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P30839 (AL3A2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty aldehyde dehydrogenase

EC=1.2.1.3
Alternative name(s):
Aldehyde dehydrogenase 4
Aldehyde dehydrogenase family 3 member A2
Microsomal aldehyde dehydrogenase
Short name=msALDH
Gene names
Name:Aldh3a2
Synonyms:Aldh4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid By similarity.

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Fatty aldehyde dehydrogenase
PRO_0000056476

Regions

Topological domain1 – 463463Cytoplasmic
Transmembrane464 – 48017Helical; Potential
Nucleotide binding185 – 1906NAD Potential
Motif481 – 4844Prevents secretion from ER By similarity

Sites

Active site2071 By similarity
Active site2411 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30839 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 9F50CB34AB64C31D

FASTA48454,082
        10         20         30         40         50         60 
MERQVQRLRQ TFRSGRSRPL RFRLQQLEAL RRMVQEREKD ILAAIAADLS KSELNAYSHE 

        70         80         90        100        110        120 
VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE PLGVVLIIGA WNYPFVLTLQ 

       130        140        150        160        170        180 
PLVGAIAAGN AAIVKPSELS ENTAKILAEL LPQYLDQDLY MIVNGGVEET TELLRQRFDH 

       190        200        210        220        230        240 
ILYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDRDC DLDVACRRIT WGKYMNCGQT 

       250        260        270        280        290        300 
CIAPDYILCE ASSQDQIVQK IKDTVKDFYG ENVKASPDYE RIINLRHFKR IKSLLEGQKI 

       310        320        330        340        350        360 
AFGGETDEAT RYIAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVEEAIN FINDREKPLA 

       370        380        390        400        410        420 
LYIFSHNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG GVGASGMGAY HGKYSFDTFS 

       430        440        450        460        470        480 
HQRPCLLKGL KGESVNKLRY PPNSESKVSW SKFFLLKQFN KGRLQLLLLV CLVAVAAVIV 


KDQL 

« Hide

References

[1]"Molecular cloning, sequencing, and expression of cDNA for rat liver microsomal aldehyde dehydrogenase."
Miyauchi K., Masaki R., Taketani S., Yamamoto A., Akayama M., Tashiro Y.
J. Biol. Chem. 266:19536-19542(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 93-110; 236-255 AND 408-427.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73714 mRNA. Translation: AAA41555.1.
PIRA41028.
RefSeqNP_113919.2. NM_031731.2.
UniGeneRn.9113.

3D structure databases

ProteinModelPortalP30839.
SMRP30839. Positions 5-443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP30839. 1 interaction.
MINTMINT-4564816.
STRING10116.ENSRNOP00000045886.

Proteomic databases

PaxDbP30839.
PRIDEP30839.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID65183.
KEGGrno:65183.
UCSCRGD:61866. rat.

Organism-specific databases

CTD224.
RGD61866. Aldh3a2.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271515.
HOVERGENHBG050483.
KOK00128.
PhylomeDBP30839.

Gene expression databases

GenevestigatorP30839.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PANTHERPTHR11699:SF15. PTHR11699:SF15. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF036492. ALDH. 1 hit.
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614089.
PROP30839.

Entry information

Entry nameAL3A2_RAT
AccessionPrimary (citable) accession number: P30839
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families