Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-selectin

Gene

Sell

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • glycolipid binding Source: RGD

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • positive regulation of neutrophil chemotaxis Source: RGD
  • regulation of apoptotic process Source: RGD
  • response to hyperoxia Source: RGD
  • response to linoleic acid Source: RGD
  • response to oleic acid Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectin
Alternative name(s):
CD62 antigen-like family member L
Leukocyte adhesion molecule 1
Short name:
LAM-1
Leukocyte-endothelial cell adhesion molecule 1
Short name:
LECAM1
Lymph node homing receptor
Lymphocyte antigen 22
Short name:
Ly-22
Lymphocyte surface MEL-14 antigen
CD_antigen: CD62L
Gene namesi
Name:Sell
Synonyms:Lnhr, Ly-22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3655. Sell.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 332294ExtracellularSequence analysisAdd
BLAST
Transmembranei333 – 35523HelicalSequence analysisAdd
BLAST
Topological domaini356 – 37217CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Propeptidei29 – 3810By similarityPRO_0000017487
Chaini39 – 372334L-selectinPRO_0000017488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 155By similarity
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi128 ↔ 147By similarity
Disulfide bondi160 ↔ 171By similarity
Disulfide bondi165 ↔ 180By similarity
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi182 ↔ 191By similarity
Disulfide bondi197 ↔ 241By similarity
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence analysis
Disulfide bondi227 ↔ 254By similarity
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence analysis
Disulfide bondi259 ↔ 303By similarity
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence analysis
Disulfide bondi289 ↔ 316By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30836.
PRIDEiP30836.

PTM databases

SwissPalmiP30836.

Expressioni

Tissue specificityi

Expressed in peripheral blood mononuclear cells (PBMC), spleen and thymus.1 Publication

Inductioni

Down-regulated by mitogen stimulation of PBMC and spleen T-cells.1 Publication

Interactioni

Subunit structurei

Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003733.

Structurei

3D structure databases

ProteinModelPortaliP30836.
SMRiP30836. Positions 39-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 155101C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini156 – 19237EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini195 – 25662Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini257 – 31862Sushi 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3T. Eukaryota.
ENOG410YB82. LUCA.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP30836.
PhylomeDBiP30836.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFPWRCQSA QRGSWSFLKL WIRTLLCCDL LPHHGTHCWT YHYSERSMNW
60 70 80 90 100
ENARKFCKHN YTDLVAIQNK REIEYLEKTL PKNPTYYWIG IRKIGKTWTW
110 120 130 140 150
VGTNKTLTKE AENWGTGEPN NKKSKEDCVE IYIKRERDSG KWNDDACHKR
160 170 180 190 200
KAALCYTASC QPESCNRHGE CVETINNNTC ICDPGYYGPQ CQYVIQCEPL
210 220 230 240 250
KAPELGTMNC IHPLGDFSFQ SQCAFNCSEG SELLGNAKTE CGASGNWTYL
260 270 280 290 300
EPICQVIQCM PLAAPDLGTM ECSHPLANFS FTSACTFTCS EETDLIGERK
310 320 330 340 350
TVCRSSGSWS SPSPICQKTK RSFSKIKEGD YNPLFIPVAV MVTAFSGLAF
360 370
IIWLARRLKK GKKSQERMDD PY
Length:372
Mass (Da):42,441
Last modified:July 1, 1993 - v1
Checksum:i3B88AE0F1E4D191A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10831 mRNA. Translation: BAA01613.1.
PIRiS23936.
UniGeneiRn.10461.

Genome annotation databases

UCSCiRGD:3655. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10831 mRNA. Translation: BAA01613.1.
PIRiS23936.
UniGeneiRn.10461.

3D structure databases

ProteinModelPortaliP30836.
SMRiP30836. Positions 39-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003733.

PTM databases

SwissPalmiP30836.

Proteomic databases

PaxDbiP30836.
PRIDEiP30836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3655. rat.

Organism-specific databases

RGDi3655. Sell.

Phylogenomic databases

eggNOGiENOG410IS3T. Eukaryota.
ENOG410YB82. LUCA.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP30836.
PhylomeDBiP30836.

Miscellaneous databases

PROiP30836.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLYAM1_RAT
AccessioniPrimary (citable) accession number: P30836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.