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P30823 (CTR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High affinity cationic amino acid transporter 1

Short name=CAT-1
Short name=CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor
Ecotropic retrovirus receptor
Short name=ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter
Gene names
Name:Slc7a1
Synonyms:Atrc1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length624 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 624624High affinity cationic amino acid transporter 1
PRO_0000054263

Regions

Topological domain1 – 3535Cytoplasmic Potential
Transmembrane36 – 5722Helical; Potential
Topological domain58 – 614Extracellular Potential
Transmembrane62 – 8221Helical; Potential
Topological domain83 – 10220Cytoplasmic Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 16239Extracellular Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 1918Cytoplasmic Potential
Transmembrane192 – 21221Helical; Potential
Topological domain213 – 24129Extracellular Potential
Transmembrane242 – 26221Helical; Potential
Topological domain263 – 28220Cytoplasmic Potential
Transmembrane283 – 30220Helical; Potential
Topological domain303 – 33230Extracellular Potential
Transmembrane333 – 35321Helical; Potential
Topological domain354 – 37926Cytoplasmic Potential
Transmembrane380 – 40021Helical; Potential
Topological domain401 – 4033Extracellular Potential
Transmembrane404 – 42421Helical; Potential
Topological domain425 – 48763Cytoplasmic Potential
Transmembrane488 – 50821Helical; Potential
Topological domain509 – 52113Extracellular Potential
Transmembrane522 – 54625Helical; Potential
Topological domain547 – 5548Cytoplasmic Potential
Transmembrane555 – 57521Helical; Potential
Topological domain576 – 5794Extracellular Potential
Transmembrane580 – 60021Helical; Potential
Topological domain601 – 62424Cytoplasmic Potential

Amino acid modifications

Glycosylation2221N-linked (GlcNAc...) Potential
Glycosylation2311N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1111F → L in L10152. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P30823 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 33339B2F74E5F052

FASTA62467,267
        10         20         30         40         50         60 
MGCKNLLSLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV YVLAGAVARE 

        70         80         90        100        110        120 
NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS 

       130        140        150        160        170        180 
YIIGTSSVAR AWSATFDELI GKPIGEFSRQ HMALNAPGVL AQTPDIFAVI IIIILTGLLT 

       190        200        210        220        230        240 
LGVKESAMVN KIFTCINVLV LCFIMVSGFV KGSIENWQLT ENKSSPLCGN NDTNVKYGEG 

       250        260        270        280        290        300 
GFMPFGFSGV LSGAATCFYA FVGFDCIATT GEEVKNPQKA IPVGIVASLL ICFIAYFGVS 

       310        320        330        340        350        360 
AALTLMMPYF CLDTDSPLPG AFKYRGWEEA KYAVAVGSLC ALSTSPLGSM FPMPRVIYAM 

       370        380        390        400        410        420 
AEDGLLFKFL AKINDRTKTP IIATVTSGAI AAVMAFLFEL KDLVDLMSIG TLLAYSLVAA 

       430        440        450        460        470        480 
CVLVLRYQPE QPNLVYQMAR TTDELDQVDQ NEMVSASESQ TGFLPAAEKF SLKTILSPKN 

       490        500        510        520        530        540 
MEPSKFSGLI VNISAGLLAV LIITVCIVAV LGREALAEGT LWAVFVMTGS VLLCMLVTGI 

       550        560        570        580        590        600 
IWRQPESKTK LSFKVPFVPV LPVLSIFVNI YLMMQLDQGT WVRFAVWMLI AFAIYFGYGV 

       610        620 
WHSEEASLAA GQAKTPDSNL DQCK 

« Hide

References

[1]Takase-Yoden S., Watanabe R.
Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of the cationic amino acid transporter (system y+) of the rat blood-brain barrier."
Stoll J., Wadhwani K.C., Smith Q.R.
J. Neurochem. 60:1956-1959(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-288.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D67087 mRNA. Translation: BAA11090.1.
L10152 mRNA. No translation available.
RefSeqNP_037243.1. NM_013111.2.
UniGeneRn.9439.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP30823.

Proteomic databases

PaxDbP30823.
PRIDEP30823.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25648.
KEGGrno:25648.
UCSCRGD:3716. rat.

Organism-specific databases

CTD6541.
RGD3716. Slc7a1.

Phylogenomic databases

eggNOGCOG0531.
HOGENOMHOG000250623.
HOVERGENHBG000280.
InParanoidP30823.
KOK13863.
PhylomeDBP30823.

Gene expression databases

GenevestigatorP30823.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00906. 2A0303. 1 hit.
ProtoNetSearch...

Other

NextBio607511.

Entry information

Entry nameCTR1_RAT
AccessionPrimary (citable) accession number: P30823
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families