ID BASR_ECOLI Reviewed; 222 AA. AC P30843; Q2M6J1; Q5MNC7; Q5MNC9; Q5MNE0; Q5MNE5; Q5MNF2; Q5MNH0; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 29-AUG-2003, sequence version 3. DT 27-MAR-2024, entry version 171. DE RecName: Full=Transcriptional regulatory protein BasR; GN Name=basR; Synonyms=pmrA; OrderedLocusNames=b4113, JW4074; OS Escherichia coli (strain K12). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=K12; RX PubMed=8282725; DOI=10.1093/oxfordjournals.jbchem.a124180; RA Nagasawa S., Ishige K., Mizuno T.; RT "Novel members of the two-component signal transduction genes in RT Escherichia coli."; RL J. Biochem. 114:350-357(1993). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND REGULATION BY PMRD. RC STRAIN=ECOR 1, ECOR 10, ECOR 11, ECOR 12, ECOR 13, ECOR 14, ECOR 15, RC ECOR 16, ECOR 17, ECOR 18, ECOR 19, ECOR 2, ECOR 20, ECOR 21, ECOR 22, RC ECOR 24, ECOR 25, ECOR 26, ECOR 27, ECOR 3, ECOR 30, ECOR 33, ECOR 34, RC ECOR 35, ECOR 36, ECOR 37, ECOR 38, ECOR 4, ECOR 40, ECOR 41, ECOR 42, RC ECOR 43, ECOR 44, ECOR 45, ECOR 46, ECOR 47, ECOR 48, ECOR 5, ECOR 51, RC ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 59, ECOR 6, RC ECOR 60, ECOR 61, ECOR 62, ECOR 63, ECOR 64, ECOR 65, ECOR 66, ECOR RC 67, ECOR 68, ECOR 69, ECOR 7, ECOR 70, ECOR 71, ECOR 72, ECOR 8, ECOR RC 9, and O2:HN / ECOR 50 / P97 / UPEC; RX PubMed=15569938; DOI=10.1073/pnas.0406038101; RA Winfield M.D., Groisman E.A.; RT "Phenotypic differences between Salmonella and Escherichia coli resulting RT from the disparate regulation of homologous genes."; RL Proc. Natl. Acad. Sci. U.S.A. 101:17162-17167(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=7610040; DOI=10.1093/nar/23.12.2105; RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.; RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region RT from 92.8 through 100 minutes."; RL Nucleic Acids Res. 23:2105-2119(1995). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., RA Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1462(1997). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 RT and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [6] RP PHOSPHORYLATION. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=15522865; DOI=10.1074/jbc.m410104200; RA Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.; RT "Functional characterization in vitro of all two-component signal RT transduction systems from Escherichia coli."; RL J. Biol. Chem. 280:1448-1456(2005). CC -!- FUNCTION: Member of the two-component regulatory system BasS/BasR. BasR CC induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS CC loci, all involved in resistance to polymyxin (By similarity). CC {ECO:0000250}. CC -!- SUBUNIT: Homodimer. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. CC -!- INDUCTION: The eptA-basRS operon is positively autoregulated by BasR CC under high iron or aluminum concentration conditions. {ECO:0000250}. CC -!- PTM: Phosphorylated by BasS. {ECO:0000269|PubMed:15522865}. CC -!- MISCELLANEOUS: The activity of the BasR protein is in some natural CC isolates, but not in strain K12, controlled at a post-transcriptional CC level by the PmrD protein under low Mg(2+) concentration conditions. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D14055; BAA03143.1; -; Genomic_DNA. DR EMBL; AY725270; AAV92717.1; -; Genomic_DNA. DR EMBL; AY725271; AAV92718.1; -; Genomic_DNA. DR EMBL; AY725272; AAV92719.1; -; Genomic_DNA. DR EMBL; AY725273; AAV92720.1; -; Genomic_DNA. DR EMBL; AY725274; AAV92721.1; -; Genomic_DNA. DR EMBL; AY725275; AAV92722.1; -; Genomic_DNA. DR EMBL; AY725276; AAV92723.1; -; Genomic_DNA. DR EMBL; AY725277; AAV92724.1; -; Genomic_DNA. DR EMBL; AY725278; AAV92725.1; -; Genomic_DNA. DR EMBL; AY725279; AAV92726.1; -; Genomic_DNA. DR EMBL; AY725280; AAV92727.1; -; Genomic_DNA. DR EMBL; AY725281; AAV92728.1; -; Genomic_DNA. DR EMBL; AY725282; AAV92729.1; -; Genomic_DNA. DR EMBL; AY725283; AAV92730.1; -; Genomic_DNA. DR EMBL; AY725284; AAV92731.1; -; Genomic_DNA. DR EMBL; AY725285; AAV92732.1; -; Genomic_DNA. DR EMBL; AY725286; AAV92733.1; -; Genomic_DNA. DR EMBL; AY725287; AAV92734.1; -; Genomic_DNA. DR EMBL; AY725288; AAV92735.1; -; Genomic_DNA. DR EMBL; AY725289; AAV92736.1; -; Genomic_DNA. DR EMBL; AY725290; AAV92737.1; -; Genomic_DNA. DR EMBL; AY725291; AAV92738.1; -; Genomic_DNA. DR EMBL; AY725292; AAV92739.1; -; Genomic_DNA. DR EMBL; AY725293; AAV92740.1; -; Genomic_DNA. DR EMBL; AY725294; AAV92741.1; -; Genomic_DNA. DR EMBL; AY725295; AAV92742.1; -; Genomic_DNA. DR EMBL; AY725296; AAV92743.1; -; Genomic_DNA. DR EMBL; AY725297; AAV92744.1; -; Genomic_DNA. DR EMBL; AY725298; AAV92745.1; -; Genomic_DNA. DR EMBL; AY725299; AAV92746.1; -; Genomic_DNA. DR EMBL; AY725300; AAV92747.1; -; Genomic_DNA. DR EMBL; AY725301; AAV92748.1; -; Genomic_DNA. DR EMBL; AY725302; AAV92749.1; -; Genomic_DNA. DR EMBL; AY725303; AAV92750.1; -; Genomic_DNA. DR EMBL; AY725304; AAV92751.1; -; Genomic_DNA. DR EMBL; AY725305; AAV92752.1; -; Genomic_DNA. DR EMBL; AY725306; AAV92753.1; -; Genomic_DNA. DR EMBL; AY725307; AAV92754.1; -; Genomic_DNA. DR EMBL; AY725308; AAV92755.1; -; Genomic_DNA. DR EMBL; AY725309; AAV92756.1; -; Genomic_DNA. DR EMBL; AY725310; AAV92757.1; -; Genomic_DNA. DR EMBL; AY725311; AAV92758.1; -; Genomic_DNA. DR EMBL; AY725312; AAV92759.1; -; Genomic_DNA. DR EMBL; AY725313; AAV92760.1; -; Genomic_DNA. DR EMBL; AY725314; AAV92761.1; -; Genomic_DNA. DR EMBL; AY725315; AAV92762.1; -; Genomic_DNA. DR EMBL; AY725316; AAV92763.1; -; Genomic_DNA. DR EMBL; AY725317; AAV92764.1; -; Genomic_DNA. DR EMBL; AY725318; AAV92765.1; -; Genomic_DNA. DR EMBL; AY725319; AAV92766.1; -; Genomic_DNA. DR EMBL; AY725320; AAV92767.1; -; Genomic_DNA. DR EMBL; AY725321; AAV92768.1; -; Genomic_DNA. DR EMBL; AY725322; AAV92769.1; -; Genomic_DNA. DR EMBL; AY725323; AAV92770.1; -; Genomic_DNA. DR EMBL; AY725324; AAV92771.1; -; Genomic_DNA. DR EMBL; AY725325; AAV92772.1; -; Genomic_DNA. DR EMBL; AY725326; AAV92773.1; -; Genomic_DNA. DR EMBL; AY725327; AAV92774.1; -; Genomic_DNA. DR EMBL; AY725328; AAV92775.1; -; Genomic_DNA. DR EMBL; AY725329; AAV92776.1; -; Genomic_DNA. DR EMBL; AY725330; AAV92777.1; -; Genomic_DNA. DR EMBL; AY725331; AAV92778.1; -; Genomic_DNA. DR EMBL; AY725332; AAV92779.1; -; Genomic_DNA. DR EMBL; AY725333; AAV92780.1; -; Genomic_DNA. DR EMBL; U14003; AAA97012.1; -; Genomic_DNA. DR EMBL; U00096; AAC77074.1; -; Genomic_DNA. DR EMBL; AP009048; BAE78115.1; -; Genomic_DNA. DR PIR; H65220; H65220. DR RefSeq; NP_418537.1; NC_000913.3. DR RefSeq; WP_000697919.1; NZ_STEB01000014.1. DR RefSeq; WP_000697926.1; NZ_LN832404.1. DR AlphaFoldDB; P30843; -. DR SMR; P30843; -. DR BioGRID; 4263083; 96. DR DIP; DIP-9201N; -. DR IntAct; P30843; 5. DR STRING; 511145.b4113; -. DR jPOST; P30843; -. DR PaxDb; 511145-b4113; -. DR EnsemblBacteria; AAC77074; AAC77074; b4113. DR GeneID; 948631; -. DR KEGG; ecj:JW4074; -. DR KEGG; eco:b4113; -. DR PATRIC; fig|1411691.4.peg.2587; -. DR EchoBASE; EB1572; -. DR eggNOG; COG0745; Bacteria. DR HOGENOM; CLU_000445_30_1_6; -. DR InParanoid; P30843; -. DR OMA; YQGHSDN; -. DR OrthoDB; 9802426at2; -. DR PhylomeDB; P30843; -. DR BioCyc; EcoCyc:BASR-MONOMER; -. DR PRO; PR:P30843; -. DR Proteomes; UP000000318; Chromosome. DR Proteomes; UP000000625; Chromosome. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central. DR GO; GO:0000156; F:phosphorelay response regulator activity; IDA:EcoCyc. DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central. DR GO; GO:0000160; P:phosphorelay signal transduction system; IDA:EcoCyc. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IMP:EcoCyc. DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. DR GO; GO:0010041; P:response to iron(III) ion; IMP:EcoCyc. DR CDD; cd17624; REC_OmpR_PmrA-like; 1. DR CDD; cd00383; trans_reg_C; 1. DR Gene3D; 3.40.50.2300; -; 1. DR Gene3D; 6.10.250.690; -; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR011006; CheY-like_superfamily. DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd. DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor. DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver. DR InterPro; IPR039420; WalR-like. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR PANTHER; PTHR48111; REGULATOR OF RPOS; 1. DR PANTHER; PTHR48111:SF80; TRANSCRIPTIONAL REGULATORY PROTEIN BASR; 1. DR Pfam; PF00072; Response_reg; 1. DR Pfam; PF00486; Trans_reg_C; 1. DR SMART; SM00448; REC; 1. DR SMART; SM00862; Trans_reg_C; 1. DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1. DR SUPFAM; SSF52172; CheY-like; 1. DR PROSITE; PS51755; OMPR_PHOB; 1. DR PROSITE; PS50110; RESPONSE_REGULATORY; 1. PE 1: Evidence at protein level; KW Activator; Antibiotic resistance; Cytoplasm; DNA-binding; Phosphoprotein; KW Reference proteome; Transcription; Transcription regulation; KW Two-component regulatory system. FT CHAIN 1..222 FT /note="Transcriptional regulatory protein BasR" FT /id="PRO_0000081023" FT DOMAIN 2..116 FT /note="Response regulatory" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169" FT DNA_BIND 124..218 FT /note="OmpR/PhoB-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091" FT MOD_RES 51 FT /note="4-aspartylphosphate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169" FT VARIANT 29 FT /note="S -> G (in strain: ECOR 1, ECOR 10, ECOR 11, ECOR FT 12, ECOR 13, ECOR 14, ECOR 15, ECOR 16, ECOR 17, ECOR 18, FT ECOR 19, ECOR 2, ECOR 20, ECOR 21, ECOR 22, ECOR 24, ECOR FT 25, ECOR 26, ECOR 27, ECOR 3, ECOR 30, ECOR 33, ECOR 34, FT ECOR 35, ECOR 36, ECOR 37, ECOR 38, ECOR 4, ECOR 40, ECOR FT 41, ECOR 42, ECOR 43, ECOR 44, ECOR 45, ECOR 46, ECOR 47, FT ECOR 48, ECOR 5, ECOR 50, ECOR 51, ECOR 52, ECOR 53, ECOR FT 54, ECOR 55, ECOR 56, ECOR 57, ECOR 59, ECOR 6, ECOR 60, FT ECOR 61, ECOR 62, ECOR 63, ECOR 64, ECOR 65, ECOR 66, ECOR FT 67, ECOR 68, ECOR 69, ECOR 7, ECOR 70, ECOR 71, ECOR 72, FT ECOR 8 and ECOR 9)" FT VARIANT 31 FT /note="T -> S (in strain: ECOR 35, ECOR 36, ECOR 38, ECOR FT 40, ECOR 41, ECOR 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, FT ECOR 56, ECOR 57, ECOR 59, ECOR 60, ECOR 61, ECOR 62, ECOR FT 63 and ECOR 64, ECOR 65 and ECOR 66)" FT VARIANT 128 FT /note="I -> N (in strain: ECOR 51, ECOR 52, ECOR 53, ECOR FT 54, ECOR 55, ECOR 56, ECOR 57, ECOR 59, ECOR 60, ECOR 61, FT ECOR 62, ECOR 63 and ECOR 64)" FT VARIANT 129 FT /note="V -> L (in strain: ECOR 19)" FT VARIANT 144 FT /note="G -> S (in strain: ECOR 44, ECOR 48, ECOR 50, ECOR FT 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 57, FT ECOR 59, ECOR 60, ECOR 61, ECOR 62, ECOR 63, ECOR 64 and FT ECOR 72)" FT VARIANT 207 FT /note="R -> P (in strain: ECOR 27)" FT VARIANT 214 FT /note="Y -> F (in strain: ECOR 27)" FT CONFLICT 29 FT /note="S -> T (in Ref. 1)" FT /evidence="ECO:0000305" SQ SEQUENCE 222 AA; 25031 MW; 8588F9F23A1B8625 CRC64; MKILIVEDDT LLLQGLILAA QTEGYACDSV TTARMAEQSL EAGHYSLVVL DLGLPDEDGL HFLARIRQKK YTLPVLILTA RDTLTDKIAG LDVGADDYLV KPFALEELHA RIRALLRRHN NQGESELIVG NLTLNMGRRQ VWMGGEELIL TPKEYALLSR LMLKAGSPVH REILYNDIYN WDNEPSTNTL EVHIHNLRDK VGKARIRTVR GFGYMLVANE EN //