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Protein

High affinity cationic amino acid transporter 1

Gene

SLC7A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAmino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.3.3.9 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cationic amino acid transporter 1
Short name:
CAT-11 Publication
Short name:
CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor homolog
Ecotropic retrovirus receptor homolog
Solute carrier family 7 member 1Imported
System Y+ basic amino acid transporter
Gene namesi
Name:SLC7A1Imported
Synonyms:ATRC11 Publication, ERRImported, REC1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139514.12
HGNCiHGNC:11057 SLC7A1
MIMi104615 gene
neXtProtiNX_P30825

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 57HelicalSequence analysisAdd BLAST22
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 102CytoplasmicSequence analysisAdd BLAST20
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 162ExtracellularSequence analysisAdd BLAST39
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 246ExtracellularSequence analysisAdd BLAST34
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 287CytoplasmicSequence analysisAdd BLAST20
Transmembranei288 – 307HelicalSequence analysisAdd BLAST20
Topological domaini308 – 337ExtracellularSequence analysisAdd BLAST30
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 384CytoplasmicSequence analysisAdd BLAST26
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 408ExtracellularSequence analysis3
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Topological domaini430 – 492CytoplasmicSequence analysisAdd BLAST63
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 526ExtracellularSequence analysisAdd BLAST13
Transmembranei527 – 551HelicalSequence analysisAdd BLAST25
Topological domaini552 – 559CytoplasmicSequence analysis8
Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
Topological domaini581 – 584ExtracellularSequence analysis4
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Topological domaini606 – 629CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6541
OpenTargetsiENSG00000139514
PharmGKBiPA35917

Chemistry databases

DrugBankiDB00125 L-Arginine
DB00123 L-Lysine
DB00129 L-Ornithine

Polymorphism and mutation databases

BioMutaiSLC7A1
DMDMi1706185

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542611 – 629High affinity cationic amino acid transporter 1Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi216N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi226N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP30825
MaxQBiP30825
PaxDbiP30825
PeptideAtlasiP30825
PRIDEiP30825

PTM databases

iPTMnetiP30825
PhosphoSitePlusiP30825
SwissPalmiP30825

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000139514
CleanExiHS_SLC7A1
ExpressionAtlasiP30825 baseline and differential
GenevisibleiP30825 HS

Organism-specific databases

HPAiHPA039721

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F05EBI-4289564,EBI-743099

Protein-protein interaction databases

BioGridi112432, 66 interactors
IntActiP30825, 10 interactors
STRINGi9606.ENSP00000370128

Structurei

3D structure databases

ProteinModelPortaliP30825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119151
HOGENOMiHOG000250623
HOVERGENiHBG000280
InParanoidiP30825
KOiK13863
OMAiTIKWIVT
OrthoDBiEOG091G05NM
PhylomeDBiP30825
TreeFamiTF315212

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR004755 Cat_AA_permease
IPR029485 CAT_C
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00906 2A0303, 1 hit

Sequencei

Sequence statusi: Complete.

P30825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY
110 120 130 140 150
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GRPIGEFSRT
160 170 180 190 200
HMTLNAPGVL AENPDIFAVI IILILTGLLT LGVKESAMVN KIFTCINVLV
210 220 230 240 250
LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG KPGVGGFMPF
260 270 280 290 300
GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA
310 320 330 340 350
YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS
360 370 380 390 400
LLGSMFPMPR VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA
410 420 430 440 450
FLFDLKDLVD LMSIGTLLAY SLVAACVLVL RYQPEQPNLV YQMASTSDEL
460 470 480 490 500
DPADQNELAS TNDSQLGFLP EAEMFSLKTI LSPKNMEPSK ISGLIVNIST
510 520 530 540 550
SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA VVTGVIWRQP
560 570 580 590 600
ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY
610 620
FGYGLWHSEE ASLDADQART PDGNLDQCK
Length:629
Mass (Da):67,638
Last modified:October 1, 1996 - v1
Checksum:i717734D4793647C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23R → P in CAA40560 (PubMed:1348489).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59155 mRNA Translation: CAA41869.1
X57303 mRNA Translation: CAA40560.1
AF078107 mRNA Translation: AAC27721.1
AL596114 Genomic DNA No translation available.
BC063303 mRNA Translation: AAH63303.1
BC069358 mRNA Translation: AAH69358.1
BC115407 mRNA Translation: AAI15408.1
CCDSiCCDS9333.1
PIRiS29685
RefSeqiNP_003036.1, NM_003045.4
XP_005266564.1, XM_005266507.3
XP_016876205.1, XM_017020716.1
UniGeneiHs.14846

Genome annotation databases

EnsembliENST00000380752; ENSP00000370128; ENSG00000139514
GeneIDi6541
KEGGihsa:6541
UCSCiuc001uso.4 human

Similar proteinsi

Entry informationi

Entry nameiCTR1_HUMAN
AccessioniPrimary (citable) accession number: P30825
Secondary accession number(s): Q5JR50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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