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Protein

Somatostatin receptor type 1

Gene

SSTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.

GO - Molecular functioni

  • neuropeptide binding Source: GO_Central
  • somatostatin receptor activity Source: MGI

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • cellular response to estradiol stimulus Source: GO_Central
  • cerebellum development Source: Ensembl
  • digestion Source: ProtInc
  • forebrain development Source: Ensembl
  • glutamate receptor signaling pathway Source: Ensembl
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • negative regulation of cell proliferation Source: ProtInc
  • neuropeptide signaling pathway Source: GO_Central
  • response to nutrient Source: ProtInc
  • response to starvation Source: Ensembl
  • somatostatin signaling pathway Source: GO_Central
  • spermatogenesis Source: Ensembl
  • synaptic transmission Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 1
Short name:
SS-1-R
Short name:
SS1-R
Short name:
SS1R
Alternative name(s):
SRIF-2
Gene namesi
Name:SSTR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:11330. SSTR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
BLAST
Transmembranei57 – 8428Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini85 – 9410CytoplasmicSequence Analysis
Transmembranei95 – 12026Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini121 – 13111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei132 – 15322Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini154 – 17522CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini197 – 21923ExtracellularSequence AnalysisAdd
BLAST
Transmembranei220 – 24425Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini245 – 27026CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei271 – 29626Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini297 – 3037ExtracellularSequence Analysis
Transmembranei304 – 32724Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini328 – 39164CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • neuron projection Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36154.

Chemistry

DrugBankiDB00104. Octreotide.
DB06663. Pasireotide.

Polymorphism and mutation databases

BioMutaiSSTR1.
DMDMi401124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Somatostatin receptor type 1PRO_0000070116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi130 ↔ 208PROSITE-ProRule annotation
Lipidationi339 – 3391S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30872.
PRIDEiP30872.

PTM databases

PhosphoSiteiP30872.

Expressioni

Tissue specificityi

Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.

Gene expression databases

BgeeiP30872.
CleanExiHS_SSTR1.
GenevestigatoriP30872.

Organism-specific databases

HPAiHPA031506.

Interactioni

Subunit structurei

Interacts with SKB1.1 Publication

Protein-protein interaction databases

BioGridi112629. 3 interactions.
STRINGi9606.ENSP00000267377.

Structurei

3D structure databases

ProteinModelPortaliP30872.
SMRiP30872. Positions 58-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274661.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP30872.
KOiK04217.
OMAiLLHHWPF.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP30872.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPNGTASSP SSSPSPSPGS CGEGGGSRGP GAGAADGMEE PGRNASQNGT
60 70 80 90 100
LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL
110 120 130 140 150
AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV
160 170 180 190 200
LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA
210 220 230 240 250
NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM
260 270 280 290 300
RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD
310 320 330 340 350
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP
360 370 380 390
VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCTSRITT L
Length:391
Mass (Da):42,686
Last modified:July 1, 1993 - v1
Checksum:i85C99AFFF339A43D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81829 Genomic DNA. Translation: AAA58247.1.
AY322536 Genomic DNA. Translation: AAP84349.1.
BC035618 mRNA. Translation: AAH35618.1.
CCDSiCCDS9666.1.
PIRiA41795.
RefSeqiNP_001040.1. NM_001049.2.
UniGeneiHs.248160.

Genome annotation databases

EnsembliENST00000267377; ENSP00000267377; ENSG00000139874.
GeneIDi6751.
KEGGihsa:6751.
UCSCiuc001wul.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81829 Genomic DNA. Translation: AAA58247.1.
AY322536 Genomic DNA. Translation: AAP84349.1.
BC035618 mRNA. Translation: AAH35618.1.
CCDSiCCDS9666.1.
PIRiA41795.
RefSeqiNP_001040.1. NM_001049.2.
UniGeneiHs.248160.

3D structure databases

ProteinModelPortaliP30872.
SMRiP30872. Positions 58-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112629. 3 interactions.
STRINGi9606.ENSP00000267377.

Chemistry

BindingDBiP30872.
ChEMBLiCHEMBL2111436.
DrugBankiDB00104. Octreotide.
DB06663. Pasireotide.
GuidetoPHARMACOLOGYi355.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30872.

Polymorphism and mutation databases

BioMutaiSSTR1.
DMDMi401124.

Proteomic databases

PaxDbiP30872.
PRIDEiP30872.

Protocols and materials databases

DNASUi6751.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267377; ENSP00000267377; ENSG00000139874.
GeneIDi6751.
KEGGihsa:6751.
UCSCiuc001wul.1. human.

Organism-specific databases

CTDi6751.
GeneCardsiGC14P038677.
HGNCiHGNC:11330. SSTR1.
HPAiHPA031506.
MIMi182451. gene.
neXtProtiNX_P30872.
PharmGKBiPA36154.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274661.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP30872.
KOiK04217.
OMAiLLHHWPF.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP30872.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiSomatostatin_receptor_1.
GenomeRNAii6751.
NextBioi26336.
PROiP30872.
SOURCEiSearch...

Gene expression databases

BgeeiP30872.
CleanExiHS_SSTR1.
GenevestigatoriP30872.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001116. Somatstn_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00587. SOMATOSTTN1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney."
    Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S.
    Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast."
    Schwaerzler A., Kreienkamp H.-J., Richter D.
    J. Biol. Chem. 275:9557-9562(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SKB1.

Entry informationi

Entry nameiSSR1_HUMAN
AccessioniPrimary (citable) accession number: P30872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 27, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.