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P30839

- AL3A2_RAT

UniProt

P30839 - AL3A2_RAT

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Protein

Fatty aldehyde dehydrogenase

Gene
Aldh3a2, Aldh4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid By similarity.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei207 – 2071 By similarity
Active sitei241 – 2411 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi185 – 1906NAD Reviewed prediction

GO - Molecular functioni

  1. 3-chloroallyl aldehyde dehydrogenase activity Source: RGD
  2. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
  3. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

GO - Biological processi

  1. formaldehyde metabolic process Source: RGD
  2. response to reactive oxygen species Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty aldehyde dehydrogenase (EC:1.2.1.3)
Alternative name(s):
Aldehyde dehydrogenase 4
Aldehyde dehydrogenase family 3 member A2
Microsomal aldehyde dehydrogenase
Short name:
msALDH
Gene namesi
Name:Aldh3a2
Synonyms:Aldh4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi61866. Aldh3a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 463463CytoplasmicAdd
BLAST
Transmembranei464 – 48017Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytosol Source: RGD
  2. endoplasmic reticulum Source: HGNC
  3. extrinsic component of endoplasmic reticulum membrane Source: RGD
  4. integral component of membrane Source: UniProtKB-KW
  5. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Fatty aldehyde dehydrogenasePRO_0000056476Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PaxDbiP30839.
PRIDEiP30839.

Expressioni

Gene expression databases

GenevestigatoriP30839.

Interactioni

Protein-protein interaction databases

IntActiP30839. 1 interaction.
MINTiMINT-4564816.
STRINGi10116.ENSRNOP00000045886.

Structurei

3D structure databases

ProteinModelPortaliP30839.
SMRiP30839. Positions 5-443.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi481 – 4844Prevents secretion from ER By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
KOiK00128.
PhylomeDBiP30839.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30839-1 [UniParc]FASTAAdd to Basket

« Hide

MERQVQRLRQ TFRSGRSRPL RFRLQQLEAL RRMVQEREKD ILAAIAADLS    50
KSELNAYSHE VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE 100
PLGVVLIIGA WNYPFVLTLQ PLVGAIAAGN AAIVKPSELS ENTAKILAEL 150
LPQYLDQDLY MIVNGGVEET TELLRQRFDH ILYTGNTAVG KIVMEAAAKH 200
LTPVTLELGG KSPCYIDRDC DLDVACRRIT WGKYMNCGQT CIAPDYILCE 250
ASSQDQIVQK IKDTVKDFYG ENVKASPDYE RIINLRHFKR IKSLLEGQKI 300
AFGGETDEAT RYIAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVEEAIN 350
FINDREKPLA LYIFSHNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG 400
GVGASGMGAY HGKYSFDTFS HQRPCLLKGL KGESVNKLRY PPNSESKVSW 450
SKFFLLKQFN KGRLQLLLLV CLVAVAAVIV KDQL 484
Length:484
Mass (Da):54,082
Last modified:July 1, 1993 - v1
Checksum:i9F50CB34AB64C31D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73714 mRNA. Translation: AAA41555.1.
PIRiA41028.
RefSeqiNP_113919.2. NM_031731.2.
UniGeneiRn.9113.

Genome annotation databases

GeneIDi65183.
KEGGirno:65183.
UCSCiRGD:61866. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73714 mRNA. Translation: AAA41555.1 .
PIRi A41028.
RefSeqi NP_113919.2. NM_031731.2.
UniGenei Rn.9113.

3D structure databases

ProteinModelPortali P30839.
SMRi P30839. Positions 5-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30839. 1 interaction.
MINTi MINT-4564816.
STRINGi 10116.ENSRNOP00000045886.

Proteomic databases

PaxDbi P30839.
PRIDEi P30839.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 65183.
KEGGi rno:65183.
UCSCi RGD:61866. rat.

Organism-specific databases

CTDi 224.
RGDi 61866. Aldh3a2.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271515.
HOVERGENi HBG050483.
KOi K00128.
PhylomeDBi P30839.

Miscellaneous databases

NextBioi 614089.
PROi P30839.

Gene expression databases

Genevestigatori P30839.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF036492. ALDH. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, sequencing, and expression of cDNA for rat liver microsomal aldehyde dehydrogenase."
    Miyauchi K., Masaki R., Taketani S., Yamamoto A., Akayama M., Tashiro Y.
    J. Biol. Chem. 266:19536-19542(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 93-110; 236-255 AND 408-427.
    Tissue: Liver.

Entry informationi

Entry nameiAL3A2_RAT
AccessioniPrimary (citable) accession number: P30839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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