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P30839

- AL3A2_RAT

UniProt

P30839 - AL3A2_RAT

Protein

Fatty aldehyde dehydrogenase

Gene

Aldh3a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid By similarity.By similarity

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei207 – 2071By similarity
    Active sitei241 – 2411By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi185 – 1906NADSequence Analysis

    GO - Molecular functioni

    1. 3-chloroallyl aldehyde dehydrogenase activity Source: RGD
    2. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
    3. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

    GO - Biological processi

    1. formaldehyde metabolic process Source: RGD
    2. response to reactive oxygen species Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty aldehyde dehydrogenase (EC:1.2.1.3)
    Alternative name(s):
    Aldehyde dehydrogenase 4
    Aldehyde dehydrogenase family 3 member A2
    Microsomal aldehyde dehydrogenase
    Short name:
    msALDH
    Gene namesi
    Name:Aldh3a2
    Synonyms:Aldh4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi61866. Aldh3a2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. endoplasmic reticulum Source: HGNC
    3. extrinsic component of endoplasmic reticulum membrane Source: RGD
    4. integral component of membrane Source: UniProtKB-KW
    5. nucleus Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Fatty aldehyde dehydrogenasePRO_0000056476Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.

    Proteomic databases

    PaxDbiP30839.
    PRIDEiP30839.

    Expressioni

    Gene expression databases

    GenevestigatoriP30839.

    Interactioni

    Protein-protein interaction databases

    IntActiP30839. 1 interaction.
    MINTiMINT-4564816.
    STRINGi10116.ENSRNOP00000045886.

    Structurei

    3D structure databases

    ProteinModelPortaliP30839.
    SMRiP30839. Positions 5-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 463463CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei464 – 48017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi481 – 4844Prevents secretion from ERBy similarity

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271515.
    HOVERGENiHBG050483.
    KOiK00128.
    PhylomeDBiP30839.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036492. ALDH. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30839-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERQVQRLRQ TFRSGRSRPL RFRLQQLEAL RRMVQEREKD ILAAIAADLS    50
    KSELNAYSHE VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE 100
    PLGVVLIIGA WNYPFVLTLQ PLVGAIAAGN AAIVKPSELS ENTAKILAEL 150
    LPQYLDQDLY MIVNGGVEET TELLRQRFDH ILYTGNTAVG KIVMEAAAKH 200
    LTPVTLELGG KSPCYIDRDC DLDVACRRIT WGKYMNCGQT CIAPDYILCE 250
    ASSQDQIVQK IKDTVKDFYG ENVKASPDYE RIINLRHFKR IKSLLEGQKI 300
    AFGGETDEAT RYIAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVEEAIN 350
    FINDREKPLA LYIFSHNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG 400
    GVGASGMGAY HGKYSFDTFS HQRPCLLKGL KGESVNKLRY PPNSESKVSW 450
    SKFFLLKQFN KGRLQLLLLV CLVAVAAVIV KDQL 484
    Length:484
    Mass (Da):54,082
    Last modified:July 1, 1993 - v1
    Checksum:i9F50CB34AB64C31D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73714 mRNA. Translation: AAA41555.1.
    PIRiA41028.
    RefSeqiNP_113919.2. NM_031731.2.
    UniGeneiRn.9113.

    Genome annotation databases

    GeneIDi65183.
    KEGGirno:65183.
    UCSCiRGD:61866. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73714 mRNA. Translation: AAA41555.1 .
    PIRi A41028.
    RefSeqi NP_113919.2. NM_031731.2.
    UniGenei Rn.9113.

    3D structure databases

    ProteinModelPortali P30839.
    SMRi P30839. Positions 5-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P30839. 1 interaction.
    MINTi MINT-4564816.
    STRINGi 10116.ENSRNOP00000045886.

    Proteomic databases

    PaxDbi P30839.
    PRIDEi P30839.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 65183.
    KEGGi rno:65183.
    UCSCi RGD:61866. rat.

    Organism-specific databases

    CTDi 224.
    RGDi 61866. Aldh3a2.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271515.
    HOVERGENi HBG050483.
    KOi K00128.
    PhylomeDBi P30839.

    Miscellaneous databases

    NextBioi 614089.
    PROi P30839.

    Gene expression databases

    Genevestigatori P30839.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036492. ALDH. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, sequencing, and expression of cDNA for rat liver microsomal aldehyde dehydrogenase."
      Miyauchi K., Masaki R., Taketani S., Yamamoto A., Akayama M., Tashiro Y.
      J. Biol. Chem. 266:19536-19542(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 93-110; 236-255 AND 408-427.
      Tissue: Liver.

    Entry informationi

    Entry nameiAL3A2_RAT
    AccessioniPrimary (citable) accession number: P30839
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3