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Protein

High affinity cationic amino acid transporter 1

Gene

Slc7a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.By similarity

GO - Molecular functioni

  1. arginine transmembrane transporter activity Source: RGD
  2. basic amino acid transmembrane transporter activity Source: RGD

GO - Biological processi

  1. arginine transport Source: RGD
  2. basic amino acid transport Source: RGD
  3. regulation of TOR signaling Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cationic amino acid transporter 1
Short name:
CAT-1
Short name:
CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor
Ecotropic retrovirus receptor
Short name:
ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter
Gene namesi
Name:Slc7a1
Synonyms:Atrc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3716. Slc7a1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei36 – 5722HelicalSequence AnalysisAdd
BLAST
Topological domaini58 – 614ExtracellularSequence Analysis
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 10220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 16239ExtracellularSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Topological domaini184 – 1918CytoplasmicSequence Analysis
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST
Topological domaini213 – 24129ExtracellularSequence AnalysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence AnalysisAdd
BLAST
Topological domaini263 – 28220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei283 – 30220HelicalSequence AnalysisAdd
BLAST
Topological domaini303 – 33230ExtracellularSequence AnalysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence AnalysisAdd
BLAST
Topological domaini354 – 37926CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence AnalysisAdd
BLAST
Topological domaini401 – 4033ExtracellularSequence Analysis
Transmembranei404 – 42421HelicalSequence AnalysisAdd
BLAST
Topological domaini425 – 48763CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei488 – 50821HelicalSequence AnalysisAdd
BLAST
Topological domaini509 – 52113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei522 – 54625HelicalSequence AnalysisAdd
BLAST
Topological domaini547 – 5548CytoplasmicSequence Analysis
Transmembranei555 – 57521HelicalSequence AnalysisAdd
BLAST
Topological domaini576 – 5794ExtracellularSequence Analysis
Transmembranei580 – 60021HelicalSequence AnalysisAdd
BLAST
Topological domaini601 – 62424CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 624624High affinity cationic amino acid transporter 1PRO_0000054263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP30823.
PRIDEiP30823.

PTM databases

PhosphoSiteiP30823.

Expressioni

Gene expression databases

GenevestigatoriP30823.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP30823.
PhylomeDBiP30823.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

P30823-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCKNLLSLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY
110 120 130 140 150
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GKPIGEFSRQ
160 170 180 190 200
HMALNAPGVL AQTPDIFAVI IIIILTGLLT LGVKESAMVN KIFTCINVLV
210 220 230 240 250
LCFIMVSGFV KGSIENWQLT ENKSSPLCGN NDTNVKYGEG GFMPFGFSGV
260 270 280 290 300
LSGAATCFYA FVGFDCIATT GEEVKNPQKA IPVGIVASLL ICFIAYFGVS
310 320 330 340 350
AALTLMMPYF CLDTDSPLPG AFKYRGWEEA KYAVAVGSLC ALSTSPLGSM
360 370 380 390 400
FPMPRVIYAM AEDGLLFKFL AKINDRTKTP IIATVTSGAI AAVMAFLFEL
410 420 430 440 450
KDLVDLMSIG TLLAYSLVAA CVLVLRYQPE QPNLVYQMAR TTDELDQVDQ
460 470 480 490 500
NEMVSASESQ TGFLPAAEKF SLKTILSPKN MEPSKFSGLI VNISAGLLAV
510 520 530 540 550
LIITVCIVAV LGREALAEGT LWAVFVMTGS VLLCMLVTGI IWRQPESKTK
560 570 580 590 600
LSFKVPFVPV LPVLSIFVNI YLMMQLDQGT WVRFAVWMLI AFAIYFGYGV
610 620
WHSEEASLAA GQAKTPDSNL DQCK
Length:624
Mass (Da):67,267
Last modified:October 1, 1996 - v1
Checksum:i33339B2F74E5F052
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111F → L in L10152. (PubMed:8473910)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67087 mRNA. Translation: BAA11090.1.
L10152 mRNA. No translation available.
UniGeneiRn.9439.

Genome annotation databases

UCSCiRGD:3716. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67087 mRNA. Translation: BAA11090.1.
L10152 mRNA. No translation available.
UniGeneiRn.9439.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP30823.

Proteomic databases

PaxDbiP30823.
PRIDEiP30823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3716. rat.

Organism-specific databases

RGDi3716. Slc7a1.

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP30823.
PhylomeDBiP30823.

Miscellaneous databases

NextBioi607511.

Gene expression databases

GenevestigatoriP30823.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Takase-Yoden S., Watanabe R.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of the cationic amino acid transporter (system y+) of the rat blood-brain barrier."
    Stoll J., Wadhwani K.C., Smith Q.R.
    J. Neurochem. 60:1956-1959(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-288.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCTR1_RAT
AccessioniPrimary (citable) accession number: P30823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 4, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.