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P30825

- CTR1_HUMAN

UniProt

P30825 - CTR1_HUMAN

Protein

High affinity cationic amino acid transporter 1

Gene

SLC7A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.

    GO - Molecular functioni

    1. arginine transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. amino acid transport Source: Reactome
    2. ion transport Source: Reactome
    3. transmembrane transport Source: Reactome
    4. transport Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.3.3.9. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High affinity cationic amino acid transporter 1
    Short name:
    CAT-1
    Short name:
    CAT1
    Alternative name(s):
    Ecotropic retroviral leukemia receptor homolog
    Ecotropic retrovirus receptor homolog
    Short name:
    ERR
    Solute carrier family 7 member 1
    System Y+ basic amino acid transporter
    Gene namesi
    Name:SLC7A1
    Synonyms:ATRC1, ERR, REC1L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:11057. SLC7A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35917.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 629629High affinity cationic amino acid transporter 1PRO_0000054261Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi216 – 2161N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi226 – 2261N-linked (GlcNAc...)1 Publication
    Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP30825.
    PaxDbiP30825.
    PeptideAtlasiP30825.
    PRIDEiP30825.

    PTM databases

    PhosphoSiteiP30825.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiP30825.
    BgeeiP30825.
    CleanExiHS_SLC7A1.
    GenevestigatoriP30825.

    Organism-specific databases

    HPAiHPA039721.

    Interactioni

    Protein-protein interaction databases

    BioGridi112432. 4 interactions.
    IntActiP30825. 1 interaction.
    MINTiMINT-3012079.
    STRINGi9606.ENSP00000370128.

    Structurei

    3D structure databases

    ProteinModelPortaliP30825.
    SMRiP30825. Positions 43-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 614ExtracellularSequence Analysis
    Topological domaini83 – 10220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 16239ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 1918CytoplasmicSequence Analysis
    Topological domaini213 – 24634ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini268 – 28720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 33730ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini359 – 38426CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini406 – 4083ExtracellularSequence Analysis
    Topological domaini430 – 49263CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini514 – 52613ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini552 – 5598CytoplasmicSequence Analysis
    Topological domaini581 – 5844ExtracellularSequence Analysis
    Topological domaini606 – 62924CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei409 – 42921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei493 – 51321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei527 – 55125HelicalSequence AnalysisAdd
    BLAST
    Transmembranei560 – 58021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei585 – 60521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    HOGENOMiHOG000250623.
    HOVERGENiHBG000280.
    InParanoidiP30825.
    KOiK13863.
    OMAiRMIAGAH.
    OrthoDBiEOG72C501.
    PhylomeDBiP30825.
    TreeFamiTF315212.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsiTIGR00906. 2A0303. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P30825-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV    50
    YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY 100
    SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GRPIGEFSRT 150
    HMTLNAPGVL AENPDIFAVI IILILTGLLT LGVKESAMVN KIFTCINVLV 200
    LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG KPGVGGFMPF 250
    GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA 300
    YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS 350
    LLGSMFPMPR VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA 400
    FLFDLKDLVD LMSIGTLLAY SLVAACVLVL RYQPEQPNLV YQMASTSDEL 450
    DPADQNELAS TNDSQLGFLP EAEMFSLKTI LSPKNMEPSK ISGLIVNIST 500
    SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA VVTGVIWRQP 550
    ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY 600
    FGYGLWHSEE ASLDADQART PDGNLDQCK 629
    Length:629
    Mass (Da):67,638
    Last modified:October 1, 1996 - v1
    Checksum:i717734D4793647C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231R → P in CAA40560. (PubMed:1348489)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59155 mRNA. Translation: CAA41869.1.
    X57303 mRNA. Translation: CAA40560.1.
    AF078107 mRNA. Translation: AAC27721.1.
    AL596114 Genomic DNA. Translation: CAI39913.1.
    BC063303 mRNA. Translation: AAH63303.1.
    BC069358 mRNA. Translation: AAH69358.1.
    BC115407 mRNA. Translation: AAI15408.1.
    CCDSiCCDS9333.1.
    PIRiS29685.
    RefSeqiNP_003036.1. NM_003045.4.
    XP_005266564.1. XM_005266507.1.
    UniGeneiHs.14846.

    Genome annotation databases

    EnsembliENST00000380752; ENSP00000370128; ENSG00000139514.
    GeneIDi6541.
    KEGGihsa:6541.
    UCSCiuc001uso.3. human.

    Polymorphism databases

    DMDMi1706185.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59155 mRNA. Translation: CAA41869.1 .
    X57303 mRNA. Translation: CAA40560.1 .
    AF078107 mRNA. Translation: AAC27721.1 .
    AL596114 Genomic DNA. Translation: CAI39913.1 .
    BC063303 mRNA. Translation: AAH63303.1 .
    BC069358 mRNA. Translation: AAH69358.1 .
    BC115407 mRNA. Translation: AAI15408.1 .
    CCDSi CCDS9333.1.
    PIRi S29685.
    RefSeqi NP_003036.1. NM_003045.4.
    XP_005266564.1. XM_005266507.1.
    UniGenei Hs.14846.

    3D structure databases

    ProteinModelPortali P30825.
    SMRi P30825. Positions 43-430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112432. 4 interactions.
    IntActi P30825. 1 interaction.
    MINTi MINT-3012079.
    STRINGi 9606.ENSP00000370128.

    Chemistry

    DrugBanki DB00125. L-Arginine.
    DB00123. L-Lysine.
    DB00129. L-Ornithine.

    Protein family/group databases

    TCDBi 2.A.3.3.9. the amino acid-polyamine-organocation (apc) family.

    PTM databases

    PhosphoSitei P30825.

    Polymorphism databases

    DMDMi 1706185.

    Proteomic databases

    MaxQBi P30825.
    PaxDbi P30825.
    PeptideAtlasi P30825.
    PRIDEi P30825.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380752 ; ENSP00000370128 ; ENSG00000139514 .
    GeneIDi 6541.
    KEGGi hsa:6541.
    UCSCi uc001uso.3. human.

    Organism-specific databases

    CTDi 6541.
    GeneCardsi GC13M030083.
    HGNCi HGNC:11057. SLC7A1.
    HPAi HPA039721.
    MIMi 104615. gene.
    neXtProti NX_P30825.
    PharmGKBi PA35917.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0531.
    HOGENOMi HOG000250623.
    HOVERGENi HBG000280.
    InParanoidi P30825.
    KOi K13863.
    OMAi RMIAGAH.
    OrthoDBi EOG72C501.
    PhylomeDBi P30825.
    TreeFami TF315212.

    Enzyme and pathway databases

    Reactomei REACT_13796. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    ChiTaRSi SLC7A1. human.
    GeneWikii SLC7A1.
    GenomeRNAii 6541.
    NextBioi 25451.
    PROi P30825.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30825.
    Bgeei P30825.
    CleanExi HS_SLC7A1.
    Genevestigatori P30825.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsi TIGR00906. 2A0303. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor."
      Yoshimoto T., Yoshimoto E., Meruelo D.
      Virology 185:10-17(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14."
      Albritton L.M., Bowcock A.M., Eddy R.L., Morton C.C., Tseng L., Farrer L.A., Cavalli-Sforza L.L., Shows T.B., Cunningham J.M.
      Genomics 12:430-434(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Urinary bladder.
    3. "Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1."
      Kamath S.G., Furesz T.C., Way B.A., Smith C.H.
      J. Membr. Biol. 171:55-62(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    6. Bienvenut W.V.
      Submitted (JUN-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 5-15; 131-142 AND 361-373, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-216 AND ASN-226.
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiCTR1_HUMAN
    AccessioniPrimary (citable) accession number: P30825
    Secondary accession number(s): Q5JR50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3