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Protein

High affinity cationic amino acid transporter 1

Gene

Slc7a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.By similarity
(Microbial infection) Acts as a receptor for the ecotropic murine retroviral leukemia virus.1 Publication

GO - Molecular functioni

  • arginine transmembrane transporter activity Source: RGD
  • basic amino acid transmembrane transporter activity Source: RGD

GO - Biological processi

  • arginine transport Source: RGD
  • basic amino acid transport Source: RGD
  • regulation of TOR signaling Source: RGD

Keywordsi

Molecular functionReceptor
Biological processAmino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cationic amino acid transporter 1
Short name:
CAT-1By similarity
Short name:
CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor
Ecotropic retrovirus receptor1 Publication
Short name:
EcoR1 Publication
Solute carrier family 7 member 1Imported
System Y+ basic amino acid transporter
Gene namesi
Name:Slc7a1Imported
Synonyms:Atrc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3716. Slc7a1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 57HelicalSequence analysisAdd BLAST22
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 102CytoplasmicSequence analysisAdd BLAST20
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 162ExtracellularSequence analysisAdd BLAST39
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 241ExtracellularSequence analysisAdd BLAST29
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 282CytoplasmicSequence analysisAdd BLAST20
Transmembranei283 – 302HelicalSequence analysisAdd BLAST20
Topological domaini303 – 332ExtracellularSequence analysisAdd BLAST30
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354 – 379CytoplasmicSequence analysisAdd BLAST26
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 403ExtracellularSequence analysis3
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 487CytoplasmicSequence analysisAdd BLAST63
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 521ExtracellularSequence analysisAdd BLAST13
Transmembranei522 – 546HelicalSequence analysisAdd BLAST25
Topological domaini547 – 554CytoplasmicSequence analysis8
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21
Topological domaini576 – 579ExtracellularSequence analysis4
Transmembranei580 – 600HelicalSequence analysisAdd BLAST21
Topological domaini601 – 624CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542631 – 624High affinity cationic amino acid transporter 1Add BLAST624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei618PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP30823.
PRIDEiP30823.

PTM databases

PhosphoSitePlusiP30823.
SwissPalmiP30823.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001234.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP30823.
PhylomeDBiP30823.

Family and domain databases

InterProiView protein in InterPro
IPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
PfamiView protein in Pfam
PF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

P30823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCKNLLSLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY
110 120 130 140 150
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GKPIGEFSRQ
160 170 180 190 200
HMALNAPGVL AQTPDIFAVI IIIILTGLLT LGVKESAMVN KIFTCINVLV
210 220 230 240 250
LCFIMVSGFV KGSIENWQLT ENKSSPLCGN NDTNVKYGEG GFMPFGFSGV
260 270 280 290 300
LSGAATCFYA FVGFDCIATT GEEVKNPQKA IPVGIVASLL ICFIAYFGVS
310 320 330 340 350
AALTLMMPYF CLDTDSPLPG AFKYRGWEEA KYAVAVGSLC ALSTSPLGSM
360 370 380 390 400
FPMPRVIYAM AEDGLLFKFL AKINDRTKTP IIATVTSGAI AAVMAFLFEL
410 420 430 440 450
KDLVDLMSIG TLLAYSLVAA CVLVLRYQPE QPNLVYQMAR TTDELDQVDQ
460 470 480 490 500
NEMVSASESQ TGFLPAAEKF SLKTILSPKN MEPSKFSGLI VNISAGLLAV
510 520 530 540 550
LIITVCIVAV LGREALAEGT LWAVFVMTGS VLLCMLVTGI IWRQPESKTK
560 570 580 590 600
LSFKVPFVPV LPVLSIFVNI YLMMQLDQGT WVRFAVWMLI AFAIYFGYGV
610 620
WHSEEASLAA GQAKTPDSNL DQCK
Length:624
Mass (Da):67,267
Last modified:October 1, 1996 - v1
Checksum:i33339B2F74E5F052
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111F → L in L10152 (PubMed:8473910).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67087 mRNA. Translation: BAA11090.1.
L10152 mRNA. No translation available.
UniGeneiRn.9439.

Genome annotation databases

UCSCiRGD:3716. rat.

Similar proteinsi

Entry informationi

Entry nameiCTR1_RAT
AccessioniPrimary (citable) accession number: P30823
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families