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P30870 (GLNE_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate-ammonia-ligase adenylyltransferase

EC=2.7.7.42
Alternative name(s):
Glutamine-synthetase adenylyltransferase
Short name=ATase
[Glutamate--ammonia-ligase] adenylyltransferase
Gene names
Name:glnE
Ordered Locus Names:b3053, JW3025
OrganismEscherichia coli (strain K12)
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length946 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Adenylation and deadenylation of glutamate--ammonia ligase. Ref.1

Catalytic activity

ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. HAMAP MF_00802

Sequence similarities

Belongs to the glnE family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 946946Glutamate-ammonia-ligase adenylyltransferase HAMAP MF_00802
PRO_0000209244

Regions

Region91 – 302212GlnE 1 HAMAP MF_00802
Region609 – 830222GlnE 2 HAMAP MF_00802

Experimental info

Sequence conflict5241Missing in CAA79892. Ref.1
Sequence conflict624 – 6252QL → PV in CAA79892. Ref.1

Secondary structure

........................................................ 946
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P30870 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 6FD2D7BDC619DB83

FASTA946108,418
        10         20         30         40         50         60 
MKPLSSPLQQ YWQTVVERLP EPLAEESLSA QAKSVLTFSD FVQDSVIAHP EWLTELESQP 

        70         80         90        100        110        120 
PQADEWQHYA AWLQEALCNV SDEAGLMREL RLFRRRIMVR IAWAQTLALV TEESILQQLS 

       130        140        150        160        170        180 
YLAETLIVAA RDWLYDACCR EWGTPCNAQG EAQPLLILGM GKLGGGELNF SSDIDLIFAW 

       190        200        210        220        230        240 
PEHGCTQGGR RELDNAQFFT RMGQRLIKVL DQPTQDGFVY RVDMRLRPFG ESGPLVLSFA 

       250        260        270        280        290        300 
ALEDYYQEQG RDWERYAMVK ARIMGDSEGV YANELRAMLR PFVFRRYIDF SVIQSLRNMK 

       310        320        330        340        350        360 
GMIAREVRRR GLTDNIKLGA GGIREIEFIV QVFQLIRGGR EPSLQSRSLL PTLSAIAELH 

       370        380        390        400        410        420 
LLSENDAEQL RVAYLFLRRL ENLLQSINDE QTQTLPSDEL NRARLAWAMD FADWPQLTGA 

       430        440        450        460        470        480 
LTAHMTNVRR VFNELIGDDE SETQEESLSE QWRELWQDAL QEDDTTPVLA HLSEDDRKQV 

       490        500        510        520        530        540 
LTLIADFRKE LDKRTIGPRG RQVLDHLMPH LLSDVCARED AAVTLSRITA LLVGIVTRTT 

       550        560        570        580        590        600 
YLELLSEFPA ALKHLISLCA ASPMIASQLA RYPLLLDELL DPNTLYQPTA TDAYRDELRQ 

       610        620        630        640        650        660 
YLLRVPEDDE EQQLEALRQF KQAQLLRIAA ADIAGTLPVM KVSDHLTWLA EAMIDAVVQQ 

       670        680        690        700        710        720 
AWVQMVARYG KPNHLNEREG RGFAVVGYGK LGGWELGYSS DLDLIFLHDC PMDAMTDGER 

       730        740        750        760        770        780 
EIDGRQFYLR LAQRIMHLFS TRTSSGILYE VDARLRPSGA AGMLVTSAEA FADYQKNEAW 

       790        800        810        820        830        840 
TWEHQALVRA RVVYGDPQLT AHFDAVRREI MTLPREGKTL QTEVREMREK MRAHLGNKHR 

       850        860        870        880        890        900 
DRFDIKADEG GITDIEFITQ YLVLRYAHEK PKLTRWSDNV RILELLAQND IMEEQEAMAL 

       910        920        930        940 
TRAYTTLRDE LHHLALQELP GHVSEDCFTA ERELVRASWQ KWLVEE 

« Hide

References

« Hide 'large scale' references
[1]"The genes of the glutamine synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli."
van Heeswijk W.C., Rabenberg M., Westerhoff H.V., Kahn D.D.
Mol. Microbiol. 9:443-458(1993) [PubMed: 8412694] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: K12 / CS520.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Structure of the N-terminal domain of Escherichia coli glutamine synthetase adenylyltransferase."
Xu Y., Zhang R., Joachimiak A., Carr P.D., Huber T., Vasudevan S.G., Ollis D.L.
Structure 12:861-869(2004) [PubMed: 15130478] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-440.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z21844 Genomic DNA. Translation: CAA79892.1.
U00096 Genomic DNA. Translation: AAC76089.1.
AP009048 Genomic DNA. Translation: BAE77104.1.
PIRC65093.
RefSeqNP_417525.1. NC_000913.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1V4AX-ray2.00A1-440[»]
3K7DX-ray2.40A/B449-946[»]
ProteinModelPortalP30870.
SMRP30870. Positions 1-437, 449-945.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-9780N.
IntActP30870. 2 interactions.

PTM databases

PhosSiteP30870.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000001929; EBESCP00000001929; EBESCG00000001582.
EBESCT00000014398; EBESCP00000013689; EBESCG00000013459.
GeneID947552.
GenomeReviewsGene locus JW3025 in contig AP009048_GR.
Gene locus b3053 in contig U00096_GR.
KEGGecj:JW3025.
eco:b3053.
PATRIC32121518. VBIEscCol129921_3146.

Organism-specific databases

EchoBASEEB1559.
EcoGeneEG11602. glnE.

Phylogenomic databases

eggNOGCOG1391.
GeneTreeEBGT00050000010757.
HOGENOMHBG687047.
OMAVEHRIQM.
PhylomeDBP30870.
ProtClustDBPRK11072.

Enzyme and pathway databases

BioCycEcoCyc:GLNE-MONOMER.
MetaCyc:GLNE-MONOMER.

Gene expression databases

GenevestigatorP30870.

Family and domain databases

HAMAPMF_00802. GlnE.
[Tree]
InterProIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
KOK00982.
PfamPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNE_ECOLI
AccessionPrimary (citable) accession number: P30870
Secondary accession number(s): P78107, Q2M9F2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: January 25, 2012
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families