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Protein

Aldehyde dehydrogenase 1

Gene

ALDH1

Organism
Entamoeba histolytica
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei273 – 2731PROSITE-ProRule annotation
Active sitei307 – 3071PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi251 – 2566NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase 1 (EC:1.2.1.3)
Gene namesi
Name:ALDH1
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Aldehyde dehydrogenase 1PRO_0000056432Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP30840.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAYVLSLSD VLFNILFIGV CILSVLLLIS HALKYIIGDS KEKKLFNQRL
60 70 80 90 100
EQIKNQQPLE PTKYQDIQTI CKTLKESYST NALRHLDARK EVLYCLYRMV
110 120 130 140 150
LDNKQAISNA IREDLHRDVG MCVAEVNSVI HEINFLRKNL NKYLKRKQVP
160 170 180 190 200
TVCAQLFGKS FVEREPYGCV CVISPWNFPA NLSLIPCAGA LACGNTVFLK
210 220 230 240 250
MSKYSMATSK LIAELCDKYI PSEYLRCEYL TGREAIQECC SASFDYYFFT
260 270 280 290 300
GSTYVGKLIN QAAAEKMVPA TLELGGKNPA IVDKSVNLKV AAKRIAWAKS
310 320 330 340 350
INAGQICVCV DHVFVPRSIK NEFCEAVKNS FIKFFGEDQK KSEDFGRIIT
360 370 380 390 400
KSAAKKMKEI IDQSDVYYGG EVDIENKYVQ PTILQNVKID DLCMKEEIFG
410 420 430 440 450
PILPVIEYDT LDEVFEMVKQ HPNPLACYVF TEDNDMFEHV IANINSGAIY
460 470 480 490 500
NNDSIVHLLN PNLPFGGNCQ SGIGCYHGKY TFDTFSRPRA VCNGHTSFDL
510 520
SLKDWPFTSF QSWAVDRMAA SEIPVVSYL
Length:529
Mass (Da):59,774
Last modified:July 1, 1993 - v1
Checksum:i441DDA2E8DEA0961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05667 Unassigned DNA. Translation: AAA19741.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05667 Unassigned DNA. Translation: AAA19741.1.

3D structure databases

ProteinModelPortaliP30840.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG1012.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structures of alcohol and aldehyde dehydrogenase genes of Entamoeba histolytica."
    Samuelson J., Zhang W.W., Kumar A., Descoteaux S., Shen P.S., Bailey G.
    Arch. Med. Res. 23:31-33(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiALDH1_ENTHI
AccessioniPrimary (citable) accession number: P30840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.