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P30825

- CTR1_HUMAN

UniProt

P30825 - CTR1_HUMAN

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Protein

High affinity cationic amino acid transporter 1

Gene

SLC7A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.1 Publication

GO - Molecular functioni

  1. arginine transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. ion transport Source: Reactome
  3. transmembrane transport Source: Reactome
  4. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.3.9. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cationic amino acid transporter 1
Short name:
CAT-1
Short name:
CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor homolog
Ecotropic retrovirus receptor homolog
Short name:
ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter
Gene namesi
Name:SLC7A1
Synonyms:ATRC1, ERR, REC1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:11057. SLC7A1.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei36 – 5722HelicalSequence AnalysisAdd
BLAST
Topological domaini58 – 614ExtracellularSequence Analysis
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 10220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 16239ExtracellularSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Topological domaini184 – 1918CytoplasmicSequence Analysis
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST
Topological domaini213 – 24634ExtracellularSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Topological domaini268 – 28720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei288 – 30720HelicalSequence AnalysisAdd
BLAST
Topological domaini308 – 33730ExtracellularSequence AnalysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence AnalysisAdd
BLAST
Topological domaini359 – 38426CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence AnalysisAdd
BLAST
Topological domaini406 – 4083ExtracellularSequence Analysis
Transmembranei409 – 42921HelicalSequence AnalysisAdd
BLAST
Topological domaini430 – 49263CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei493 – 51321HelicalSequence AnalysisAdd
BLAST
Topological domaini514 – 52613ExtracellularSequence AnalysisAdd
BLAST
Transmembranei527 – 55125HelicalSequence AnalysisAdd
BLAST
Topological domaini552 – 5598CytoplasmicSequence Analysis
Transmembranei560 – 58021HelicalSequence AnalysisAdd
BLAST
Topological domaini581 – 5844ExtracellularSequence Analysis
Transmembranei585 – 60521HelicalSequence AnalysisAdd
BLAST
Topological domaini606 – 62924CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35917.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 629629High affinity cationic amino acid transporter 1PRO_0000054261Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi216 – 2161N-linked (GlcNAc...); atypical1 Publication
Glycosylationi226 – 2261N-linked (GlcNAc...)1 Publication
Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP30825.
PaxDbiP30825.
PeptideAtlasiP30825.
PRIDEiP30825.

PTM databases

PhosphoSiteiP30825.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiP30825.
CleanExiHS_SLC7A1.
ExpressionAtlasiP30825. baseline and differential.
GenevestigatoriP30825.

Organism-specific databases

HPAiHPA039721.

Interactioni

Protein-protein interaction databases

BioGridi112432. 4 interactions.
IntActiP30825. 1 interaction.
MINTiMINT-3012079.
STRINGi9606.ENSP00000370128.

Structurei

3D structure databases

ProteinModelPortaliP30825.
SMRiP30825. Positions 43-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP30825.
KOiK13863.
OMAiRMIAGAH.
OrthoDBiEOG72C501.
PhylomeDBiP30825.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

P30825-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY
110 120 130 140 150
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GRPIGEFSRT
160 170 180 190 200
HMTLNAPGVL AENPDIFAVI IILILTGLLT LGVKESAMVN KIFTCINVLV
210 220 230 240 250
LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG KPGVGGFMPF
260 270 280 290 300
GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA
310 320 330 340 350
YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS
360 370 380 390 400
LLGSMFPMPR VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA
410 420 430 440 450
FLFDLKDLVD LMSIGTLLAY SLVAACVLVL RYQPEQPNLV YQMASTSDEL
460 470 480 490 500
DPADQNELAS TNDSQLGFLP EAEMFSLKTI LSPKNMEPSK ISGLIVNIST
510 520 530 540 550
SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA VVTGVIWRQP
560 570 580 590 600
ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY
610 620
FGYGLWHSEE ASLDADQART PDGNLDQCK
Length:629
Mass (Da):67,638
Last modified:October 1, 1996 - v1
Checksum:i717734D4793647C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231R → P in CAA40560. (PubMed:1348489)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59155 mRNA. Translation: CAA41869.1.
X57303 mRNA. Translation: CAA40560.1.
AF078107 mRNA. Translation: AAC27721.1.
AL596114 Genomic DNA. Translation: CAI39913.1.
BC063303 mRNA. Translation: AAH63303.1.
BC069358 mRNA. Translation: AAH69358.1.
BC115407 mRNA. Translation: AAI15408.1.
CCDSiCCDS9333.1.
PIRiS29685.
RefSeqiNP_003036.1. NM_003045.4.
XP_005266564.1. XM_005266507.1.
UniGeneiHs.14846.

Genome annotation databases

EnsembliENST00000380752; ENSP00000370128; ENSG00000139514.
GeneIDi6541.
KEGGihsa:6541.
UCSCiuc001uso.3. human.

Polymorphism databases

DMDMi1706185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59155 mRNA. Translation: CAA41869.1 .
X57303 mRNA. Translation: CAA40560.1 .
AF078107 mRNA. Translation: AAC27721.1 .
AL596114 Genomic DNA. Translation: CAI39913.1 .
BC063303 mRNA. Translation: AAH63303.1 .
BC069358 mRNA. Translation: AAH69358.1 .
BC115407 mRNA. Translation: AAI15408.1 .
CCDSi CCDS9333.1.
PIRi S29685.
RefSeqi NP_003036.1. NM_003045.4.
XP_005266564.1. XM_005266507.1.
UniGenei Hs.14846.

3D structure databases

ProteinModelPortali P30825.
SMRi P30825. Positions 43-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112432. 4 interactions.
IntActi P30825. 1 interaction.
MINTi MINT-3012079.
STRINGi 9606.ENSP00000370128.

Chemistry

DrugBanki DB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Protein family/group databases

TCDBi 2.A.3.3.9. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSitei P30825.

Polymorphism databases

DMDMi 1706185.

Proteomic databases

MaxQBi P30825.
PaxDbi P30825.
PeptideAtlasi P30825.
PRIDEi P30825.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380752 ; ENSP00000370128 ; ENSG00000139514 .
GeneIDi 6541.
KEGGi hsa:6541.
UCSCi uc001uso.3. human.

Organism-specific databases

CTDi 6541.
GeneCardsi GC13M030083.
HGNCi HGNC:11057. SLC7A1.
HPAi HPA039721.
MIMi 104615. gene.
neXtProti NX_P30825.
PharmGKBi PA35917.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00760000119151.
HOGENOMi HOG000250623.
HOVERGENi HBG000280.
InParanoidi P30825.
KOi K13863.
OMAi RMIAGAH.
OrthoDBi EOG72C501.
PhylomeDBi P30825.
TreeFami TF315212.

Enzyme and pathway databases

Reactomei REACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSi SLC7A1. human.
GeneWikii SLC7A1.
GenomeRNAii 6541.
NextBioi 25451.
PROi P30825.
SOURCEi Search...

Gene expression databases

Bgeei P30825.
CleanExi HS_SLC7A1.
ExpressionAtlasi P30825. baseline and differential.
Genevestigatori P30825.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
TIGRFAMsi TIGR00906. 2A0303. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor."
    Yoshimoto T., Yoshimoto E., Meruelo D.
    Virology 185:10-17(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14."
    Albritton L.M., Bowcock A.M., Eddy R.L., Morton C.C., Tseng L., Farrer L.A., Cavalli-Sforza L.L., Shows T.B., Cunningham J.M.
    Genomics 12:430-434(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Urinary bladder.
  3. "Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1."
    Kamath S.G., Furesz T.C., Way B.A., Smith C.H.
    J. Membr. Biol. 171:55-62(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Placenta.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. Bienvenut W.V.
    Submitted (JUN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 5-15; 131-142 AND 361-373, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-216 AND ASN-226.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCTR1_HUMAN
AccessioniPrimary (citable) accession number: P30825
Secondary accession number(s): Q5JR50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3