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P30825 (CTR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High affinity cationic amino acid transporter 1

Short name=CAT-1
Short name=CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor homolog
Ecotropic retrovirus receptor homolog
Short name=ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter
Gene names
Name:SLC7A1
Synonyms:ATRC1, ERR, REC1L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length629 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 629629High affinity cationic amino acid transporter 1
PRO_0000054261

Regions

Topological domain1 – 3535Cytoplasmic Potential
Transmembrane36 – 5722Helical; Potential
Topological domain58 – 614Extracellular Potential
Transmembrane62 – 8221Helical; Potential
Topological domain83 – 10220Cytoplasmic Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 16239Extracellular Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 1918Cytoplasmic Potential
Transmembrane192 – 21221Helical; Potential
Topological domain213 – 24634Extracellular Potential
Transmembrane247 – 26721Helical; Potential
Topological domain268 – 28720Cytoplasmic Potential
Transmembrane288 – 30720Helical; Potential
Topological domain308 – 33730Extracellular Potential
Transmembrane338 – 35821Helical; Potential
Topological domain359 – 38426Cytoplasmic Potential
Transmembrane385 – 40521Helical; Potential
Topological domain406 – 4083Extracellular Potential
Transmembrane409 – 42921Helical; Potential
Topological domain430 – 49263Cytoplasmic Potential
Transmembrane493 – 51321Helical; Potential
Topological domain514 – 52613Extracellular Potential
Transmembrane527 – 55125Helical; Potential
Topological domain552 – 5598Cytoplasmic Potential
Transmembrane560 – 58021Helical; Potential
Topological domain581 – 5844Extracellular Potential
Transmembrane585 – 60521Helical; Potential
Topological domain606 – 62924Cytoplasmic Potential

Amino acid modifications

Glycosylation2161N-linked (GlcNAc...); atypical Ref.7
Glycosylation2261N-linked (GlcNAc...) Ref.7
Glycosylation2351N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict231R → P in CAA40560. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P30825 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 717734D4793647C5

FASTA62967,638
        10         20         30         40         50         60 
MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV YVLAGAVARE 

        70         80         90        100        110        120 
NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS 

       130        140        150        160        170        180 
YIIGTSSVAR AWSATFDELI GRPIGEFSRT HMTLNAPGVL AENPDIFAVI IILILTGLLT 

       190        200        210        220        230        240 
LGVKESAMVN KIFTCINVLV LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG 

       250        260        270        280        290        300 
KPGVGGFMPF GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA 

       310        320        330        340        350        360 
YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS LLGSMFPMPR 

       370        380        390        400        410        420 
VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA FLFDLKDLVD LMSIGTLLAY 

       430        440        450        460        470        480 
SLVAACVLVL RYQPEQPNLV YQMASTSDEL DPADQNELAS TNDSQLGFLP EAEMFSLKTI 

       490        500        510        520        530        540 
LSPKNMEPSK ISGLIVNIST SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA 

       550        560        570        580        590        600 
VVTGVIWRQP ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY 

       610        620 
FGYGLWHSEE ASLDADQART PDGNLDQCK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor."
Yoshimoto T., Yoshimoto E., Meruelo D.
Virology 185:10-17(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14."
Albritton L.M., Bowcock A.M., Eddy R.L., Morton C.C., Tseng L., Farrer L.A., Cavalli-Sforza L.L., Shows T.B., Cunningham J.M.
Genomics 12:430-434(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Urinary bladder.
[3]"Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1."
Kamath S.G., Furesz T.C., Way B.A., Smith C.H.
J. Membr. Biol. 171:55-62(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[4]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[6]Bienvenut W.V.
Submitted (JUN-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 5-15; 131-142 AND 361-373, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
[7]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-216 AND ASN-226.
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59155 mRNA. Translation: CAA41869.1.
X57303 mRNA. Translation: CAA40560.1.
AF078107 mRNA. Translation: AAC27721.1.
AL596114 Genomic DNA. Translation: CAI39913.1.
BC063303 mRNA. Translation: AAH63303.1.
BC069358 mRNA. Translation: AAH69358.1.
BC115407 mRNA. Translation: AAI15408.1.
PIRS29685.
RefSeqNP_003036.1. NM_003045.4.
XP_005266564.1. XM_005266507.1.
UniGeneHs.14846.

3D structure databases

ProteinModelPortalP30825.
SMRP30825. Positions 43-430.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112432. 4 interactions.
IntActP30825. 1 interaction.
MINTMINT-3012079.
STRING9606.ENSP00000370128.

Chemistry

DrugBankDB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Protein family/group databases

TCDB2.A.3.3.9. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteP30825.

Polymorphism databases

DMDM1706185.

Proteomic databases

PaxDbP30825.
PeptideAtlasP30825.
PRIDEP30825.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380752; ENSP00000370128; ENSG00000139514.
GeneID6541.
KEGGhsa:6541.
UCSCuc001uso.3. human.

Organism-specific databases

CTD6541.
GeneCardsGC13M030083.
HGNCHGNC:11057. SLC7A1.
HPAHPA039721.
MIM104615. gene.
neXtProtNX_P30825.
PharmGKBPA35917.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0531.
HOGENOMHOG000250623.
HOVERGENHBG000280.
InParanoidP30825.
KOK13863.
OMARMIAGAH.
OrthoDBEOG72C501.
PhylomeDBP30825.
TreeFamTF315212.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.

Gene expression databases

ArrayExpressP30825.
BgeeP30825.
CleanExHS_SLC7A1.
GenevestigatorP30825.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00906. 2A0303. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC7A1. human.
GeneWikiSLC7A1.
GenomeRNAi6541.
NextBio25451.
PROP30825.
SOURCESearch...

Entry information

Entry nameCTR1_HUMAN
AccessionPrimary (citable) accession number: P30825
Secondary accession number(s): Q5JR50
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM