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Protein

High affinity cationic amino acid transporter 1

Gene

Slc7a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.By similarity

GO - Molecular functioni

GO - Biological processi

  • arginine transport Source: RGD
  • basic amino acid transport Source: RGD
  • L-ornithine transmembrane transport Source: GO_Central
  • regulation of TOR signaling Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cationic amino acid transporter 1
Short name:
CAT-1
Short name:
CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor
Ecotropic retrovirus receptor
Short name:
ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter
Gene namesi
Name:Slc7a1
Synonyms:Atrc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3716. Slc7a1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 57HelicalSequence analysisAdd BLAST22
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 102CytoplasmicSequence analysisAdd BLAST20
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 162ExtracellularSequence analysisAdd BLAST39
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 241ExtracellularSequence analysisAdd BLAST29
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 282CytoplasmicSequence analysisAdd BLAST20
Transmembranei283 – 302HelicalSequence analysisAdd BLAST20
Topological domaini303 – 332ExtracellularSequence analysisAdd BLAST30
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354 – 379CytoplasmicSequence analysisAdd BLAST26
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 403ExtracellularSequence analysis3
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 487CytoplasmicSequence analysisAdd BLAST63
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 521ExtracellularSequence analysisAdd BLAST13
Transmembranei522 – 546HelicalSequence analysisAdd BLAST25
Topological domaini547 – 554CytoplasmicSequence analysis8
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21
Topological domaini576 – 579ExtracellularSequence analysis4
Transmembranei580 – 600HelicalSequence analysisAdd BLAST21
Topological domaini601 – 624CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542631 – 624High affinity cationic amino acid transporter 1Add BLAST624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1
Modified residuei618PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP30823.
PRIDEiP30823.

PTM databases

PhosphoSitePlusiP30823.
SwissPalmiP30823.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001234.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP30823.
PhylomeDBiP30823.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 4 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

P30823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCKNLLSLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY
110 120 130 140 150
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GKPIGEFSRQ
160 170 180 190 200
HMALNAPGVL AQTPDIFAVI IIIILTGLLT LGVKESAMVN KIFTCINVLV
210 220 230 240 250
LCFIMVSGFV KGSIENWQLT ENKSSPLCGN NDTNVKYGEG GFMPFGFSGV
260 270 280 290 300
LSGAATCFYA FVGFDCIATT GEEVKNPQKA IPVGIVASLL ICFIAYFGVS
310 320 330 340 350
AALTLMMPYF CLDTDSPLPG AFKYRGWEEA KYAVAVGSLC ALSTSPLGSM
360 370 380 390 400
FPMPRVIYAM AEDGLLFKFL AKINDRTKTP IIATVTSGAI AAVMAFLFEL
410 420 430 440 450
KDLVDLMSIG TLLAYSLVAA CVLVLRYQPE QPNLVYQMAR TTDELDQVDQ
460 470 480 490 500
NEMVSASESQ TGFLPAAEKF SLKTILSPKN MEPSKFSGLI VNISAGLLAV
510 520 530 540 550
LIITVCIVAV LGREALAEGT LWAVFVMTGS VLLCMLVTGI IWRQPESKTK
560 570 580 590 600
LSFKVPFVPV LPVLSIFVNI YLMMQLDQGT WVRFAVWMLI AFAIYFGYGV
610 620
WHSEEASLAA GQAKTPDSNL DQCK
Length:624
Mass (Da):67,267
Last modified:October 1, 1996 - v1
Checksum:i33339B2F74E5F052
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111F → L in L10152 (PubMed:8473910).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67087 mRNA. Translation: BAA11090.1.
L10152 mRNA. No translation available.
UniGeneiRn.9439.

Genome annotation databases

UCSCiRGD:3716. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67087 mRNA. Translation: BAA11090.1.
L10152 mRNA. No translation available.
UniGeneiRn.9439.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001234.

PTM databases

PhosphoSitePlusiP30823.
SwissPalmiP30823.

Proteomic databases

PaxDbiP30823.
PRIDEiP30823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3716. rat.

Organism-specific databases

RGDi3716. Slc7a1.

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP30823.
PhylomeDBiP30823.

Miscellaneous databases

PROiP30823.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 4 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCTR1_RAT
AccessioniPrimary (citable) accession number: P30823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.