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P30840

- ALDH1_ENTHI

UniProt

P30840 - ALDH1_ENTHI

Protein

Aldehyde dehydrogenase 1

Gene

ALDH1

Organism
Entamoeba histolytica
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei273 – 2731PROSITE-ProRule annotation
    Active sitei307 – 3071PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi251 – 2566NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
    2. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase 1 (EC:1.2.1.3)
    Gene namesi
    Name:ALDH1
    OrganismiEntamoeba histolytica
    Taxonomic identifieri5759 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Aldehyde dehydrogenase 1PRO_0000056432Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP30840.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036492. ALDH. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30840-1 [UniParc]FASTAAdd to Basket

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    MEAYVLSLSD VLFNILFIGV CILSVLLLIS HALKYIIGDS KEKKLFNQRL    50
    EQIKNQQPLE PTKYQDIQTI CKTLKESYST NALRHLDARK EVLYCLYRMV 100
    LDNKQAISNA IREDLHRDVG MCVAEVNSVI HEINFLRKNL NKYLKRKQVP 150
    TVCAQLFGKS FVEREPYGCV CVISPWNFPA NLSLIPCAGA LACGNTVFLK 200
    MSKYSMATSK LIAELCDKYI PSEYLRCEYL TGREAIQECC SASFDYYFFT 250
    GSTYVGKLIN QAAAEKMVPA TLELGGKNPA IVDKSVNLKV AAKRIAWAKS 300
    INAGQICVCV DHVFVPRSIK NEFCEAVKNS FIKFFGEDQK KSEDFGRIIT 350
    KSAAKKMKEI IDQSDVYYGG EVDIENKYVQ PTILQNVKID DLCMKEEIFG 400
    PILPVIEYDT LDEVFEMVKQ HPNPLACYVF TEDNDMFEHV IANINSGAIY 450
    NNDSIVHLLN PNLPFGGNCQ SGIGCYHGKY TFDTFSRPRA VCNGHTSFDL 500
    SLKDWPFTSF QSWAVDRMAA SEIPVVSYL 529
    Length:529
    Mass (Da):59,774
    Last modified:July 1, 1993 - v1
    Checksum:i441DDA2E8DEA0961
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05667 Unassigned DNA. Translation: AAA19741.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05667 Unassigned DNA. Translation: AAA19741.1 .

    3D structure databases

    ProteinModelPortali P30840.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1012.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036492. ALDH. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structures of alcohol and aldehyde dehydrogenase genes of Entamoeba histolytica."
      Samuelson J., Zhang W.W., Kumar A., Descoteaux S., Shen P.S., Bailey G.
      Arch. Med. Res. 23:31-33(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiALDH1_ENTHI
    AccessioniPrimary (citable) accession number: P30840
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3