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P30823

- CTR1_RAT

UniProt

P30823 - CTR1_RAT

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Protein
High affinity cationic amino acid transporter 1
Gene
Slc7a1, Atrc1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.

GO - Molecular functioni

  1. arginine transmembrane transporter activity Source: RGD
  2. cationic amino acid transmembrane transporter activity Source: RGD

GO - Biological processi

  1. arginine transport Source: RGD
  2. basic amino acid transport Source: RGD
  3. regulation of TOR signaling Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cationic amino acid transporter 1
Short name:
CAT-1
Short name:
CAT1
Alternative name(s):
Ecotropic retroviral leukemia receptor
Ecotropic retrovirus receptor
Short name:
ERR
Solute carrier family 7 member 1
System Y+ basic amino acid transporter
Gene namesi
Name:Slc7a1
Synonyms:Atrc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3716. Slc7a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei36 – 5722Helical; Reviewed prediction
Add
BLAST
Topological domaini58 – 614Extracellular Reviewed prediction
Transmembranei62 – 8221Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 10220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Topological domaini124 – 16239Extracellular Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Topological domaini184 – 1918Cytoplasmic Reviewed prediction
Transmembranei192 – 21221Helical; Reviewed prediction
Add
BLAST
Topological domaini213 – 24129Extracellular Reviewed prediction
Add
BLAST
Transmembranei242 – 26221Helical; Reviewed prediction
Add
BLAST
Topological domaini263 – 28220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei283 – 30220Helical; Reviewed prediction
Add
BLAST
Topological domaini303 – 33230Extracellular Reviewed prediction
Add
BLAST
Transmembranei333 – 35321Helical; Reviewed prediction
Add
BLAST
Topological domaini354 – 37926Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Reviewed prediction
Add
BLAST
Topological domaini401 – 4033Extracellular Reviewed prediction
Transmembranei404 – 42421Helical; Reviewed prediction
Add
BLAST
Topological domaini425 – 48763Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei488 – 50821Helical; Reviewed prediction
Add
BLAST
Topological domaini509 – 52113Extracellular Reviewed prediction
Add
BLAST
Transmembranei522 – 54625Helical; Reviewed prediction
Add
BLAST
Topological domaini547 – 5548Cytoplasmic Reviewed prediction
Transmembranei555 – 57521Helical; Reviewed prediction
Add
BLAST
Topological domaini576 – 5794Extracellular Reviewed prediction
Transmembranei580 – 60021Helical; Reviewed prediction
Add
BLAST
Topological domaini601 – 62424Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 624624High affinity cationic amino acid transporter 1
PRO_0000054263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP30823.
PRIDEiP30823.

PTM databases

PhosphoSiteiP30823.

Expressioni

Gene expression databases

GenevestigatoriP30823.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP30823.
KOiK13863.
PhylomeDBiP30823.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

P30823-1 [UniParc]FASTAAdd to Basket

« Hide

MGCKNLLSLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV    50
YVLAGAVARE NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY 100
SYVTVGELWA FITGWNLILS YIIGTSSVAR AWSATFDELI GKPIGEFSRQ 150
HMALNAPGVL AQTPDIFAVI IIIILTGLLT LGVKESAMVN KIFTCINVLV 200
LCFIMVSGFV KGSIENWQLT ENKSSPLCGN NDTNVKYGEG GFMPFGFSGV 250
LSGAATCFYA FVGFDCIATT GEEVKNPQKA IPVGIVASLL ICFIAYFGVS 300
AALTLMMPYF CLDTDSPLPG AFKYRGWEEA KYAVAVGSLC ALSTSPLGSM 350
FPMPRVIYAM AEDGLLFKFL AKINDRTKTP IIATVTSGAI AAVMAFLFEL 400
KDLVDLMSIG TLLAYSLVAA CVLVLRYQPE QPNLVYQMAR TTDELDQVDQ 450
NEMVSASESQ TGFLPAAEKF SLKTILSPKN MEPSKFSGLI VNISAGLLAV 500
LIITVCIVAV LGREALAEGT LWAVFVMTGS VLLCMLVTGI IWRQPESKTK 550
LSFKVPFVPV LPVLSIFVNI YLMMQLDQGT WVRFAVWMLI AFAIYFGYGV 600
WHSEEASLAA GQAKTPDSNL DQCK 624
Length:624
Mass (Da):67,267
Last modified:October 1, 1996 - v1
Checksum:i33339B2F74E5F052
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111F → L in L10152. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D67087 mRNA. Translation: BAA11090.1.
L10152 mRNA. No translation available.
RefSeqiNP_037243.1. NM_013111.2.
UniGeneiRn.9439.

Genome annotation databases

GeneIDi25648.
KEGGirno:25648.
UCSCiRGD:3716. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D67087 mRNA. Translation: BAA11090.1 .
L10152 mRNA. No translation available.
RefSeqi NP_037243.1. NM_013111.2.
UniGenei Rn.9439.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P30823.

Proteomic databases

PaxDbi P30823.
PRIDEi P30823.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25648.
KEGGi rno:25648.
UCSCi RGD:3716. rat.

Organism-specific databases

CTDi 6541.
RGDi 3716. Slc7a1.

Phylogenomic databases

eggNOGi COG0531.
HOGENOMi HOG000250623.
HOVERGENi HBG000280.
InParanoidi P30823.
KOi K13863.
PhylomeDBi P30823.

Miscellaneous databases

NextBioi 607511.

Gene expression databases

Genevestigatori P30823.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
TIGRFAMsi TIGR00906. 2A0303. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Takase-Yoden S., Watanabe R.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of the cationic amino acid transporter (system y+) of the rat blood-brain barrier."
    Stoll J., Wadhwani K.C., Smith Q.R.
    J. Neurochem. 60:1956-1959(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-288.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCTR1_RAT
AccessioniPrimary (citable) accession number: P30823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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