P30872 (SSR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Somatostatin receptor type 1
Short name=SS-1-R
Short name=SS1-R
Short name=SS1R

Alternative name(s):
SRIF-2

Gene names

Name:

SSTR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.
Subunit structure	Interacts with SKB1. Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement PubMed 8405411. Source: ProtInc cellular response to estradiol stimulus Inferred from electronic annotation. Source: Compara cerebellum development Inferred from electronic annotation. Source: Compara digestion Traceable author statement Ref.1. Source: ProtInc forebrain development Inferred from electronic annotation. Source: Compara glutamate receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Traceable author statement PubMed 9886848. Source: ProtInc response to nutrient Traceable author statement Ref.1. Source: ProtInc response to starvation Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	somatostatin receptor activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Somatostatin receptor type 1		PRO_0000070116
Regions
	Topological domain	1 – 56	56	Extracellular Potential
	Transmembrane	57 – 84	28	Helical; Name=1; Potential
	Topological domain	85 – 94	10	Cytoplasmic Potential
	Transmembrane	95 – 120	26	Helical; Name=2; Potential
	Topological domain	121 – 131	11	Extracellular Potential
	Transmembrane	132 – 153	22	Helical; Name=3; Potential
	Topological domain	154 – 175	22	Cytoplasmic Potential
	Transmembrane	176 – 196	21	Helical; Name=4; Potential
	Topological domain	197 – 219	23	Extracellular Potential
	Transmembrane	220 – 244	25	Helical; Name=5; Potential
	Topological domain	245 – 270	26	Cytoplasmic Potential
	Transmembrane	271 – 296	26	Helical; Name=6; Potential
	Topological domain	297 – 303	7	Extracellular Potential
	Transmembrane	304 – 327	24	Helical; Name=7; Potential
	Topological domain	328 – 391	64	Cytoplasmic Potential
Amino acid modifications
	Lipidation	339	1	S-palmitoyl cysteine Potential
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	44	1	N-linked (GlcNAc...) Potential
	Glycosylation	48	1	N-linked (GlcNAc...) Potential
	Disulfide bond	130 ↔ 208		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30872 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 85C99AFFF339A43D	FASTA	391	42,686
	10 20 30 40 50 60 MFPNGTASSP SSSPSPSPGS CGEGGGSRGP GAGAADGMEE PGRNASQNGT LSEGQGSAIL 70 80 90 100 110 120 ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL AIADELLMLS VPFLVTSTLL 130 140 150 160 170 180 RHWPFGALLC RLVLSVDAVN MFTSIYCLTV LSVDRYVAVV HPIKAARYRR PTVAKVVNLG 190 200 210 220 230 240 VWVLSLLVIL PIVVFSRTAA NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC 250 260 270 280 290 300 LCYVLIIAKM RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD 310 320 330 340 350 360 DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP VDYYATALKS 370 380 390 RAYSVEDFQP ENLESGGVFR NGTCTSRITT L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney." Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S. Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast." Schwaerzler A., Kreienkamp H.-J., Richter D. J. Biol. Chem. 275:9557-9562(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SKB1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M81829 Genomic DNA. Translation: AAA58247.1. AY322536 Genomic DNA. Translation: AAP84349.1. BC035618 mRNA. Translation: AAH35618.1.
IPI	IPI00027804.
PIR	A41795.
RefSeq	NP_001040.1. NM_001049.2.
UniGene	Hs.248160.
3D structure databases
ProteinModelPortal	P30872.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000267377.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P30872.
Polymorphism databases
DMDM	401124.
Proteomic databases
PaxDb	P30872.
PRIDE	P30872.
Protocols and materials databases
DNASU	6751.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000267377; ENSP00000267377; ENSG00000139874.
GeneID	6751.
KEGG	hsa:6751.
UCSC	uc001wul.1. human.
Organism-specific databases
CTD	6751.
GeneCards	GC14P038677.
HGNC	HGNC:11330. SSTR1.
HPA	CAB009773.
MIM	182451. gene.
neXtProt	NX_P30872.
PharmGKB	PA36154.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274661.
HOGENOM	HOG000230485.
HOVERGEN	HBG106919.
InParanoid	P30872.
KO	K04217.
OMA	LLHHWPF.
OrthoDB	EOG44J2J9.
PhylomeDB	P30872.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P30872.
CleanEx	HS_SSTR1.
Genevestigator	P30872.
GermOnline	ENSG00000139874. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000586. Somatstn_rcpt. IPR001116. Somatstn_rcpt_1. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00587. SOMATOSTTN1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P30872.
ChEMBL	CHEMBL1917.
DrugBank	DB00104. Octreotide.
GenomeRNAi	6751.
NextBio	26336.
SOURCE	Search...

Entry information

Entry name

SSR1_HUMAN

Accession

Primary (citable) accession number: P30872

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.