P30825 (CTR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
High affinity cationic amino acid transporter 1
Short name=CAT-1
Short name=CAT1

Alternative name(s):
Ecotropic retroviral leukemia receptor homolog
Ecotropic retrovirus receptor homolog
Short name=ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter

Gene names

Name:	SLC7A1
Synonyms:	ATRC1, ERR, REC1L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	629 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	amino acid transport Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	arginine transmembrane transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 629	629	High affinity cationic amino acid transporter 1		PRO_0000054261
Regions
	Topological domain	1 – 35	35	Cytoplasmic Potential
	Transmembrane	36 – 57	22	Helical; Potential
	Topological domain	58 – 61	4	Extracellular Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Topological domain	83 – 102	20	Cytoplasmic Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Topological domain	124 – 162	39	Extracellular Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Topological domain	184 – 191	8	Cytoplasmic Potential
	Transmembrane	192 – 212	21	Helical; Potential
	Topological domain	213 – 246	34	Extracellular Potential
	Transmembrane	247 – 267	21	Helical; Potential
	Topological domain	268 – 287	20	Cytoplasmic Potential
	Transmembrane	288 – 307	20	Helical; Potential
	Topological domain	308 – 337	30	Extracellular Potential
	Transmembrane	338 – 358	21	Helical; Potential
	Topological domain	359 – 384	26	Cytoplasmic Potential
	Transmembrane	385 – 405	21	Helical; Potential
	Topological domain	406 – 408	3	Extracellular Potential
	Transmembrane	409 – 429	21	Helical; Potential
	Topological domain	430 – 492	63	Cytoplasmic Potential
	Transmembrane	493 – 513	21	Helical; Potential
	Topological domain	514 – 526	13	Extracellular Potential
	Transmembrane	527 – 551	25	Helical; Potential
	Topological domain	552 – 559	8	Cytoplasmic Potential
	Transmembrane	560 – 580	21	Helical; Potential
	Topological domain	581 – 584	4	Extracellular Potential
	Transmembrane	585 – 605	21	Helical; Potential
	Topological domain	606 – 629	24	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	216	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	226	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	235	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	23	1	R → P in CAA40560. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P30825 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 717734D4793647C5	FASTA	629	67,638
	10 20 30 40 50 60 MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV YVLAGAVARE 70 80 90 100 110 120 NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS 130 140 150 160 170 180 YIIGTSSVAR AWSATFDELI GRPIGEFSRT HMTLNAPGVL AENPDIFAVI IILILTGLLT 190 200 210 220 230 240 LGVKESAMVN KIFTCINVLV LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG 250 260 270 280 290 300 KPGVGGFMPF GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA 310 320 330 340 350 360 YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS LLGSMFPMPR 370 380 390 400 410 420 VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA FLFDLKDLVD LMSIGTLLAY 430 440 450 460 470 480 SLVAACVLVL RYQPEQPNLV YQMASTSDEL DPADQNELAS TNDSQLGFLP EAEMFSLKTI 490 500 510 520 530 540 LSPKNMEPSK ISGLIVNIST SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA 550 560 570 580 590 600 VVTGVIWRQP ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY 610 620 FGYGLWHSEE ASLDADQART PDGNLDQCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor." Yoshimoto T., Yoshimoto E., Meruelo D. Virology 185:10-17(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14." Albritton L.M., Bowcock A.M., Eddy R.L., Morton C.C., Tseng L., Farrer L.A., Cavalli-Sforza L.L., Shows T.B., Cunningham J.M. Genomics 12:430-434(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Urinary bladder.
[3]	"Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1." Kamath S.G., Furesz T.C., Way B.A., Smith C.H. J. Membr. Biol. 171:55-62(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[6]	Bienvenut W.V. Submitted (JUN-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 5-15; 131-142 AND 361-373, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
[7]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-216 AND ASN-226, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X59155 mRNA. Translation: CAA41869.1. X57303 mRNA. Translation: CAA40560.1. AF078107 mRNA. Translation: AAC27721.1. AL596114 Genomic DNA. Translation: CAI39913.1. BC063303 mRNA. Translation: AAH63303.1. BC069358 mRNA. Translation: AAH69358.1. BC115407 mRNA. Translation: AAI15408.1.
IPI	IPI00027728.
PIR	S29685.
RefSeq	NP_003036.1. NM_003045.4.
UniGene	Hs.14846.
3D structure databases
ProteinModelPortal	P30825.
ModBase	Search...
Protein-protein interaction databases
IntAct	P30825. 1 interaction.
MINT	MINT-3012079.
STRING	9606.ENSP00000370128.
PTM databases
PhosphoSite	P30825.
Polymorphism databases
DMDM	1706185.
Proteomic databases
PaxDb	P30825.
PeptideAtlas	P30825.
PRIDE	P30825.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380752; ENSP00000370128; ENSG00000139514.
GeneID	6541.
KEGG	hsa:6541.
UCSC	uc001uso.3. human.
Organism-specific databases
CTD	6541.
GeneCards	GC13M030083.
HGNC	HGNC:11057. SLC7A1.
HPA	HPA039721.
MIM	104615. gene.
neXtProt	NX_P30825.
PharmGKB	PA35917.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0531.
HOGENOM	HOG000250623.
HOVERGEN	HBG000280.
InParanoid	P30825.
KO	K13863.
OMA	VKNWQLT.
OrthoDB	EOG40VVP6.
PhylomeDB	P30825.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_19419. Amino acid and oligopeptide SLC transporters.
Gene expression databases
ArrayExpress	P30825.
Bgee	P30825.
CleanEx	HS_SLC7A1.
Genevestigator	P30825.
GermOnline	ENSG00000139514. Homo sapiens.
Family and domain databases
InterPro	IPR002293. AA/rel_permease1. IPR015606. Cat-AATrans. IPR004755. Cat_AA_permease. [Graphical view]
PANTHER	PTHR11785. PTHR11785. 1 hit. PTHR11785:SF53. PTHR11785:SF53. 1 hit.
PIRSF	PIRSF006060. AA_transporter. 1 hit.
TIGRFAMs	TIGR00906. 2A0303. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	SLC7A1. human.
DrugBank	DB00125. L-Arginine. DB00123. L-Lysine. DB00129. L-Ornithine.
GenomeRNAi	6541.
NextBio	25451.
SOURCE	Search...

Entry information

Entry name

CTR1_HUMAN

Accession

Primary (citable) accession number: P30825
Secondary accession number(s): Q5JR50

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.