P30842 (CROM_OMMSL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Omega-crystallin
Organism	Ommastrephes sloanei (Arrow squid) (Sloane's squid)
Taxonomic identifier	215440 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Mollusca › Cephalopoda › Coleoidea › Neocoleoidea › Decapodiformes › Teuthida › Oegopsina › Ommastrephidae › Nototodarus

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Omega-crystallins are structural components of squids and octopi eye lens. Contain relatively little if any DHAL activity.
Tissue specificity	Lens.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Molecular function	Eye lens protein
Gene Ontology (GO)
Molecular function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro structural constituent of eye lens Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 495	494	Omega-crystallin		PRO_0000056602

Sequences

	Sequence		Length	Mass (Da)
	P30842 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: C43473A2C4DF67F1	FASTA	495	56,091
	10 20 30 40 50 60 MAGIPPPTRN PEIKHNKIFI NNQFVNSTSN KAYPVYNPCD NEKVCEVQEG DKSDIDKAVQ 70 80 90 100 110 120 ACKAAFKRGT PWRRMDASRL GHLLYRLADL MERDIAYMAS LETMDTGKPY KNSYQDMVHC 130 140 150 160 170 180 IQVLRYFAGW ADKNMGESIP VDGDFFCYTR NEPVGVCGLL IPYNYPMLMM TWKMAPALAC 190 200 210 220 230 240 GNCMIVKPAE QTPLTALYCA SLIKEAGFPP GVVNVVPGFG KICGQYISSH QEINKVSFTG 250 260 270 280 290 300 STEVGMLVMQ DAGKSNLKRC SMQLSGKCPL VVFEDTELDF AVQQAHEAAF QNMGQCRWSG 310 320 330 340 350 360 SRTYVHENIY DEFVKRAVEK ATSRKTGDPY EMDTEHGPQI DEEQYKKIME FIKKGKDKGA 370 380 390 400 410 420 QLKCGGNRHG DKGFYVEPTV FSDVTDEMKF SQEEIFGPVQ LIMKFKDMDE VIDRCNNTDY 430 440 450 460 470 480 GMAAAIFTND INRSITFTHA MYCGTVWVNT YNHWFPQAPF GGYKKSGLYR EMGKYTLQEY 490 TEVKNIVYRI PQKNS

References

[1]	"Aldehyde dehydrogenase-derived omega-crystallins of squid and octopus. Specialization for lens expression." Zinovieva R.D., Tomarev S.I., Piatigorsky J. J. Biol. Chem. 268:11449-11455(1993) [PubMed: 7684383] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L06903 Genomic DNA. Translation: AAA29406.1.
3D structure databases
ProteinModelPortal	P30842.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CROM_OMMSL

Accession

Primary (citable) accession number: P30842

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	January 23, 2007
Last modified:	October 19, 2011
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)