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Protein

High affinity cationic amino acid transporter 1

Gene

SLC7A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.1 Publication

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: Reactome
  • arginine transport Source: Ensembl
  • L-ornithine transmembrane transport Source: GO_Central
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139514-MONOMER.
ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.3.9. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cationic amino acid transporter 1
Short name:
CAT-1
Short name:
CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor homolog
Ecotropic retrovirus receptor homolog
Short name:
ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter
Gene namesi
Name:SLC7A1
Synonyms:ATRC1, ERR, REC1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:11057. SLC7A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 57HelicalSequence analysisAdd BLAST22
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 102CytoplasmicSequence analysisAdd BLAST20
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 162ExtracellularSequence analysisAdd BLAST39
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 246ExtracellularSequence analysisAdd BLAST34
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 287CytoplasmicSequence analysisAdd BLAST20
Transmembranei288 – 307HelicalSequence analysisAdd BLAST20
Topological domaini308 – 337ExtracellularSequence analysisAdd BLAST30
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 384CytoplasmicSequence analysisAdd BLAST26
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 408ExtracellularSequence analysis3
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Topological domaini430 – 492CytoplasmicSequence analysisAdd BLAST63
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 526ExtracellularSequence analysisAdd BLAST13
Transmembranei527 – 551HelicalSequence analysisAdd BLAST25
Topological domaini552 – 559CytoplasmicSequence analysis8
Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
Topological domaini581 – 584ExtracellularSequence analysis4
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Topological domaini606 – 629CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6541.
OpenTargetsiENSG00000139514.
PharmGKBiPA35917.

Chemistry databases

DrugBankiDB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Polymorphism and mutation databases

BioMutaiSLC7A1.
DMDMi1706185.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542611 – 629High affinity cationic amino acid transporter 1Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi216N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi226N-linked (GlcNAc...)1 Publication1
Glycosylationi235N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP30825.
MaxQBiP30825.
PaxDbiP30825.
PeptideAtlasiP30825.
PRIDEiP30825.

PTM databases

iPTMnetiP30825.
PhosphoSitePlusiP30825.
SwissPalmiP30825.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000139514.
CleanExiHS_SLC7A1.
ExpressionAtlasiP30825. baseline and differential.
GenevisibleiP30825. HS.

Organism-specific databases

HPAiHPA039721.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F05EBI-4289564,EBI-743099

Protein-protein interaction databases

BioGridi112432. 59 interactors.
IntActiP30825. 6 interactors.
MINTiMINT-3012079.
STRINGi9606.ENSP00000370128.

Structurei

3D structure databases

ProteinModelPortaliP30825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP30825.
KOiK13863.
OMAiLAMIICP.
OrthoDBiEOG091G05NM.
PhylomeDBiP30825.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

P30825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY
110 120 130 140 150
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GRPIGEFSRT
160 170 180 190 200
HMTLNAPGVL AENPDIFAVI IILILTGLLT LGVKESAMVN KIFTCINVLV
210 220 230 240 250
LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG KPGVGGFMPF
260 270 280 290 300
GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA
310 320 330 340 350
YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS
360 370 380 390 400
LLGSMFPMPR VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA
410 420 430 440 450
FLFDLKDLVD LMSIGTLLAY SLVAACVLVL RYQPEQPNLV YQMASTSDEL
460 470 480 490 500
DPADQNELAS TNDSQLGFLP EAEMFSLKTI LSPKNMEPSK ISGLIVNIST
510 520 530 540 550
SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA VVTGVIWRQP
560 570 580 590 600
ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY
610 620
FGYGLWHSEE ASLDADQART PDGNLDQCK
Length:629
Mass (Da):67,638
Last modified:October 1, 1996 - v1
Checksum:i717734D4793647C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23R → P in CAA40560 (PubMed:1348489).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59155 mRNA. Translation: CAA41869.1.
X57303 mRNA. Translation: CAA40560.1.
AF078107 mRNA. Translation: AAC27721.1.
AL596114 Genomic DNA. Translation: CAI39913.1.
BC063303 mRNA. Translation: AAH63303.1.
BC069358 mRNA. Translation: AAH69358.1.
BC115407 mRNA. Translation: AAI15408.1.
CCDSiCCDS9333.1.
PIRiS29685.
RefSeqiNP_003036.1. NM_003045.4.
XP_005266564.1. XM_005266507.3.
XP_016876205.1. XM_017020716.1.
UniGeneiHs.14846.

Genome annotation databases

EnsembliENST00000380752; ENSP00000370128; ENSG00000139514.
GeneIDi6541.
KEGGihsa:6541.
UCSCiuc001uso.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59155 mRNA. Translation: CAA41869.1.
X57303 mRNA. Translation: CAA40560.1.
AF078107 mRNA. Translation: AAC27721.1.
AL596114 Genomic DNA. Translation: CAI39913.1.
BC063303 mRNA. Translation: AAH63303.1.
BC069358 mRNA. Translation: AAH69358.1.
BC115407 mRNA. Translation: AAI15408.1.
CCDSiCCDS9333.1.
PIRiS29685.
RefSeqiNP_003036.1. NM_003045.4.
XP_005266564.1. XM_005266507.3.
XP_016876205.1. XM_017020716.1.
UniGeneiHs.14846.

3D structure databases

ProteinModelPortaliP30825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112432. 59 interactors.
IntActiP30825. 6 interactors.
MINTiMINT-3012079.
STRINGi9606.ENSP00000370128.

Chemistry databases

DrugBankiDB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Protein family/group databases

TCDBi2.A.3.3.9. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiP30825.
PhosphoSitePlusiP30825.
SwissPalmiP30825.

Polymorphism and mutation databases

BioMutaiSLC7A1.
DMDMi1706185.

Proteomic databases

EPDiP30825.
MaxQBiP30825.
PaxDbiP30825.
PeptideAtlasiP30825.
PRIDEiP30825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380752; ENSP00000370128; ENSG00000139514.
GeneIDi6541.
KEGGihsa:6541.
UCSCiuc001uso.4. human.

Organism-specific databases

CTDi6541.
DisGeNETi6541.
GeneCardsiSLC7A1.
HGNCiHGNC:11057. SLC7A1.
HPAiHPA039721.
MIMi104615. gene.
neXtProtiNX_P30825.
OpenTargetsiENSG00000139514.
PharmGKBiPA35917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP30825.
KOiK13863.
OMAiLAMIICP.
OrthoDBiEOG091G05NM.
PhylomeDBiP30825.
TreeFamiTF315212.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139514-MONOMER.
ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSLC7A1. human.
GeneWikiiSLC7A1.
GenomeRNAii6541.
PROiP30825.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139514.
CleanExiHS_SLC7A1.
ExpressionAtlasiP30825. baseline and differential.
GenevisibleiP30825. HS.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCTR1_HUMAN
AccessioniPrimary (citable) accession number: P30825
Secondary accession number(s): Q5JR50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.