potential
Transmembrane132 – 15322Helical; Name=3; Potential
Topological domain154 – 17522Cytoplasmic Potential
Transmembrane176 – 19621Helical; Name=4; Potential
Topological domain197 – 21923Extracellular Potential
Transmembrane220 – 24425Helical; Name=5; Potential
Topological domain245 – 27026Cytoplasmic Potential
Transmembrane271 – 29626Helical; Name=6; Potential
Topological domain297 – 3037Extracellular Potential
Transmembrane304 – 32724Helical; Name=7; Potential
Topological domain328 – 39164Cytoplasmic Potential

Amino acid modifications

Lipidation3391S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation481N-linked (GlcNAc...) Potential
Disulfide bond130 ↔ 208 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30872 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 85C99AFFF339A43D

FASTA39142,686
        10         20         30         40         50         60 
MFPNGTASSP SSSPSPSPGS CGEGGGSRGP GAGAADGMEE PGRNASQNGT LSEGQGSAIL 

        70         80         90        100        110        120 
ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL AIADELLMLS VPFLVTSTLL 

       130        140        150        160        170        180 
RHWPFGALLC RLVLSVDAVN MFTSIYCLTV LSVDRYVAVV HPIKAARYRR PTVAKVVNLG 

       190        200        210        220        230        240 
VWVLSLLVIL PIVVFSRTAA NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC 

       250        260        270        280        290        300 
LCYVLIIAKM RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD 

       310        320        330        340        350        360 
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP VDYYATALKS 

       370        380        390 
RAYSVEDFQP ENLESGGVFR NGTCTSRITT L 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney."
Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.
Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast."
Schwaerzler A., Kreienkamp H.-J., Richter D.
J. Biol. Chem. 275:9557-9562(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SKB1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81829 Genomic DNA. Translation: AAA58247.1.
AY322536 Genomic DNA. Translation: AAP84349.1.
BC035618 mRNA. Translation: AAH35618.1.
PIRA41795.
RefSeqNP_001040.1. NM_001049.2.
UniGeneHs.248160.

3D structure databases

ProteinModelPortalP30872.
SMRP30872. Positions 56-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112629. 3 interactions.
STRING9606.ENSP00000267377.

Chemistry

BindingDBP30872.
ChEMBLCHEMBL2111436.
DrugBankDB00104. Octreotide.
GuidetoPHARMACOLOGY355.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30872.

Polymorphism databases

DMDM401124.

Proteomic databases

PaxDbP30872.
PRIDEP30872.

Protocols and materials databases

DNASU6751.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267377; ENSP00000267377; ENSG00000139874.
GeneID6751.
KEGGhsa:6751.
UCSCuc001wul.1. human.

Organism-specific databases

CTD6751.
GeneCardsGC14P038677.
HGNCHGNC:11330. SSTR1.
HPAHPA031506.
MIM182451. gene.
neXtProtNX_P30872.
PharmGKBPA36154.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274661.
HOGENOMHOG000230485.
HOVERGENHBG106919.
InParanoidP30872.
KOK04217.
OMALLHHWPF.
OrthoDBEOG7BKCVQ.
PhylomeDBP30872.
TreeFamTF315737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP30872.
CleanExHS_SSTR1.
GenevestigatorP30872.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSomatostatin_receptor_1.
GenomeRNAi6751.
NextBio26336.
PROP30872.
SOURCESearch...

Entry information

Entry nameSSR1_HUMAN
AccessionPrimary (citable) accession number: P30872
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries