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Protein

Fatty aldehyde dehydrogenase

Gene

Aldh3a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:1717467). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (By similarity).By similarity1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei207PROSITE-ProRule annotation1
Active sitei241PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi185 – 190NADSequence analysis6

GO - Molecular functioni

GO - Biological processi

  • formaldehyde metabolic process Source: RGD
  • response to reactive oxygen species Source: RGD

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty aldehyde dehydrogenase (EC:1.2.1.31 Publication)
Alternative name(s):
Aldehyde dehydrogenase 4
Aldehyde dehydrogenase family 3 member A2
Microsomal aldehyde dehydrogenase
Short name:
msALDH
Gene namesi
Name:Aldh3a2
Synonyms:Aldh4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61866 Aldh3a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 463Cytoplasmic1 PublicationAdd BLAST463
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564761 – 484Fatty aldehyde dehydrogenaseAdd BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei293PhosphoserineBy similarity1

Post-translational modificationi

The N-terminus is blocked.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP30839
PRIDEiP30839

PTM databases

CarbonylDBiP30839
iPTMnetiP30839
PhosphoSitePlusiP30839

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP30839, 1 interactor
STRINGi10116.ENSRNOP00000061762

Structurei

3D structure databases

ProteinModelPortaliP30839
SMRiP30839
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi481 – 484Prevents secretion from ERBy similarity4

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2456 Eukaryota
COG1012 LUCA
HOGENOMiHOG000271515
HOVERGENiHBG050483
InParanoidiP30839
KOiK00128
PhylomeDBiP30839

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

P30839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERQVQRLRQ TFRSGRSRPL RFRLQQLEAL RRMVQEREKD ILAAIAADLS
60 70 80 90 100
KSELNAYSHE VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE
110 120 130 140 150
PLGVVLIIGA WNYPFVLTLQ PLVGAIAAGN AAIVKPSELS ENTAKILAEL
160 170 180 190 200
LPQYLDQDLY MIVNGGVEET TELLRQRFDH ILYTGNTAVG KIVMEAAAKH
210 220 230 240 250
LTPVTLELGG KSPCYIDRDC DLDVACRRIT WGKYMNCGQT CIAPDYILCE
260 270 280 290 300
ASSQDQIVQK IKDTVKDFYG ENVKASPDYE RIINLRHFKR IKSLLEGQKI
310 320 330 340 350
AFGGETDEAT RYIAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVEEAIN
360 370 380 390 400
FINDREKPLA LYIFSHNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG
410 420 430 440 450
GVGASGMGAY HGKYSFDTFS HQRPCLLKGL KGESVNKLRY PPNSESKVSW
460 470 480
SKFFLLKQFN KGRLQLLLLV CLVAVAAVIV KDQL
Length:484
Mass (Da):54,082
Last modified:July 1, 1993 - v1
Checksum:i9F50CB34AB64C31D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73714 mRNA Translation: AAA41555.1
PIRiA41028
RefSeqiNP_113919.2, NM_031731.2
UniGeneiRn.9113

Genome annotation databases

GeneIDi65183
KEGGirno:65183
UCSCiRGD:61866 rat

Similar proteinsi

Entry informationi

Entry nameiAL3A2_RAT
AccessioniPrimary (citable) accession number: P30839
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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