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P30823

- CTR1_RAT

UniProt

P30823 - CTR1_RAT

Protein

High affinity cationic amino acid transporter 1

Gene

Slc7a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.

    GO - Molecular functioni

    1. arginine transmembrane transporter activity Source: RGD

    GO - Biological processi

    1. arginine transport Source: RGD
    2. basic amino acid transport Source: RGD
    3. regulation of TOR signaling Source: RGD

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Amino-acid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High affinity cationic amino acid transporter 1
    Short name:
    CAT-1
    Short name:
    CAT1
    Alternative name(s):
    Ecotropic retroviral leukemia receptor
    Ecotropic retrovirus receptor
    Short name:
    ERR
    Solute carrier family 7 member 1
    System Y+ basic amino acid transporter
    Gene namesi
    Name:Slc7a1
    Synonyms:Atrc1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3716. Slc7a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 624624High affinity cationic amino acid transporter 1PRO_0000054263Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP30823.
    PRIDEiP30823.

    PTM databases

    PhosphoSiteiP30823.

    Expressioni

    Gene expression databases

    GenevestigatoriP30823.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 614ExtracellularSequence Analysis
    Topological domaini83 – 10220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 16239ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 1918CytoplasmicSequence Analysis
    Topological domaini213 – 24129ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini263 – 28220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini303 – 33230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini354 – 37926CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini401 – 4033ExtracellularSequence Analysis
    Topological domaini425 – 48763CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini509 – 52113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini547 – 5548CytoplasmicSequence Analysis
    Topological domaini576 – 5794ExtracellularSequence Analysis
    Topological domaini601 – 62424CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei283 – 30220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei404 – 42421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei488 – 50821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei522 – 54625HelicalSequence AnalysisAdd
    BLAST
    Transmembranei555 – 57521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei580 – 60021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    HOGENOMiHOG000250623.
    HOVERGENiHBG000280.
    InParanoidiP30823.
    KOiK13863.
    PhylomeDBiP30823.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsiTIGR00906. 2A0303. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P30823-1 [UniParc]FASTAAdd to Basket

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    MGCKNLLSLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV    50
    YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY 100
    SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GKPIGEFSRQ 150
    HMALNAPGVL AQTPDIFAVI IIIILTGLLT LGVKESAMVN KIFTCINVLV 200
    LCFIMVSGFV KGSIENWQLT ENKSSPLCGN NDTNVKYGEG GFMPFGFSGV 250
    LSGAATCFYA FVGFDCIATT GEEVKNPQKA IPVGIVASLL ICFIAYFGVS 300
    AALTLMMPYF CLDTDSPLPG AFKYRGWEEA KYAVAVGSLC ALSTSPLGSM 350
    FPMPRVIYAM AEDGLLFKFL AKINDRTKTP IIATVTSGAI AAVMAFLFEL 400
    KDLVDLMSIG TLLAYSLVAA CVLVLRYQPE QPNLVYQMAR TTDELDQVDQ 450
    NEMVSASESQ TGFLPAAEKF SLKTILSPKN MEPSKFSGLI VNISAGLLAV 500
    LIITVCIVAV LGREALAEGT LWAVFVMTGS VLLCMLVTGI IWRQPESKTK 550
    LSFKVPFVPV LPVLSIFVNI YLMMQLDQGT WVRFAVWMLI AFAIYFGYGV 600
    WHSEEASLAA GQAKTPDSNL DQCK 624
    Length:624
    Mass (Da):67,267
    Last modified:October 1, 1996 - v1
    Checksum:i33339B2F74E5F052
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti111 – 1111F → L in L10152. (PubMed:8473910)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D67087 mRNA. Translation: BAA11090.1.
    L10152 mRNA. No translation available.
    RefSeqiNP_037243.1. NM_013111.2.
    UniGeneiRn.9439.

    Genome annotation databases

    GeneIDi25648.
    KEGGirno:25648.
    UCSCiRGD:3716. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D67087 mRNA. Translation: BAA11090.1 .
    L10152 mRNA. No translation available.
    RefSeqi NP_037243.1. NM_013111.2.
    UniGenei Rn.9439.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P30823.

    Proteomic databases

    PaxDbi P30823.
    PRIDEi P30823.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25648.
    KEGGi rno:25648.
    UCSCi RGD:3716. rat.

    Organism-specific databases

    CTDi 6541.
    RGDi 3716. Slc7a1.

    Phylogenomic databases

    eggNOGi COG0531.
    HOGENOMi HOG000250623.
    HOVERGENi HBG000280.
    InParanoidi P30823.
    KOi K13863.
    PhylomeDBi P30823.

    Miscellaneous databases

    NextBioi 607511.

    Gene expression databases

    Genevestigatori P30823.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsi TIGR00906. 2A0303. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Takase-Yoden S., Watanabe R.
      Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of the cationic amino acid transporter (system y+) of the rat blood-brain barrier."
      Stoll J., Wadhwani K.C., Smith Q.R.
      J. Neurochem. 60:1956-1959(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-288.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiCTR1_RAT
    AccessioniPrimary (citable) accession number: P30823
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3