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Protein

Somatostatin receptor type 1

Gene

SSTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

GO - Molecular functioni

  • neuropeptide binding Source: GO_Central
  • somatostatin receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP30872

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 1
Short name:
SS-1-R
Short name:
SS1-R
Short name:
SS1R
Alternative name(s):
SRIF-2
Gene namesi
Name:SSTR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000139874.5
HGNCiHGNC:11330 SSTR1
MIMi182451 gene
neXtProtiNX_P30872

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56ExtracellularSequence analysisAdd BLAST56
Transmembranei57 – 84Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini85 – 94CytoplasmicSequence analysis10
Transmembranei95 – 120Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini121 – 131ExtracellularSequence analysisAdd BLAST11
Transmembranei132 – 153Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini154 – 175CytoplasmicSequence analysisAdd BLAST22
Transmembranei176 – 196Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini197 – 219ExtracellularSequence analysisAdd BLAST23
Transmembranei220 – 244Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini245 – 270CytoplasmicSequence analysisAdd BLAST26
Transmembranei271 – 296Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini297 – 303ExtracellularSequence analysis7
Transmembranei304 – 327Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini328 – 391CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6751
OpenTargetsiENSG00000139874
PharmGKBiPA36154

Chemistry databases

ChEMBLiCHEMBL1917
DrugBankiDB00104 Octreotide
DB06663 Pasireotide
GuidetoPHARMACOLOGYi355

Polymorphism and mutation databases

BioMutaiSSTR1
DMDMi401124

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701161 – 391Somatostatin receptor type 1Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 208PROSITE-ProRule annotation
Lipidationi339S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30872
PeptideAtlasiP30872
PRIDEiP30872

PTM databases

iPTMnetiP30872
PhosphoSitePlusiP30872

Expressioni

Tissue specificityi

Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.

Gene expression databases

BgeeiENSG00000139874
CleanExiHS_SSTR1
GenevisibleiP30872 HS

Organism-specific databases

HPAiHPA031506

Interactioni

Subunit structurei

Interacts with SKB1.1 Publication

Protein-protein interaction databases

BioGridi112629, 3 interactors
STRINGi9606.ENSP00000267377

Chemistry databases

BindingDBiP30872

Structurei

3D structure databases

ProteinModelPortaliP30872
SMRiP30872
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230485
HOVERGENiHBG106919
InParanoidiP30872
KOiK04217
OMAiLLHHWPF
OrthoDBiEOG091G0HEN
PhylomeDBiP30872
TreeFamiTF315737

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000586 Somatstn_rcpt
IPR001116 Somatstn_rcpt_1
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00246 SOMATOSTATNR
PR00587 SOMATOSTTN1R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPNGTASSP SSSPSPSPGS CGEGGGSRGP GAGAADGMEE PGRNASQNGT
60 70 80 90 100
LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL
110 120 130 140 150
AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV
160 170 180 190 200
LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA
210 220 230 240 250
NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM
260 270 280 290 300
RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD
310 320 330 340 350
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP
360 370 380 390
VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCTSRITT L
Length:391
Mass (Da):42,686
Last modified:July 1, 1993 - v1
Checksum:i85C99AFFF339A43D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81829 Genomic DNA Translation: AAA58247.1
AY322536 Genomic DNA Translation: AAP84349.1
BC035618 mRNA Translation: AAH35618.1
CCDSiCCDS9666.1
PIRiA41795
RefSeqiNP_001040.1, NM_001049.2
UniGeneiHs.248160

Genome annotation databases

EnsembliENST00000267377; ENSP00000267377; ENSG00000139874
GeneIDi6751
KEGGihsa:6751
UCSCiuc001wul.2 human

Similar proteinsi

Entry informationi

Entry nameiSSR1_HUMAN
AccessioniPrimary (citable) accession number: P30872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 25, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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