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P30840 (ALDH1_ENTHI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase 1

EC=1.2.1.3
Gene names
Name:ALDH1
OrganismEntamoeba histolytica
Taxonomic identifier5759 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Aldehyde dehydrogenase 1
PRO_0000056432

Regions

Nucleotide binding251 – 2566NAD By similarity

Sites

Active site2731 By similarity
Active site3071 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30840 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 441DDA2E8DEA0961

FASTA52959,774
        10         20         30         40         50         60 
MEAYVLSLSD VLFNILFIGV CILSVLLLIS HALKYIIGDS KEKKLFNQRL EQIKNQQPLE 

        70         80         90        100        110        120 
PTKYQDIQTI CKTLKESYST NALRHLDARK EVLYCLYRMV LDNKQAISNA IREDLHRDVG 

       130        140        150        160        170        180 
MCVAEVNSVI HEINFLRKNL NKYLKRKQVP TVCAQLFGKS FVEREPYGCV CVISPWNFPA 

       190        200        210        220        230        240 
NLSLIPCAGA LACGNTVFLK MSKYSMATSK LIAELCDKYI PSEYLRCEYL TGREAIQECC 

       250        260        270        280        290        300 
SASFDYYFFT GSTYVGKLIN QAAAEKMVPA TLELGGKNPA IVDKSVNLKV AAKRIAWAKS 

       310        320        330        340        350        360 
INAGQICVCV DHVFVPRSIK NEFCEAVKNS FIKFFGEDQK KSEDFGRIIT KSAAKKMKEI 

       370        380        390        400        410        420 
IDQSDVYYGG EVDIENKYVQ PTILQNVKID DLCMKEEIFG PILPVIEYDT LDEVFEMVKQ 

       430        440        450        460        470        480 
HPNPLACYVF TEDNDMFEHV IANINSGAIY NNDSIVHLLN PNLPFGGNCQ SGIGCYHGKY 

       490        500        510        520 
TFDTFSRPRA VCNGHTSFDL SLKDWPFTSF QSWAVDRMAA SEIPVVSYL 

« Hide

References

[1]"Primary structures of alcohol and aldehyde dehydrogenase genes of Entamoeba histolytica."
Samuelson J., Zhang W.W., Kumar A., Descoteaux S., Shen P.S., Bailey G.
Arch. Med. Res. 23:31-33(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05667 Unassigned DNA. Translation: AAA19741.1.

3D structure databases

ProteinModelPortalP30840.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1012.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF036492. ALDH. 1 hit.
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH1_ENTHI
AccessionPrimary (citable) accession number: P30840
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families