Reviewed, UniProtKB/Swiss-Prot P30840 (ALDH1_ENTHI)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase 1
    EC=1.2.1.3

Gene names

Name:

ALDH1

Organism

Entamoeba histolytica

Taxonomic identifier

5759 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	Aldehyde dehydrogenase 1		PRO_0000056432
Regions
	Nucleotide binding	251 – 256	6	NAD By similarity
Sites
	Active site	273	1	By similarity
	Active site	307	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30840-1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 441DDA2E8DEA0961	FASTA	529	59,774
	10 20 30 40 50 60 MEAYVLSLSD VLFNILFIGV CILSVLLLIS HALKYIIGDS KEKKLFNQRL EQIKNQQPLE 70 80 90 100 110 120 PTKYQDIQTI CKTLKESYST NALRHLDARK EVLYCLYRMV LDNKQAISNA IREDLHRDVG 130 140 150 160 170 180 MCVAEVNSVI HEINFLRKNL NKYLKRKQVP TVCAQLFGKS FVEREPYGCV CVISPWNFPA 190 200 210 220 230 240 NLSLIPCAGA LACGNTVFLK MSKYSMATSK LIAELCDKYI PSEYLRCEYL TGREAIQECC 250 260 270 280 290 300 SASFDYYFFT GSTYVGKLIN QAAAEKMVPA TLELGGKNPA IVDKSVNLKV AAKRIAWAKS 310 320 330 340 350 360 INAGQICVCV DHVFVPRSIK NEFCEAVKNS FIKFFGEDQK KSEDFGRIIT KSAAKKMKEI 370 380 390 400 410 420 IDQSDVYYGG EVDIENKYVQ PTILQNVKID DLCMKEEIFG PILPVIEYDT LDEVFEMVKQ 430 440 450 460 470 480 HPNPLACYVF TEDNDMFEHV IANINSGAIY NNDSIVHLLN PNLPFGGNCQ SGIGCYHGKY 490 500 510 520 TFDTFSRPRA VCNGHTSFDL SLKDWPFTSF QSWAVDRMAA SEIPVVSYL

References

[1]	"Primary structures of alcohol and aldehyde dehydrogenase genes of Entamoeba histolytica." Samuelson J., Zhang W.W., Kumar A., Descoteaux S., Shen P.S., Bailey G. Arch. Med. Res. 23:31-33(1992) [PubMed: 1340318] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L05667 Unassigned DNA. Translation: AAA19741.1.
3D structure databases
SMR	P30840. Positions 67-501.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.2.1.3. 323.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR012394. Aldehyde_DH_NAD(P). [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF15. ALDH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF036492. ALDH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH1_ENTHI

Accession

Primary (citable) accession number: P30840

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	January 19, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)